Presentation
To the best of our knowledge, bizarre atypical presentation of sporotrichosis, in an immunocompetent is a rare presentation. [e-ijd.org]
A 40-year-old Caucasian man presented to the dermatology clinic at Baylor College of Medicine, Houston, Texas, in February 2003, for the evaluation of three nonhealing ulcers. [ncbi.nlm.nih.gov]
She was commenced on itraconazole 200 mg daily for treatment of lymphocutaneous sporotrichosis, the most common presentation of the disease. She re-presented to our clinic 12 months later with very poor compliance. [medicaljournals.se]
[…] and present with pneumonia They may or may not have skin lesions Bones and joint disease Patients typically present with a subacute or chronic inflammatory arthritis involving one or more joints They may or may not have skin lesions Disseminated disease [dermnetnz.org]
Entire Body System
- Pain
It may cause breathing difficulties, chest pain, cough, fever, fatigue, and unintentional weight loss. Sporotrichosis can also be spread to humans from infected animals (especially cats) through scratches and bites. [healthline.com]
The lesions are small, firm, dusky red to violaceous in color and pain, if present, is generally mild. [consultant360.com]
However, it is inconvenient to administer and side effects are common although not serious and include metallic taste, nausea, abdominal pain, and salivary gland enlargement. [clinicalgate.com]
Case report The patient initially presented to our dermatology outpatient clinic in March 2010 with painful papules and nodules on the dorsal aspect of her left foot. Sporotrichosis was confirmed with serology and culture. [medicaljournals.se]
Complications secondary to Sporotrichosis usually occur in individuals with compromised immune systems and may include the following: Infection of the bone Arthritis - joint pain and infection Pneumonia; lung infection Meningitis: Inflammation/infection [dovemed.com]
- Chronic Infection
Sporotrichosis is a subacute or chronic infection caused by Sporothrix schenckii. [ncbi.nlm.nih.gov]
Sporotrichosis is a subacute or chronic infection caused by the saprophytic dimorphic fungus Sporothrix schenckii. [e-ijd.org]
Sporotrichosis Definition Sporotrichosis is a chronic infection caused by the microscopic fungus Sporothrix schenckii. [medical-dictionary.thefreedictionary.com]
Sporotrichosis is a chronic infection of the fungus Sporothrix schenckii ( S. schenckii ) that usually affects the skin (although it has other, rare forms that affect the lungs, joints and bones). Sporotrichosis lesion. [healthinplainenglish.com]
Most commonly, sporotrichosis is a chronic infection characterized by nodular lesions of subcutaneous tissue and adjacent lymphatics that suppurate (make pus), ulcerate (digest the tissue) and drain. [botit.botany.wisc.edu]
- Asymptomatic
All patients were asymptomatic visually. The ocular disease was bilateral in two patients. The lesion size ranged from 1/3 to 2 disc diameters. None of the patients had vitritis. [ncbi.nlm.nih.gov]
During this period he also noticed asymptomatic multiple crusted plaques over right hand. [ijdvl.com]
He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. [ajtmh.org]
Case report A 68-year-old male farmer from Durango, Mexico, presented to his local family physician with a 4-year history of asymptomatic scaly nodules and plaques on his face. [elsevier.es]
- Weight Loss
Symptoms of disseminated sporotrichosis include: Weight loss Loss of appetite or anorexia Bony lesions This form of the disease can lead to or be accompanied by arthritis and osteomyelitis or infection of the bones. [healthinplainenglish.com]
It may cause breathing difficulties, chest pain, cough, fever, fatigue, and unintentional weight loss. Sporotrichosis can also be spread to humans from infected animals (especially cats) through scratches and bites. [healthline.com]
The infection can spread to joints and bones (called osteoarticular sporotrichosis) as well as the central nervous system and the brain (called sporotrichosis meningitis).The symptoms of disseminated sporotrichosis include weight loss, anorexia, and appearance [en.wikipedia.org]
Pulmonary disease may present with a productive cough, occasionally with haemoptysis, along with fever and weight loss. [fidssa.co.za]
Deep infection with sporotrichosis is more difficult to recognize and has few distinguishing characteristics,4,1019 although patients with pulmonary involvement may have signs of systemic illness with nonproductive coughs, weight loss, and malaise.20,21 [healio.com]
- Lymphadenopathy
There was no regional lymphadenopathy and other systemic examination was normal. She was investigated with the clinical diagnosis of disseminated tuberculosis. [ijdvl.com]
Satellite lesions develop along the path of the lymphatic vessels (sporotrichoid spread) and associated lymphadenopathy occurs. [emedicine.com]
Mucosal lesions are often associated with pre-auricular and submandibular lymphadenopathy. Fixed: This lesion forms a painless plaque and tends not to spread locally. The natural history is that of a chronic, non-healing ulcer over weeks or months. [fidssa.co.za]
Respiratoric
- Pneumonia
Discomfort Secondary skin infections (such as staph or strep) People with a weakened immune system may develop: Arthritis Bone infection Complications from medicines -- amphotericin B can have serious side effects Lung and breathing problems (such as pneumonia [nlm.nih.gov]
Immunodepressed individuals develop disseminated infections and/or pneumonia that can cause shortness of breath, cough, and fever. [medicinenet.com]
With this type you many get pneumonia, shortness of breath, fever, and coughing. [austincc.edu]
- Sputum
A confirming diagnosis is done through culturing S. schenckii fungus in the pus, sputum (saliva, phlegm, mucus or spit), synovial tissue biopsy, and arthrocentesis or bone drainage. [healthinplainenglish.com]
The confirming diagnosis remains culturing the fungus from the skin, sputum, synovial fluid, and cerebrospinal fluid. Smears should be taken from the draining tracts and ulcers. [en.wikipedia.org]
Aspirated material from a lesion, tissue biopsy samples, sputum or body fluids can be inoculated directly onto Sabouraud’s dextrose agar and incubated at room temperature. Growth may be noted within 5 days but can take a few weeks. [fidssa.co.za]
Diagnostic approachDiagnosis is made by isolating Sporothrix schenckii from exudate of cutaneous lesionsor sputum in common culture media (Sabouraud dextrose agar with antibiotics). [dokumen.tips]
In case of disseminated infections, other specimens, such as sputum, urine, blood, and cerebrospinal and synovial fluids, can be analyzed, depending on the affected organs. [doi.org]
Jaw & Teeth
- Oral Ulcers
Recent involvement of the fingers and toes, as well as shallow oral ulcerations in the mouth, resulted in increasing pain and prompted her to seek emergency medical treatment. [consultant360.com]
Musculoskeletal
- Arthritis
Any case of intractable arthritis or skin ulcers, which does not improve, despite adequate immunosuppressive therapy, is likely to be suspicious of sporotrichosis. [ncbi.nlm.nih.gov]
Body-wide (systemic) sporotrichosis can cause lung and breathing problems, bone infection, arthritis, and infection of the nervous system. The health care provider will examine you and ask about your symptoms. [nlm.nih.gov]
Skin
- Ulcer
In addition to the nonhealing ulcer on his left forearm, which he had acquired several months earlier, he had also developed a 3.0 cm ulcer on his right arm and a 3.0 cm ulcer on his central back. The patient refused biopsies at this visit. [ncbi.nlm.nih.gov]
History of excursion to Amazon rain forest 1-month prior to the onset of ulceration was present. [e-ijd.org]
Any case of intractable arthritis or skin ulcers, which does not improve, despite adequate immunosuppressive therapy, is likely to be suspicious of sporotrichosis. [jstage.jst.go.jp]
Small ulcers appear as lines on the skin as the infection moves up an arm or leg. These sores do not heal unless they are treated, and they may last for years. The sores may sometimes drain small amounts of pus. [nlm.nih.gov]
- Papule
[…] l'archivio di file multimediali liberi Jump to navigation Jump to search sporotricosi primary systemic mycosis that results in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results in formation of red papule [commons.wikimedia.org]
(a) Multiple ulcerated papules and nodules on the left lower limb extending along the lymphatic channels. (b) Left fifth digit with marked ulceration and destruction of the underlying bone structure. [medicaljournals.se]
Nevus (smooth muscle hamartoma) Dermatofibroma (sclerosing hemangioma) Eccrine Poroma Eccrine Spiradenoma Eccrine Syringoma Ephelide and Lentigines Ephelide and Lentigines (Continued) Epidermal Inclusion Cyst Epidermal Nevus Fibrofolliculoma Fibrous Papule [euro-libris.ro]
Sporotrichose en primary systemic mycosis that results in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation Un cas de sporotrichose, avec sporotrichides [fr.glosbe.com]
Disseminated ulcerated papules and nodules. Cutaneous disseminated sporotrichosis. Arch Dermatol. 1996 Aug. 132(8):963-4, 966-7. [Medline]. Zhang Z, Liu X, Lv X, Lin J. [emedicine.com]
- Skin Ulcer
Any case of intractable arthritis or skin ulcers, which does not improve, despite adequate immunosuppressive therapy, is likely to be suspicious of sporotrichosis. [ncbi.nlm.nih.gov]
The disease causes ulcers on the skin that are painless but do not heal, as well as nodules or knots in the lymph channels near the surface of the body. [medical-dictionary.thefreedictionary.com]
[…] effects Lung and breathing problems (such as pneumonia ) Brain infection ( meningitis ) Widespread (disseminated) disease Make an appointment with your provider if you develop persistent skin lumps or skin ulcers that do not go away. [nlm.nih.gov]
Workup
X-Ray
- Cavitary Lesion
Surgery may be indicated for relapsing or refractory/pulmonary cavitary lesions or for mediastinal mass lesions although it has not been demonstrated that this helps prevent mediastinal fibrosis. [doi.org]
Microbiology
- Nocardia Asteroides
Usually three genera areresponsible: Nocardia, Actinomadura and Streptomyces. [dokumen.tips]
Treatment
Terbinafine was well tolerated and the frequency of drug‐related AEs was slightly higher in the 1000 mg treatment group. Both doses of terbinafine were well‐tolerated and effective for the treatment of sporotrichosis. [doi.org]
However, the benefits and adverse reactions of these treatments have not yet been systematically reviewed. Objectives: To assess the effects of oral potassium iodide for the treatment of sporotrichosis. [cochrane.org]
[…] reports and nonrandomized treatment trials. [web.archive.org]
Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. [books.google.com]
The optimal treatment of systemic sporotrichosis in HIV-positive patients is as yet unknown. [ncbi.nlm.nih.gov]
Prognosis
(Outcomes/Resolutions) The prognosis of Sporotrichosis is generally good with appropriate treatment Disseminated Sporotrichosis may become fatal for patients with weak immune systems. [dovemed.com]
Outlook and prognosis Excellent for cutaneous and lymphocutaneous disease, with cure rates exceeding 95%. [life-worldwide.org]
Outlook (Prognosis) With treatment, full recovery is likely. Disseminated sporotrichosis is more difficult to treat and requires several months of therapy. Disseminated sporotrichosis can be life-threatening for people with a weakened immune system. [ufhealth.org]
The prognosis for patients with lymphocutaneous sporotrichosis is generally regarded as excellent3,4,31"33 with little anticipated functional compromise or cosmetic deformity. [healio.com]
[2, 3] Age Sporotrichosis may occur in any age, but it typically affects adults, reflecting their more frequent participation in veterinary care, gardening, woodworking, and occupational situations in which puncture wounds may occur. [2, 3, 6, 7, 8] Prognosis [emedicine.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
Incidence of specific etiology and role of methods for specific etiologic diagnosis of primary acute pericarditis. Am J Cardiol 1995; 75:378-382 Chapter 9 SPECIFIC PERICARDIAL DISORDERS Congenital malformations and acquired diseases 1. [books.google.es]
Although consistent with sarcoidosis, these findings were insufficient to exclude other etiologies, including disseminated fungal infection. [ncbi.nlm.nih.gov]
(Etiology) Sporotrichosis is a skin infection caused by the fungus Sporothrix schenckii This fungus is found on rose thorns, hay, sphagnum moss, twigs and decaying vegetables The fungus enters the skin through cuts or scrapes made by thorns, barbs, pine [dovemed.com]
Sporotrichosis By: Brittney Majefski Etiologic agent: Sporothrix schenckii(3). General characteristics : Sporotrichosis is a fungal disease that is scene all over the world. [austincc.edu]
Epidemiology
Meningeal and pulmonary sporotrichosis are difficult to diagnose and treat, with less positive outcomes. 2015 review: Global Epidemiology of Sporotrichosis Images Appearance of a nodule in the skin lesion which is an early feature of sporotrichosis An [life-worldwide.org]
Dixon, Nosocomial aspergillosis: Environmental microbiology, hospital epidemiology, diagnosis and treatment, European Journal of Epidemiology, 1989, 5, 2, 131 CrossRef 19 David W. Denning, Richard M. Tucker, Linda H. Hansen, David A. [onlinelibrary.wiley.com]
Flavio Queiroz-Telles, Marcio Nucci, Arnaldo Lopes Colombo, Angela Tobón and Angela Restrepo, Mycoses of implantation in Latin America: an overview of epidemiology, clinical manifestations, diagnosis and treatment, Medical Mycology, 49, 3, (225), (2011 [doi.org]
[Sporotrichosis: prevalence, clinical and epidemiological features in a reference center in Colombia]. Rev Iberoam Micol. 2010 Jun 30. 27(2):75-9. [Medline]. Barros MB, de Almeida Paes R, Schubach AO. Sporothrix schenckii and Sporotrichosis. [emedicine.com]
病原体 Sporothrix schenckii [GN: ssck ] 治療薬 テルビナフィン塩酸塩 [DR: D02219 ] イトラコナゾール [DR: D00350 ] リンク ICD-11: 1F2J ICD-10: B42 MeSH: D013174 MedlinePlus: 001338 文献 PMID: 25526781 著者 Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T, Li S タイトル Global epidemiology [genome.jp]
Pathophysiology
& Vitamin K Antagonists: Anticoagulation Affects on the Clotting Cascade Wilson’s Disease Section 9 - Genodermatoses and Syndromes Addison’s Disease Amyloid Basal Cell Nevus Syndrome Carney Complex Cushing's Syndrome and Disease Cushing's Syndrome: Pathophysiology [euro-libris.ro]
This contributed significantly to the current understanding of Sporothrix schenckii, its growth patterns, and its mechanisms of dissemination. [2, 3] Pathophysiology Sporotrichosis infections can be either cutaneous or extracutaneous. [emedicine.com]
A thorough review of the topic was published by Barros et al in 2011. [5] Pathophysiology Infection with the dimorphic soil fungus S schenckii is usually acquired from organic matter through cutaneous inoculation. [emedicine.medscape.com]
Prevention
Response to treatment is variable and chronic suppressive therapy is probably needed to prevent relapse. [ncbi.nlm.nih.gov]
How Can I Prevent Sporotrichosis? There is no vaccine to prevent sporotrichosis. [medicinenet.com]
Prevention of this disease includes wearing long sleeves and gloves while working with soil, hay bales, rose bushes, pine seedlings, and sphagnum moss. Also, keeping cats indoors is a preventative measure. [en.wikipedia.org]
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. [cdc.gov]