Characterized by hyperglycemia, symptoms of diabetes include frequent urination, increased thirst, dehydration, weight loss, blurred vision, fatigue, and, occasionally, coma. [encyclopedia.com]

In the milder forms, children initially appear normal, but during infection, surgery, or other physical stress, they can develop vomiting, staggering, confusion, and coma. [merckmanuals.com]

It is characterized by hypoglycemia or low blood sugar, lethargy or lack of energy and vomiting. [biotechnologyforums.com]

Several days after birth, infants with organic acidemias may present to the physician or emergency room with a “sepsis-like” picture including vomiting, lethargy, bulging fontanelle, decreased responsiveness, and/or abnormal respirations. [clinicaladvisor.com]

They refused to eat, followed by vomiting, rapid respirations, lethargy, and coma. Seizures are common. [maine.gov]

[…] hypotonia respiratory compromise/apnoea progressive encephalopathy and seizures clinical picture often mistaken for sepsis Childhood: recurrent unexplained vomiting with severe dehydration stroke like episodes acute liver or renal failure cardiomyopathy [rch.org.au]

Later onset of acute, intermittent attacks of coma, lethargy or other neurologic findings Chronic presentation with hypotonia, failure to thrive, and vomiting, which can be punctuated by intermittent crises 3-MCC deficiency can present as a Reye-like [clinicaladvisor.com]

Infants diagnosed clinically prior to newborn screening exhibited failure to thrive, muscle weakness, and developmental delay. [maine.gov]

[…] to thrive/orotic acid in urineOral uridine memorize [memorize.com]

In general, infants and children who present with the following signs/symptoms may be investigated for a congenital metabolic disease, depending on their entire clinical picture and medical case history: Failure to thrive Growth failure Developmental [mindd.org]

Considerations in Older Infants and Children Older infants with inborn errors of metabolism may demonstrate paroxysmal stupor, lethargy, emesis, failure to thrive, or organomegaly. [aafp.org]

• Other symptoms include failure to walk or talk, seizures, tremor, microcephaly, nausea and vomiting, an eczema-like rash, • Lighter skin and hair than their family members, aggressive or self-injurious behavior, hyperactivity, and sometimes psychiatric [slideshare.net]

Other symptoms include seizures, nausea and vomiting, an eczema-like rash, lighter skin and hair than their family members, aggressive or self-injurious behavior, hyperactivity, and sometimes psychiatric symptoms. [encognitive.com]

Persistent vomiting in infancy with no clear explanation should raise suspicion of IEM, possibly a defect of protein metabolism. Presence of severe metabolic acidosis with increased anion gap should arouse suspicion of an IEM. [patient.info]

[…] tremor/asterixis/slurring/somnolence/vomiting/cerebral edema/blurred vision) PhenylketonuriaPhenylalanine hydroxylase (or cofactor tetrahydrobiopterin)Phenylalanine/phenylketones in urineNoneARMental retardation/growth retardation/seizures/fair skin/eczema [memorize.com]

Symptoms can include delayed mental or social skills, seizures or tremors, hyperactivity, skin rashes (eczema), small head size, and a musty odor in the child's breath, skin, or urine. [whattoexpect.com]

• Other symptoms include failure to walk or talk, seizures, tremor, microcephaly, nausea and vomiting, an eczema-like rash, • Lighter skin and hair than their family members, aggressive or self-injurious behavior, hyperactivity, and sometimes psychiatric [slideshare.net]

Untreated individuals may also develop microcephaly, delayed or absent speech, seizures, eczema, and behavioral abnormalities. Early treatment of PKU is associated with improved intellectual outcome. [maine.gov]

Other symptoms include seizures, nausea and vomiting, an eczema-like rash, lighter skin and hair than their family members, aggressive or self-injurious behavior, hyperactivity, and sometimes psychiatric symptoms. [encognitive.com]

In monoamine biosynthesis disorders, seizures are rare, but paroxysmal dystonia is frequently misdiagnosed as seizures. Therefore, the incidence of seizures in disorders of amino acid metabolism is variable. [ncbi.nlm.nih.gov]

In the most severe form, infants have vomiting and lethargy and then develop neurologic abnormalities, including seizures and coma, during the first days of life and can die within days to weeks if untreated. [merckmanuals.com]

This condition shows dehydration, seizures, ketoacidosis, coma, lethargy and hypoglycemia. Maple syrup urine is genetically classified or it can be through the sequence of its signs and symptoms. [biotechnologyforums.com]

The metabolic encephalopathy is often accompanied by respiratory depression, seizures, and hypoxic-ischemic brain injury. [neuropathology-web.org]

Hypoglycaemia and/or seizures treated as per guidelines See Hypoglycaemia Intravenous medications to chelate or divert toxic metabolites, or replenish deficient metabolites, depending on metabolic problem (e.g. [rch.org.au]

When galactose builds up in a baby’s system it can damage the liver, kidneys, eyes and brain, causing vomiting, jaundice, convulsions, and eventually liver disease, kidney failure, retardation, and death. [whattoexpect.com]

People with Fabry's disease eventually develop kidney failure and heart disease, although most often they live into adulthood. Kidney failure may lead to high blood pressure, which may result in stroke. [encognitive.com]

Persons with the classic form of methylmalonic acidemia (MMA), caused by a defect in the enzyme methylmalonyl-CoA mutase, have symptoms similar to individuals with propionic acidemia but may also develop the long-term complication of kidney failure. [britannica.com]

Type 1 diabetes is more likely to lead to kidney failure. About 40 percent of people with type 1 diabetes develop severe kidney disease and kidney failure by the age of fifty. [encyclopedia.com]