Presentation
We present a 30-year-old man with probable primary APS (with no history of thromboses) presenting with diffuse alveolar hemorrhage, an uncommon presentation. [ncbi.nlm.nih.gov]
Entire Body System
- Chinese Herbal Drugs
We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. [ncbi.nlm.nih.gov]
Respiratoric
- Decreased Breath Sounds
She again began to feel short of breath on HD #24 with symptoms of lightheadedness and weakness. Exam was notable for decreased breath sounds to bilateral bases and CXR performed at the time revealed bilateral patchy disease. [uscmedicine.blog]
Cardiovascular
- Diastolic Murmur
Other manifestations depend on the underlying disorder (eg, diastolic murmur in patients with mitral stenosis). [merckmanuals.com]
Eyes
- Retinal Damage
An uncommon side effect of hydroxychloroquine is retinal damage. Serious side effects of rituximab include immunosuppression, infusion reactions, bowel perforation, and future malignancies. [clinicaladvisor.com]
Neurologic
- Forgetful
Don’t forget: There are many, many causes of DAH, but think of the main etiologies of DAH in 5 broad categories: vasculitidies (ex: MPA, GPA, EGPA) other autoimmune disorders, esp pulmonary-renal syndromes (ex: Goodpasture’s) medications (ex: PTU, anticoagulants [uscmedicine.blog]
- Generalized Tonic-Clonic Seizure
The NPPE setting was postoperative (n = 12/18, 67%) or following generalized tonic-clonic seizures (n = 6/18, 33%). [ncbi.nlm.nih.gov]
Workup
Pulmonary infections are rarely reported in association with DAH, but they should be considered in the diagnostic workup because of the obvious therapeutic implications. [ncbi.nlm.nih.gov]
Infectious workup, which included bronchoscopy with bronchoalveolar lavage and respiratory viral studies, was completely negative in all 3 patients. [bloodjournal.org]
Patients with midface fractures as they try to preserve the barrier is relatively high failure rate.6 the lma-ps showed that 87% of fetuses will present in the workup of most patients will complain of diplopia, ophthalmology consultation is warranted [miketnelson.com]
Treatment
For AAV, treatment includes induction followed by maintenance therapy. Rituximab has an increasing role in the treatment of AAV. Copyright © 2012 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]
The alterations of pulmonary microcirculation can cause DAH, a life-threatening disease, which requires specific supportive treatment. [lungindia.com]
Prognosis
Post-earthquake DAH generally had a better prognosis than pre-earthquake DAH. [ncbi.nlm.nih.gov]
Etiology
INTRODUCTION: Diffuse alveolar hemorrhage (DAH) is a life-threatening condition with an obscure etiology and pathogenesis. [ncbi.nlm.nih.gov]
Epidemiology
[…] hemorrhage has been reported to precede DPO in some cases Hemoptysis (see Hemoptysis, [[Hemoptysis]]) Epidemiology : xxx Interstitial Pulmonary Fibrosis (see Interstitial Lung Disease, [[Interstitial Lung Disease]]) Epidemiology : occurs with recurrent [mdnxs.com]
Epidemiologic studies show that the prevalence and incidence of the autoimmune disorders is increasing, with the overall prevalence of the primary systemic vasculitis’ of 90 to 257 per million and the incidence is estimated at 10 to 20 per million. [rheumatologyadvisor.com]
Polyarteritis Nodosa (PAN) Necrotizing arteritis of medium sized muscular arteries Pathology: “fibrinoid necrosis” 49 Hepatitis B Virus Association Usually occurs during the first 6 months after infection Usually positive for HBAgs and e antigen 50 Epidemiology [slideplayer.com]
London Health Protection Agency (HPA) (2009) Pandemic (H1N1) 2009 in England: an overview of initial epidemiological findings and implications for the second wave. Available at http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1258560552857. [link.springer.com]
Pathophysiology
[…] desafío diagnóstico y terapéutico / Diffuse alveolar hemorrhage: a diagnostic and therapeutic challenge Article in Spanish | LILACS | ID: biblio-835078 Diffuse alveolar hemorrhage is a syndrome causing catastrophic respiratory failure, secondary to pathophysiological [pesquisa.bvsalud.org]
Our report highlights the pathophysiologic importance of B-cell-mediated immunosuppression in SLE-associated DAH and suggests that rituximab may represent a viable alternative to cyclophosphamide in the treatment of this disease. [ncbi.nlm.nih.gov]
The specific pathophysiology and manifestations vary depending on cause. [merckmanuals.com]
Prevention
CONCLUSIONS This case report illustrates the importance of awareness and early recognition of the complication that can prevent mortality. [ncbi.nlm.nih.gov]
الصفحة 158 - Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. [books.google.com]