Phenylephrine: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever [web.archive.org]

INDICATIONS Benadryl Allergy (diphenhydramine) Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat temporarily relieves these symptoms due [rxlist.com]

Bottles Get relief from hay fever and seasonal allergies! Mini tablets are easy to swallow, yet pack a punch against allergies with 25 mg of the antihistamine Diphenhydramine Hydrochloride. [dollartree.com]

[…] pronounced as (dye fen hye' dra meen) Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. [medlineplus.gov]

A rare occurrence of DPH abuse via documented intravenous administration leading to death is presented. [ncbi.nlm.nih.gov]

After intravenous administration of 0.8 mg/kg diphenhydramine, a prolonged half-life was noted in patients with chronic liver disease which correlated with the severity of the disease 16. [drugbank.ca]

He was found unconscious and hypotensive. His serum potassium concentration was 8.3 mEq/L and the ECG revealed a coved-type ST-segment elevation in leads V2-V3. [ncbi.nlm.nih.gov]

Use gastric lavage if patient is unconscious or ipecac fails. Treat hypotension with vasopressors and control seizures with diazepam or phenytoin. Don’t give stimulants. [glowm.com]

Hypotension, manifest as dizziness, shock and unconsciousness or both, occurs in only 10 to 30% of individuals with anaphylaxis ( Brown 2001 ; Brown 2004a ; Kemp 2002 ; Lieberman 2003 ; Simons 2002 ). [doi.org]

energy, restlessness, nervousness, euphoria, anxiety, hallucinations, insomnia, irritability [ Ref ] Cardiovascular Rare (0.01% to 0.1%): Palpitations, hypotension, arrhythmia Frequency not reported : Tachycardia, chest tightness, extrasystoles [ Ref [drugs.com]

sickness remedies) D00669 Diphenhydramine hydrochloride (JP17/USP) Allergic agents 52 Antihistamine based drugs D00669 Diphenhydramine hydrochloride (JP17/USP) Agents for integumentary system 57 Analgesic, antipruritic, astringent, and anti-inflammatory [kegg.jp]

While xerostomia can be a mild aggravation for the patient and may not appear to be clinically relevant, chronic xerostomia can increase the risk for dental caries as well as worsen symptoms of gastroesophageal reflux disease (GERD). [ebmconsult.com]

Interactions Found Interactions Found Serious - Use Alternative Significant - Monitor Closely All Interactions Sort By: Adverse Effects Frequency Not Defined Sedation Confusion Anticholinergic effects May decrease cognitive function in geriatric patients Xerostomia [reference.medscape.com]

Diphenhydramine toxicity commonly manifests with antimuscarinic features, including dry mucous membranes, tachycardia, urinary retention, mydriasis, tachycardia, and encephalopathy. [ncbi.nlm.nih.gov]

[…] of hands, legs, or feet; tremor; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; wheezing; yellowing of the skin or eyes. [web.archive.org]

One case report of a pregnant woman who ingested a large amount of diphenhydramine in an attempted suicide developed strong, regular uterine contractions that were halted by the administration of intravenous magnesium. [web.archive.org]

Diphenhydramine/Ibuprofen: Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion [web.archive.org]

[…] infants, diphenhydramine in over-dosage may cause convulsions or death May cause significant sedation or paradoxical excitation/akethesia Diphenhydramine has additive effects with alcohol and other CNS depressants Antihistamines may cause dizziness, confusion [orangecountyfl.net]

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, confusion, constipation, or trouble urinating. Drowsiness, dizziness, and confusion can increase the risk of falling. [webmd.com]

] Other Common (1% to 10%): Fatigue Frequency not reported : Lassitude, tinnitus, acute labyrinthitis, asthenia, chills, impaired performance (including impaired driving, work, and/or information processing) [ Ref ] Psychiatric Rare (0.01% to 0.1%): Confusion [drugs.com]

The generalized seizures continued for duration of 30 min, despite the intravenous administration of 8 mg of lorazepam. The patient underwent endotracheal intubation and a propofol infusion terminated her seizures. [ncbi.nlm.nih.gov]

[…] reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever; hallucinations; seizure [web.archive.org]

Midazolam was administered with seizure resolution. Examination revealed 4-mm reactive pupils; nystagmus; warm, dry, flushed skin; and altered mental status. [doi.org]