Presentation
The latter is of particular interest in the present context. [books.google.de]
Family history should be reviewed in all patients with DCM, especially in those patients who present before the age of 60. [gwumc.edu]
[citation needed] Pulmonary embolism[edit] Pulmonary embolism classically presents with an acute onset of shortness of breath.[2] Other presenting symptoms include pleuritic chest pain, cough, hemoptysis, and fever.[2] Risk factors include deep vein thrombosis [en.wikipedia.org]
HCM, on the other hand, freqently initially presents with chest pain which can mimick that present in angina. [healthengine.com.au]
Workup
Serum
- Erythroblast
EncodeE4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 VCAP SKNSH RWPE1 MCF7 K562 JURKAT HL60 HEPG2 HELA GM12878 ESC DU145 A549 GATA1 Other C4 zinc finger-type factorsPublic + EncodeERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT K562 ERYTHROID ERYTHROBLAST [tagc.univ-mrs.fr]
Treatment
Primary endpoint was mortality rate during treatment. Results After one year treatment, there were 5 deaths in metoprolol group and 4 in placebo group. 2 patients deteriorated in metoprolol, 9 in placebo group. [dict.cnki.net]
Food and Drug Administration has chosen Wave Life Sciences’ planned phase 2/3 study of suvodirsen, its lead experimental therapy for the treatment of Duchenne muscular dystrophy, to break new ground. [globalgenes.org]
Treatment of the underlying disease Treatment of heart failure Sodium restriction ACE inhibitors, beta blockers, diuretics, digoxin See “Treatment” in CHF. [amboss.com]
Treatment is directed at the cause. [msdmanuals.com]
If pregnancy is continued, treatment must be adjusted while considering the fetus.19 Table 2 summarises treatment that is recommended for DCM and PPCM. Figure 2 summarises medical treatment for all cardiomyopaties. [heart.bmj.com]
Prognosis
However, severity of disease and prognosis varies widely according to the genetic features involved. Certain genes are associated with a worse prognosis. [healthengine.com.au]
The prognosis of dilated cardiomyopathy varies considerably depending on many factors. In general, the prognosis worsens as the heart becomes more dilated and functions less well. Abnormal heart rhythms also indicate a worse prognosis. [msdmanuals.com]
[…] cause of familial DCM, being reported in 12-25% of cases.3–5 The second most prevalent gene in familial DCM (LMNA) codes for lamin A/C, variants of which are found in around 10-15% of cases.6,7 DCM patients with LMNA mutations are reported to have worse prognosis [revportcardiol.org]
The prognosis in idiopathic dilated cardiomyopathy may be poorer than the prognosis for most cancers, whereas tachycardia-induced cardiomyopathy can be cured completely by restoring sinus rhythm. [ecgwaves.com]
HFpEF With Severe Pulmonary Hypertension Linked to Increased Mortality Patients with heart failure, severe pulmonary hypertension, and a preserved ejection fraction of ≥50% had a worse prognosis when compared with other patients with heart failure and [thecardiologyadvisor.com]
Etiology
Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology [amboss.com]
II – Forms A) Etiology The etiology of DCM is heterogeneous. In developed countries CAD and myocardial infarction (MI) are the most common causes of HF, approximating 50-75% of all HF patients. [escardio.org]
A systematic approach to define the etiology is essential for determination of the most effective treatment strategy. [emedicine.medscape.com]
At present there is no consensus on how to classify CMs on the basis of etiology, physiology or treatment, as their origin and pathophysiology are not well understood. [revportcardiol.org]
Epidemiology
Genetics Mutations: Q131E; R279C Allelic with: CMD 1CC CMH 21 ● Chromosome 7p12.1-q21; Dominant Epidemiology: 1 family Clinical Onset age: 13 years to Adult Cardiac failure Sudden death CMH 22 ● Myopalladin gene (MYPN) ; Chromosome 10q21.3; Dominant [neuromuscular.wustl.edu]
Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology [amboss.com]
[…] girdle muscular dystrophy type 2A Synonym(s): - LGMD2B - Limb-girdle muscular dystrophy due to dysferlin deficiency Classification (Orphanet): - Rare genetic disease - Rare neurologic disease Classification (ICD10): - Diseases of the nervous system - Epidemiological [csbg.cnb.csic.es]
Rockville, MD, 2000 ↵ Kahn HA, Sempos CT: Statistical Methods in Epidemiology. [care.diabetesjournals.org]
Relevant External Links for GATAD1 Genetic Association Database (GAD) GATAD1 Human Genome Epidemiology (HuGE) Navigator GATAD1 Atlas of Genetics and Cytogenetics in Oncology and Haematology: GATAD1 No data available for Genatlas for GATAD1 Gene Homozygosity [genecards.org]
Pathophysiology
Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology Clinical [amboss.com]
The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an idiopathic DCM. [software.broadinstitute.org]
"Epidemiology and pathophysiology of Takotsubo syndrome" (PDF). Nature Reviews Cardiology. 12 (7): 387–97. doi:10.1038/nrcardio.2015.39. hdl:10044/1/25730. [en.wikipedia.org]
Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms. Heart Fail Rev 2010;15:605-11. 41. Singh K, Carson K, Shah R, Sawhney G, Singh B, Parsaik A, et al. [e-jnc.org]
Prevention
In some cases, it prevents the heart from relaxing and filling with blood as it should. Over time, it can affect the other heart chambers. [medicinenet.com]
Treating cardiomyopathy There's usually no cure for cardiomyopathy, but the treatments can be effective at controlling symptoms and preventing complications. [nhs.uk]
His research aims to find better ways to diagnose, treat and prevent people dying from this disease, and beat the heartbreak. Donate [bhf.org.uk]
Prevention Healthy lifestyle habits can help you prevent or minimize the effects of dilated cardiomyopathy. If you have dilated cardiomyopathy: Don't smoke. Don't drink alcohol, or drink in moderation. Don't use cocaine or other illegal drugs. [mayoclinic.org]
Nemours Cardiac Center at Nemours/Alfred I. duPont Hospital for Children 1600 Rockland Road, Wilmington, DE 19803 | Get Map & Directions » Children’s heart conditions can’t be prevented, but a lot can be done to improve their hearts at any age. [nemours.org]