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Diffuse Intrinsic Pontine Glioma
DIPG
Drug delivery to diffuse intrinsic pontine glioma (DIPG) - Fphar-08-00495-g004
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma - graphical abstract
Mutations in diffuse intrinsic pontine glioma samples from several anatomical locations - Ncomms11185-f1
Palliative Care Options for a Young Adult Patient with a Diffuse Intrinsic Pontine Glioma - Fig. 1D (cropped)
Palliative Care Options for a Young Adult Patient with a Diffuse Intrinsic Pontine Glioma - Fig. 1 (cropped)
Palliative Care Options for a Young Adult Patient with a Diffuse Intrinsic Pontine Glioma - Fig. 2 (cropped)
Palliative Care Options for a Young Adult Patient with a Diffuse Intrinsic Pontine Glioma - Fig. 3 (cropped)
Presentation
- At presentation, DIPG blood volume was 60 27 % of that measured for normal cerebellum. Citrate, which is not detectable in normal brain tissue, was present in DIPG at concentrations of 3.81 1.44 mmol/kg tissue.[ncbi.nlm.nih.gov]
- The authors present a case of diffuse intrinsic pontine glioma presenting in a newborn with stridor and respiratory distress that progressed to respiratory failure.[ncbi.nlm.nih.gov]
- Here, we present the first comprehensive protein, mRNA, and methylation profiles of fresh-frozen DIPG specimens (n 14), normal brain tissue (n 10), and other pediatric brain tumors (n 17).[ncbi.nlm.nih.gov]
- A 4-year-old male presented with rapid-onset cranial nerve palsy and ataxia. Brain magnetic resonance imaging (MRI) revealed a pontine mass lesion with discordant conventional and advanced imaging.[ncbi.nlm.nih.gov]
- We present here the initial experience of administering Celyvir, autologous mesenchymal stem cells infected with ICOVIR-5, an oncolytic adenovirus that selectively replicates in cancer cells, by means of superselective intra-arterial delivery, in a patient[ncbi.nlm.nih.gov]
Entire Body System
Pathologist
- […] deidentified but linked clinical, imaging, histopathological, and genomic repositories, the IDIPGR uses standardized case report forms for uniform data collection; serial imaging and histopathology are centrally reviewed by IDIPGR neuro-radiologists and neuro-pathologists[ncbi.nlm.nih.gov]
Plethora
- A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and cytotoxic activity.[ncbi.nlm.nih.gov]
Respiratoric
Respiratory Distress
- The authors present a case of diffuse intrinsic pontine glioma presenting in a newborn with stridor and respiratory distress that progressed to respiratory failure.[ncbi.nlm.nih.gov]
Stridor
- The authors present a case of diffuse intrinsic pontine glioma presenting in a newborn with stridor and respiratory distress that progressed to respiratory failure.[ncbi.nlm.nih.gov]
Gastrointestinal
Constipation
- Some of the chemotherapy agents are associated with fatigue, diarrhea, constipation, and headache. These side effects can be effectively managed under most circumstances.[danafarberbostonchildrens.org]
Psychiatrical
Withdrawn
- Three patients were withdrawn from study treatment due to haematological toxicity and 10 had a dose reduction. No other significant toxicity related to temozolomide was noted.[ncbi.nlm.nih.gov]
Neurologic
Cranial Nerve Involvement
- Two patients were younger than 3 years, one lacked signs of pontine cranial nerve involvement, and three had longer duration of symptoms at diagnosis. One patient had a radiologically atypical tumor and one had a tumor originating in the medulla.[ncbi.nlm.nih.gov]
Lethargy
- A 7-month-old baby girl presented with lethargy and poor oral feeding. She had the mild fever for 1 month. Brain computed tomography revealed the hypodense lesion in the pons.[ncbi.nlm.nih.gov]
Urogenital
Incontinence
- Grade 3 and higher toxicities including hypokalemia and fatigue occurred in 6 %, hypernatremia in 18 %, fatigue and urinary incontinence in 6 %, and somnolence in 12 %.[ncbi.nlm.nih.gov]
Urinary Incontinence
- Grade 3 and higher toxicities including hypokalemia and fatigue occurred in 6 %, hypernatremia in 18 %, fatigue and urinary incontinence in 6 %, and somnolence in 12 %.[ncbi.nlm.nih.gov]
Treatment
- ’s largest pediatric glioma treatment programs.[danafarberbostonchildrens.org]
- Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs.[ncbi.nlm.nih.gov]
- Treatment also resulted in an increased γH2AX expression, indicating induction of DNA damage. PLK1 inhibition resulted in radiosensitization of DIPG cells.[ncbi.nlm.nih.gov]
- Corticosteroids greatly affected MD and must be considered a confounding factor when interpreting MD results in the context of treatment response.[ncbi.nlm.nih.gov]
- Brainstem CED for diffuse intrinsic pontine glioma (DIPG) treatment is appealing because this tumor is compact and has no definitive treatment.[ncbi.nlm.nih.gov]
Prognosis
- Diffuse intrinsic pontine gliomas have poor prognosis. We report on 2 patients with diffuse intrinsic pontine glioma treated with radiation, followed by temozolamide 200 mg/m/d for 5 days every 28 days and bevacizumab 10 mg/kg/dose every 14 days.[ncbi.nlm.nih.gov]
- Despite decades of clinical trials, there has been no improvement in prognosis since the introduction of radiotherapy over thirty years ago.[ncbi.nlm.nih.gov]
- INTRODUCTION: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months.[ncbi.nlm.nih.gov]
- KEYWORDS: glioma; immunotherapy; pontine; prognosis; targeted; therapy[ncbi.nlm.nih.gov]
- This article summarizes the epidemiology, clinical presentation, diagnosis, prognosis, molecular genetics, current treatment, and future therapeutic directions for diffuse intrinsic pontine glioma.[ncbi.nlm.nih.gov]
Etiology
- Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology. J Neurosurg 1996 Sep; 85: 458–67 PubMed CrossRef Google Scholar 229. Varelas PN, Rehman M, Pierce W, et al.[dx.doi.org]
Epidemiology
- This article summarizes the epidemiology, clinical presentation, diagnosis, prognosis, molecular genetics, current treatment, and future therapeutic directions for diffuse intrinsic pontine glioma.[ncbi.nlm.nih.gov]
- .); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.[ncbi.nlm.nih.gov]
- .); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.[ncbi.nlm.nih.gov]
- Fisher, Epidemiology of Pediatric Central Nervous System Tumors, Brain Tumors in Children, 10.1007/978-3-319-43205-2_1, (1-15), (2018).[dx.doi.org]
- One-month prevalence of mental disorders in the United States: based on five epidemiologic catchment area sites. Arch Gen Psychiatry 1988; 45: 977–86 PubMed CrossRef Google Scholar 9. Pardridge WM. Blood-brain barrier delivery.[dx.doi.org]
Sex distribution
Age distribution
Pathophysiology
- Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, California, USA. [5] Present addresses: Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology[ncbi.nlm.nih.gov]
- Author information 1 Department of Neurology, Stanford University, Palo Alto, CA 94305, USA. 2 Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School[ncbi.nlm.nih.gov]
Prevention
- However, with diseases such as brain tumors, the BBB can also prevent diagnostic and therapeutic agents from reaching their target.[en.wikipedia.org]
- Gliomas are highly vascularized tumors, suggesting that the prevention of vessel formation by anti-angiogenic treatment might be effective.[ncbi.nlm.nih.gov]
- Communication between the surgical resection cavity and the ventricular system should be avoided to prevent the wafers from migrating into the ventricular system and causing obstructivehydrocephalus.[web.archive.org]