(14/15) ( Oldfors [1994] ), were described in patients presenting heart failure. [dmd.nl]

On this page you can find some general statistics about the data present in DIDA. General database statistics Variant effects Almost all variants present in DIDA are non-synonymous: 68.41% are missense, 13.74% are frameshift and 8.79% are nonsense. [dida.ibsquare.be]

These patients present X-linked inheritance, dominant cardiac involvement and raised levels of serum creatine phosphokinase. [link.springer.com]

A heritable pattern is present in 20 to 30% of cases. Most familial CMD pedigrees show an autosomal dominant pattern of inheritance, usually presenting in the second or third decade of life (summary by Levitas et al., 2010, pubmed:20551992). [flybase.org]

• Palpitations

  He gave history of palpitation off and on at rest, associated with chest pain and breathlessness in the last 2 years. There was no definite aggravating or relieving factor. [ijpmonline.org]

  […] mechanisms: Right-sided heart failure : decreased rRV output → systemic circulation congestion → clinical features of right-sided heart failure (backward failure with predominant systemic congestion) Clinical features Exertional dyspnea Angina pectoris Palpitations [amboss.com]

  The most common presentation was shortness of breath (58%), followed by palpitation (17%). Diastolic dysfunction was noted in all patients, whereas systolic dysfunction was subclinical in four, mild to moderate in four, and severe in three patients. [cags.org.ae]

  The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. [uniprot.org]

  Describe the idiopathic and nonidiopathic causes of DCM -Be able to clinically manage patients with DCM Case Study: You are a third year medical student asked to do a history and physical on a 30 year-old patient presenting with 3-month history of palpitations [gwumc.edu]

• Keratosis

  […] ventricular dysplasia, Dilated cardiomyopathy (DCM) AD 44 129 DSP Cardiomyopathy, dilated, with wooly hair, keratoderma, and tooth agenesis, Arrhythmogenic right ventricular dysplasia, familial, Cardiomyopathy, dilated, with wooly hair and keratoderma, Keratosis [blueprintgenetics.com]

The detailed diagnostic workup and possible red flags are presented in Table 3. [intechopen.com]

Workup is focused on identifying any possible reversible causes. Recommended laboratory testing includes thyroid function tests, HIV serology, electrolytes, and iron studies (to rule out hemochromatosis). [statpearls.com]

The diagnosis of a particular seizure type, and of a specific type of epilepsy (epilepsy syndrome), directs the diagnostic workup of these patients and their initial therapy. [ncbi.nlm.nih.gov]

• Premature Atrial Contractions

  Stage I occurs in the second and third decades and is characterized by absence of symptoms, normal heart size, sinus bradycardia, and premature atrial contractions. Stage II is marked by first-degree AV block in the third and fourth decades. [gwumc.edu]

Management and treatment In some patients, treatment may not be required. [orpha.net]

Treatment of the underlying disease Treatment of heart failure Sodium restriction ACE inhibitors, beta blockers, diuretics, digoxin See “Treatment” in CHF. [amboss.com]

It’s important that families affected by cardiomyopathy receive accurate assessment, diagnosis, treatment and support from specialists. [bhf.org.uk]

Managing treatment for Heart Disease is a highly personalized process. [familyheart.stanford.edu]

Advanced colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 21, 2010: v93 – v97 9. Levin B et. Al. (2008). [labtestsonline.cz]

Overall, the prognosis of patients with dilated cardiomyopathy is guarded. [statpearls.com]

Prognosis Status of Prognosis Patients with DCM generally have an ominous prognosis. DCM is a frequent cause of heart failure and the primary indication for heart implantation [18]. [oatext.com]

Prognosis MSL is basically a benign condition but in some cases, there may be serious physical, cosmetic and psychological repercussions. Associated disorders may affect the prognosis. [orpha.net]

The prognosis of DCM patients is variable and depends on multiple risk factors. [intechopen.com]

Identification of these areas and restoration of their perfusion through revascularization might improve the ejection fraction and long-term prognosis. [clevelandclinicmeded.com]

The risk factors for heart transplantation or death vary depending on the etiology of pediatric dilated cardiomyopathy, researchers found. [medpagetoday.com]

All analyses were performed by etiologic group. [scholarlyrepository.miami.edu]

Carcinoma/radiotherapy, Laryngeal Neoplasms/radiotherapy, Pemphigus/etiology, Radiation Injuries/etiology, Acantholysis/drug therapy, Acantholysis/etiology, Acantholysis/pathology, Adrenal Cortex Hormones/therapeutic use, Antigens/immunology, Antineoplastic [pesquisa.bvsalud.org]

Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology [amboss.com]

Etiology Etiology is a study of the cause of disease conditions useful for guiding therapeutic management [4]. The etiology of DCM is extremely heterogeneous. [oatext.com]

Psoriasis/epidemiology, Adolescent, Adult, Aged, Aged, 80 and over, Algeria/epidemiology, Cross-Sectional Studies, Female, Humans, Incidence, Male, Middle Aged, Morocco/epidemiology, Pruritus/epidemiology, Pruritus/etiology, Psoriasis/etiology, Psoriasis [pesquisa.bvsalud.org]

Mutations: Q131E; R279C Allelic with: CMD 1CC CMH 21 ● Chromosome 7p12.1-q21; Dominant Epidemiology: 1 family Clinical Onset age: 13 years to Adult Cardiac failure Sudden death CMH 22 ● Myopalladin gene (MYPN) ; Chromosome 10q21.3; Dominant Genetics [neuromuscular.wustl.edu]

Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology [amboss.com]

Summary Epidemiology Multiple symmetric lipomatosis (MSL) primarily affects men and has a sex ratio of 15:1 to 30:1, depending on the region. The disorder may occur in all ethnic groups. [orpha.net]

Clinical features Diagnostics Pathology Treatment Complications Hypertrophic cardiomyopathy Epidemiology Etiology Pathophysiology Clinical features Diagnostics Pathology Treatment Restrictive cardiomyopathy Epidemiology Etiology Pathophysiology Clinical [amboss.com]

Reference Human - 26926 2q31 TTN titin Mouse - 33467 2 D Ttn titin Rat - - 3q23 Ttn titin Previous and Unofficial Names cardiomyopathy, dilated 1G (autosomal dominant) | CMD1G | connectin | mdm | MYLK5 | shru | TMD Clinically-Relevant Mutations and Pathophysiology [guidetopharmacology.org]

[…] complex Cypher/ ZASP encodes for a part of the Z-line in cardiac and skeletal muscle, participating in the assembly and targeting of cytoskeletal proteins TAZ gene with unknown function causing X-linked dilated cardiomyopathy, which suggests that the pathophysiology [123sonography.com]

This chapter provides a review of dilated cardiomyopathy with specific focus on the pathophysiological aspects and genetic etiology of the disease. [intechopen.com]

The idiopathic category should continue to diminish as more information explaining pathophysiologic mechanisms, specifically genetic-environmental interactions, becomes available. Toxins are a significant cause. [emedicine.medscape.com]

Key benefits include: Clarify diagnosis and risk for sudden cardiac arrest Target medical management and prevention of cardiac arrest and other complications Adjust management in those with DCM due to a specific cardiac genotype, or underlying conditions [ambrygen.com]

Both salt and water restrictions are necessary to prevent symptoms. Patients should remain physically active or enroll in a cardiac rehab program. [statpearls.com]

However, all these approaches need further research. 2.9 Prevention of sudden cardiac death The most effective therapy of malignant VTs and thus prevention of SCD in DCM patients is the implantation of an ICD. [intechopen.com]

The primary indication of ICD therapy is the prevention of sudden cardiac death in idiopathic DCM and selected secondary DCM. [oatext.com]

Early diagnosis is indicated for 2 reasons: treatment of significant arrhythmias may prevent sudden unexpected death, and genetic counseling can be provided. [gwumc.edu]