The cases presented here indicate that disease progression and relapse may be associated with selective outgrowth of a specific FLC producing clone. [learningcenter.ehaweb.org]

Herrera, Ahmet Dogan Humana Press, 17.08.2015 - 542 Seiten The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. [books.google.de]

Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. [books.google.com]

Clinical Presentation A young male with a 2-year old history of streptococcal throat infection now presents with 5 grams of proteinuria and a creatinine of 0.93 mg/dL. [cases.renalpathsoc.org]

Clinically, the presentation is often indolent with slowly progressive renal insufficiency. [theisn.org]

• Anemia

  Treatment of bone disease, management of anemia, management of renmal porblems, management of infections, management of hypercalcemia. [quizlet.com]

  Here, we report a rare case of myeloma with combined LCPT, CSH, and MCN attributable to free κ LC that presented clinically as uremia and anemia. [bmcnephrol.biomedcentral.com]

  Symptoms and Signs Symptoms and signs are predominantly those of the myeloma (eg, skeletal pain, pathologic fractures, diffuse osteoporosis, bacterial infections, hypercalcemia, normochromic-normocytic anemia out of proportion to the degree of renal failure [merckmanuals.com]

   Common complications of MM include hypercalcemia, renal impairment, infection, skeletal lesions, and anemia. [slideshare.net]

  Cystitis Hemorrhagic Fever with Renal Syndrome (HFRS, Hantavirus Renal Disease, Korean Hemorrhagic Fever, Epidemic Hemorrhagic Fever, Nephropathis Epidemica) Hemosiderinuria Hemosiderosis related to Paroxysmal Nocturnal Hemoglobinuria and Hemolytic Anemia [thekaiganfoundation.com]

• Inflammation

  The light chain casts generate intense inflammation via the activation of c-Src and NF-κB, and subsequent chemotaxis of immune cells leads to further damage of the kidney ( 11 ). If the obstruction is not eliminated, the damage becomes irreversible. [jci.org]

  Figure 3: Hematoxylin and eosin (H&E) stain, 400x magnification, demonstrates dense lymphoplasmacytic inflammation with rare scattered eosinophils. [cases.renalpathsoc.org]

  […] remain to be determined. a Department of Renal Physiology, DHU Fire, Bichat Hospital b Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hôpitaux de Paris c Paris Diderot University d INSERM 1149, Center of Research on Inflammation [journals.lww.com]

• Muscle Weakness

  QI9 CLINICAL MANIFESTATIONS OF ACQUIRED FANCONI'S SYNDROME Patients with FS most often seek medical attention for back or bone pain, fatigue, or myalgias.zl, 25 Proximal muscle weakness is not uncommon. [docslide.net]

• Aggressive Behavior

  Thus, p53 and Ki67 immunostaining in routine BM biopsies may be helpful for the detection of MM with potentially aggressive behavior. [thedoctorsdoctor.com]

• Somnolence

  Complications: neuropathy, somnolence, constipation, legs edema, DVT (esp with steroids). Analog of thalidomide, more potent, no somnolence, constipation nor neuropathy. SE: neutropenia. [quizlet.com]

  - Headaches - Vertigo - Ataxia - Nystagmus - Hearing loss - Paresthesias - Altered mental status: confusion, somnolence, stupor, coma - Seizures 4) Systemic and cardiorespiratory symptoms - Fatigue - Anorexia - Dyspnea, hypoxia - CHF - Volume overload [myelomapennstate.net]

• Nystagmus

  - Headaches - Vertigo - Ataxia - Nystagmus - Hearing loss - Paresthesias - Altered mental status: confusion, somnolence, stupor, coma - Seizures 4) Systemic and cardiorespiratory symptoms - Fatigue - Anorexia - Dyspnea, hypoxia - CHF - Volume overload [myelomapennstate.net]

• Neurologic Manifestation

  Ophthalmologist may detect dilated retinal veins, with sausage-like segmentation, and retinal hemorrhages. 3) Neurologic symptoms Neurologic manifestations are frequent and varied. - Headaches - Vertigo - Ataxia - Nystagmus - Hearing loss - Paresthesias [myelomapennstate.net]

[…] inclusive and trusted 2017 18 :170 https://doi.org/10.1186/s12882-017-0584-8 © The Author(s). 2017 Received: 19 July 2016 Accepted: 15 May 2017 Published: 25 May 2017 Abstract Background The diagnosis of myeloma, a plasma dyscrasia, often results from the workup [bmcnephrol.biomedcentral.com]

Treatment • The Treatment of Renal Failure in Multiple Myeloma: Vnitr Lek. 2009 Jun; 55(6): 570-82.  Reversible causes (Dehydration, Ca↑ ++, NSAID-induced, IV contrast) should always be excluded or corrected accordingly.  Treatment regimens with high-dose [slideshare.net]

Leung W, Sandlund JT, Hudson MM et al (2001) Second malignancy after treatment of childhood non-Hodgkin lymphoma. [link.springer.com]

Management and treatment Treatment of osteomalacia is based on phosphate, calcium and vitamin D supplementation. [orpha.net]

In either form without treatment, virtually all renal lesions progress to renal failure. [merckmanuals.com]

Treatment of underlying plasma cell dyscrasia or lymphoma MICROSCOPIC PATHOLOGY Histologic Features Glomeruli Normal Tubules Intracellular crystalline inclusions within proximal tubular epithelial cells Similar crystals in bone marrow plasma cells Not [basicmedicalkey.com]

Introduction • Advances in Chronic Kidney Disease: Volume: 19, Issue: 5, Pages: 342-35, Sep 2012  Renal impairment is associated with a large tumor mass and consequently confers a poor prognosis.  The prognosis of MM has been improved with the introduction [slideshare.net]

Kidney disease is a major predictor of overall prognosis in multiple myeloma. Prognosis is good for patients with tubulointerstitial and glomerular LCDD who receive treatment. [merckmanuals.com]

Although limited data are available, renal prognosis appears to be closely tied to the prognosis of the underlying malignancy. [theisn.org]

PCM associated with acquired Fanconi syndrome (FS) shows crystalline LC deposition in renal proximal tubular epithelial cells and has a good prognosis. [3] Crystalline LC deposits in PCM not associated with CSH or FS do not influence the prognosis of [ijpmonline.org]

Prognosis Crystal accumulation within the bone marrow may lead to pancytopenia. Most patients die from complications of chemotherapy or of causes other than myeloma. [orpha.net]

Herrera, Ahmet Dogan Humana Press, 17.08.2015 - 542 Seiten The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. [books.google.de]

Haque SK, Ariceta G, Batlle D (2012) Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies. Nephrol Dial Transplant 27:4273–4287 CrossRef PubMed PubMedCentral 2. [springermedizin.de]

Haque SK, Ariceta G, Batlle D (2012) Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies. Nephrol Dial Transplant 27:4273–4287 CrossRef PubMed PubMedCentral Google Scholar 2. [link.springer.com]

Related disorder with proximal tubular damage by toxic light chains Definitions Chronic tubulointerstitial nephropathy caused by intracytoplasmic crystalline inclusions composed of monoclonal light chains present in proximal tubular epithelial cells ETIOLOGY [basicmedicalkey.com]

[…] reabsorbed by proximal tubule, where they are degraded In LCFS, abnormal light chain, usually kappa (VK1 subgroup), is resistant to enzymatic breakdown Nephrotoxic light chains crystallize or precipitate within lysosomes in proximal tubules CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Summary Epidemiology Prevalence is unknown but around 100 cases have been described in the literature so far. [orpha.net]

Multiple myeloma epidemiology 2nd most common hematologic cancer in US (10%), 14,000 cases anually, 1% of cancers, 2% of cancer deaths. Mean age at diagnosis: 65-68, African-americans more than whites, men more common. [quizlet.com]

Abbreviations: 51CrEDTA = chromium- 51 ethylenediamine tetraacetic acid, CCr = creatinine clearance, CCr-S = part of creatinine clearance attributable to secretion, CKD EPI = chronic kidney disease—epidemiology collaboration, eGFR = estimated glomerular [journals.lww.com]

Such epidemiological studies would be greatly facilitated by the development of antibodies directed against the HHV-8 viral proteins uniquely present in myeloma. [thedoctorsdoctor.com]

The Kidney, Physiology and Pathophysiology. New York: Raven Press, 1985: 869-84. ‏ الصفحة 176 - Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. [books.google.com]

The studies of Basnayake et al. 6 in this issue of JASN examine the basis for this inflammatory behavior by exposing human proximal tubular epithelial cells to pathophysiologically relevant concentrations of light chains derived from patients with myeloma [doi.org]

Baum M (1998) The Fanconi syndrome of cystinosis: insights into the pathophysiology. Pediatr Nephrol 12:492–497 CrossRef PubMed 14. [springermedizin.de]

Baum M (1998) The Fanconi syndrome of cystinosis: insights into the pathophysiology. Pediatr Nephrol 12:492–497 CrossRef PubMed Google Scholar 14. [link.springer.com]

Management of multiple myeloma Prevention of volume depletion and maintenance of a high urine flow rate Management of multiple myeloma and prevention of volume depletion (eg, using normal saline for volume expansion) to maintain a high urine flow rate [merckmanuals.com]

Early stages to prevent bone disease and slow tumor development. [quizlet.com]

A direct or indirect causal effect of HHV-8 has potentially enormous implications for the therapeutic benefit of antiviral agents and preventative strategies using vaccines. [thedoctorsdoctor.com]