See: and Maybe there is some simple ideas that may help, such as a topical cream that the doctor can order to help with burning pains at night (Dr. [neuropathysupportnetwork.org]

These fibers convey aching, burning pain and temperature sensation and also include the sympathetic, postganglionic motor nerves. Their speed is approximately 1 meter/second. [dartmouth.edu]

blindness Microcytic anemia with liver iron overload Oguchi disease 22q11.2 deletion syndrome 2q37 microdeletion syndrome Acrokeratosis verruciformis of Hopf Acute myeloid leukemia with t(8;21)(q22;q22) translocation Adams-Oliver syndrome Aicardi-Goutières [csbg.cnb.csic.es]

blindness X-linked dystonia-parkinsonism/Lubag Schindler disease type 1 FG syndrome 2 Absence of fingerprints congenital milia 8p23.1 duplication syndrome Biemond syndrome 2 Sjogren-Larsson syndrome Craniofacial dyssynostosis Pseudoxanthoma elasticum [checkrare.com]

retardation Pillay syndrome Glucose-galactose malabsorption Spastic ataxia Charlevoix-Saguenay type Autosomal dominant palmoplantar keratoderma and congenital alopecia McKusick Kaufman syndrome Branchial arch syndrome X-linked Testotoxicosis Frasier [checkrare.com]

retardation TANC1 Ptosis, congenital ZFHX4 Pyridoxine-dependent epilepsy ALDH7A1 Pyruvate carboxylase deficiency PC Renpenning syndrome PQBP1 Rett syndrome preserved speech variant MECP2 Rigid spine muscular dystrophy SELENON Rippling muscle disease [centogene.com]

incontinence) in some cases uncontrollable bowel (bowel incontinence) Management Medical Management Babies born or children who have developed with hydrocephalus usually require swift treatment to reduce the pressure on their brain. [physio-pedia.com]

[…] in infancy or childhood, difficulty in running, twisting of ankles, pes cavus (planus at onset) and hammertoes, progressive peroneal atrophy with steppage gait, foot drop, mild sensory ataxia, weakness/wasting of hand intrinsic muscles, stocking-glove [neupsykey.com]

paralysis Agammaglobulinemia, microcephaly, and severe dermatitis Renal hypouricemia Microcephaly sparse hair mental retardation seizures Dentinogenesis imperfecta type 2 Early-onset, autosomal dominant Alzheimer disease Microduplication Xp11.22-p11.23 [checkrare.com]

paralysis, infantile onset ascending ALS2 Spastic paraplegia type 74, autosomal recessive IBA57 Spastic paraplegia type 74, autosomal recessive IBA57 SPG1 L1CAM SPG2 PLP1 SPG3A ATL1 SPG4 SPAST SPG5A CYP7B1 SPG6 NIPA1 SPG7 SPG7 SPG8 KIAA0196 SPG10 KIF5A [centogene.com]

seizures plus type 2 SCN1A Generalized epilepsy with febrile seizures plus type 3 GABRG2 Generalized epilepsy with febrile seizures plus type 7 SCN9A Gerstmann-Straussler disease PRNP Giant axonal neuropathy type 1 GAN Gillespie syndrome ITPR1 GLUT1 [centogene.com]

seizures, and sinoatrial block Miyoshi myopathy MYH7-related scapuloperoneal myopathy Multiple system atrophy Hirschsprung's disease Pseudoneonatal adrenoleukodystrophy Bangstad syndrome Spondylocarpotarsal synostosis syndrome Eosinophilic fasciitis [checkrare.com]

Early Onset: Severe forms may have infant hypotonia with delayed motor milestones, toe walking and even arthrogryposis; most present before age 20, with clumsiness and abnormal gait. [now.aapmr.org]

A clinical vignette is as follows: Two patients, father and son, presented with slowly progressive weakness since childhood, affecting the arms more than the legs, and numbness in the hands and feet. [emedicine.medscape.com]