Status in Israel Presentation and Status in Health Basket Presentation Basket Yarpa Pharmasoft Gel 30 g 12878 6357 Gel 100 g 89740 6423 Dosage Adults and children: Apply 2 to 4 times per day on the areas to be treated in a thin layer and massage lightly [medic.co.il]

Case examples Case 1 A 15-year old boy presents to your office with his mother for evaluation of recurrent spontaneous urticaria. He complains about a tingling sensation of the lips and tongue. [onlinelibrary.wiley.com]

• Tachycardia

  Some first generation H1A potentially cause dose-related cardiac adverse effects, including sinus tachycardia, reflex tachycardia, supraventricular arrhythmias, and after intentional large overdose, for example, diphenhydramine 0.5 to 1 g, prolongation [medcraveonline.com]

  Adenosine The risk or severity of Tachycardia can be increased when Adenosine is combined with Dimetindene. Agomelatine Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Dimetindene. [go.drugbank.com]

  Cyproheptadine 8 2–4 + Desloratadine 24 5 +/− Fexofenadine 24 60 +/− Loratadine >24 10 +/− Phenindamine 4–6 25 +/− Terfenadinea 12 60 +/− aWithdrawn from the US market because of reports of prolonged-QT syndrome and torsade-type atypical ventricular tachycardia [accessmedicine.mhmedical.com]

  Patients with cardiovascular symptoms may show dizziness, drop in blood pressure, syncope, or tachycardia. With respect to the respiratory tract, afflicted patients generally display symptoms like dyspnea, stridor, and coughing. [onlinelibrary.wiley.com]

• Hypotension

  Do not use a stimulant; vasopressors may be used to normalise hypotension. Important notes Storage: Do not store above 25°C. Manufacturer Novartis Consumer Health, Switzerland [medic.co.il]

  The early, preferably intramuscular, administration of epinephrine has been recommended by European and German guidelines as first-line therapy 9, as soon as symptoms such as hypotension, syncope, stridor, dyspnea, or cardiac arrest set in. [onlinelibrary.wiley.com]

  Blood hypotension is also possible. In its terminal phase, coma can be aggravated by cardiorespiratory colapse and death. There has been no report of a fatal outcome of Dimethindene overdosage. [go.drugbank.com]

• Mydriasis

  The symptoms are the following: depression of the CNS with dizziness (especially in adults), stimulation of the CNS and an antimuscarinic effect (especially in children) with excitation, ataxia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth [medic.co.il]

  […] produce the following symptoms: CNS depression accompanied by drowsiness (especially in adults), CNS stimulation and antimuscarinic effects (especially in children) including the following: excitation, ataxia, hallucinations, tonic or clonic spasms, mydriasis [go.drugbank.com]

• Dizziness

  The symptoms are the following: depression of the CNS with dizziness (especially in adults), stimulation of the CNS and an antimuscarinic effect (especially in children) with excitation, ataxia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth [medic.co.il]

  Few minutes after administration of the booster injection, she complains about a progressive tightness in her chest, dizziness, and an itching rash. [onlinelibrary.wiley.com]

• Ataxia

  The symptoms are the following: depression of the CNS with dizziness (especially in adults), stimulation of the CNS and an antimuscarinic effect (especially in children) with excitation, ataxia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth [medic.co.il]

  […] with other antihistaminic drugs, overdosage can produce the following symptoms: CNS depression accompanied by drowsiness (especially in adults), CNS stimulation and antimuscarinic effects (especially in children) including the following: excitation, ataxia [go.drugbank.com]

• Irritability

  Benzalkonium chloride: irritant and can cause skin reactions. Avoid applying over large areas, especially in infants and young children. Avoid prolonged exposure to the sun of the areas treated. [medic.co.il]

Type Small Molecule Groups Approved, Investigational Structure Weight Average: 292.418 Monoisotopic: 292.193948778 Chemical Formula C20H24N2 Synonyms Dimethindene Dimetindene Dimetindeno Indication Indicated as symptomatic treatment of allergic reactions [go.drugbank.com]

Once the diagnosis of anaphylaxis is made, stage-oriented treatment has to be implemented. [onlinelibrary.wiley.com]

The product cannot be used as a treatment for known allergies to insect bites (systemic pharmaceutical forms are available for this purpose). [medic.co.il]

Also loratadine and cetirizine have been available for several years; these drugs are also less sedating and have been approved for marketing,1,3,4,6,11,12 these two nonsedating H1A at doses three to six times higher than clinically recommended for treatment [medcraveonline.com]

More accurate epidemiologic data is not available, in part due to the lack of uniformly implemented ICD coding for anaphylaxis and the fact that not every allergic emergency is actually treated by a physician 3. [onlinelibrary.wiley.com]

Pathophysiology and classification of severity Anaphylaxis is defined as a mast cell-dependent reaction with acute onset and potentially fatal outcome 4. [onlinelibrary.wiley.com]

In the next few years the perception of drug-induced cardiovascular toxicity might easily change because of the approval of safer drugs or refinements of techniques for predicting, managing, or preventing such toxicity. None. [medcraveonline.com]

Prevention Apart from the acute intervention, preventive measures should be established for patients following a severe allergic reaction. [onlinelibrary.wiley.com]