It may be present in healthy individuals with no predisposing etiological factors (2-4). [ncbi.nlm.nih.gov]

• Pain

  M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02AX Other topical products for joint and muscular pain M02AX03 Dimethyl sulfoxide D01043 Dimethyl sulfoxide (USP/INN) Other DBs CAS: 67-68-5 PubChem: 7848106 ChEBI: 28262 ChEMBL: CHEMBL504 DrugBank: [kegg.jp]

  A significant number of patients receiving analgesic therapy with opioids report persisting pain of a higher intensity than the pain in those who were not on this class of drugs. [ncbi.nlm.nih.gov]

  Washing the bladder with DMSO improves symptoms such as pain associated with interstitial cystitis. Possibly Effective for A chronic pain condition called complex regional pain syndrome. [webmd.com]

• Inflammation

  It is rapidly absorbed when applied to the skin and has been shown to reduce pain and inflammation. However, there are concerns of adverse effects including damage to the nerves. [mskcc.org]

  For the treatment of: swelling, bruising, muscles inflammation or discomfort, tendons inflammation, tendon sheaths, ligaments, joints closed injuries. [grovet.com]

  Inflammation. DMSO is an antioxidant, free radical scavenger, and reduces inflammation. It is particularly effective for inflammation in the genital and urinary tracts. Auto-immune ailments. Relief of many such ailments. Scleroderma. [growyouthful.com]

  It reduces inflammation in joints and in areas where trauma has occurred as the result of injury, and can be used as a carrier for other medications. [cayuseshop.com]

  In addition, DMSO has been studied as a medication for the treatment of inflammation, cystitis, and arthritis. [ncbi.nlm.nih.gov]

• Swelling

  Basic Medical Properties: DMSO is recommended as a topical application to reduce acute swelling due to trauma. DMSO is a rapidly absorbed skin penetrant. [amazon.com]

  For the treatment of: swelling, bruising, muscles inflammation or discomfort, tendons inflammation, tendon sheaths, ligaments, joints closed injuries. [grovet.com]

  It was also shown to relieve pain and swelling, relax muscles, relieve arthritis, improve blood supply and slow the growth of bacteria. [kat-chem.hu]

  Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. [drugs.com]

• Unconsciousness

  If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. [cameochemicals.noaa.gov]

  Further processing may transfer the induced activity patterns to higher brain regions, where they may be experienced consciously and unconsciously as sensations related to the specific volatiles. [doi.org]

• Severe Pain

  This report describes a case of local toxicity consisting of severe pain after its use in a pediatric patient. An illustration shows the extravasation area. [ncbi.nlm.nih.gov]

• Nausea

  RESULTS: Although 48 h after transplantation no differences were observed in controlled nausea (Numerical Rating Scale (NRS) 0-100, ≤25) or vomiting, significantly fewer patients had no episodes of vomiting, no antiemetic rescue therapy, and no nausea [ncbi.nlm.nih.gov]

  Side effects of DMSO taken internally include headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation and anorexia. Topical DMSO also can cause skin irritation and dermatitis. [arthritis.org]

  Side effects associated with its use include nausea, headache, and skin rash. Further, since DMSO is a "carrier" chemical, it could deliver harmful substances into the bloodstream, if they are present in impure DMSO through use on the skin. [web.archive.org]

• Vomiting

  RESULTS: Although 48 h after transplantation no differences were observed in controlled nausea (Numerical Rating Scale (NRS) 0-100, ≤25) or vomiting, significantly fewer patients had no episodes of vomiting, no antiemetic rescue therapy, and no nausea [ncbi.nlm.nih.gov]

  Inhalation of DMSO vapor can cause irritation of the respiratory tract, and at higher concentrations may cause vomiting, chills, headache, and dizziness. [chemicalbook.com]

  Side effects of DMSO taken internally include headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation and anorexia. Topical DMSO also can cause skin irritation and dermatitis. [arthritis.org]

• Diarrhea

  A 37 year-old man with adult-onset Still's disease suffered from diarrhea. Upper and lower gastrointestinal endoscopy revealed edematous mucosa, white patches, erosions and bleeding and amyloid deposits were demonstrated in biopsy specimens. [ncbi.nlm.nih.gov]

  Side effects of DMSO taken internally include headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation and anorexia. Topical DMSO also can cause skin irritation and dermatitis. [arthritis.org]

  Some side effects of taking DMSO include skin reactions, dry skin, headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation, breathing problems, vision problems, blood problems, and allergic reactions. [webmd.com]

• Heart Disease

  Allergies, Alzheimer's disease, antibiotic, antioxidant, antiplatelet, bladder disorders, burns, closed head trauma, colitis (inflamed colon), fibromyalgia (pain disorder), gallstones, heart disease, high cholesterol, high or low blood pressure, infection [thesourcenatural.com]

• Halitosis

  "Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulphide". J. Clin. Periodontol. 34 (9): 748–55. doi : 10.1111/j.1600-051X.2007.01116.x. [en.wikipedia.org]

  Plus and Minus Icon Reported: Garlic taste in mouth, dry skin, erythema and pruritis (2), urine discoloration, halitosis, agitation, hypotension, sedation dizziness (13). [mskcc.org]

• Flushing

  Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. [cameochemicals.noaa.gov]

  In case of eye contact, immediately flush eyes with water and call a physician. Do not refrigerate, as liquid DMSO crystallizes at temperatures below 67 degrees fahrenheit. This does not harm the product - just thaw at room temperature. [shoppe.listentoyourgut.com]

  To treat it, your doctor may flush DMSO into your bladder using a catheter over several of weeks. It’s also available in pill form and as a topical lotion, but these formulations are not approved for use by the FDA. [healthline.com]

  Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area. [drugs.com]

• Contusion

  Contusions and bruises, sprains and strains, tennis elbow, tendonitis, tenosynovitis, bursitis, neuralgia (nerve pain). [grovet.com]

• Seizure

  Among the central nervous system side effects the epileptic seizures, stroke, transient and temporary leucoencephalopathy, and global amnesia are well known. [ncbi.nlm.nih.gov]

  […] bad breath, body odor, constipation, destruction of red blood cells, diarrhea, dizziness, eosinophilia (increased white blood cells), fluid build-up in the lungs, flu-like symptoms, flushing, garlic taste, headache, memory loss, nausea, neurotoxicity, seizure [thesourcenatural.com]

[…] in Siemianowice Śląskie, Siemianowice Śląskie, Poland. 5 Dr Stanislaw Sakiel Center for Burns Treatment in Siemianowice Śląskie, Siemianowice Śląskie, Poland. 6 Dr Stanislaw Sakiel Center for Burns Treatment in Siemianowice Śląskie, Siemianowice Śląskie [ncbi.nlm.nih.gov]

Two of the 3 cases had a dismal prognosis. A brief review of the literature is presented. [ncbi.nlm.nih.gov]

It may be present in healthy individuals with no predisposing etiological factors (2-4). [ncbi.nlm.nih.gov]

Interstitial Cystitis: Update on Etiologies and Therapeutic Options. J Women's Health & Gender-Based Med 1999; 6:745. 3. Parkin J, et al. Intravesical Dimethyl Sulfoxide (DMSO) for Interstitial Cystitis -A Practical Approach. [rxlist.com]

Pathophysiology of acute neurological and cardiac toxicity is unclear, but may also be idiosyncratic. Clinicians should be aware of the toxicity of cryoprotectant agents during PBSC infusion. [ncbi.nlm.nih.gov]

Nilius B, Appendino G, Owsianik G (2012) The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch 464: 425–458. View Article Google Scholar 24. [doi.org]

The prevention and treatment of vesicant extravasation presents unique nursing challenges. In two case studies, the authors describe the clinical response of patients to dimethyl sulfoxide after multivesicant extravasation. [ncbi.nlm.nih.gov]