Seven patients died, with sepsis being the main cause of death. Diffuse mesangial sclerosis must be suspected in a child that presents with early onset proteinuria and/or rapidly progressive renal failure. [ncbi.nlm.nih.gov]

However, neither megalocornea, Dandy-Walker malformation, postaxial hexadactyly, rocker-bottom feet, nor atrial septal defect, as observed in our patient, has been reported previously in association with DMS. [ncbi.nlm.nih.gov]

Abstract Clinical and pathological findings in four Turkish infants with isolated diffuse mesangial sclerosis (DMS) are presented. [ncbi.nlm.nih.gov]

Pregnancy was terminated because of elevated maternal serum alpha-fetoprotein and ultrasonographic evidence of severe oligohydramnios, intrauterine growth retardation, non-visualization of the bladder, dolichocephaly and possible mild hydrocephalus. [ncbi.nlm.nih.gov]

Abnormal distribution of WT1 and PAX2 was also observed in isolated diffuse mesangial sclerosis suggesting that a defect in WT1 could also be operative in isolated diffuse mesangial sclerosis. [ncbi.nlm.nih.gov]

Diffuse mesangial sclerosis is a kidney condition that begins early in childhood and rapidly progresses to kidney failure. It is usually associated with other conditions such as Denys-Drash Syndrome. [patientslikeme.com]