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Dihydrocodeine


Presentation

  • After chronic high-dosage use, dihydrocodeine was the main salivary analyte and N-nordihydrocodeine was present in a few samples.[ncbi.nlm.nih.gov]
  • The incidence and severity of pain and nausea experienced by 40 primigravid day patients who presented for vaginal termination of pregnancy were examined.[ncbi.nlm.nih.gov]
  • We investigated the merit of dihydrocodeine tartrate for withdrawal in detoxifying 20 methadone-maintained patients presenting for treatment at the Leeds Addiction Unit (LAU).[ncbi.nlm.nih.gov]
  • The present GC-SID method has been compared carefully with GC-NPD (nitrogen-phosphorus detection) using the same extracts; the sensitivity of GC-SID was more than ten times greater than that of GC-NPD, with background noise correspondingly lower.[ncbi.nlm.nih.gov]
  • The present study found little interindividual variation in the activity of human liver microsomes for glucuronidation of DHC.[ncbi.nlm.nih.gov]
Camping
  • Whole cell opioid-receptor affinity and effects on cAMP accumulation of dihydrocodeine and its metabolites were determined in differentiated SH-SY5Y neuroblastoma cells.[ncbi.nlm.nih.gov]
Constipation
  • It is well accepted that long-term administration of opioids results in a dose-related constipation. No data so far have demonstrated conclusively whether such constipation is also seen after intake of a controlled release formulation.[ncbi.nlm.nih.gov]
  • Tramadol therapy was connected with better emotional functioning, less constipation and financial problems. PS deteriorated in both tramadol and DHC groups.[ncbi.nlm.nih.gov]
  • Patients on CR dihydrocodeine developed some constipation as expected and the dextropropoxyphene/paracetamol patients suffered from impaired concentration.[ncbi.nlm.nih.gov]
  • Ask your doctor for advice if you get constipated while taking dihydrocodeine. Dry mouth. Abdominal pain. Finding it difficult to pass urine. Headache. Itching, sweating, flushing or skin rash. Loss of appetite.[netdoctor.co.uk]
  • . - Constipation. - Gastric irritation. - Anorexia. - Cramps. - Dry mouth. - Hypotension. - Hypothermia. - Palpitations. - Bradycardia. - Urinary retention. - Tolerance, dependence. - Decreased libido.[nursingtimes.net]
Suggestibility
  • DHC and DHC-6-G concentrations increased similarly during both treatment periods which suggest their prominent role in DHC analgesia.[ncbi.nlm.nih.gov]
  • These findings would suggest that dihydrocodeine should not be routinely used for detoxification from opiates in the prison setting.[ncbi.nlm.nih.gov]
  • Comparison of the results from the inhibition studies with those reported previously for codeine and morphine suggest that the UDP-glucuronosyltransferase isoform UGT2B7 is involved in the glucuronidation of DHC.[ncbi.nlm.nih.gov]
  • There is insufficient evidence to support or refute the suggestion that paracetamol alone, or in combination with codeine or dihydrocodeine, works in any neuropathic pain condition.[ncbi.nlm.nih.gov]
  • These results suggest that dihydrocodeine and methadone in overdose both have a significant effect on central and peripheral hemodynamics.[ncbi.nlm.nih.gov]

Treatment

  • Compliance with randomized treatment differed by randomized group and was affected by experiences in custody during follow-up. Those randomized to dihydrocodeine were more likely to switch treatments.[ncbi.nlm.nih.gov]
  • Colonic transit times only increased significantly during treatment with dihydrocodeine. Sensation and pain thresholds were lower pre-treatment in both groups than in controls and increased during treatment.[ncbi.nlm.nih.gov]
  • Nausea and vomiting were more pronounced in the dihydrocodeine than in the dextropropoxyphene/paracetamol group after the first week's treatment but by the end of the study there was no significant treatment difference in any of the volunteered side-effects[ncbi.nlm.nih.gov]
  • Concurrently with the relief of cough, the number of night awakenings was decreased significantly by both drugs, with no difference between the two treatments.[ncbi.nlm.nih.gov]
  • The aim of the study was to assess the impact of tramadol and DHC treatment on quality of life (QL) and performance status (PS) of patients with cancer pain.[ncbi.nlm.nih.gov]

Epidemiology

  • There are a small number of published case reports of perinatal arterial stroke and neonatal withdrawal in infants of women who used codeine in the weeks before delivery, however no epidemiological studies have investigated these associations.[medicinesinpregnancy.org]
Sex distribution
Age distribution

Pathophysiology

  • Augmented chemosensitivity is important in the pathophysiology of chronic heart failure.[ncbi.nlm.nih.gov]

Prevention

  • Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis.[emedicinehealth.com]
  • However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.[mayoclinic.org]
  • Subutex stimulates the opiate receptors enough to prevent withdrawal without getting a strong opiate effect.[netmums.com]
  • Oh, and you'll find out pretty quickly that DHC constipates as well as Imodium (loperamide, which is just codeine with something bolted to the side to prevent it getting into the brain and being converted to morphine like codeine does).[pistonheads.com]
  • Check with the nurses, but the sickness might be prevented if you've eaten before you take the tablets. there's no harm in trying it if you're in pain. If it makes you feel sick, don't take it again. had those painkillers and they do a good job!![thestudentroom.co.uk]

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