Edit concept Question Editor Create issue ticket

Dimercaprol

British Anti Lewisite


Presentation

  • Questions regarding the complete and current content of product labeling / specification / presentation should be directed to SGPharma.[sgpharma.com]
  • Questions regarding the complete and current content of product labeling / specification / presentation should be directed to SGPharma .[sgpharma.com]
  • The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder.[neurology.org]
  • The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union.[echa.europa.eu]
Fever
  • A side effect apparently peculiar to children is a fever which develops after the second or third injection and persists until treatment with dimercaprol is terminated.[sgpharma.com]
  • Warnings/Precautions Warnings Local Effects Possible injection site pain or sterile abscesses at injection site. a b Fever Children may experience fever usually starting after second or third dose; a b may persist throughout therapy b until drug discontinued[drugs.com]
  • Adverse reactions CNS: pain or tightness in throat, chest, or hands; headache; paresthesia; muscle pain or weakness, anxiety, fever. CV: transient increase in blood pressure (returns to normal in 2 hours), tachycardia.[glowm.com]
Collapse
  • Drug Scheduling External Liaison Group (DSELG) Practice and Regulatory Standards Expand/Collapse Practice and Regulatory Standards Pharmacists Pharmacy Technicians General Practice Resources Policies and Positions Programs and Services Expand/Collapse[napra.ca]
  • Cardiovascular collapse, anuria and hepatic disturbance recovered in a few days and the patient could be discharged on the 15th day.[ncbi.nlm.nih.gov]
  • […] appear 15–30 minutes following the injection; BP usually returns to normal within 2 hours. a Use with caution in patients with hypertension. a Repeated high doses may cause capillary damage and loss of protein from the circulation leading to vascular collapse[drugs.com]
High Fever
  • Not in PubMed (Among patients with Wilson disease treated with BAL in doses of 200 to 300 mg twice daily for several months, injections were often painful and toxic reactions included high fever, worsening of neurologic signs, hallucinations, delirium[livertox.nih.gov]
Rhinorrhea
  • Nausea and vomiting; headache; burning sensations in the eyes, lips, mouth, and throat, sometimes accompanied by lacrimation, rhinorrhea, or salivation; myalgias; paresthesias; fever (particularly in children); a sensation of constriction in the chest[accessmedicine.mhmedical.com]
  • Special Senses: Rhinorrhea; burning sensation, feeling of pain and constriction in throat. GI: Nausea, vomiting; burning sensation in lips and mouth, halitosis, salivation; abdominal pain, metabolic acidosis.[robholland.com]
  • EENT: blepharospasm, conjunctivitis, lacrimation, rhinorrhea, excessive salivation. GI: nausea; vomiting; burning sensation in lips, mouth, and throat; abdominal pain. GU: burning sensation in penis. Skin: pain at injection site, sweating.[glowm.com]
  • Blepharal spasm, conjunctivitis, lacrimation, rhinorrhea, and salivation may also occur. When the drug is applied topically, it produces erythema and edema. American Society of Health System Pharmacists; AHFS Drug Information 2010.[pharmacompass.com]
Vomiting
  • OVERDOSAGE : Symptoms of overdosage include malaise, nausea, vomiting, lacrimation and salivation, burning sensation of lips, mouth, throat and eyes with headache. A sense of constriction of the throat and chest.[sgpharma.com]
  • GI: nausea; vomiting; burning sensation in lips, mouth, and throat; abdominal pain. GU: burning sensation in penis. Skin: pain at injection site, sweating. Effects on lab test results None reported.[glowm.com]
  • These include systolic and diastolic hypertension, tachycardia, nausea, vomiting, chest pain, headache, and sterile abscess at the injection site.[remm.nlm.gov]
  • Side effects include injection site reactions, local pain and sterile abscesses as well as systemic symptoms such as nausea, vomiting, headache, dizziness, spasms, sweating, excessive lacrimation or salivation, and skin or body tingling, burning and pain[livertox.nih.gov]
Nausea
  • Side effects include tachycardia, hypertension, nausea and vomiting, severe headaches, and a sense of constriction of the chest; barbiturates are usually ordered to relieve the symptoms, which should subside within an hour.[medical-dictionary.thefreedictionary.com]
  • OVERDOSAGE : Symptoms of overdosage include malaise, nausea, vomiting, lacrimation and salivation, burning sensation of lips, mouth, throat and eyes with headache. A sense of constriction of the throat and chest.[sgpharma.com]
  • These include systolic and diastolic hypertension, tachycardia, nausea, vomiting, chest pain, headache, and sterile abscess at the injection site.[remm.nlm.gov]
Abdominal Pain
  • Rare etiology of abdominal pain in an adolescent female. Clin Pediatr (Phila) 2015; 54: 94-7.[livertox.nih.gov]
  • . • Gastrointestinal : Abdominal pain. • Local : Pain and abscess. • Eye And ENT : Increased tears, throat pain, eye pain, runny nose. • Miscellaneous : Fever, sweating of the forehead, hands and other areas.[medindia.net]
  • pain, headache, tingling of the hands and other extremities, a feeling of constriction in the chest and throat, sweating of the forehead and hands.[sgpharma.com]
Halitosis
  • GI: Nausea, vomiting; burning sensation in lips and mouth, halitosis, salivation; abdominal pain, metabolic acidosis. Urogenital: Burning sensation in penis, renal damage.[robholland.com]
Bad Taste
  • Patient education • Advise patient that drug may cause a bad taste in the mouth or bad breath. It also may cause a burning sensation of the lips, mouth, throat, eyes, and penis, and pain in the teeth.[glowm.com]
Diastolic Hypertension
  • These include systolic and diastolic hypertension, tachycardia, nausea, vomiting, chest pain, headache, and sterile abscess at the injection site.[remm.nlm.gov]
Myalgia
  • Give 3 mg/kg IM every 12 hours for 7 – 10 days depending on the clinical response Lead encephalopathy: Commence dimercaprol 4 hours before commencing EDTA Give 4 mg/kg every 4 hours for 5 days Side effects: Pain and sterile abscess formation Fever and myalgia[lifeinthefastlane.com]
  • Nausea and vomiting; headache; burning sensations in the eyes, lips, mouth, and throat, sometimes accompanied by lacrimation, rhinorrhea, or salivation; myalgias; paresthesias; fever (particularly in children); a sensation of constriction in the chest[accessmedicine.mhmedical.com]
Urticaria
  • Mercury causes urticaria progressing to weeping dermatitis, leukopenia, anemia, diarrhea, salivation, liver damage, and renal damage progressing to acute renal failure with anuria.[ncbi.nlm.nih.gov]
Headache
  • . • Frequent : Hypertension, tachycardia, nausea, vomiting, burning sensation of lips, inflammation of mucous membranes, sweating, cramps, and headache. • Central Nervous System : CNS stimulation, headache, tingling, malaise. • Gastrointestinal : Abdominal[medindia.net]
  • OVERDOSAGE : Symptoms of overdosage include malaise, nausea, vomiting, lacrimation and salivation, burning sensation of lips, mouth, throat and eyes with headache. A sense of constriction of the throat and chest.[sgpharma.com]
  • These include systolic and diastolic hypertension, tachycardia, nausea, vomiting, chest pain, headache, and sterile abscess at the injection site.[remm.nlm.gov]
Seizure
  • Overdose and treatment Signs and symptoms of overdose include vomiting, seizures, stupor, coma, hypertension, and tachycardia; they subside in 1 to 6 hours. Support CV and respiratory status; control seizures with diazepam.[glowm.com]
  • Dimercaprol has been shown to induce seizure in animal studies and also is nephrotoxic. absorption After intra-muscular injection. half life The drug has a short half life. route of elimination Urine. Terms of Use[genelabs.com]
  • Central nervous system depression and seizures have occurred in overdose. Use in pregnancy. FDA Category C (indeterminate [See Introduction in Section III]). High doses of BAL are teratogenic and embryotoxic in mice.[accessmedicine.mhmedical.com]
  • […] soon as possible: Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue Pain or tightness in the chest, hands or throat Fast, irregular heartbeat Fever High blood pressure Irritation, pain at site where injected Seizures[pillpack.com]
Paresthesia
  • Mild reactions include pain at the injection site, nausea, excessive salivation, and paresthesia. di·mer·cap·rol ( dī'mĕr-kap'rol ) A chelating agent, developed as an antidote for lewisite and other arsenical poisons; also used as an antidote for antimony[medical-dictionary.thefreedictionary.com]
  • Nausea and vomiting; headache; burning sensations in the eyes, lips, mouth, and throat, sometimes accompanied by lacrimation, rhinorrhea, or salivation; myalgias; paresthesias; fever (particularly in children); a sensation of constriction in the chest[accessmedicine.mhmedical.com]
  • CNS: Headache, anxiety, muscle pain or weakness, restlessness, paresthesias, tremors, convulsions, shock. CV: Elevated BP, tachycardia. Special Senses: Rhinorrhea; burning sensation, feeling of pain and constriction in throat.[robholland.com]
Lethargy
  • This case report describes an accidental zinc chloride poisoning in a child, with lethargy as the most pronounced clinical sign. Clinical evaluation and chelator therapy are discussed.[pharmacompass.com]
  • At blood-lead concentrations of 50 ug/dl or higher, lead poisoning can produce the following symptoms: decreased play activity, lethargy, anorexia, sporadic vomiting, intermittent abdominal pain, and constipation.[cdc.gov]
Apathy
  • Signs of acute lead encephalopathy include coma, seizures, bizarre behavior, ataxia, apathy, incoordination, vomiting, alteration in consciousness, and subtle loss of recently acquired skills (1).[cdc.gov]

Workup

Activated Partial Thromboplastin Time Prolonged
  • Investigations Activated partial thromboplastin time prolonged, blood zinc decreased Paediatric population A side effect apparently peculiar to children is a fever which develops after the second or third injection, and persists until treatment with dimercaprol[medicines.org.uk]
Liver Biopsy
  • PubMed Citation (31 year old soldier with history of gunshot wound developed abdominal pain and jaundice, but normal ALT levels despite liver biopsy showing steatohepaittis; evaluation of anemia demonstrated lead poisoning, that responded partially to[livertox.nih.gov]

Treatment

  • However, it is not necessarily the treatment of choice for toxicity to these metals. Dimercaprol has been used as an adjunct in the treatment of the acute encephalopathy of lead toxicity.[en.wikipedia.org]
  • […] most recent AAP and CDC recommendations for information regarding chelation therapy. a i Ineffective in the treatment of poisoning resulting from arsine gas (AsH 3 ). a May be effective in the treatment of gold-induced dermatitis and gold-induced thrombocytopenia[drugs.com]
  • Treatment included folic acid and dimercaprol administration, hemodialysis, and exchange transfusion.[ncbi.nlm.nih.gov]
  • On July 21, 1940, the Oxford lab first synthesized BAL.[2] For security reasons It was initially termed OX 217 and not declared to the public until 1945.[3] BAL was involved early on in the treatment of other conditions because of it known chelation profile[chm.bris.ac.uk]

Etiology

  • ETIOLOGY OF CHROME DERMATITIS AND ITS FREQUENCY IN INDUSTRY CHROME compounds (chromic acid, chromates, and bichromates) are exceedingly active chemically and are powerful skin irritants.[jamanetwork.com]
  • Rare etiology of abdominal pain in an adolescent female. Clin Pediatr (Phila) 2015; 54: 94-7.[livertox.nih.gov]

Epidemiology

  • MD, Office of the Medical Examiner, District 8, Gainesville, NP Chopra, MD, Lake County, CL Bush, Office of Laboratory Svcs, JJ Witte, MD, JJ Sacks, MD, Acting State Epidemiologist, Florida Dept of Health and Rehabilitative Svcs; Div of Field Svcs, Epidemiology[cdc.gov]
Sex distribution
Age distribution

Prevention

  • Lead poisoning: from screening to primary prevention. Pediatrics. 1993; 92:176-83. [PubMed 8516071] 105. Agency for Toxic Substances and Disease Registry.[web.archive.org]
  • Preventing lead poisoning in young children: a statement by the Centers for Disease Control October 1991. Atlanta, GA: Centers for Disease Control, National Center for Environmental Health and Injury Control 1991-537-304.[drugs.com]
  • Awareness of toxicity and prevention remain the most important approaches.[ncbi.nlm.nih.gov]
  • Ephedrine or an antihistamine is sometimes administered to prevent symptoms. Patient & Family Education Drink as much fluid as the physician will permit. Do not breast feed while taking this drug without consulting physician.[robholland.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!