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Disseminated Blastomycosis


Presentation

  • Six cases presented with cutaneous lesions, and five of these were found to have other systemic involvement.[ncbi.nlm.nih.gov]
Fever
  • This is a case report of a 29-year-old woman who presented with weight loss, fever, fatigue, and pneumonia.[ncbi.nlm.nih.gov]
  • Patient denied SOB, fevers, chills, night sweats, unintentional weight loss, sick contacts, or recent travel. He was previously diagnosed with left upper lobe CAP in February 2016 and was treated with azithromycin.[shmabstracts.com]
  • BY VIRUSES 141 HYDATID DISEASE 145 FILARIASIS 151 SCHISTOSOMIASIS 155 NEUROC YSTICERCOSIS 161 OTHER DISEASES CAUSED BY HELMINTHS 167 THE CHOICE OF THE BEST RADIOPHARMACEUTICAL TO IMAGE SPECIFIC CLINICAL SITUATIONS IN PATIENTS WITH INFECTION A... 173 FEVER[books.google.com]
Weight Loss
  • This is a case report of a 29-year-old woman who presented with weight loss, fever, fatigue, and pneumonia.[ncbi.nlm.nih.gov]
  • Patient denied SOB, fevers, chills, night sweats, unintentional weight loss, sick contacts, or recent travel. He was previously diagnosed with left upper lobe CAP in February 2016 and was treated with azithromycin.[shmabstracts.com]
  • The symptoms include fever, night sweats, weight loss, fatigue, dyspnea, cough, sputum production, and hemoptysis. The chest radiograph shows upper lobe cavitary infiltrates, masslike lesions, or multiple nodular lesions (see Figure 40-4).[aibolita.com]
Chills
  • Our case was a 47-year-old man with past medical history significant for diabetes, hyperlipidemia, and chronic pancreatitis who presented with a 2-week history of fever, chills, rigors, constipation, and 10 pound weight loss.[ncbi.nlm.nih.gov]
  • A 39-year-old man presented with acute hemoptysis and chills. Computed tomography (CT) of his chest showed an infiltrate in the right upper lobe (Panel A), and he was treated with levofloxacin.[nejm.org]
  • Patient denied SOB, fevers, chills, night sweats, unintentional weight loss, sick contacts, or recent travel. He was previously diagnosed with left upper lobe CAP in February 2016 and was treated with azithromycin.[shmabstracts.com]
  • -Symptoms include high fever, chills, productive cough, and pleuritic chest pain. Sputum is purulent or mucopurulent. Blastomycosis: Clinical manifestations: Chronic pulmonary blastomycosis.[quizlet.com]
  • When it resembles bacterial pneumonia, symptoms include high fever, chills, a productive cough with brown or bloody-looking sputum, and chest pain of the lungs.[encyclopedia.com]
Malaise
  • Acute Blastomycosis Blastomycosis typically presents as a flulike illness characterized by fever, malaise, fatigue, weight loss, and pulmonary involvement.[hivinsite.ucsf.edu]
  • Fever, chills, night sweats, malaise, and weight loss are common. When the infection is severe, the patient can present in septic shock, can have symptoms and signs of adrenal insufficiency, and can develop disseminated intravascular coagulation.[mdpi.com]
Increased Energy
  • These findings suggest that increased energy intake rather than transfer factor therapy was responsible for the child's recovery, and they emphasize the importance of adequate nutrition in the maintenance of intact cellular immunity.[ncbi.nlm.nih.gov]
Pleural Effusion
  • Lymphadenopathy and pleural effusions may be uncommonly present. Promoted articles (advertising)[radiopaedia.org]
  • Pleural effusion occurs occasionally. Some patients have rapidly progressive infections, and acute respiratory distress syndrome may develop. In extrapulmonary disseminated blastomycosis, symptoms depend on the organ involved.[merckmanuals.com]
  • The lesions may be cavitary, nodular, fi-brotic, or masslike in appearance.31,32 Hilar and mediastinal lymphadenopathy and pleural effusions are uncommonly seen.[what-when-how.com]
Constipation
  • Our case was a 47-year-old man with past medical history significant for diabetes, hyperlipidemia, and chronic pancreatitis who presented with a 2-week history of fever, chills, rigors, constipation, and 10 pound weight loss.[ncbi.nlm.nih.gov]

Workup

  • After admission, workup of his symptoms was initiated including CT chest which revealed several sternal and thyroid lesions. Other lab work included fungal serologies and biopsies of both his sternal and thyroid lesions.[shmabstracts.com]
  • As the physician does a workup usually a chest x-ray is ordered, which will alert the physician that there is something different from the ordinary pneumonia going on.[nethealthbook.com]
  • Laboratory Identification: The workup revealed a thermally dimorphic fungus with a mold form growing in the laboratory at 25 C and a yeast form present in the surgical pathology specimen.[labmedicineblog.com]
  • We have reviewed the utilization of diagnostic techniques in the workup of patients with pulmonary blastomycosis, defined their diagnostic yields, and proposed an optimal diagnostic approach for the patient in whom pulmonary blastomycosis is considered[thedoctorsdoctor.com]
Lymphocytopenia
  • Idiopathic CD4 lymphocytopenia presenting as refractory cryptococcal meningitis. Ann Indian Acad Neurol 2010;13:136-8. [ PUBMED ] 9. Mukherjee A, Lodha R, Kabra SK. Idiopathic CD4 T-cell lymphocytopenia.[ijdvl.com]
Pleural Effusion
  • Lymphadenopathy and pleural effusions may be uncommonly present. Promoted articles (advertising)[radiopaedia.org]
  • Pleural effusion occurs occasionally. Some patients have rapidly progressive infections, and acute respiratory distress syndrome may develop. In extrapulmonary disseminated blastomycosis, symptoms depend on the organ involved.[merckmanuals.com]
  • The lesions may be cavitary, nodular, fi-brotic, or masslike in appearance.31,32 Hilar and mediastinal lymphadenopathy and pleural effusions are uncommonly seen.[what-when-how.com]

Treatment

  • The published experience with systemic mycoses and amphotericin B treatment in pregnant women is reviewed.[ncbi.nlm.nih.gov]
  • A high clinical suspicion would help with early diagnosis and appropriate treatment.[shmabstracts.com]
  • Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization[books.google.com]

Prognosis

  • Therapy must be individualized and must be given for life.49 Prognosis Of all the endemic mycoses, infection with C. immitis is the least responsive to currently available antifungal agents.[what-when-how.com]

Etiology

  • The etiology of the patient's pulmonary infection was not known, but tuberculosis was an important consideration.[ncbi.nlm.nih.gov]
  • In spite of diligent investigations by many competent investigators, we still do not know the ecological niche inhabited by the etiologic agent. We have many tantalizing clues but no definite answers.[books.google.com]
  • Radiograph of both knees and elbows revealed creeping type of periosteal reaction, which was suggestive of fungal etiology [Figure 5] a and b.[ijdvl.com]
  • Blastomycosis: Organ involvement and etiologic diagnosis. A review of 123 patients from Mississippi. Ann Diagn Pathol 2000;4:391-406. 5. Garvey K, Hinshaw M, Vanness E.[ijpd.in]
  • GROSS APPEARANCE/CLINICAL VARIANTS CHARACTERIZATION General Blastomycosis: organ involvement and etiologic diagnosis. A review of 123 patients from Mississippi. Lemos LB, Guo M, Baliga M.[thedoctorsdoctor.com]

Epidemiology

  • Patient Population: Prevalence and Epidemiology Knee // Shoulder & Elbow // Hip // Spine // Foot & Ankle // Hand & Wrist Fragility Fractures: Diagnosis and Treatment Shoulder & Elbow The Characteristics of Surgeons Performing Total Shoulder Arthroplasty[mdedge.com]
  • Epidemiology: North America and parts of Africa. Cases have been reported in India. Reservoir: These are normally present in soil. Mode of infection: Enters body by inhalation.[histopathology-india.net]
  • Currently, a number of uncertainties still surround the origins, characteristics, causes, and other important medical facts (that is, the epidemiology) of blastomycosis.[encyclopedia.com]
  • Epidemiology and clinical spectrum of blastomycosis diagnosed at Manitoba hospitals. Clin Infect Dis. 2002 May 15;34(10):1310-6. 4. Hannah EL, Bailey AM, Hajjeh R, Gershman K, Lindsley M, Hoffman RE.[hivinsite.ucsf.edu]
  • The epidemiology of histoplasmosis: A review. Semin. Respir.[mdpi.com]
Sex distribution
Age distribution

Prevention

  • Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization[books.google.com]
  • (November 6, 2017) Centers for Disease Control and Prevention. CDC Features: Pneumonia can be prevented—vaccines can help. Available online at . Accessed on September 8, 2018. (November 10, 2017) Centers for Disease Control and Prevention.[labtestsonline.it]

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