[…] with a cane; 5, walking with crutches; 6, walking with a walker; 7, wheelchair bound; and 8, bedridden. [nature.com]

While some SMAs lead to death in infancy, other types can present with mild weakness in an otherwise healthy adult. Based on the type of muscles affected, spinal muscular atrophies can be divided into proximal and distal SMAs. [blueprintgenetics.com]

Neurological examination showed an asymmetric tetraparesis, with muscle atrophy, predominantly in the lower limbs, associated to profound global arreflexia, bradykinesia, muscle rigidity, with cogwheeling, rest tremor (right hand), postural instability [deepdyve.com]

One family member demonstrated vocal cord palsy as the initial sign of disease; however, in the other family hand muscle weakness was the first major symptom. No affected patients demonstrated sensory loss or upper motor neuron involvements. [ncbi.nlm.nih.gov]

In affected FC465 members, respiratory difficulty during exercise was the initial and predominant symptom; however, in affected FC654 members, hand muscle weakness was the first dominant symptom. [spandidos-publications.com]

Physical examination revealed atrophy and weakness of small hand muscles and mild atrophy and weakness of the lower limbs. There was generalized hyperreflexia with the exception of ankle reflexes which were diminished. [ncbi.nlm.nih.gov]

Maintaining proper axon diameter is essential for the efficient transmission of nerve impulses. The function of heat shock protein beta-8 is not well understood, but studies have shown that it interacts with heat shock protein beta-1. [ghr.nlm.nih.gov]

There was generalized hyperreflexia with the exception of ankle reflexes which were diminished. Her 25year-old son had only stiffness of both legs at the age of 22. Physical examination revealed only generalized hyporeflexia. [ncbi.nlm.nih.gov]

Neurological examination showed an asymmetric tetraparesis, with muscle atrophy, predominantly in the lower limbs, associated to profound global arreflexia, bradykinesia, muscle rigidity, with cogwheeling, rest tremor (right hand), postural instability [deepdyve.com]

Neurological examination showed an asymmetric tetraparesis, with muscle atrophy, predominantly in the lower limbs, associated to profound global arreflexia, bradykinesia, muscle rigidity, with cogwheeling, rest tremor (right hand), postural instability [deepdyve.com]

Dementia, gliosis and expression of the small heat shock proteins HSP27 and alpha B-crystallin in Parkinsons' disease. Neuroreport 1999 ; 10 : 2273 - 2276 Sharp P, Krishnan M, Pullar O, Navarrete R, Wells D, de Belleroche J. [nature.com]