At presentation, DIPG blood volume was 60 27 % of that measured for normal cerebellum. Citrate, which is not detectable in normal brain tissue, was present in DIPG at concentrations of 3.81 1.44 mmol/kg tissue. [ncbi.nlm.nih.gov]

• Plethora

  A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and cytotoxic activity. [ncbi.nlm.nih.gov]

• Respiratory Distress

  The authors present a case of diffuse intrinsic pontine glioma presenting in a newborn with stridor and respiratory distress that progressed to respiratory failure. [ncbi.nlm.nih.gov]

• Stridor

  The authors present a case of diffuse intrinsic pontine glioma presenting in a newborn with stridor and respiratory distress that progressed to respiratory failure. [ncbi.nlm.nih.gov]

• Withdrawn

  Three patients were withdrawn from study treatment due to haematological toxicity and 10 had a dose reduction. No other significant toxicity related to temozolomide was noted. [ncbi.nlm.nih.gov]

• Lethargy

  A 7-month-old baby girl presented with lethargy and poor oral feeding. She had the mild fever for 1 month. Brain computed tomography revealed the hypodense lesion in the pons. [ncbi.nlm.nih.gov]

• Incontinence

  Grade 3 and higher toxicities including hypokalemia and fatigue occurred in 6 %, hypernatremia in 18 %, fatigue and urinary incontinence in 6 %, and somnolence in 12 %. [ncbi.nlm.nih.gov]

• Urinary Incontinence

  Grade 3 and higher toxicities including hypokalemia and fatigue occurred in 6 %, hypernatremia in 18 %, fatigue and urinary incontinence in 6 %, and somnolence in 12 %. [ncbi.nlm.nih.gov]

’s largest pediatric glioma treatment programs. [danafarberbostonchildrens.org]

Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs. [ncbi.nlm.nih.gov]

Treatment of diffuse pontine gliomas. Follow @ReflectsOfGrace [web.archive.org]

Diffuse intrinsic pontine gliomas have poor prognosis. We report on 2 patients with diffuse intrinsic pontine glioma treated with radiation, followed by temozolamide 200 mg/m/d for 5 days every 28 days and bevacizumab 10 mg/kg/dose every 14 days. [ncbi.nlm.nih.gov]

Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology. J Neurosurg 1996 Sep; 85: 458–67 PubMed CrossRef Google Scholar 229. Varelas PN, Rehman M, Pierce W, et al. [dx.doi.org]

This article summarizes the epidemiology, clinical presentation, diagnosis, prognosis, molecular genetics, current treatment, and future therapeutic directions for diffuse intrinsic pontine glioma. [ncbi.nlm.nih.gov]

Fisher, Epidemiology of Pediatric Central Nervous System Tumors, Brain Tumors in Children, 10.1007/978-3-319-43205-2_1, (1-15), (2018). [dx.doi.org]

Stanford University, Stanford, California, USA. [4] Department of Pathology, Stanford University, Stanford, California, USA. [5] Present addresses: Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology [ncbi.nlm.nih.gov]

However, with diseases such as brain tumors, the BBB can also prevent diagnostic and therapeutic agents from reaching their target. [en.wikipedia.org]

Gliomas are highly vascularized tumors, suggesting that the prevention of vessel formation by anti-angiogenic treatment might be effective. [ncbi.nlm.nih.gov]

Communication between the surgical resection cavity and the ventricular system should be avoided to prevent the wafers from migrating into the ventricular system and causing obstructivehydrocephalus. [web.archive.org]