It can be associated with: Chest discomfort Leg swelling Difficulty breathing at night Patients develop these symptoms slowly, over years, thinking they are just getting older, and start to do less and less activity. [sharecare.com]

Although heart failure (HF) is a major cause of premature mortality, there is little information regarding its prevalence and associated risk factors in patients with rheumatoid arthritis (RA). [jrheum.org]

Leg venous stasis and ulcers: Poor circulation can cause skin to thicken, change color and look shiny. Hair may fall out and ulcers can develop if you sustain an injury. [baptisthealth.com]

Diastolic heart failure: neglected or misdiagnosed? J Am Coll Cardiol. 2002; 39 (1):138–141. [ PubMed ] [ Google Scholar ] 14. Smith GL, Masoudi FA, Vaccarino V, Radford MJ, Krumholz HM. [ncbi.nlm.nih.gov]

Unless the simpler model were preferred, the interaction could be neglected and it was checked whether the two-level factor was significant. [erj.ersjournals.com]

Banerjee P, Banerjee T, Khand A, C lark AL, Cleland JG: Diastolic heart failure: neglected or misdiagnosed? J Am Coll Cardiol 2002, 39: 138-141. 10.1016/S0735-1097(01)01704-1 83. [cardiovascularultrasound.biomedcentral.com]