Presentation
Snapshot A 60-year-old man presents to his cardiologist for worsening shortness of breath and easy fatigability. He began developing symptoms a few months prior to presentation. [step2.medbullets.com]
Lakhhdar et al. reported the case of two brothers (25 and 23 years) and their sister (who died at 14) presenting a DCM and for whom the celiac disease was discovered whereas they presented no digestive symptoms [ 17 ]. [ncbi.nlm.nih.gov]
In more severe cases, affected individuals present with signs and symptoms of heart failure. Young children often have poor appetite and cachexia. [revportcardiol.org]
The present review article will focus on the role of CMR in the evaluation of present condition, analysing respective strengths and limitations in the light of current literature and technological developments. 1. [hindawi.com]
We present the case of a 70-year-old man with primary cardiac lymphoma involving interatrial septum, presenting as atrial flutter and total heart block. [pesquisa.bvsalud.org]
Entire Body System
- Fatigue
Signs and symptoms of familial dilated cardiomyopathy can include an irregular heartbeat (arrhythmia), shortness of breath (dyspnea), extreme tiredness (fatigue), fainting episodes (syncope), and swelling of the legs and feet. [ncbi.nlm.nih.gov]
Symptoms of dilated cardiomyopathy — such as fatigue and shortness of breath — can mimic other health conditions. A person with dilated cardiomyopathy might not notice any symptoms at first. But dilated cardiomyopathy can become life-threatening. [mayoclinic.org]
Some people experience fatigue or vague abdominal discomfort. However, if the liver becomes inflamed due to excess fat you may also experiences the following symptoms: 1. Poor appetite 2. Weight loss 3. Abdominal pain 4. [dailystar.co.uk]
The 57-year-old man with a 2-year history of DCM had been hospitalized for chronic fatigue and dyspnea secondary to heart failure (New York Heart Association class III). [rheumnow.com]
Workup
For these reasons, routine diagnostic imaging workup of patients with DCM (including echocardiography, selective coronary angiography, and, when indicated, endomyocardial biopsy) has been integrated in the last few years with the use of cardiac magnetic [hindawi.com]
Workup is focused on identifying any possible reversible causes. Recommended laboratory testing includes thyroid function tests, HIV serology, electrolytes, and iron studies (to rule out hemochromatosis). [statpearls.com]
Treatment
Before the treatment he had ejection fraction of 18%. Discussing with his cardiologists we decided for immunoadsorption therapy. We performed 5 cycles on consecutive days in Intensive Care Unit. [hungary.pure.elsevier.com]
To date, there are no specific treatment options for DCM patients but heart transplantation. [embopress.org]
[…] should be performed or administered Class IIa - reasonable to perform procedure or administer treatment, but additional studies with focused objectives needed Class IIb - procedure or treatment may be considered; additional studies with broad objectives [dynamed.com]
Cardiomyopathy is a serious medical condition that requires treatment. Without treatment, the disease may progress and become life threatening. [medicalnewstoday.com]
Treatment Specific treatments are not available for most patients with IDC. [heart.bmj.com]
Prognosis
The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD/heart transplantation-free survival can be prolonged. [hungary.pure.elsevier.com]
Overall, the prognosis of patients with dilated cardiomyopathy is guarded. [statpearls.com]
The accurate assessment of prognosis in patients with cardiomyopathy is critical. [revespcardiol.org]
The prognosis of dilated cardiomyopathy varies considerably depending on many factors. In general, the prognosis worsens as the heart becomes more dilated and functions less well. Abnormal heart rhythms also indicate a worse prognosis. [merckmanuals.com]
In addition, identifying the probable cause of DCM helps tailor specific therapies to improve prognosis. [ncbi.nlm.nih.gov]
Etiology
The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. [hungary.pure.elsevier.com]
Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology [amboss.com]
Dyspnea/etiology, Ileum/abnormalities, Infant, Premature, Diseases/diagnosis, Diagnosis, Differential, Dyspnea/diagnosis, Female, Humans, Infant, Newborn, Pulmonary Atelectasis/etiology, Respiratory Insufficiency/etiology 10. [pesquisa.bvsalud.org]
The identification of Chagas etiology in patients with dilated cardiomyopathy was of prognostic significance. [revespcardiol.org]
It is also impossible to be sure which was the more significant etiology, or if both played a major role, as the simultaneous treatment of both situations prevented a clearer definition of the etiology. [revportcardiol.org]
Epidemiology
Mutations: Q131E; R279C Allelic with: CMD 1CC CMH 21 ● Chromosome 7p12.1-q21; Dominant Epidemiology: 1 family Clinical Onset age: 13 years to Adult Cardiac failure Sudden death CMH 22 ● Myopalladin gene (MYPN) ; Chromosome 10q21.3; Dominant Genetics [neuromuscular.wustl.edu]
Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology [amboss.com]
Cardiomyopathies/epidemiology, Adolescent, Adult, Age Distribution, Cardiomyopathies/complications, Cardiomyopathies/therapy, Child, Child, Preschool, Croatia/epidemiology, Female, Hospitals, University/statistics & numerical data, Humans, Infant, Infant [pesquisa.bvsalud.org]
Summary Epidemiology To date, all cases of DCMA reported involve individuals from the Dariusleut Hutterite population, an endogamous population of the Great Plains region of Canada and the northern United States. [orpha.net]
Relevant External Links for ACTC1 Genetic Association Database (GAD) ACTC1 Human Genome Epidemiology (HuGE) Navigator ACTC1 Atlas of Genetics and Cytogenetics in Oncology and Haematology: ACTC1 No data available for Genatlas for ACTC1 Gene Prevalence [genecards.org]
Pathophysiology
Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology Clinical [amboss.com]
In this video series Michael Linares, RN from Simple Nursing helps explain the nursing pathophysiology, signs and symptoms, causes, pathology, treatment options for various diagnosis, which are expected to know for the NCLEX, HESI, ATI, and Kaplan proctor [youtube.com]
Cardiac Sodium Channel Dysfunction and Dilated Cardiomyopathy: A Contemporary Reappraisal of Pathophysiological Concepts. J. Clin. Med. 2019, 8, 1029. [mdpi.com]
Cardiovascular Institute of Alberta and University of Calgary, Calgary, AB, Canada 9Max Delbrueck Center for Molecular Medicine, Berlin, Germany 10Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands 11Institute for Integrative Pathophysiology [embopress.org]
Prevention
Since the rotavirus vaccines became available, studies have shown that they prevent thousands of children from becoming sick and being hospitalized each year. [mayoclinic.org]
[…] s2.ogv 20 s, 640 × 480; 13.52 MB Play media Prevention-of-exercised-induced-cardiomyopathy-following-Pip-PMO-treatment-in-dystrophic-mdx-mice-srep08986-s3.ogv 18 s, 640 × 480; 6.92 MB Play media Prevention-of-exercised-induced-cardiomyopathy-following-Pip-PMO-treatment-in-dystrophic-mdx-mice-srep08986 [commons.wikimedia.org]
Centers for Disease Control and Prevention [medlineplus.gov]
Can Rotavirus Be Prevented? The rotavirus vaccine can prevent many causes of rotavirus. The vaccine is a liquid given by mouth to babies at ages 2 and 4 months, and again at 6 months, depending on the vaccine brand. [kidshealth.org]
[edit] Secondary prevention is preventing further sequelae of already established disease. [en.wikipedia.org]