Lakhhdar et al. reported the case of two brothers (25 and 23 years) and their sister (who died at 14) presenting a DCM and for whom the celiac disease was discovered whereas they presented no digestive symptoms [ 17 ]. [ncbi.nlm.nih.gov]

Snapshot A 60-year-old man presents to his cardiologist for worsening shortness of breath and easy fatigability. He began developing symptoms a few months prior to presentation. [step2.medbullets.com]

In more severe cases, affected individuals present with signs and symptoms of heart failure. Young children often have poor appetite and cachexia. [revportcardiol.org]

The present review article will focus on the role of CMR in the evaluation of present condition, analysing respective strengths and limitations in the light of current literature and technological developments. 1. [hindawi.com]

• Fatigue

  Signs and symptoms of familial dilated cardiomyopathy can include an irregular heartbeat (arrhythmia), shortness of breath (dyspnea), extreme tiredness (fatigue), fainting episodes (syncope), and swelling of the legs and feet. [ncbi.nlm.nih.gov]

  Some people experience fatigue or vague abdominal discomfort. However, if the liver becomes inflamed due to excess fat you may also experiences the following symptoms: 1. Poor appetite 2. Weight loss 3. Abdominal pain 4. [dailystar.co.uk]

  The 57-year-old man with a 2-year history of DCM had been hospitalized for chronic fatigue and dyspnea secondary to heart failure (New York Heart Association class III). [rheumnow.com]

  Symptoms of dilated cardiomyopathy — such as fatigue and shortness of breath — can mimic other health conditions. A person with dilated cardiomyopathy might not notice any symptoms at first. But dilated cardiomyopathy can become life-threatening. [mayoclinic.org]

• Diarrhea

  […] cause of severe, dehydrating diarrhea in infants and young children. [kidshealth.org]

  Overview Rotavirus is a very contagious virus that causes diarrhea. It's the most common cause of diarrhea in infants and children worldwide, resulting in over 215,000 deaths annually. [mayoclinic.org]

  Symptoms include severe diarrhea, vomiting, fever, and dehydration. Almost all children in the U.S. are likely to be infected with rotavirus before their 5th birthday. Infections happen most often in the winter and spring. [medlineplus.gov]

  This includes infants with moderate or severe diarrhea or vomiting. Babies who are mildly ill can get the vaccine. [cdc.gov]

  Direct inquiry revealed chronic diarrhea, abdominal pain and bloating since the early infancy; weight loss since two years, late menarche (at the age of 15 years) and secondary amenorrhea since two years. [symbiosisonlinepublishing.com]

• Osteoporosis

  Osteoporosis: secondary to immunosuppressant drugs. Acute rejection: between 20-40% of patients have at least one episode of acute rejection. Acute rejection causes diastolic dysfunction. [patient.info]

  The patient reported pre-existing hypertension and osteoporosis. Notably, she had been investigated 4 years ago for left ventricular impairment of unknown aetiology. There was no history of venous thromboembolic disease. [edm.bioscientifica.com]

  Osteogenesis imperfecta Osteogenesis imperfecta type I Osteogenesis imperfecta type III Osteogenesis imperfecta type III Osteogenesis imperfecta with normal sclerae, dominant form Osteogenesis imperfecta, recessive perinatal lethal Osteoglophonic dysplasia Osteoporosis [pentacorelab.hu]

  166710 COL1A1 collagen, type I, alpha 1 Enf-641 Osteoporosis, postmenopausal 166710 COL1A2 collagen, type I, alpha 2 Enf-642 Osteosarcoma 259500 TP53 tumor protein p53 Enf-643 Otofaciocervical syndrome 166780 EYA1 eyes absent homolog 1 (Drosophila) Enf [ac-gen.com]

• Dysautonomia

  […] multiple, with myopia and conductive deafness Erythrocytosis, familial, 2 Erythrokeratodermia variabilis et progressiva Esophageal cancer Fabry's disease Facioscapulohumeral muscular dystrophy Familial cancer of breast Familial colorectal cancer Familial dysautonomia [pentacorelab.hu]

  […] channel, voltage-gated, type IX, alpha subunit Enf-284 Du Pan syndrome 228900 GDF5 growth differentiation factor 5 Enf-285 Duane-radial ray syndrome 607323 SALL4 sal-like 4 (Drosophila) Enf-286 Duchenne muscular dystrophy 310200 DMD dystrophin Enf-287 Dysautonomia [ac-gen.com]

For these reasons, routine diagnostic imaging workup of patients with DCM (including echocardiography, selective coronary angiography, and, when indicated, endomyocardial biopsy) has been integrated in the last few years with the use of cardiac magnetic [hindawi.com]

Workup is focused on identifying any possible reversible causes. Recommended laboratory testing includes thyroid function tests, HIV serology, electrolytes, and iron studies (to rule out hemochromatosis). [statpearls.com]

Before the treatment he had ejection fraction of 18%. Discussing with his cardiologists we decided for immunoadsorption therapy. We performed 5 cycles on consecutive days in Intensive Care Unit. [hungary.pure.elsevier.com]

[…] should be performed or administered Class IIa - reasonable to perform procedure or administer treatment, but additional studies with focused objectives needed Class IIb - procedure or treatment may be considered; additional studies with broad objectives [dynamed.com]

To date, there are no specific treatment options for DCM patients but heart transplantation. [embopress.org]

Cardiomyopathy is a serious medical condition that requires treatment. Without treatment, the disease may progress and become life threatening. [medicalnewstoday.com]

Treatment Specific treatments are not available for most patients with IDC. [heart.bmj.com]

Overall, the prognosis of patients with dilated cardiomyopathy is guarded. [statpearls.com]

The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD/heart transplantation-free survival can be prolonged. [hungary.pure.elsevier.com]

The accurate assessment of prognosis in patients with cardiomyopathy is critical. [revespcardiol.org]

The prognosis of dilated cardiomyopathy varies considerably depending on many factors. In general, the prognosis worsens as the heart becomes more dilated and functions less well. Abnormal heart rhythms also indicate a worse prognosis. [merckmanuals.com]

In addition, identifying the probable cause of DCM helps tailor specific therapies to improve prognosis. [ncbi.nlm.nih.gov]

Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology [amboss.com]

The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. [hungary.pure.elsevier.com]

Dyspnea/etiology, Ileum/abnormalities, Infant, Premature, Diseases/diagnosis, Diagnosis, Differential, Dyspnea/diagnosis, Female, Humans, Infant, Newborn, Pulmonary Atelectasis/etiology, Respiratory Insufficiency/etiology 10. [pesquisa.bvsalud.org]

The identification of Chagas etiology in patients with dilated cardiomyopathy was of prognostic significance. [revespcardiol.org]

It is also impossible to be sure which was the more significant etiology, or if both played a major role, as the simultaneous treatment of both situations prevented a clearer definition of the etiology. [revportcardiol.org]

Mutations: Q131E; R279C Allelic with: CMD 1CC CMH 21 ● Chromosome 7p12.1-q21; Dominant Epidemiology: 1 family Clinical Onset age: 13 years to Adult Cardiac failure Sudden death CMH 22 ● Myopalladin gene (MYPN) ; Chromosome 10q21.3; Dominant Genetics [neuromuscular.wustl.edu]

Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology [amboss.com]

Cardiomyopathies/epidemiology, Adolescent, Adult, Age Distribution, Cardiomyopathies/complications, Cardiomyopathies/therapy, Child, Child, Preschool, Croatia/epidemiology, Female, Hospitals, University/statistics & numerical data, Humans, Infant, Infant [pesquisa.bvsalud.org]

Summary Epidemiology To date, all cases of DCMA reported involve individuals from the Dariusleut Hutterite population, an endogamous population of the Great Plains region of Canada and the northern United States. [orpha.net]

Relevant External Links for ACTC1 Genetic Association Database (GAD) ACTC1 Human Genome Epidemiology (HuGE) Navigator ACTC1 Atlas of Genetics and Cytogenetics in Oncology and Haematology: ACTC1 No data available for Genatlas for ACTC1 Gene Prevalence [genecards.org]

Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology Clinical [amboss.com]

Cardiac Sodium Channel Dysfunction and Dilated Cardiomyopathy: A Contemporary Reappraisal of Pathophysiological Concepts. J. Clin. Med. 2019, 8, 1029. [mdpi.com]

In this video series Michael Linares, RN from Simple Nursing helps explain the nursing pathophysiology, signs and symptoms, causes, pathology, treatment options for various diagnosis, which are expected to know for the NCLEX, HESI, ATI, and Kaplan proctor [youtube.com]

Cardiovascular Institute of Alberta and University of Calgary, Calgary, AB, Canada 9Max Delbrueck Center for Molecular Medicine, Berlin, Germany 10Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands 11Institute for Integrative Pathophysiology [embopress.org]

[…] s2.ogv 20 s, 640 × 480; 13.52 MB Play media Prevention-of-exercised-induced-cardiomyopathy-following-Pip-PMO-treatment-in-dystrophic-mdx-mice-srep08986-s3.ogv 18 s, 640 × 480; 6.92 MB Play media Prevention-of-exercised-induced-cardiomyopathy-following-Pip-PMO-treatment-in-dystrophic-mdx-mice-srep08986 [commons.wikimedia.org]

Since the rotavirus vaccines became available, studies have shown that they prevent thousands of children from becoming sick and being hospitalized each year. [mayoclinic.org]

Centers for Disease Control and Prevention [medlineplus.gov]

Can Rotavirus Be Prevented? The rotavirus vaccine can prevent many causes of rotavirus. The vaccine is a liquid given by mouth to babies at ages 2 and 4 months, and again at 6 months, depending on the vaccine brand. [kidshealth.org]

[edit] Secondary prevention is preventing further sequelae of already established disease. [en.wikipedia.org]