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Diffuse Neonatal Hemangiomatosis
Diffuse Neonatal Haemangiomatosis

Presentation

CHF is an unusual presentation of DNH in neonates and can be mistaken for a variety of congenital heart diseases. [ncbi.nlm.nih.gov]

Cardiac failure, hepatomegaly, respiratory distress, and multi-organ system failure may be present. [medcraveonline.com]

Hemangiomatosis, defined as multiple (typically five or more) hemangiomas, presents with small cutaneous hemangiomas that may occur anywhere on the skin or mucous membranes. [medscape.com]

However, the dosing can vary based on the severity of the illness present. [en.wikipedia.org]

Maldonado Medicine Definitions 2020 A 53-day-old male patient who presented to the hospital for skin lesions and upper gastrointestinal bleeding experienced a satisfactory evolution and is currently asymptomatic with disseminated neonatal hemangiomatosis [semanticscholar.org]

Entire Body System

  • Congestive Heart Failure

    We report a neonate having around 490 cutaneous and multiple diffuse liver hemangiomas presenting as congestive heart failure. [ncbi.nlm.nih.gov]

    All of the infants who had multiple or diffuse injuries were assessed and screened for congestive heart failure and hypothyroidism, in which four patients later developed congestive heart failure. [en.wikipedia.org]

    Congestive heart failure (CHF) was the primary cause of death. The mortality rate was 77.4% in untreated patients and 27% in treated patients. [onlinelibrary.wiley.com]

    The high cardiac output leads to congestive heart failure, presenting with poor growth or feeding, tachycardia, tachypnea, cardiac murmur, abdominal distension, or hepatomegaly. [medcraveonline.com]

  • Asymptomatic

    Maldonado Medicine Definitions 2020 A 53-day-old male patient who presented to the hospital for skin lesions and upper gastrointestinal bleeding experienced a satisfactory evolution and is currently asymptomatic with disseminated neonatal hemangiomatosis [semanticscholar.org]

    In most cases, hepatic hemangiomas are asymptomatic and only rarely cause major complications. Despite being histologically benign, this disease is associated with a mortality rate between 50% and 90% [6]. Go to... [medcraveonline.com]

  • Swelling

    Some common side effects can be mood changes, elevated blood pressure, swelling of the face, weight gain, and stomach upset. [en.wikipedia.org]

  • Anemia

    The common side effects tend to be mild and include constipation, stomach pain, acid reflux, and anemia. [en.wikipedia.org]

Cardiovascular

  • Heart Failure

    All of the infants who had multiple or diffuse injuries were assessed and screened for congestive heart failure and hypothyroidism, in which four patients later developed congestive heart failure. [en.wikipedia.org]

    We report a neonate having around 490 cutaneous and multiple diffuse liver hemangiomas presenting as congestive heart failure. [ncbi.nlm.nih.gov]

    Congestive heart failure (CHF) was the primary cause of death. The mortality rate was 77.4% in untreated patients and 27% in treated patients. [onlinelibrary.wiley.com]

    The high cardiac output leads to congestive heart failure, presenting with poor growth or feeding, tachycardia, tachypnea, cardiac murmur, abdominal distension, or hepatomegaly. [medcraveonline.com]

Skin

  • Angiomatosis

    […] action=getRecordDetail&idt=3875748 Other title Neonatal disseminated angiomatosis. Report of a case in an infant with tetralogy of Fallot (en) Author HAMDI, F1 ; CUNY, J. F1 ; TRUCHETET, F1 ; LAMBERT, A2 ; MARCHAL, C2 [1] CHR Metz-Thionville, hôp. [pascal-francis.inist.fr]

  • Skin Disease

    Congenital diseases of the skin. [pascal-francis.inist.fr]

Treatment

[…] to corticosteroid treatment. [en.wikipedia.org]

However, complete failure of treatment and rebound growth following cessation of treatment with this drug has also been documented [14,15]. [ncbi.nlm.nih.gov]

Proper tapering of oral steroids and side effects of medications should be discussed with parents of infants receiving treatment. [medscape.com]

Recently, new treatments have tried to diminish the mortality rates of DHN; corticosteroids are considered the first line of treatment, it is well known that corticoids produce vasoconstriction, both arteriolar and capillary, and accelerate the involution [medcraveonline.com]

National Center for Advancing Translational Sciences Home Browse by Disease Diffuse Neonatal Hemangiomatosis Diffuse Neonatal Hemangiomatosis About the Disease Diagnosis & Treatment Living with the Disease Research Disease at a Glance Symptoms Causes [rarediseases.info.nih.gov]

Prognosis

The diagnosis, prognosis, and treatment expectations should be discussed with parents. Many families are relieved to know that most hemangiomas resolve without complications, but the slow regression of hemangiomas should be emphasized. [medscape.com]

Hemangiomas otherwise are the most common vascular tumours of infancy with excellent prognosis. [ncbi.nlm.nih.gov]

Diffuse hepatic hemangiomatosis carries a poor prognosis and high risk of mortality.[10] Epidemiology[edit] The cause of IH is not completely clear and infants often do not show signs of IH when discharged after birth.[11] However, several risk factors [en.wikipedia.org]

Epidemiology

Diffuse hepatic hemangiomatosis carries a poor prognosis and high risk of mortality.[10] Epidemiology[edit] The cause of IH is not completely clear and infants often do not show signs of IH when discharged after birth.[11] However, several risk factors [en.wikipedia.org]

Prevention

The exact mechanism of action is not entirely understood, but it has been proposed that the constriction of blood vessels and prevention of new blood vessel formation could be contributing to its efficacy. [en.wikipedia.org]

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