[…] promiscuity High CYP Inhibitory Promiscuity 0.5637 Ames test Non AMES toxic 0.5454 Carcinogenicity Non-carcinogens 0.9431 Biodegradation Not ready biodegradable 0.9888 Rat acute toxicity 2.7060 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak [go.drugbank.com]

In patients with respiratory tract dysfunction, infections, pulmonary embolism, and, especially in children, foreign body aspiration have to be ruled out. [onlinelibrary.wiley.com]

onset of symptoms that points to an anaphylactic reaction. [onlinelibrary.wiley.com]

Moreover, fluids should be replaced and, in case of respiratory distress, short-acting ß-2 agonists inhaled. [onlinelibrary.wiley.com]

Some first generation H1A potentially cause dose-related cardiac adverse effects, including sinus tachycardia, reflex tachycardia, supraventricular arrhythmias, and after intentional large overdose, for example, diphenhydramine 0.5 to 1 g, prolongation [medcraveonline.com]

Adenosine The risk or severity of Tachycardia can be increased when Adenosine is combined with Dimetindene. Agomelatine Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Dimetindene. [go.drugbank.com]

Cyproheptadine 8 2–4 + Desloratadine 24 5 +/− Fexofenadine 24 60 +/− Loratadine >24 10 +/− Phenindamine 4–6 25 +/− Terfenadinea 12 60 +/− aWithdrawn from the US market because of reports of prolonged-QT syndrome and torsade-type atypical ventricular tachycardia [accessmedicine.mhmedical.com]

Patients with cardiovascular symptoms may show dizziness, drop in blood pressure, syncope, or tachycardia. With respect to the respiratory tract, afflicted patients generally display symptoms like dyspnea, stridor, and coughing. [onlinelibrary.wiley.com]

Do not use a stimulant; vasopressors may be used to normalise hypotension. Important notes Storage: Do not store above 25°C. Manufacturer Novartis Consumer Health, Switzerland [medic.co.il]

The early, preferably intramuscular, administration of epinephrine has been recommended by European and German guidelines as first-line therapy 9, as soon as symptoms such as hypotension, syncope, stridor, dyspnea, or cardiac arrest set in. [onlinelibrary.wiley.com]

Blood hypotension is also possible. In its terminal phase, coma can be aggravated by cardiorespiratory colapse and death. There has been no report of a fatal outcome of Dimethindene overdosage. [go.drugbank.com]

disease.68 As discussed earlier, the common feature of H1A that cause Torsades de pointes is their ability to block hERG channels and to prolong the QT interval. [medcraveonline.com]

The product cannot be used as a treatment for known allergies to insect bites (systemic pharmaceutical forms are available for this purpose). [medic.co.il]

spasms (uterus, bronchi etc.) [onlinelibrary.wiley.com]

redness, urine retention and fever. [medic.co.il]

The symptoms are the following: depression of the CNS with dizziness (especially in adults), stimulation of the CNS and an antimuscarinic effect (especially in children) with excitation, ataxia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth [medic.co.il]

Few minutes after administration of the booster injection, she complains about a progressive tightness in her chest, dizziness, and an itching rash. [onlinelibrary.wiley.com]

The symptoms are the following: depression of the CNS with dizziness (especially in adults), stimulation of the CNS and an antimuscarinic effect (especially in children) with excitation, ataxia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth [medic.co.il]

[…] with other antihistaminic drugs, overdosage can produce the following symptoms: CNS depression accompanied by drowsiness (especially in adults), CNS stimulation and antimuscarinic effects (especially in children) including the following: excitation, ataxia [go.drugbank.com]

The symptoms are the following: depression of the CNS with dizziness (especially in adults), stimulation of the CNS and an antimuscarinic effect (especially in children) with excitation, ataxia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth [medic.co.il]

[…] produce the following symptoms: CNS depression accompanied by drowsiness (especially in adults), CNS stimulation and antimuscarinic effects (especially in children) including the following: excitation, ataxia, hallucinations, tonic or clonic spasms, mydriasis [go.drugbank.com]

This can induce Torsades de pointes that it is a ventricular tachycardia associated with delayed cardiac repolarization that can manifest as a prolonged QT interval on the electrocardiogram and that may cause syncope, seizure, ventricular fibrillation [medcraveonline.com]