Presentation
The present study of 19 families with African iron overload failed to show evidence that the ferroportin (Q248H) mutation is responsible for the condition. [ncbi.nlm.nih.gov]
Further, the present results do not prove that the present subjects with heavy liver iron staining had systemic iron overload. [bmcclinpathol.biomedcentral.com]
HLA haplotype analysis in the present cases and a review of HLA haplotype frequencies in various populations made it possible to determine the probable ethnic/racial origins of the HFE mutations in both of the present patients. [nature.com]
Gastrointestinal
- Vomiting
[…] enzyme deficiency that affects glycogen metabolism Sickle cell anemia Thalassemia, a disorder in which the body produces an abnormal type of hemoglobin If there is too much iron in your drinking water, you may begin to experience stomach cramps, nausea, vomiting [advancedwatersoftening.com]
Early signs of iron poisoning within 6 hours include vomiting and diarrhea, fever, hyperglycemia, and leukocytosis. Later signs include hypotension, metabolic acidosis, lethargy, seizures, and coma. [library.med.utah.edu]
Early symptoms of iron poisoning may include stomach pain, nausea and vomiting. Gradually, the excess iron accumulates in internal organs, causing potentially fatal damage to the brain and liver. [healthline.com]
Likely causes for noncompliance with deferasirox therapy are nausea, vomiting, stomach upsets, and the chalky taste, all of which are common yet less serious side effects. [clinicaladvisor.com]
Liver, Gall & Pancreas
- Liver Dysfunction
Transferrin saturation above normal range in male and female also need additional testing.Chemical evidence of tissue vitamin C deficiency and mild to moderate liver dysfunction are likely to be seen in individuals with African iron overload. [en.wikipedia.org]
Musculoskeletal
- Osteoporosis
It is a cause of hepatic fibrosis and cirrhosis, and associations with diabetes mellitus, peritonitis, scurvy and osteoporosis have been described. African iron overload may be a cause of hepatocellular carcinoma. [ncbi.nlm.nih.gov]
Excess iron in vital organs, even in mild cases of iron overload, increases the risk for liver disease (cirrhosis, cancer), heart attack or heart failure, diabetes mellitus, osteoarthritis, osteoporosis, metabolic syndrome, hypothyroidism, hypogonadism [blackdoctor.org]
Other less common findings may include heart disease, high blood pressure, fluid accumulation in abdominal area, osteoporosis, and diabetes. [diseaseinfosearch.org]
Osteoporosis secondary to ascorbic acid deficiency is common in malnourished individuals. Association with heart disease, elevated sugar or diabetes and increased pigmentation has been described. [irondisorders.org]
According to the Iron Disorders Institute, excess iron increases one’s risk of developing: Diabetes Heart attacks Hypogonadism Hypothyroidism Liver diseases such as cirrhosis or cancer of the liver Metabolic syndrome Osteoarthritis Osteoporosis Consuming [advancedwatersoftening.com]
Psychiatrical
- Withdrawn
Phlebotomy Iron overload disease can be simply and effectively treated using a procedure called phlebotomy, in which blood is regularly withdrawn from the arm veins to reduce excess iron stores in the body. [health24.com]
Urogenital
- Kidney Failure
failure, blindness, and heart problems Congestive heart failure, if too much iron builds up in the heart and the body cannot circulate enough blood to meet its needs Irregular heart rhythms, or arrhythmias, leading to chest pain, palpitations and dizziness [medicalnewstoday.com]
Treatment
Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances. [books.google.de]
With this type of treatment, Dr. Italiano said fatigue typically improves, as does skin color, cardiac function and liver function. However, Dr. [sandiegouniontribune.com]
Share your finds with others. 0 0 Post New Thread Discussions: 0 Messages: 0 TREATMENTS Drugs, supplements, therapies and treatments based on scientific studies. 0 0 Post New Thread Discussions: 0 Messages: 0 NATURAL TREATMENTS Treatments scientifically [diseasemaps.org]
Prognosis
Prognosis - Bantu siderosis In Bantu siderosis, the resulting iron overload can eventually damage tissues and organs. Iron overload in the liver may lead to chronic liver disease (cirrhosis). [checkorphan.org]
When HHC is found early and properly managed, long-term prognosis, including life expectancy, should not differ from that of persons without the disorder. [diagnose-me.com]
Prognosis [ 3 ] C282Y homozygous patients with clinically ascertained HC have an increased risk of developing liver disease and hepatocellular carcinoma. [patient.info]
In one series of patients who presented with cardiomyopathy associated with hemochromatosis, therapeutic phlebotomy improved the prognosis in 70%; untreated patients had a worsening of their condition and mean survival of only one year. [library.med.utah.edu]
Prognosis of this disease depends on the organ damage at diagnosis. When disease such as HH is diagnosed by genetic testing, ferritin and TS can be periodically monitored and intervention can be planned before organ damage occurs. [clinicaladvisor.com]
Etiology
Wei‐Chen Lee and Miin‐Fu Chen, Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, Malignant Liver Tumors, (52-55), (2009). [doi.org]
Abstract Although HLA-linked hemochromatosis greatly increases the risk for hepatocellular carcinoma in people of European ancestry, iron overload in Africa is not thought to be etiologically related to this malignancy. [ncbi.nlm.nih.gov]
Etiology Hereditary Hemochromatosis HFE-Related C282Y Homozygosity C282Y/H63D Compound Heterozygosity Other Mutations of HFE Non-HFE-Related Juvenile Hemochromatosis Autosomal Dominant Hemochromatosis (Solomon Islands) Secondary Iron Overload Iron-Loading [mdnxs.com]
Iron overload, irrespective of the underlying etiology, has varying manifestations, depending on the organs affected by the excessive iron deposit. [karger.com]
Epidemiology
In 57 in-depth chapters they cover all aspects of pathophysiology, epidemiology, diagnosis and treatment. [books.google.com]
L… One Citation Epidemiology and aetiology of hepatocellular carcinoma in Sub-Saharan Africa D. MakA. [semanticscholar.org]
Wei‐Chen Lee and Miin‐Fu Chen, Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, Malignant Liver Tumors, (52-55), (2009). [doi.org]
Early diagnosis and treatment are therefore essential. [ 1 ] Aetiology and epidemiology [ 2 ] Defects of the HFE gene (located on the short arm of chromosome 6) cause the majority of cases of inherited haemochromatosis, which is therefore often referred [patient.info]
Epidemiology: The prevalance of HH, especially its classic form, is very high in white populations. The prevalance rate in Americans is roughly 1/200 for homozygosity, 1/50 for compound heterozygosity, and 1/10 for heterozygosity. [clinicaladvisor.com]
Pathophysiology
Adewoye, Pathophysiology of iron overload-induced renal injury and dysfunction: Roles of renal oxidative stress and systemic inflammatory mediators, Pathophysiology, 10.1016/j.pathophys.2019.03.002, (2019). William C. [doi.org]
In 57 in-depth chapters they cover all aspects of pathophysiology, epidemiology, diagnosis and treatment. [books.google.com]
(See “Pathophysiology and diagnosis of iron overload syndromes”, section on ‘High levels of ferritin in the absence of iron overload’ and “Clinical features and diagnosis of hemophagocytic lymphohistiocytosis”, section on ‘Serum ferritin levels’.) — # [mdnxs.com]
Prevention
Finley, Chemical Versus Food Forms of Selenium in Cancer Prevention, Functional Foods & Nutraceuticals in Cancer Prevention, (55-86), (2008). [doi.org]
Can iron overload disease be prevented? Iron overload disease is fully preventable when it is diagnosed and treated early enough. [health24.com]
Measures to prevent and treat this condition are needed. [ncbi.nlm.nih.gov]
Centers for Disease Control and Prevention Iron (National Institutes of Health, Office of Dietary Supplements) Also in Spanish [medlineplus.gov]