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Dimethyl Sulfoxide


Presentation

  • It may be present in healthy individuals with no predisposing etiological factors (2-4).[ncbi.nlm.nih.gov]
Wound Infection
  • Author information 1 Department of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA. jtarrand@mdanderson.org Abstract Effective skin antisepsis is of central importance in the prevention of wound infections,[ncbi.nlm.nih.gov]
Halitosis
  • Plus and Minus Icon Reported: Garlic taste in mouth, dry skin, erythema and pruritis (2), urine discoloration, halitosis, agitation, hypotension, sedation dizziness (13).[mskcc.org]
  • "Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulphide". J. Clin. Periodontol. 34 (9): 748–55. doi : 10.1111/j.1600-051X.2007.01116.x. PMID 17716310.[en.wikipedia.org]
Incontinence
  • Adverse effects, 24-hour pad weights, episodes of incontinence, postvoid residuals, and scores on the Blaivas-Groutz anti-incontinence scale, Indevus Urgency Severity Scale, Incontinence Impact Questionnaire-short form, and Urogenital Distress Inventory[ncbi.nlm.nih.gov]
Tonic-Clonic Seizure
  • Herein we report a 52-year-old man who experienced tonic-clonic seizure within minutes after the initiation of DMSO cryopreserved autologous PBPC infusion.[ncbi.nlm.nih.gov]

Workup

Pulmonary Infiltrate
  • We conclude that a therapeutic trial with transdermal DMSO administration brought about a marked regression of the pulmonary infiltrate.[ncbi.nlm.nih.gov]

Treatment

  • […] in Siemianowice Śląskie, Siemianowice Śląskie, Poland. 5 Dr Stanislaw Sakiel Center for Burns Treatment in Siemianowice Śląskie, Siemianowice Śląskie, Poland. 6 Dr Stanislaw Sakiel Center for Burns Treatment in Siemianowice Śląskie, Siemianowice Śląskie[ncbi.nlm.nih.gov]
  • Length of treatment varied from one to eleven years in 79 patients, with the majority receiving ten to twenty treatments over times averaging one to three years.[dmso.org]

Prognosis

  • Given the poor prognosis of AL and the promising results of dose-intensive chemotherapy with autologous PBSC transplantation, careful patient selection and intensive monitoring are mandatory in order to further pursue this therapeutic approach.[ncbi.nlm.nih.gov]

Etiology

  • It may be present in healthy individuals with no predisposing etiological factors (2-4).[ncbi.nlm.nih.gov]
  • Interstitial Cystitis: Update on Etiologies and Therapeutic Options. J Women's Health & Gender-Based Med 1999; 6:745. 3. Parkin J, et al. Intravesical Dimethyl Sulfoxide (DMSO) for Interstitial Cystitis -A Practical Approach.[rxlist.com]

Pathophysiology

  • Pathophysiology of acute neurological and cardiac toxicity is unclear, but may also be idiosyncratic. Clinicians should be aware of the toxicity of cryoprotectant agents during PBSC infusion.[ncbi.nlm.nih.gov]
  • Nilius B, Appendino G, Owsianik G (2012) The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch 464: 425–458. View Article Google Scholar 24.[doi.org]

Prevention

  • METHODS: A multicenter, randomized, three-arm, open-label trial in four Italian large bone marrow transplant centers was conducted to assess the effectiveness of orange aroma in preventing NV related to DMSO.[ncbi.nlm.nih.gov]

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