Presentation
// Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p176 A definition of the term "Argyll Robertson pupil," which pertains to a symptom present in paralysis and locomotor ataxia, is presented. [connection.ebscohost.com]
Small fiber modalities are involved earlier than large fiber deficits (burning; lancinating pain; deep muscle ache); later loss of vibration and proprioception in the legs-if severe may present as diabetic pseudo-tabes. [neurodiffdx.com]
The pseudotabes syndrome, when present, usually occurs during the course of diabetes, but may present itself as the initial clinical manifestation of diabetes before the overt stage of hyperglycemia and glycosuria. [eurekamag.com]
PowerPoint Presentation: Small epidermal nerve fibers stain positive for the neuronal antigen protein gene product 9.5 (PGP 9.5). Treatment : Strict glucose control from the time of diagnosis of DM is the most important aspect of treatment. [authorstream.com]
Entire Body System
- Pain
Intestinal crises (abdominal pain and diarrhea), rectal crises (painful tenesmus), and laryngeal crises (pain in the larynx, hoarseness, and stridor) are rare. [std-aid.com]
In none was there any complaint of pain. [documents.tips]
These questionnaires use verbal descriptors and pain qualities as a basis for distinguishing neuropathic pain from other types of chronic pain such as nociceptive pain [49]. [oncohemakey.com]
Deep, aching, severe night pains Paroxysmal jabbing pain Pain – small fiber neuropathy Diabetic Peripheral Neuropathy - 6 More severe cases – Pain & temp loss with intact vibration and position sense; the reflexes and power may be normal – suggests A [slideserve.com]
Postherpetic Neuralgia: Pain that follows herpes zoster infection. [quizlet.com]
- Asymptomatic
The nephropathy that develops in type 2 DM differs from that of type 1 DM in the following respects: (1) Microalbuminuria or macroalbuminuria may be present when type 2 DM is diagnosed reflecting its long asymptomatic period; (2) Hypertension more commonly [freethesaurus.com]
[…] neuropathy Inflammatory neuropathy Compression Neuropathy in Diabetics Median nerve at the carpal tunnel: Related to body mass index in diabetic patients 6–12% of CTS patients have diabetes 10% of diabetic patients has asymptomatic CTS Median nerve neuropathy [neurodiffdx.com]
Known As Diabetic neuropathy is also known as acute painful diabetic neuropathy, amyotrophy due to type 2 diabetes mellitus, amyotrophy in diabetes type 2, asymmetric diabetic proximal motor neuropathy, asymptomatic diabetic neuropathy, charcot’s arthropathy [healthresearchfunding.org]
10-CM E11.40 Type 2 diabetes mellitus with diabetic neuropathy, unspecified Approximate Synonyms Acute painful diabetic neuropathy Amyotrophy due to type 2 diabetes mellitus Amyotrophy, in diabetes type 2 Asymmetric diabetic proximal motor neuropathy Asymptomatic [icd9data.com]
- Falling
Patient stands, BP aft 2 m. Normal response- fall of <10 mmHg, Borderline - fall of 10–29 mmHg Abnormal - fall of >30 mmHg with symptoms 44. Diastolic blood pressure response to isometric exercise Squeeze handgrip dynamometer to a max. [slideshare.net]
Insulin requirements fall to prepregnancy levels within the first 24 hours after delivery. The order in which obese people with type 2 diabetes eat their food can affect their blood sugar levels a small study suggests. [gospelblues.eu]
Dizziness, drowsiness, trouble sleeping, and confusion can increase the risk of falling. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. [webmd.com]
[…] acute symptoms indicating CHOA onset and progress (Fig. 15.8 ) Fig. 15.8 Foot in the CHOA acute stage. ( a ) Acute CHOA in the region of the ankle with a marked swelling of soft structures; ( b ) involvement of the left foot with swelling and subsequent fall [musculoskeletalkey.com]
Plasma insulin levels fall, and insulin secretory responses to glucose become impaired during surgery. 17 – 19 The mechanism of the impaired β-cell responsiveness during surgery is unclear, and the defect is poorly correlated with ambient intraoperative [spectrum.diabetesjournals.org]
- Surgical Procedure
It is therefore imperative that careful attention be paid to the metabolic status of people with diabetes undergoing surgical procedures. [spectrum.diabetesjournals.org]
Full Text: In Brief I Diabetes is associated with increased requirement for surgical procedures and increased postoperative morbidity and mortality. [go.galegroup.com]
- Pallor
Here, I show that her physical ailments spanned 30 years and included sore mouth, pallor, paresthesias, the Lhermitte symptom, fever, headaches, fatigue, resting tachycardia, edema, episodic weight loss, progressive weakness, ataxia, and visual impairment [muse.jhu.edu]
Gastrointestinal
- Nausea
Symptoms may include Numbness in your hands, legs, or feet Shooting pains, burning, or tingling Nausea, vomiting, constipation, or diarrhea Problems with sexual function Urinary problems Dizziness when you change positions quickly Your doctor will diagnose [icdlist.com]
DOC for motion sickness: Hyoscine (transdermal)[Hyoscine aka Scopolamine: also Prescribed to 'Prevent' nausea & vomiting caused by Motion Sickness & Vertigo.] 7. Commonest sife-effect of Cisapride is: Diarrhea 8. [mypgnotes.com]
The most common form is a gastric crisis consisting of intense epigastric pain, nausea, and vomiting. [std-aid.com]
Side Effects Side Effects Nausea, vomiting, trouble sleeping, dizziness, headache, or nervousness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [webmd.com]
- Vomiting
Common side-effect of Cisplatin: Vomiting 12. Vitamin deficiency noticed with phenytoin use: Folic acid,Vitamin D, and some says vitamin K as well. 13. DOC for lithium induced Polyuria: Amiloride 14. [mypgnotes.com]
Symptoms may include Numbness in your hands, legs, or feet Shooting pains, burning, or tingling Nausea, vomiting, constipation, or diarrhea Problems with sexual function Urinary problems Dizziness when you change positions quickly Your doctor will diagnose [icdlist.com]
These drugs form the mainstay of treatment during vomiting bouts. [jnnp.bmj.com]
The most common form is a gastric crisis consisting of intense epigastric pain, nausea, and vomiting. [std-aid.com]
Cardiovascular
- Hypotension
Authors, , Source MeSH Aged Basal Ganglia Diseases Diabetic Neuropathies Humans Hypotension, Orthostatic Male Peripheral Nervous System Diseases Pub Type(s) Journal Article Language pol PubMed ID 4337654 TY - JOUR T1 - [Pseudotabes diabetica in the light [unboundmedicine.com]
MEDICINE MAHARAT NAKORNRAJSIMA HOSPITAL 2 About 60-70% have mild to severe forms of nervous system damage, including: Impaired sensation or pain in the feet or hands Slowed digestion of food in the stomach Carpal tunnel syndrome Orthostatic hypotension [slideplayer.com]
ORTHOSTATIC HYPOTENSION The most serious clinical consequence of vascular denervation is orthostatic hypotension. [jnnp.bmj.com]
[…] exam w opthalmoscope Ketone breath Candida infection Dental infection around gums Carotid equality & bruits Percuss and auscultate for infection Pneumonia percussion note Injection site bruises & fat dystrophy Acanthosis nigricans Skin tags Postural hypotension [quizlet.com]
- Vascular Disease
Many other medical and surgical disorders affect the spinal cord, including vascular disease, decom pression sickness, degenerative disorders and multiple sclerosis. In this book Dr. Critchley and Dr. [books.google.de]
[…] demyelinating disease · syringomyelia (bilateral Horner's syndrome) · intrinsic cervical cord disease (vascular or neoplastic) · cervical node metastases · local (neck) neoplasia · local (neck) trauma, eg. stab wound · carotid or aortic aneurysm · cervical [sinoemedicalassociation.org]
Nonatheromatous peripheral vascular disease of the lower extremity in diabetes mellitus. Diabetes 1959;8:261-273. 2. LoGerfo FW, Coffman JD. Current concepts. Vascular and microvascular disease of the foot in diabetes. Implications for foot care. [diabetesaid.com]
DryHines TJEA: The role of diabetes in the development of degenerative vascular disease: with special reference to the incidence of retinitis and peripheral neuritis, Ann. Int. Med. 14: 1893, 1941. LinkGoogle Scholar This content is PDF only. [acpjournals.org]
Eyes
- Eye Pain
Clinically, patients notice the onset of eye pain or headache, followed by diplopia. The ophthalmoplegia reflects muscle weakness in the distribution of a single oculomotor nerve. [mitchmedical.us]
Skin
- Foot Ulcer
▲ diabetic neuroarthropathy diabetic neuroarthropathy diabetic neuropathic cachexia Diabetic Neuropathic Foot Ulcer Diabetic Neuropathic Plantar Ulcer Diabetic neuropathies Diabetic neuropathies diabetic neuropathy diabetic neuropathy diabetic neuropathy [medical-dictionary.thefreedictionary.com]
Young MJ, Manes C, Boulton AJM: Vibration perception threshold predicts foot ulceration. Diabet Med 1992;9(suppl 2):542. [karger.com]
Annual comprehensive foot examination should be done in all diabetic patients to identify risk conditions suggestive of ulcers and amputations But for patients with insensate feet, foot deformities, or a history of foot ulcers, feet examination should [specialty.mims.com]
DM 2 w diabetic neuropathic foot ulcer, DM 2 w diabetic neuropathic heel and midfoot ulcer, DM 2 w diabetic neuropathic toe ulcer, DM 2 w diabetic neuropathy, DM 2 W diabetic peripheral neuropathy, DM 2 w diabetic peripheral sensory neuropathy, DM 2 [healthresearchfunding.org]
DM 2 w diabetic neuropathic foot ulcer DM 2 w diabetic neuropathic heel and midfoot ulcer DM 2 w diabetic neuropathic toe ulcer DM 2 w diabetic neuropathy DM 2 W diabetic peripheral neuropathy DM 2 w diabetic peripheral sensory neuropathy DM 2 W diabetic [icd9data.com]
Musculoskeletal
- Neuropathic Arthropathy
[…] ankle ulcer due to type 2 diabetes mellitus, neuropathic arthropathy due to type 2 diabetes mellitus, neuropathic foot ulcer due to type 2 diabetes mellitus, neuropathic midfoot AND/OR heel ulcer due to type 2 diabetes mellitus, neuropathic toe ulcer [healthresearchfunding.org]
arthropathy Unlike syphilis diabetic neuroapthic arthropathy involves small joints of feet Diabetic pseudotabes Diabetic lumbosacral radiculoplexus neuropathy (Bruns-Garland syndrome): Clinical features Males more frequently affected than females Pain [authorstream.com]
- Back Pain
[…] narrowed Subluxation of the FACET JOINTS Spondylolisthesis - slippage of one vertebra over another Boney Changes: Clinical Features of Bony Changes Clinical Features of Bony Changes: Multiple root involvement Widespread arthritic changes Long standing low back [quizlet.com]
Neurologic
- Myelopathy
[…] diabetic glomerulosclerosis diabetic glucose tolerance diabetic glycosuria diabetic hand diabetic ketoacidosis diabetic lipemia diabetic macroangiopathy diabetic macular edema diabetic maculopathy diabetic mastopathy diabetic microangiopathy diabetic myelopathy [medical-dictionary.thefreedictionary.com]
GarlandTaverner HD: Diabetic myelopathy, Brit. M. J. 1: 1405, 1953. CrossrefMedlineGoogle Scholar 12. BrochKlovstad OJO: Polyneuritis in diabetes mellitus, Acta med. Scandinav. 127: 514, 1947. CrossrefMedlineGoogle Scholar 13. [acpjournals.org]
The term diabetic myelopathy was introduced by Bruns in 1890 and was displaced by Garland in 1955 when it became clinically and pathologically apparent that the disease process was not a myelopathy. '123' Garland suggested the intentionally nonlocalizing [mitchmedical.us]
H. el al: diabetic Myelopathy. Brit.Med... 1: 1405-1408.1953. 25. GARLAND. H. diabetic amyothophy. British Medical Journal 26-1287,1955. 26. HAMILTON, C.R. et al.: Diabetic Amyotrophy, clinical and electromicroscopic studies in six patients, Amer. [revistaendocrino.org]
· complex partial seizures · secondarily generalised partial seizure · temporal lobe epilepsy · Jacksonian seizures other: hysterical faints unknown cause (40%) ABSENT LOWER LIMB REFLEXES WITH EXTENSOR PLANTAR RESPONSE · diabetes mellitus + cervical myelopathy [sinoemedicalassociation.org]
- Seizure
') · akinetic (atonic) seizures · myoclonus with loss of consciousness partial (focal; usually no LOC, unless with 2° generalisation): · simple partial seizures · complex partial seizures · secondarily generalised partial seizure · temporal lobe epilepsy [sinoemedicalassociation.org]
Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, seizure. A very serious allergic reaction to this drug is rare. [webmd.com]
Hereditary Neuropathies: Porphyria Porphyria abnormal heme metabolism acute motor neuropathy with autonomic findings precipitated by barbiturates or other drugs associated with recurrent episodes of seizures, psychiatric disturbances, abdominal pain Bell's [quizlet.com]
- Decreased Proprioception
When these manifestations coexist with decreased proprioception in the feet, "pseudotabetic" gait may occur. diabetic tabes An obsolete term for diabetic neuropathy. See also: tabes [medical-dictionary.thefreedictionary.com]
- Abnormal Gait
DANIL HAMMOUDI.MD SINOE MEDICAL ASSOCIATION DETAILS ARE COMING FOR EACH OF THESE SYNDROME ABNORMAL GAIT (excluding orthopaedic causes) hemiplegia (cerebrovascular accident involving motor cortex or pyramidal tract) parkinsonism (shuffling / festinant) [sinoemedicalassociation.org]
- Giddiness
Patients may then complain at the least of mild giddiness and at most may be disabled by the condition, unable to stand for more than a few minutes at a time, although this state is very rare. [jnnp.bmj.com]
Urogenital
- Overflow Incontinence
[…] due to colonic hypomotility is more common than diarrhea. Bacterial overgrowth may occur. 25. Impaired bladder sensation - first symptom of GU dysfunction. Bladder atony - prolonged intervals between voiding, urinary retention, overflow incontinence [slideshare.net]
Gradually, residual urine volume increases and, in severe cases, gross bladder retention occurs with abdominal swelling and sometimes overflow incontinence as well. Bladder capacity may exceed one litre. [jnnp.bmj.com]
- Uremia
Orthostatic hypotension and sexual dysfunction Mechano dynamic and static allodynia; hyperalgesia are common Cramps of the feet and thigh (neurogenic cramps) Differential diagnosis of burning feet DM HIV (Distal neuropathy) INH Pyridoxine excess or deficiency Uremia [neurodiffdx.com]
The most important differential diagnoses from the general medicine perspective include neuropathies caused by alcohol abuse, uremia, hypothyroidism, vitamin B 12 deficiency, peripheral arterial disease, paraneoplastic syndromes, inflammatory and infectious [oncohemakey.com]
- Urinary Incontinence
Faecal And Urinary Incontinence The expression of TRPV1 in the bladder is, however, not restricted to afferent nerves urothelium, detrusor muscle and fibroblasts also express TRPV1 in the human bladder 140. [europeanmedical.info]
Treatment
Neurosyphilis: Diagnosis and Response to Treatment. Musher, Daniel M. // Clinical Infectious Diseases;10/1/2008, Vol. 47 Issue 7, p900 The author reflects on the article about the serological response to treatment of neurosyphilis. [connection.ebscohost.com]
Percutaneous electrical nerve stimulation should be considered for the treatment of PDN (Level B). Electromagnetic field treatment, low-intensity laser treatment, and Reiki therapy should probably not be considered for the treatment of PDN (Level [slideshare.net]
Uremic Polyneuropathy: Cause And Treatment Cause 300-2000 molecular weight toxins Treatment: symptomatic renal transplant Second most common cause of neuropathy Pathogenesis direct toxic effect nutritional (B1, B3, B6, B12, folic acid, zinc) Symmetric [quizlet.com]
[…] and hyperintensive treatment, the treatment of end-stage diabetic nephropathy, and combined pancreas and kidney transplantation. 2005), DD genotype of ACE gene is a predisposing factor for chronic kidney disease (CKD) terminating nephrotic syndrome in [freethesaurus.com]
Emerging Treatments in Diabetic Wound Care. [opther.eu]
Prognosis
Argyll Robertson Pupil Prognosis Most sufferers do well after treatment. The outcome is poorest for patients who suffer permanent nerve or cardiac damage. Life expectancy is poor due to inability to reverse these symptoms of such advanced disease. [patienthelp.org]
H&P( Most Important) Lumbar puncture EMG- Great for determining Myelination Serology Toxicology For This( Protein goes up, cell count is normal Guillain Bare Syndrome/ Treatment: Treatment: Supportive care Plasmapheresis IV IgG No role for steroids Prognosis [quizlet.com]
PROGNOSIS Autonomic function declines with age, but in diabetes it deteriorates, on average, faster than in normal subjects. [jnnp.bmj.com]
[…] intercostal nerve trunk involvement Focal contact hyperesthaesiae in the same area as the pain Truncal Neuropathy PowerPoint Presentation: Focal anterior abdominal wall weakness may be evident Associated weight loss in some cases may be profound Good prognosis [authorstream.com]
Causes and prognosis in 4,278 cases of paralysis of the oculomotor, trochlear, and abducens cranial nerves. Am J Ophthalmol 1992; 113: 489–496. Google Scholar | Crossref | Medline | ISI 95. Casellini, CM, Vinik, AI. [journals.sagepub.com]
Etiology
Diabetic Neuropathy—New Concepts of Its Etiology R. [semanticscholar.org]
The etiology, pathology and therapy are essentially unknown, and the diagnosis itself is one of exclusion and beset with many pitfalls.1 One of the few areas in this perplexing field that has won wide acceptance by many leading authorities is that the [acpjournals.org]
The etiologies of focal myopathies include traumatic (associated with insulin injection injury) and vascular (related to thigh muscle infarction). [mitchmedical.us]
[…] large fibers Autonomic neuropathies Small-fiber neuropathies 3 Focal/multifocal neuropathies Cranial neuropathies Thoracoabdominal radiculopathies Focal limb neuropathies Proximal neuropathies Compression and entrapment neuropathies The most important etiologic [oncohemakey.com]
Epidemiology
Five general areas are addressed in the 36 chapters: descriptive epidemiology of diabetes in the U.S., including prevalence, incidence, sociodemographic & metabolic characteristics, risk factors for developing diabetes, & mortality. [books.google.de]
Nephrology, pathology, internal medicine, diabetology, and other specialists from Germany, the US, and Lebanon address the relationship between the kidney and diabetes and cover the epidemiology, history, pathophysiology, histology, genetic risk factors [freethesaurus.com]
Williams DRR: The size of the problem: Epidemiological and economic aspects of foot problems in diabetes; in Boulton AJM, Connor H, Cavanagh PR (eds): The Foot in Diabetes, ed 2. Chichester, Wiley, 1994, pp 15–24. [karger.com]
"Blood Pressure" [SH] (epidemiology AND humans) [SH] SI Secondary Source ID The SI field identifies secondary source databanks and accession numbers, e.g., GenBank, GEO, PubChem, ClinicalTrials.gov, ISRCTN. [biomedsearch.com]
Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Pain Med 2008; 9: 660–674. Google Scholar | Crossref | Medline | ISI 12. Obrosova, IG. [journals.sagepub.com]
Pathophysiology
Regarding patients with nerve infarction, the onset is acute and painful, the pathophysiology reflects axon loss, and recovery is often slow and suboptimal. [mitchmedical.us]
Comparative renal pathophysiology relevant to IDDM and NIDDM patients. Diab Metab Rev 1988;4:453-483. 8. Cunha-Vaz JG. Studies on the pathophysiology of diabetic retinopathy. The blood-retinal barrier in diabetes. Diabetes 1983;32:20-27. 9. [diabetesaid.com]
Nephrology, pathology, internal medicine, diabetology, and other specialists from Germany, the US, and Lebanon address the relationship between the kidney and diabetes and cover the epidemiology, history, pathophysiology, histology, genetic risk factors [freethesaurus.com]
Loss of myelinated nerve fibers Segmental remyelination and demyelination Basement membranes of intraneural capillaries are thickened and duplicated Areas of perivascular inflammation ( said,dyck et al) Biochemical mechanisms Pathology and pathophysiology [authorstream.com]
[…] non noxious stimuli with sensory deficits, anoxexia, weight loss, depression Generally recovers Hyperglycemic Neuropathy Widespread parasthesias in newly diagnosed cases, after recovery from ketosis Improve rapidly with control, could have a different pathophysiologic [slideserve.com]
Prevention
[…] readings management weight gestational prevention review mellitus studies Natural Treatment for Herpes. [opther.eu]
/Avoidable - 67% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis of Alcohol 0% Unclassified 0% We Could [medicbind.com]
Controlling your blood sugar can help prevent nerve problems, or keep them from getting worse. Treatment may include pain relief and other medicines. [icdlist.com]
Diabetic neuritis is not a new condition, yet little progress seems to have been made in its prevention or cure. Although previous to 1864 symptoms suggestive of the degeneration of nerves [jamanetwork.com]