We present the case a 14-year-old girl who presented with respiratory failure secondary to DAH as the initial presenting sign of GPA. Her clinical course improved after initiation of plasmapheresis therapy and she is now in clinical remission. [ncbi.nlm.nih.gov]

• Hemophilia A

  In rare cases, it is caused by hemophilia. A 48-year-old man was admitted to our hospital for a third time due to DAH. [ncbi.nlm.nih.gov]

  […] in acquired hemophilia an incidence of 4% [ 45 ]. [jintensivecare.biomedcentral.com]

• Anemia

  It is defined by the clinical triad of hemoptysis, anemia and progressive hypoxemia. Chest radiographs reveal non-specific patchy or diffuse bilateral pulmonary consolidation. [ncbi.nlm.nih.gov]

• Sepsis

  Deaths were due to multiorgan failure, sepsis, and progressive underlying disease. No overt, clinically obvious adverse thrombotic events were observed with the use of rFVIIa. [ncbi.nlm.nih.gov]

  Abstract Favorites PDF Get Content & Permissions Open Predictive accuracy of Sepsis-3 definitions for mortality among adult critically ill patients with suspected infection Chen, Qi-Hong; Shao, Jun; Liu, Wei-Li; More Chinese Medical Journal. 132(10):1147 [cmj.org]

  (see Acute Respiratory Distress Syndrome, [[Acute Respiratory Distress Syndrome]]) Aspiration Pneumonia (see xxxx, [[xxxx]]) Drugs: cytotoxic agents, chemotherapy, antibiotics Massive Transfusion Pneumonia: viral, bacterial, Pneumocystis Jirovecii Sepsis [mdnxs.com]

  IO 2 < 300, a decrease in hemoglobin levels (between 1 and 2 g/dL), compatible bronchoscopy or bronchoalveolar lavage, and abnormal chest radiography or computed tomography have been reported in different studies. 2 Respiratory failure due to DAH and sepsis [rc.rcjournal.com]

  Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. [erj.ersjournals.com]

• Lymphadenopathy

  She had no other medical problems except for axillary lymphadenopathy. The lymph node biopsy led to a diagnosis of atypical lymphoid hyperplasia. [e-sciencecentral.org]

  Diffuse lymphadenopathy, as well as daily temperatures of 38.8c (131.6f) or higher for diarrheal disease, and, therefore, provides a wider therapeutic window, and widening of the american heart association: Endorsed by the identification of true sprains [miketnelson.com]

  Red palms and soles. 67 Bleeding and crust formation on the lips and cervical lymphadenopathy in Kawasaki disease. 68 Polymorphous exanthema on the limbs and trunk of an infant with Kawasaki disease. 69 Membranous desquamation of the fingertips. 70 Kawasaki [slideplayer.com]

• Pathologist

  Lung specimens should be read by a pediatric pathologist with expertise in lung disease ( Figure 3 and Figure 4). Figure 3. Histopathologic characteristics of pulmonary capillaritis. [clinicaladvisor.com]

• Hodgkin Lymphoma

  Type 1 is characterized by the presence of a monoclonal immunoglobulin which can be seen in lymphoproliferative disorders such as chronic lymphatic leukemia, multiple myeloma or non-Hodgkin lymphoma. [oatext.com]

• Sputum

  A 41-year-old woman exhibited bloody sputum and ground glass opacities in the lungs along with tumor growth during nivolumab therapy for multiple lung metastases of malignant melanoma. [ncbi.nlm.nih.gov]

• Cyanosis

  Pulmonary aspiration can present symptoms of wheezing, coughing, dyspnea, cyanosis, pulmonary edema, hypotension, and hypoxemia, which may progress rapidly to severe acute respiratory distress syndrome (ARDS). [kjccm.org]

  When evident clinically, the condition is usually massive. [1] The onset of pulmonary hemorrhage is characterized by cough productive of blood (hemoptysis) and worsening of oxygenation leading to cyanosis. [1] Treatment should be immediate and should [en.wikipedia.org]

  Specific signs and symptoms cyanosis: Chapter 16 jaundice: Conjugated hyperbilirubinemia in one of two styles of skin in an undesirable scar. Posttransplant lymphoproliferative disorder. [miketnelson.com]

• Epistaxis

  There are some reports about hematomas, epistaxis, and increased bleeding after neurosurgery. A review of the English-language Medical Literature revealed the description of only two other cases of VPA treatment-related alveolar bleeding. [lungindia.com]

  They started anticoagulation that was complicated by severe epistaxis and upper gastrointestinal bleeding with an unsatisfactory outcome. [rc.rcjournal.com]

  […] years-old No racial or ethnic predilection Prevalence: 5-7/100,000 84 NOSE, SINUSIS, AND EARS 90% of patients have nasal involvement, often as the first manifestation of disease. symptoms include persistant rhinorrhea, unusually severe nasal obstruction, epistaxis [slideplayer.com]

• Renal Injury

  In SLE patients with diffuse alveolar hemorrhage (DAH) and acute renal failure (ARF), the most common associated renal injury is proliferative lupus nephritis. [ncbi.nlm.nih.gov]

  Careful monitoring of complete blood counts and renal function should be performed. Appropriate dose adjustments should be made if there is evidence of neutropenia or renal injury. Rituximab is an anti-CD20 monoclonal antibody that targets B-cells. [rheumatologyadvisor.com]

Pulmonary infections are rarely reported in association with DAH, but they should be considered in the diagnostic workup because of the obvious therapeutic implications. [ncbi.nlm.nih.gov]

Infectious workup, which included bronchoscopy with bronchoalveolar lavage and respiratory viral studies, was completely negative in all 3 patients. [bloodjournal.org]

Patients with midface fractures as they try to preserve the barrier is relatively high failure rate.6 the lma-ps showed that 87% of fetuses will present in the workup of most patients will complain of diplopia, ophthalmology consultation is warranted [miketnelson.com]

• Pericardial Effusion

  He also had renal dysfunction and pericardial effusion. He was diagnosed as DAH due to SLE. He had to undergo hemodialysis for several weeks. [ncbi.nlm.nih.gov]

  Pericardial effusion. 123 Renal disease The kidney is affected in 27% of patients hematuria with proteinuria, and a pauci-immune crescentic, necrotizing glomerulonephritis are the same as for the other ANCA-associated vasculitides. 124 Gastrointestinal [slideplayer.com]

• Polyps

  […] of middle ear, unspecified ear H74.41 Polyp of right middle ear H74.42 Polyp of left middle ear H74.43 Polyp of middle ear, bilateral H74.8X1 Other specified disorders of right middle ear and mastoid H74.8X2 Other specified disorders of left middle ear [codelay.com]

  Pulmonary manifestations respond to glucocorticoid and immunosuppressive therapy with reduction of asthma and resolution of radiologic changes 121 Ear, nose, and throat involvement symptoms of “allergic” rhinitis, nasal obstruction by polyps, deafness [slideplayer.com]

For AAV, treatment includes induction followed by maintenance therapy. Rituximab has an increasing role in the treatment of AAV. Copyright © 2012 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

Post-earthquake DAH generally had a better prognosis than pre-earthquake DAH. [ncbi.nlm.nih.gov]

INTRODUCTION: Diffuse alveolar hemorrhage (DAH) is a life-threatening condition with an obscure etiology and pathogenesis. [ncbi.nlm.nih.gov]

[…] hemorrhage has been reported to precede DPO in some cases Hemoptysis (see Hemoptysis, [[Hemoptysis]]) Epidemiology : xxx Interstitial Pulmonary Fibrosis (see Interstitial Lung Disease, [[Interstitial Lung Disease]]) Epidemiology : occurs with recurrent [mdnxs.com]

Polyarteritis Nodosa (PAN) Necrotizing arteritis of medium sized muscular arteries Pathology: “fibrinoid necrosis” 49 Hepatitis B Virus Association Usually occurs during the first 6 months after infection Usually positive for HBAgs and e antigen 50 Epidemiology [slideplayer.com]

Epidemiologic studies show that the prevalence and incidence of the autoimmune disorders is increasing, with the overall prevalence of the primary systemic vasculitis’ of 90 to 257 per million and the incidence is estimated at 10 to 20 per million. [rheumatologyadvisor.com]

London Health Protection Agency (HPA) (2009) Pandemic (H1N1) 2009 in England: an overview of initial epidemiological findings and implications for the second wave. Available at http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1258560552857. [link.springer.com]

[…] desafío diagnóstico y terapéutico / Diffuse alveolar hemorrhage: a diagnostic and therapeutic challenge Article in Spanish | LILACS | ID: biblio-835078 Diffuse alveolar hemorrhage is a syndrome causing catastrophic respiratory failure, secondary to pathophysiological [pesquisa.bvsalud.org]

Our report highlights the pathophysiologic importance of B-cell-mediated immunosuppression in SLE-associated DAH and suggests that rituximab may represent a viable alternative to cyclophosphamide in the treatment of this disease. [ncbi.nlm.nih.gov]

Stay at the forefront of critical care with a practice-oriented, relevant, and well-illustrated account of the pathophysiology of critical disease, presented in a highly readable format. [books.google.com]

CONCLUSIONS This case report illustrates the importance of awareness and early recognition of the complication that can prevent mortality. [ncbi.nlm.nih.gov]

الصفحة 158 - Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. ‏ [books.google.com]