Presentation
University School Of Medicine, Ankara, Turkey An 80-years-old-man with adult polycystic kidney disease and familial multiple myeloma that is complicated with massive pericardial effusion and dilated cardiomyopathy during the course of the disease is presented [tjh.com.tr]
This presents an opportunity to invoke lifestyle changes and to provide pharmacological therapy earlier in the course of disease. [ojrd.biomedcentral.com]
Lakhhdar et al. reported the case of two brothers (25 and 23 years) and their sister (who died at 14) presenting a DCM and for whom the celiac disease was discovered whereas they presented no digestive symptoms [ 17 ]. [ncbi.nlm.nih.gov]
Snapshot A 60-year-old man presents to his cardiologist for worsening shortness of breath and easy fatigability. He began developing symptoms a few months prior to presentation. [step2.medbullets.com]
In more severe cases, affected individuals present with signs and symptoms of heart failure. Young children often have poor appetite and cachexia. [revportcardiol.org]
Entire Body System
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Fatigue
Signs and symptoms of familial dilated cardiomyopathy can include an irregular heartbeat (arrhythmia), shortness of breath (dyspnea), extreme tiredness (fatigue), fainting episodes (syncope), and swelling of the legs and feet. [ncbi.nlm.nih.gov]
Some people experience fatigue or vague abdominal discomfort. However, if the liver becomes inflamed due to excess fat you may also experiences the following symptoms: 1. Poor appetite 2. Weight loss 3. Abdominal pain 4. [dailystar.co.uk]
The 57-year-old man with a 2-year history of DCM had been hospitalized for chronic fatigue and dyspnea secondary to heart failure (New York Heart Association class III). [rheumnow.com]
Fatigue (feeling overly tired), inability to exercise, or carry out activities as usual. Weight gain, cough and congestion related to fluid retention. Palpitations or fluttering in the chest due to abnormal heart rhythms (arrhythmia). [my.clevelandclinic.org]
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Chronic Infection
Chronic infection involves the esophagus, colon, and heart. The disease is mainly distributed across Latin America, but Chagas disease may also involve regions in the United States. [emedicine.medscape.com]
To illustrate the potential of immune repertoire sequencing to monitor atypical post-transplant trajectories, these investigators analyzed 2 more patients, 1 with chronic infections and 1 with amyloidosis. [aetna.com]
Workup
For these reasons, routine diagnostic imaging workup of patients with DCM (including echocardiography, selective coronary angiography, and, when indicated, endomyocardial biopsy) has been integrated in the last few years with the use of cardiac magnetic [hindawi.com]
Workup is focused on identifying any possible reversible causes. Recommended laboratory testing includes thyroid function tests, HIV serology, electrolytes, and iron studies (to rule out hemochromatosis). [statpearls.com]
Treatment
Despite improvements in the treatment of heart failure introduced in the last 10 years, including the general availability of cardiac transplantation and better medical treatment, clinical outcome following the onset of symptoms has not substantially [ojrd.biomedcentral.com]
Before the treatment he had ejection fraction of 18{\%}. Discussing with his cardiologists we decided for immunoadsorption therapy. We performed 5 cycles on consecutive days in Intensive Care Unit. [hungary.pure.elsevier.com]
[…] should be performed or administered Class IIa - reasonable to perform procedure or administer treatment, but additional studies with focused objectives needed Class IIb - procedure or treatment may be considered; additional studies with broad objectives [dynamed.com]
Cardiomyopathy is a serious medical condition that requires treatment. Without treatment, the disease may progress and become life threatening. [medicalnewstoday.com]
To date, there are no specific treatment options for DCM patients but heart transplantation. [embopress.org]
Prognosis
Overall, the prognosis of patients with dilated cardiomyopathy is guarded. [statpearls.com]
The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD/heart transplantation-free survival can be prolonged. [hungary.pure.elsevier.com]
The accurate assessment of prognosis in patients with cardiomyopathy is critical. [revespcardiol.org]
The prognosis of dilated cardiomyopathy varies considerably depending on many factors. In general, the prognosis worsens as the heart becomes more dilated and functions less well. Abnormal heart rhythms also indicate a worse prognosis. [merckmanuals.com]
In addition, identifying the probable cause of DCM helps tailor specific therapies to improve prognosis. [ncbi.nlm.nih.gov]
Etiology
Environmental factors are also blamed in the etiology. [tjh.com.tr]
Etiology In FDC, there is clear evidence of Mendelian segregation of disease phenotype. FDC is a heterogeneous entity (Table 2). [ojrd.biomedcentral.com]
Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology [amboss.com]
The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. [hungary.pure.elsevier.com]
Dyspnea/etiology, Ileum/abnormalities, Infant, Premature, Diseases/diagnosis, Diagnosis, Differential, Dyspnea/diagnosis, Female, Humans, Infant, Newborn, Pulmonary Atelectasis/etiology, Respiratory Insufficiency/etiology 10. [pesquisa.bvsalud.org]
Epidemiology
Consequently, the genetic epidemiology of mutations in FDC genes across all FDC families remains unknown. [ojrd.biomedcentral.com]
Australian male Genetics Mutation: Lys92Arg CALR3 protein Ca -binding chaperone Localized mainly in endoplasmic/sarcoplasmic reticulum Colocalizes with: SPTLC2 CMH 20 Nexilin (NEXN) ; Chromosome 1p31.1; Dominant Epidemiology: Chinese families Genetics [neuromuscular.wustl.edu]
Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology [amboss.com]
Cardiomyopathies/epidemiology, Adolescent, Adult, Age Distribution, Cardiomyopathies/complications, Cardiomyopathies/therapy, Child, Child, Preschool, Croatia/epidemiology, Female, Hospitals, University/statistics & numerical data, Humans, Infant, Infant [pesquisa.bvsalud.org]
Summary Epidemiology To date, all cases of DCMA reported involve individuals from the Dariusleut Hutterite population, an endogamous population of the Great Plains region of Canada and the northern United States. [orpha.net]
Pathophysiology
Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology Clinical [amboss.com]
In this video series Michael Linares, RN from Simple Nursing helps explain the nursing pathophysiology, signs and symptoms, causes, pathology, treatment options for various diagnosis, which are expected to know for the NCLEX, HESI, ATI, and Kaplan proctor [youtube.com]
Cardiovascular Institute of Alberta and University of Calgary, Calgary, AB, Canada 9Max Delbrueck Center for Molecular Medicine, Berlin, Germany 10Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands 11Institute for Integrative Pathophysiology [embopress.org]
There are experimental and clinical data in animals and humans suggesting that genetic, viral, and immune factors contribute to the pathophysiology of IDC. [heart.bmj.com]
Prevention
[…] s2.ogv 20 s, 640 480; 13.52 MB Play media Prevention-of-exercised-induced-cardiomyopathy-following-Pip-PMO-treatment-in-dystrophic-mdx-mice-srep08986-s3.ogv 18 s, 640 480; 6.92 MB Play media Prevention-of-exercised-induced-cardiomyopathy-following-Pip-PMO-treatment-in-dystrophic-mdx-mice-srep08986 [commons.wikimedia.org]
Since the rotavirus vaccines became available, studies have shown that they prevent thousands of children from becoming sick and being hospitalized each year. [mayoclinic.org]
Centers for Disease Control and Prevention [medlineplus.gov]
Can Rotavirus Be Prevented? The rotavirus vaccine can prevent many causes of rotavirus. The vaccine is a liquid given by mouth to babies at ages 2 and 4 months, and again at 6 months, depending on the vaccine brand. [kidshealth.org]
[edit] Secondary prevention is preventing further sequelae of already established disease. [en.wikipedia.org]