Presentation
A 15-year old male patient presented to us with dyspnoea for four days. He had a history of fever, pseudo-membranous tonsillitis and cervical adenopathy twenty-five days prior to the presentation. [ncbi.nlm.nih.gov]
The present program has been developed on the principle that sound knowledge and reliable technology already exist for implementing community programs for the prevention and control of rheumatic fever and rheumatic heart disease with the intention of [books.google.com]
Some presentations of myocarditis, especially those related to parvovirus B19, present like an acute lateral wall myocardial infarction. [intechopen.com]
Softening and pallor of the ventricles may be present. Concomitant pericardial effusion and pericarditis may be present in cases of viral or bacterial myocarditis. [emedicine.medscape.com]
In present study, 100% mortality was observed in patients who presented with LBBB, 90% mortality was seen with CHB, and 75% mortality was seen in RBBB. [jebmh.com]
Entire Body System
- Fever
Rheumatic fever has almost disappeared from economically developed countries; this trend has paralleled improvements in standards of living. However, the recent resurgence of rheumatic fever in middle-class families in the U. S. [books.google.com]
He had a history of fever, pseudo-membranous tonsillitis and cervical adenopathy twenty-five days prior to the presentation. On examination and laboratory investigations, he had features suggestive of myocarditis with biventricular failure. [ncbi.nlm.nih.gov]
This is is seen in : Any viral fever. First week of enteric fever. Sometimes in pyogenic meningitis. Brucellosis, psittacosis. The relative bradycardia in yellow fever is known as Faget's sign. [notes.medicosnotes.com]
trench fever, human erlichiosis; and more. [books.google.de]
- Inflammation
Myocarditis refers processes of cardiac injury which are primarily the result of cardiac inflammation Overview In most cases, myocarditis results from microbial infection of the myocardium, typically of viral origin. [pathwaymedicine.org]
Characteristic features of ischemia-related inflammation include subendocardial location, a large proportion of neutrophils, extensive necrosis in relation to inflammation, and zonal necrosis in the case of nonreperfusion infarcts. [emedicine.medscape.com]
Myocarditis may result in an abnormal heart rate and inflammation of the nerves may result in paralysis. Diphtheria is usually spread between people by direct contact or through the air. It may also be spread by contaminated objects. [play.google.com]
Many secondary causes, such as a heart attack, can lead to inflammation of the myocardium and therefore the diagnosis of myocarditis cannot be made by evidence of inflammation of the myocardium alone. [16] [17] Myocardial inflammation can be suspected [en.wikipedia.org]
Complications may include myocarditis, inflammation of nerves, kidney problems, and bleeding problems due to low blood platelets. Myocarditis may result in an abnormal heart rate and inflammation of the nerves may result in paralysis. [icd.codes]
- Congestive Heart Failure
New to the third edition are: - Expanded coverage of the coronary heart disease syndromes; congestive heart failure; arrhythmias; pacing; sudden death; lipid management (including clinical results), and a completely revised and updated section on noninvasive [books.google.de]
[…] results, and without serious side-effects, in patients with congestive heart-failure. 7-9 This drug has been evaluated clinically at this hospital in five children with diphtheritic myocarditis and severe congestive heart-failure. [kundoc.com]
heart failure - ECG: ST and T wave abnormalities and arrhythmias. [mrcpart1revision.blogspot.com]
- Falling
[…] a secondary disorder in acute infectious diseases. 2 Still others believe that the most important lesion in connection with carditis is myocarditis. 3 Gibson 4 recently stressed that from the standpoint of causation the majority of cardiac ailments fall [jamanetwork.com]
This information can be crucial should you fall ill while traveling.After you leave home, there are some things you can no longer do to protect yourself and many things that are much harder to undertake. [diversalertnetwork.org]
Etiology From an etiologic perspective, myocarditis cases usually fall into 1 of the following 4 main categories: Infectious Postviral autoimmune-related Autoimmune-mediated (lupus myocarditis, giant-cell myocarditis [GCM]) Drug-associated (hypersensitivity [emedicine.medscape.com]
Singhi study sex ratio was (boys:girls) 2.2:1 In present study, out of 100 cases of culture positive diphtheria only 8 patients were adequately immunised, 92 patients were unimmunised, and most of the unimmunised children fall in the age group of 5-10 [jebmh.com]
Respiratoric
- Pharyngitis
Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2] Overview There are no specific EKG findings associated with pharyngitis, but the complications of pharyngitis may be associate cardiac rhythm [wikidoc.org]
A36.9 Diphtheria, unspecified A36.0 Pharyngeal diphtheria A36.1 Nasopharyngeal diphtheria A36.3 Cutaneous diphtheria A36.84 Diphtheritic tubulo-interstitial nephropathy A36.89 Other diphtheritic... [5minuteconsult.com]
Sore throat Viral pharyngitis, the most common cause of a sore throat. [en.wikipedia.org]
C. pseudodiptheriticum does not produce a toxin, but can cause exudative pharyngitis with a pseudomembrane. [patient.info]
- Cough
What is the epidemiology of the whooping cough? It is highly contagious, usually after exposure due to respiratory aerosol droplets during cough. [quizlet.com]
cough due to other Bordetella species without pneumonia A3781Whooping cough due to other Bordetella species with pneumonia A3790Whooping cough, unspecified species without pneumonia A3791Whooping cough, unspecified species with pneumonia PDX Collection [cms.gov]
Vaccination -- Measles Pertussis or whooping cough is a disease of the respiratory tract caused by bacteria that live in the mouth, nose and throat. This disease which is most dangerous in infants causes severe coughing spells. [sundaytimes.lk]
You can catch it from a person who has the infection and coughs or sneezes. You can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. Diphtheria usually affects the nose and throat. [coding-pro.com]
- Dyspnea
Causes are Coxsackie or adenoviral infection, Trypanosoma cruzi, Streptococcus (rheumatic carditis), diphtheria, toxoplasmosis, Lyme disease, toxins and autoimmune conditions - presents with fatigue, palpitations, chest pain, dyspnea and fulminant congestive [mrcpart1revision.blogspot.com]
Braunwald Brit cardiac output Cardiol Cardiovas Cardiovascular carotid catheter Catheterization cells Chap chest Circulation Res Clin clinical congestive heart failure contractility coronary artery curve decrease diagnosis diastolic digitalis diuretics drug dyspnea [books.google.de]
Shortness of breath Dyspnea on exertion and fatigue are common. [intechopen.com]
Clinical Features and Imaging Patients with myocarditis may be asymptomatic, may have very mild nonspecific symptoms (eg, fever, chills, and dyspnea), or may exhibit more severe symptoms (eg, palpitations, syncope, and sudden death). [emedicine.medscape.com]
It appears during the second or third week and is manifested by cardiac enlargement, arrhythmia, and congestive heart failure with dyspnea. [basicmedicalkey.com]
- Sneezing
You can catch it from a person who has the infection and coughs or sneezes. You can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. Diphtheria usually affects the nose and throat. [coding-pro.com]
Vaccination – OPV (oral polio drops) Rubella caused by a virus is spread in airborne droplets when infected people sneeze or cough. [sundaytimes.lk]
It spreads through respiratory droplets produced by cough or sneeze of infected person or someone who carries the organism but display no symptom i.e. carrier. It can also spread by contaminated fomites. [jbcr.net.in]
- Nasal Discharge
Often diphtheria presents with a nasal discharge that is initially watery and becomes purulent and blood-stained. The nostril can be sore or crusted with the pseudomembrane sometimes visible within the nostril. [patient.info]
Nasal diphtheria: Uni- or bi-lateral nasal discharge initially clear and becoming bloody. Cutaneous diphtheria: Skin lesion. Diphtheria of other sites: Lesion of conjunctiva or mucous membranes. [jpcc.in]
Cardiovascular
- Heart Disease
A. has re-emphasized the importance of this disease in the developed countries as well. Prevention and control of rheumatic fever and rheumatic heart disease is an important part of the WHO cardiovascular disease program. [books.google.com]
heart disease, cardiovascular syphilis and degenerative lesions. [jamanetwork.com]
Cardiovascular disease is the result of disorders of the heart and blood vessels and includes cerebrovascular disease, coronary heart disease (CHD) and peripheral arterial disease (PAD) ( WHO 2011b ). [cochranelibrary.com]
Cooper, Jr., MD, and a panel of leading clinical and scientific experts comprehensively review both advances in basic scientific understanding and current clinical knowledge of inflammatory heart disease. [books.google.es]
- Tachycardia
(SVT) and ventricular tachycardia (VT) Reference [wikidoc.org]
The arrhythmias noted included bundle branch block (BBB) tachyarrhythmias (ventricular tachycardia, supraventricular and junctional tachycardia). [omicsonline.org]
[…] ischxmic changes and low voltage in one, and ventricular tachycardia in one. [kundoc.com]
Tachycardia, hypotension, gallop rhythm, and cardiac murmur. Associated findings may include a rash or evidence of end organ involvement such as hepatitis or aseptic meningitis. 8. [slideshare.net]
Hoskin noted that virtually all patients admitted for diphtheria initially had tachycardia that persisted for 36-48 hours after initial treatment was given. [27] The continued presence of tachycardia following the first 36-48 hours was an indication of [teachhistmed.com]
- Cardiomegaly
Cardiomegaly and diminished systolic function occur due to myocardial damage. Typical signs of CHF occur which may progress to shock,arrythmias and sudden death. 6. [slideshare.net]
Cardiomegaly and severe congestive heart failure typically appear after the first week of illness. [intechopen.com]
Inclusion criteria were the presence of HF associated with cardiomegaly in chest teleradiography and/or left ventricle (LV) dilation with reduced contractility observed by echocardiogram. [jped.com.br]
Musculoskeletal
- Myalgia
[…] disabling myalgias [ 186 ]. [intechopen.com]
Psychiatrical
- Fear
Diphtheria was once one of the most feared conditions to affect children and adolescents, causing death due to acute laryngeal obstruction, myocarditis, or respiratory paralysis. [academic.oup.com]
Workup
(See Etiology, Clinical, and Workup.) [emedicine.medscape.com]
Microbiology
- Corynebacterium Diphtheriae
Heterogeneity of diphtheria toxin gene, tox, and its regulatory element, dtxR, in Corynebacterium diphtheria strains causing epidemic diphtheria in Russia and Ukraine. J Clin Microbiol. 1996; 34: 1711-16, PMID. [inabj.org]
Diphtheria is an acute disease that results from a localized infection and a systemic toxemia caused by exotoxin producing strains of Corynebacterium diphtheriae. [histopathology-india.net]
Pleomorphic club-shaped rods Corynebacterium diphtheriae Corynebacterium diphtheriae produces a powerful exotoxin that is responsible for diphtheria. [basicmedicalkey.com]
Patients, from which Corynebacterium diphtheria was isolated in throat swab culture, were enrolled in study. The clinical parameters, ECG and SGOT level were estimated on admission. All data were collected and statistical analyzed. [scopemed.org]
Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae.[1] Signs and symptoms may vary from mild to severe.[2] They usually start two to five days after exposure.[1] Symptoms often come on fairly gradually, beginning with a sore [play.google.com]
PR Interval
- Prolonged PR Interval
In electrocardiographic tracings, a prolonged PR interval, changes in the ST-T wave, and single or progressive cardiac dysrhythmias can occur, such as first-degree, second-degree, and third-degree heart block, atrioventricular dissociation, and ventricular [emedicine.medscape.com]
Whereas the four minor manifestations include, arthralgia, fever, elevated acute phase reactants (erythrocyte sedimentation rate, C-reactive protein) and prolonged PR interval. [intechopen.com]
Blocks
- Third Degree Atrioventricular Block
RESULTS--Eleven patients died (46%): all seven patients with third degree atrioventricular block, the patient with bifascicular block, and three of the six patients with bundle branch block. [heart.bmj.com]
block), and seven third-degree atrioventricular block 45. [jebmh.com]
ECG findings associated with myocarditis may include first-, second- or third-degree atrioventricular block, intraventricular conduction delay (widened QRS complex), bundle branch or fascicular block, reduced R wave height, abnormal Q waves, ST-T segment [intechopen.com]
- Complete Left Bundle Branch Block
Abstract A case of complete left bundle branch block complicating acute viral myocarditis successfully treated by Chinese herbal medicine is reported. Complete left bundle branch block may be less commonly encountered in myocarditis. [unboundmedicine.com]
Keywords Myocarditis Diphtheria Left Bundle Branch Block Downward Shift Complete Heart Block These keywords were added by machine and not by the authors. [link.springer.com]
Other Pathologies
- Myocardial Fibrosis
fibrosis Myocarditis NOS Type 1 Excludes acute or subacute myocarditis ( I40.- ) in (due to) diphtheria A36.81 diphtheritic A36.81 ICD-10-CM Codes Adjacent To A36.81 A32.9 Listeriosis, unspecified A33 Tetanus neonatorum A34 Obstetrical tetanus A35 Other [icd10data.com]
Treatment
Steroid therapy was given in addition to specific treatment for diphtheria in one group, while the other group was given only specific treatment. The groups were comparable regarding age, duration of illness and extent of exudate. [ncbi.nlm.nih.gov]
Holmes Springer Science & Business Media, 06.12.2007 - 2926 Seiten Cardiovascular Medicine, 3rd Edition offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease and [books.google.de]
Getting treatment for diphtheria quickly is important. If your doctor suspects that you have it, you'll start treatment before the lab tests come back. Treatment is with antibiotics. [coding-pro.com]
TY - JOUR T1 - Successful treatment of complete left bundle branch block complicating acute viral myocarditis employing Chinese herbs. [unboundmedicine.com]
Prognosis
The prognosis of left bundle branch block in diphtheritic myocarditis is usually poor. However, as he received DPT vaccination in the last 5 years the prognosis was tending to good. [jurnal.ugm.ac.id]
Prognosis in patients with diphtheric myocarditis and bradyarrhythmias: assessment of results of ventricular pacing. [heart.bmj.com]
On the clinical side they discuss the diagnosis, prognosis, and treatment of nonspecific and specific myocarditis in separate chapters devoted to such major idiopathic clinical entities as cardiac sarcoidosis, giant cell myocarditis, eosinophilic myocarditis [books.google.com]
Prognosis Patients who survive respiratory paralysis, recovery is good. Inter current respiratory infections shall carry bad prognosis. Recovery from paralysis may take several weeks to months. Views: 411 [healthdrip.com]
Prognosis The prognosis of symptomatic myocarditis: in newborns is poor and 75% mortality has been reported. The prognosis is better for children and adolescents. Recovery of ventricular function has been reported in 10-50% of patients. 14. [slideshare.net]
Etiology
In general, the histomorphology of the affected cardiac tissue is dependent on the particular etiology. Viral Etiologies A variety of viruses can result in myocarditis although Group B Coxsackie Viruses are by far the most common. [pathwaymedicine.org]
(See Etiology, Clinical, and Workup.) [emedicine.medscape.com]
Currently, the etiology of peripartum cardiomyopathy (PPCM) remains unclear. [intechopen.com]
Epidemiology
Praxis (Bern 1994), 85, 1647-1651. [ 8 ] M, M. and M, R. (2014) Diphtheria in Andhra Pradesh—A Clinical-Epidemiological Study. [scirp.org]
What is the epidemiology of the whooping cough? It is highly contagious, usually after exposure due to respiratory aerosol droplets during cough. [quizlet.com]
Biology and molecular epidemiology of diphtheria toxin and the tox gene. J Infect Dis. 2000; 181: S156-67, CrossRef. Pohl E, Goranson-Siekierke J, Choi MK, Roosild T, Holmes RK, Hol WGJ. [inabj.org]
Ten childhood killer diseases have been kept at bay through the very successful National Immunization Programme (See box for details) implemented by the Health Ministry through the Epidemiology Unit. [sundaytimes.lk]
Epidemiological criteria: An epidemiological link by human-to-human transmission. Case classification7 A: possible case: Any person meeting the clinical criteria for respiratory diphtheria. [jpcc.in]
Pathophysiology
It was Linzbach’s belief that the pathophysiologic abnormalities of the heart, including heart failure, could only be understood when quantitative structural relations of this organ were known. [onlinejacc.org]
Prevention
The result shows that steroid therapy does not prevent the occurrence of electrocardiographic changes and of neuritis in the patient with diphtheria. [ncbi.nlm.nih.gov]
Information for Parents (Centers for Disease Control and Prevention) Diphtheria: Information for Parents (American Academy of Pediatrics) Td (Tetanus and Diphtheria) Vaccine: What You Need to Know (Centers for Disease Control and Prevention) Tdap (Tetanus [icdlist.com]
Centers for Disease Control and Prevention Diphtheria Diphtheria, tetanus, and pertussis (DTaP) vaccines -- what you need to know Diphtheria: Information for Parents (Centers for Disease Control and Prevention) - PDF Diphtheria: Information for Parents [coding-pro.com]
Prevention and control of rheumatic fever and rheumatic heart disease is an important part of the WHO cardiovascular disease program. [books.google.com]
Types of participants We included participants 18 years of age and older of either sex if influenza vaccination was given as a routine influenza prevention programme, as primary prevention of myocardial infarction and as secondary prevention. [cochranelibrary.com]