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Diazinon Poisoning


Presentation

  • A clinical description of the disease is then presented and variations in India from the standard description are highlighted.[books.google.com]
  • Marked diaphoresis and copious bronchial secretions were present. He was intubated, but was alert and oriented. Bilateral severe ptosis was present. Pupils were miotic and sluggishly reactive to light stimulation. Convergence was absent.[jnnp.bmj.com]
  • Bone growth difficulties are present in four of five children. One child has delayed menarche.[ncbi.nlm.nih.gov]
  • The reason for this correlation is not known at present.[jpgmonline.com]
  • Activated charcoal, combined with a cathartic, is also indicated in most poisonings presenting within 60 minutes of ingestion.[aafp.org]
Fatigue
  • Headache, fatigue, soreness in joints, irritation of nose and throat. Yes. Fever, intense thirst, vomiting, muscle twitches, pinpoint pupils, unconsciousness. Yes.[articles.extension.org]
  • Victims may also have symptoms of anemia, including fatigue. If poisoning is severe, the victim may progress to shock and death. Zinc phosphide Poisonings by ingested zinc phosphide are extremely difficult to manage.[extension.missouri.edu]
Sputum
  • Blood, urine, stool, sputum, and CSF cultures were negative. The patient was extubated on the third day after admission, only to require reintubation for hypoxic respiratory failure. Pupillary miosis, copious secretions, and diarrhoea were noted.[jnnp.bmj.com]
Nausea
  • Convulsions Lungs Breathing difficulty Chest tightness Nervous system Anxiety Coma Dizziness Excitability Headache Weakness Tremor Twitching Skin Irritation Redness Sweating Stomach and gastrointestinal tract Abdominal cramps Diarrhea Loss of appetite Nausea[indiatoday.intoday.in]
  • […] pressure Slow or rapid heart rate Weakness NERVOUS SYSTEM Agitation Anxiety Coma Confusion Convulsions Dizziness Headache Muscle Twitching SKIN Blue lips and fingernails Sweating STOMACH AND GASTROINTESTINAL TRACT Abdominal cramps Diarrhea Loss of appetite Nausea[medlineplus.gov]
  • The signs and symptoms of Diazinon Poisoning may include: Nausea, vomiting, cramping of stomach/abdomen Chest pain or tightness Breathing difficulties; absence of breathing Headaches Irregular heart-rate Increased or decreased blood pressure (hypertension[dovemed.com]
  • Mild Poisoning or Early Symptoms of Acute Poisoning headache, fatigue, weakness, dizziness, restlessness, nervousness, perspiration, nausea, diarrhea, loss of appetite, loss of weight, thirst, moodiness, soreness in joints, skin irritation, eye irritation[articles.extension.org]
  • Acute symptoms in the family members included headaches, nausea, skin irritation, runny nose, and vomiting. The family was first evaluated at 3 months and then 3 years after the acute poisoning.[ncbi.nlm.nih.gov]
Abdominal Pain
Liver Dysfunction
  • It gives the knowledge of the therapeutic efficacy and severity of liver dysfunction. Methods: Blood samples were taken from normal male adults as control and PChE is estimated.[ijbcp.com]
Lacrimation
  • Signs and Symptoms Muscarinic signs (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock.[openanesthesia.org]
  • […] chlordane–little used due to long-term persistence in environment, and cholinesterase inhibitors–either organophosphates–esters of phosphoric acid or thiophosphoric acid, carbamates–synthetic derivatives of carbamic acid Clinical Drooling, defecation, lacrimation[medical-dictionary.thefreedictionary.com]
  • The initial symptoms of humans are nausea, dizziness, salivation, headache, sweating, lacrimation, and rhinorrhea.[en.wikipedia.org]
Ptosis
  • Bilateral severe ptosis was present. Pupils were miotic and sluggishly reactive to light stimulation. Convergence was absent. Voluntary conjugate pursuit eye movements were markedly limited in range (less than 10 ) in all directions.[jnnp.bmj.com]
Strabismus
  • J Pediatr Ophthalmol Strabismus 1982 ; 19 : 318 –19. Hata S , Bernstein E, Davis LE. Atypical ocular bobbing in acute organophosphate poisoning. Arch Neurol 1986 ; 43 : 185 –6. Wadia RS , Sadagopan C, Amin RB, et al .[jnnp.bmj.com]
Muscle Twitch
  • Twitching SKIN Blue lips and fingernails Sweating STOMACH AND GASTROINTESTINAL TRACT Abdominal cramps Diarrhea Loss of appetite Nausea and vomiting Call the poison control center for appropriate treatment instructions.[medlineplus.gov]
  • Severe or Acute Poisoning fever, intense thirst, increased rate of breathing, vomiting, uncontrollable muscle twitches, pinpoint pupils, convulsions, inability to breathe, unconsciousness.[articles.extension.org]
  • Breathing may become difficult, and muscles twitch and become weak. Rarely, shortness of breath or muscle weakness is fatal.[msdmanuals.com]
  • twitching, respiratory and/or cardiovascular depression, death Dx Hx, signs and Sx, acetylchoinesterase in RBCs and serum, which falls to 50% of normal; signs and Sx of organophosphate poisoning occur when acetylcholinesterase has fallen to 20% of normal[medical-dictionary.thefreedictionary.com]
  • There can be many symptoms, though they may not be as clear-cut in children as they are in adults: blurred vision; tearing and sweating; loss of bowel and bladder control; difficulty breathing, as the airway may fill with fluid; tremors, muscle twitching[poison.org]
Headache
  • […] and throat Small pupils (unreactive to light) Tearing, increased Heart and blood circulation Low or high blood pressure Slow or rapid heart rate Convulsions Lungs Breathing difficulty Chest tightness Nervous system Anxiety Coma Dizziness Excitability Headache[indiatoday.intoday.in]
  • THROAT Increased salivation Increased tears in the eyes Small or dilated pupils that do not react to light HEART AND BLOOD Low or high blood pressure Slow or rapid heart rate Weakness NERVOUS SYSTEM Agitation Anxiety Coma Confusion Convulsions Dizziness Headache[medlineplus.gov]
  • The signs and symptoms of Diazinon Poisoning may include: Nausea, vomiting, cramping of stomach/abdomen Chest pain or tightness Breathing difficulties; absence of breathing Headaches Irregular heart-rate Increased or decreased blood pressure (hypertension[dovemed.com]
  • Headache, fatigue, soreness in joints, irritation of nose and throat. Yes. Fever, intense thirst, vomiting, muscle twitches, pinpoint pupils, unconsciousness. Yes.[articles.extension.org]
  • Acute symptoms in the family members included headaches, nausea, skin irritation, runny nose, and vomiting. The family was first evaluated at 3 months and then 3 years after the acute poisoning.[ncbi.nlm.nih.gov]
Upbeat Nystagmus
  • Primary position upbeat nystagmus with organophosphate poisoning. J Pediatr Ophthalmol Strabismus 1982 ; 19 : 318 –19. Hata S , Bernstein E, Davis LE. Atypical ocular bobbing in acute organophosphate poisoning. Arch Neurol 1986 ; 43 : 185 –6.[jnnp.bmj.com]
Ocular Flutter
  • On the basis of clinical observation the saccadic oscillations were presumed to be opsoclonus and ocular flutter.[jnnp.bmj.com]
Ocular Bobbing
  • Atypical ocular bobbing in acute organophosphate poisoning. Arch Neurol 1986 ; 43 : 185 –6. Wadia RS , Sadagopan C, Amin RB, et al . Neurological manifestations of organophosphorus insecticide poisoning.[jnnp.bmj.com]
Nystagmus
  • In two patients with slowed voluntary eye movements, caloric stimulation revealed nystagmus in one patient and conjugate eye deviation in the other.[jnnp.bmj.com]

Workup

  • See Workup. Treatment begins with decontamination. Airway control and oxygenation are paramount. The mainstays of pharmacological therapy include atropine, pralidoxime (2-PAM), and benzodiazepines (eg, diazepam).[emedicine.medscape.com]

Treatment

  • Prolonged treatment often is needed to reverse the poisoning, including intensive care hospitalization and long-term therapy. Some toxicity may persist for weeks or months, or even longer. References Robey WC III, Meggs WJ.[indiatoday.intoday.in]
  • If the person is not decontaminated before getting to the hospital, emergency room personnel will decontaminate the person and provide other treatment.[medlineplus.gov]
  • Among individuals with alcohol and diazinon poisoning, following the treatment, the serum PChE levels were raised comparatively on 1st day. The value is 100 µmol/ml.[ijbcp.com]
  • Fecal transplant is used to treat gut infections and is now being studied as a treatment for obesity, urinary tract infections, irritable bowel syndrome and more.[nytimes.com]

Prognosis

  • The prognosis of Diazinon Poisoning is dependent on the amount of substance consumed, time between consumption and treatment, severity of the symptoms, as well as general health status of the patient If the individual can recover from the symptoms within[dovemed.com]
  • Pseudo cholinesterase activity as a guide to prognosis in malnutrition. American J clini pathol. 1973;50:712-6. Kar NC, Pearson CM. Cholinesterase and esterase activity in normal and dystrophic muscle biochemical. Colorimetric methods of analysis.[ijbcp.com]
  • […] through a vein (IV) Irrigation (washing of the skin and eyes), perhaps every few hours for several days Medicine (antidote) to reverse the effects of the poison Tube through the mouth into the stomach to wash out the stomach ( gastric lavage ) Outlook (Prognosis[indiatoday.intoday.in]
  • The clinical relevance of these changes to prognosis is not yet clear. This study was therefore, undertaken to evaluate the importance of ECG changes to the ultimate prognosis in OPC poisoning.[jpgmonline.com]
  • Prognosis Prognosis depends on the specific chemical of exposure, magnitude and time of exposure, progression of symptoms (severity), and onset for medical attention.[medical-dictionary.thefreedictionary.com]

Epidemiology

  • Each chapter begins with a shot historical account of the disease, followed by a critical evaluation of the epidemiological and/or hospital based data. This is then compared with the data of other global populations.[books.google.com]
  • Methods Statistics Trigonometry Medical & Nursing Anatomy Anesthesiology Audiology Bacteriology Biochemistry Bioethics Biomedical Science Cardiology Cardiovascular Childbirth Chiropractic Dentistry Dermatology Diagnostic Imaging Drugs Endocrinology Epidemiology[brainscape.com]
  • Although most patients rapidly become symptomatic, the onset and severity of symptoms depend on the specific compound, amount, route of exposure, and rate of metabolic degradation. [5] Epidemiology Frequency United States In 2016, the American Association[emedicine.medscape.com]
  • Journal of Exposure Science and Environmental Epidemiology. 23 (2): 190–196. doi : 10.1038/jes.2012.71. ISSN 1559-0631. PMID 22805989.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • These have included difficulties in executive functions, psychomotor speed, verbal, memory, attention, processing speed, visual-spatial functioning, and coordination. [4] Pathophysiology The primary mechanism of action of organophosphate pesticides is[emedicine.medscape.com]

Prevention

  • You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. Take the container with you to the hospital, if possible.[indiatoday.intoday.in]
  • Prevent Bee Poisoning Bees are essential for the pollination of most trees, small fruits and flowering field crops.[omafra.gov.on.ca]
  • Prevention Adherence to accepted guidelines for handling and management is the key to preventing insecticide poisoning. These may include masks, gowns, gloves, goggles, respiratory breathing machines, or hazardous material suits.[medical-dictionary.thefreedictionary.com]

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