Presentation
We present a 30-year-old man with probable primary APS (with no history of thromboses) presenting with diffuse alveolar hemorrhage, an uncommon presentation. [ncbi.nlm.nih.gov]
Entire Body System
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Chinese Herbal Drugs
We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. [ncbi.nlm.nih.gov]
Skin
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Discoid Rash
He had no history of photosensitivity, malar rash, discoid rash, arthritis, and oral ulcer. Antinuclear antibody, and anti-double stranded DNA (dsDNA) were positive with very high titers, and serum complement levels (C3, C4) were low. [ncbi.nlm.nih.gov]
Neurologic
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Generalized Seizure
CONCLUSION: NPPE-related DAH is a rare life-threatening condition occurring primarily after tonic-clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. [ncbi.nlm.nih.gov]
The second case [10] is of a 30-year-old woman, who was receiving valproic acid since the age of 20 years for generalized seizure disorder, and was hospitalized for severe anemia. [lungindia.com]
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Generalized Tonic-Clonic Seizure
The NPPE setting was postoperative (n 12/18, 67%) or following generalized tonic-clonic seizures (n 6/18, 33%). Hemoptysis was almost constant (n 17/18, 94%), yet rarely massive ( 200 cc, n 1/18, 6%), with anemia observed in 10 (56%) episodes. [ncbi.nlm.nih.gov]
Workup
Pulmonary infections are rarely reported in association with DAH, but they should be considered in the diagnostic workup because of the obvious therapeutic implications. [ncbi.nlm.nih.gov]
Infectious workup, which included bronchoscopy with bronchoalveolar lavage and respiratory viral studies, was completely negative in all 3 patients. [bloodjournal.org]
Patients with midface fractures as they try to preserve the barrier is relatively high failure rate.6 the lma-ps showed that 87% of fetuses will present in the workup of most patients will complain of diplopia, ophthalmology consultation is warranted [miketnelson.com]
Treatment
For AAV, treatment includes induction followed by maintenance therapy. Rituximab has an increasing role in the treatment of AAV. Copyright 2012 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]
Prognosis
Serum KL-6 is a biomarker for various interstitial lung disease associated with disease activity and prognosis. [ncbi.nlm.nih.gov]
Etiology
INTRODUCTION: Diffuse alveolar hemorrhage (DAH) is a life-threatening condition with an obscure etiology and pathogenesis. [ncbi.nlm.nih.gov]
Epidemiology
[…] hemorrhage has been reported to precede DPO in some cases Hemoptysis (see Hemoptysis, [[Hemoptysis]]) Epidemiology : xxx Interstitial Pulmonary Fibrosis (see Interstitial Lung Disease, [[Interstitial Lung Disease]]) Epidemiology : occurs with recurrent [mdnxs.com]
Epidemiologic studies show that the prevalence and incidence of the autoimmune disorders is increasing, with the overall prevalence of the primary systemic vasculitis’ of 90 to 257 per million and the incidence is estimated at 10 to 20 per million. [rheumatologyadvisor.com]
London Health Protection Agency (HPA) (2009) Pandemic (H1N1) 2009 in England: an overview of initial epidemiological findings and implications for the second wave. Available at . Accessed 27 February 2012 26. [link.springer.com]
Polyarteritis Nodosa (PAN) Necrotizing arteritis of medium sized muscular arteries Pathology: “fibrinoid necrosis” 49 Hepatitis B Virus Association Usually occurs during the first 6 months after infection Usually positive for HBAgs and e antigen 50 Epidemiology [slideplayer.com]
Pathophysiology
Our report highlights the pathophysiologic importance of B-cell-mediated immunosuppression in SLE-associated DAH and suggests that rituximab may represent a viable alternative to cyclophosphamide in the treatment of this disease. [ncbi.nlm.nih.gov]
[…] difusa, desafío diagnóstico y terapéutico / Diffuse alveolar hemorrhage: a diagnostic and therapeutic challenge Article in Spanish LILACS ID: biblio-835078 Diffuse alveolar hemorrhage is a syndrome causing catastrophic respiratory failure, secondary to pathophysiological [pesquisa.bvsalud.org]
Stay at the forefront of critical care with a practice-oriented, relevant, and well-illustrated account of the pathophysiology of critical disease, presented in a highly readable format. [books.google.com]
Prevention
CONCLUSIONS This case report illustrates the importance of awareness and early recognition of the complication that can prevent mortality. [ncbi.nlm.nih.gov]
الصفحة 158 - Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. [books.google.com]