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Disulfiram-like Reaction

Disulfiram like Reaction


Presentation

  • Designed specifically with physicians, pharmacologists, and other members of the health care delivery team in mind, the CRC Desk Reference of Clinical Pharmacology features more than 2,000 entries appearing in three formats: Short reviews: these present[books.google.com]
  • In the present study, chloramphenicol, furazolidone, metronidazole, and quinacrine, which are reported to produce a disulfiram-like reaction, as well as disulfiram, were administered to Wistar rats and the hepatic activities of alcohol and aldehyde dehydrogenases[ncbi.nlm.nih.gov]
  • Basis of reaction: block in metabolism of acetaldehyde, with its accumulation Ethanol may be present in a variety of over-the-counter medications and elixirs, and it may take some investigation to detect the causal relationship.[meducator3.net]
  • It presents with itching resulting in formation of red r ... Read More I want to try Disulfiram as a medication for my father to reduce and stop alcohol consumption in India. Kindly advice if it is safe to try this medication.[practo.com]
  • Presentation on theme: "Drugs That Cause Disulfiram Reaction Buy Antabuse Online to buy disulfiram disulfiram ic50 disulfiram delirium tremens disulfiram glioma drugs with disulfiram.[slideplayer.com]
Fishing
  • Read More Hello doctor, I'm suffering with skin allergy(rashes and severe itching) for the past 8years(allergic to brinjal, dry fish, dust and pollens).[practo.com]
Dyspnea
  • […] disulfiram-like reaction was cefoperazone-sulbactam.Disulfiram-like reaction mostly happened in patients who drank after taking cephalosporin.Duration before disulfiram-like reaction was 5 min-1 h from drinking.Cardiovascular manifestations included cardiopalmus,dyspnea[en.cnki.com.cn]
  • Severe reaction includes flushing, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and[newhorizonspharmalab.com]
  • At a party shortly afterward she experiences facial flushing, nausea, tachycardia, dyspnea, headache, and abdominal cramps after consuming alcohol.[medbullets.com]
  • The first patient, a 31-year-old male, drank 24 ounces of beer and 10-20 minutes elapsed before symptoms of flushing, heart palpitations, dyspnea, nausea, and headache occurred.[boards.straightdope.com]
  • Effects of Mixing Disulfiram and Alcohol Flushing Throbbing headache Throbbing neck pain Respiratory difficulty Nausea Copious vomiting Sweating Thirst Chest pain Palpitation Dyspnea Hyperventilation Low blood pressure Weakness Blurred vision These symptoms[projectknow.com]
Sneezing
  • My nose starts running, frequent sneezing and eyes start watering. i am not able to understand the roote cause.[practo.com]
Nausea
  • Features of disulfiram reaction: (1) facial flushing followed by intense vasodilation of the head and neck, with suffusion of the conjunctivae (2) throbbing headache (3) tachycardia (4) hyperpnea (5) sweating (6) nausea and vomiting (7) hypotension in[meducator3.net]
  • […] duration of action effect enzyme excretion fall in BP fluid GABA given Gram heart hepatic hypertension hypotension increase infections inhibitors inhibits irritation kidneys less levodopa lipid liver mechanism metabolism mg bid mg/kg muscles myocardial nausea[books.google.com]
  • It causes symptoms like nausea, vomiting, sweating, palpitation etc.. Not a good choice .. ... Read More Hi have very frequent allergic reactions.[practo.com]
  • Severe reaction includes flushing, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and[newhorizonspharmalab.com]
Vomiting
  • Features of disulfiram reaction: (1) facial flushing followed by intense vasodilation of the head and neck, with suffusion of the conjunctivae (2) throbbing headache (3) tachycardia (4) hyperpnea (5) sweating (6) nausea and vomiting (7) hypotension in[meducator3.net]
  • […] resistance respiratory response Rifampicin sedation soluble stimulation sulfonamides sympathetic syndrome synthesis tachycardia tetracyclines thiazides tissue tolerance toxicity treatment urinary urine vasodilatation vasodilators ventricular verapamil vomiting[books.google.com]
  • Pseudotumor Cerebri 996 Psychosis Acute 1002 Seizure Adult 1004 Sepsis 1010 Shock 1016 Sickle Cell Disease 1022 Sinusitis 1024 Sleep Apnea 1028 Smoke Inhalation 1034 Spinal Cord Syndromes 1042 Coccyx 1048 Splenic Injury 1054 Subarachnoid Hemorrhage 1076 Vomiting[books.google.com]
  • It causes symptoms like nausea, vomiting, sweating, palpitation etc.. Not a good choice .. ... Read More Hi have very frequent allergic reactions.[practo.com]
  • Symptoms of a “disulfiram-like reaction” may include: nausea and vomiting flushing of the skin stomach cramps, vomiting headache rapid heart rate chest pain difficulty breathing A similar reaction may occur with other antibiotics like cefotetan ( Cefotan[drugs.com]
Tachycardia
  • A second ingestion of 24 ounces of beer eight hours later produced facial flushing, tachycardia, diaphoresis, and pounding headache; the symptoms lasted 1.5-2 hours.[ncbi.nlm.nih.gov]
  • Features of disulfiram reaction: (1) facial flushing followed by intense vasodilation of the head and neck, with suffusion of the conjunctivae (2) throbbing headache (3) tachycardia (4) hyperpnea (5) sweating (6) nausea and vomiting (7) hypotension in[meducator3.net]
  • […] peripheral phenytoin plasma concentration platelet prevent produce prophylaxis protein quinolones receptors reduces reflex release renal resistance respiratory response Rifampicin sedation soluble stimulation sulfonamides sympathetic syndrome synthesis tachycardia[books.google.com]
  • […] patients who drank after taking cephalosporin.Duration before disulfiram-like reaction was 5 min-1 h from drinking.Cardiovascular manifestations included cardiopalmus,dyspnea,hypotension,chest distress and chest pain.Electrocardiography showed nodal tachycardia[en.cnki.com.cn]
Orthostatic Hypotension
  • Disulfiram-ethanol reaction : Head, neck, and chest flushing - Histamine-induced vasodilation Throbbing headaches Nausea, vomiting (may be refractory), diarrhea, and abdominal pain Weakness, dizziness, confusion, and anxiety Vertigo and ataxia Orthostatic[lessons4medicos.blogspot.com]
  • Concomitant use of alcohol with these medications may lead to enhanced orthostatic hypotension, putting patients at risk for injury or falls. 8,9,18 Chronic alcohol use can lead to increased metabolism and decreased effectiveness of the beta-adrenergic[uspharmacist.com]
Flushing
  • Approximately 25 hours after receiving the 3-g dose, one subject experienced facial flushing after drinking 12 fluid ounces of beer.[ncbi.nlm.nih.gov]
  • Flushing reactions: Consequences and mechanisms. Ann Intern Med. 1981; 95: 468-476.[meducator3.net]
  • This reaction is very uncomfortable, characterized by severe flushing. It may also be accompanied by tachycardia and hypotension. Tab 1 show commonly used medications that cause Disulfiram like reaction when patients consume alcohol.[newhorizonspharmalab.com]
  • Disulfiram-ethanol reaction : Head, neck, and chest flushing - Histamine-induced vasodilation Throbbing headaches Nausea, vomiting (may be refractory), diarrhea, and abdominal pain Weakness, dizziness, confusion, and anxiety Vertigo and ataxia Orthostatic[lessons4medicos.blogspot.com]
Headache
  • A second ingestion of 24 ounces of beer eight hours later produced facial flushing, tachycardia, diaphoresis, and pounding headache; the symptoms lasted 1.5-2 hours.[ncbi.nlm.nih.gov]
  • Features of disulfiram reaction: (1) facial flushing followed by intense vasodilation of the head and neck, with suffusion of the conjunctivae (2) throbbing headache (3) tachycardia (4) hyperpnea (5) sweating (6) nausea and vomiting (7) hypotension in[meducator3.net]
  • If a patient drinks alcohol on the drug, he or she will experience a range of unpleasant and even dangerous side effects like vomiting , seating, throbbing headache , confusion , and shortness of breath ; removing the urge to drink.[medicinenet.com]
  • Avoid large quantities of tyramine-containing alcoholic beverages (tap beer, vermouth, red wine.) 6 tinidazole (Tindamax) Disulfiram-like reaction which may include abdominal cramps, nausea, vomiting, headaches, flushing.[drugs.com]
Confusion
  • If a patient drinks alcohol on the drug, he or she will experience a range of unpleasant and even dangerous side effects like vomiting , seating, throbbing headache , confusion , and shortness of breath ; removing the urge to drink.[medicinenet.com]
  • Disulfiram-ethanol reaction : Head, neck, and chest flushing - Histamine-induced vasodilation Throbbing headaches Nausea, vomiting (may be refractory), diarrhea, and abdominal pain Weakness, dizziness, confusion, and anxiety Vertigo and ataxia Orthostatic[lessons4medicos.blogspot.com]
  • Severe reaction includes flushing, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion[newhorizonspharmalab.com]
  • Metronidazole: Increases risk of psychosis or confusion. Avoid use together. Tricyclic antidepressants, especially amitriptyline: May cause transient delirium. Monitor patient closely. Warfarin: May increase anticoagulant effects.[glowm.com]
  • Metronidazole : Confusion and psychoses reported in patients receiving this combination; mechanisms unknown. Phenytoin : Decreased phenytoin metabolism.[flipper.diff.org]
Dizziness
  • […] reaction: (1) facial flushing followed by intense vasodilation of the head and neck, with suffusion of the conjunctivae (2) throbbing headache (3) tachycardia (4) hyperpnea (5) sweating (6) nausea and vomiting (7) hypotension in severe reactions (8) dizziness[meducator3.net]
  • Disulfiram-ethanol reaction : Head, neck, and chest flushing - Histamine-induced vasodilation Throbbing headaches Nausea, vomiting (may be refractory), diarrhea, and abdominal pain Weakness, dizziness, confusion, and anxiety Vertigo and ataxia Orthostatic[lessons4medicos.blogspot.com]
  • A disulfiram-like drug is a drug that causes hypersensitivity to alcohol leading to nausea , vomiting , flushing , dizziness , throbbing headache , chest and abdominal discomfort , and general hangover -like symptoms among others. [1] [2] These effects[en.wikipedia.org]
  • High levels of acetaldehyde act directly on the heart and blood vessels, causing flushing, a racing heartbeat and a drop in blood pressure that causes dizziness.[netdoctor.co.uk]
  • Some of the symptoms you may experience if you use any alcohol while taking this medicine are: Blurred vision Chest pain Confusion Dizziness or fainting Fast or pounding heartbeat Flushing or redness of face Increased sweating Nausea and vomiting Throbbing[mayoclinic.org]
Vertigo
  • Streptococcal Disease 1156 Tuberculosis 1158 Tympanic Membrane Perforation 1164 Suicide Risk Evaluation 1166 Gastritis 1168 Syncope 1172 Ovarian CystTorsion 788 1195 Ventilator Management 1198 Ventricular Peritoneal Shunts 1202 Urinary Tract Fistula 1174 Vertigo[books.google.com]
  • Disulfiram-ethanol reaction : Head, neck, and chest flushing - Histamine-induced vasodilation Throbbing headaches Nausea, vomiting (may be refractory), diarrhea, and abdominal pain Weakness, dizziness, confusion, and anxiety Vertigo and ataxia Orthostatic[lessons4medicos.blogspot.com]
  • Severe reaction includes flushing, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and[newhorizonspharmalab.com]
  • High acetaldehyde levels cause unpleasant symptoms after drinking alcohol such as: Palpitations Low blood pressure Chest pain Nausea Vertigo Thirst Flushing Headache Several other symptoms These unpleasant side effects dissuade alcoholics from drinking[medicinenet.com]
  • […] produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea , hyperventilation , tachycardia , hypotension , syncope , marked uneasiness, weakness, vertigo[en.wikipedia.org]
Ataxia
  • Disulfiram-ethanol reaction : Head, neck, and chest flushing - Histamine-induced vasodilation Throbbing headaches Nausea, vomiting (may be refractory), diarrhea, and abdominal pain Weakness, dizziness, confusion, and anxiety Vertigo and ataxia Orthostatic[lessons4medicos.blogspot.com]
  • CNS and CV stimulation, arrhythmias, stroke, and seizures at high does feverfew (migraine) GI, mouth ulcers, antiplatelet actions ginkgo (intermittent claudication) GI, anxiety, insomnia, HA, antiplatelet actions kava (chronic anxiety) GI, sedation, ataxia[memorize.com]
  • Isoniazid: Increases risk of ataxia, unsteady gait, or marked behavioral changes. Don’t use together. Metronidazole: Increases risk of psychosis or confusion. Avoid use together.[glowm.com]
  • Infact alcohol induces several effects: sedation, slurred speech, ataxia and respiratory depression up to coma (with an high concentration of substance in blood)by increasing the activity of GABA on his receptor (isoform A) and by inhibition of NMDA channel[flipper.diff.org]

Workup

Nodal Tachycardia
  • tachycardia,atrial fibrillation,premature ventricular beats and alteration of ST-T that tended to be misdiagnosed as acute coronary syndrome,acute left heart failure and shock.Patients relieved from 30 min to 3 h after being actively and effectively[en.cnki.com.cn]

Treatment

  • Patients experiencing these often frightening disulfiram-type reactions seldom need specific treatment; however, it is mandatory to strongly caution patients not to consume alcoholic beverages for a few days after treatment with these cephalosporins.[ncbi.nlm.nih.gov]
  • Abstract Cefuoxime, a second-generation cephalosporin, is used in the treatment of Gram-positive infections. Here, we report a case cefuroxime-induced disulfiram-like reaction which led to sudden death of the patient.[ncbi.nlm.nih.gov]
  • . 42 Subsequently, disulfiram was approved by the FDA for the the treatment for alcoholism in 1951.[mhmedical.com]
  • Certain drugs such as metronidazole, sulfonamides, nitrofurantoin, chloramphenicol have also been implicated in causation of disulfiram-like reaction. 2 Clinical effect of azithromycin as an adjunct to non-surgical treatment of chronic periodontitis:[jpgmonline.com]
  • Read More Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.[practo.com]

Prognosis

  • The prognosis of the reaction is comparatively good. But the reaction occasionally could be severe enough to cause death. 2 Cefuroxime/alcohol interaction Reactions Weekly. 2013; 1469(1): 15[ijp-online.com]
  • […] being actively and effectively treated.There was no dead case.Conclusions Disulfiram-like reaction can be induced by the interaction of cephalosporin and alcohol drinking.It is mainly manifested as complicated and severe cardiovascular disease,but the prognosis[en.cnki.com.cn]

Epidemiology

  • […] clinical trials disulfiram is still widely prescribed today. 38, 47, 70, 95,115 Although the use of disulfiram for treating alcoholism is decreasing, its use in the management of addictions to other drugs of abuse such as cocaine is increasing. 92 Specific epidemiologic[mhmedical.com]
  • Militaris Tertiae;2003-17 9 ; 小儿口服中毒插管洗胃的研究进展 [J];Journal of Nurses Training;2010-01 10 SUN Yan-bin,SUN Ting,DUAN De-shui,et al.Jinan Municipal Centers for Disease Control and Prevention(Jinan 250001,China); Evidence-based analysis on food poisoning epidemiological[en.cnki.com.cn]
  • INR) may be monitored and warfarin’s dose adjusted as necessary. 24,25 Analgesics (Nonnarcotic) Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Aspirin: Both NSAIDs and high-dose aspirin are associated with an increased risk of GI bleeding. 8,26,27 Epidemiologic[uspharmacist.com]
Sex distribution
Age distribution

Pathophysiology

  • This section ventures into the journey of the discovery of the molecule, starting from the accidental discovery of its potential pathophysiological effects, thereafter becoming obscure due to lack of indications (alcohol use was not considered a problem[jmhhb.org]

Prevention

  • […] maragement of organophosphorus pesticide poisoning [J];Acta Academiae Medicinae Militaris Tertiae;2003-17 9 ; 小儿口服中毒插管洗胃的研究进展 [J];Journal of Nurses Training;2010-01 10 SUN Yan-bin,SUN Ting,DUAN De-shui,et al.Jinan Municipal Centers for Disease Control and Prevention[en.cnki.com.cn]
  • […] irritation kidneys less levodopa lipid liver mechanism metabolism mg bid mg/kg muscles myocardial nausea neostigmine Nifedipine occurs oedema onset of action opioid oral organisms pain patients penicillin peripheral phenytoin plasma concentration platelet prevent[books.google.com]
  • If you’d like help finding a treatment center near you that can help you prevent disulfiram overdose in the future, call 1-888-287-0471 Who Answers? today.[projectknow.com]
  • Disulfiram prevents acetaldehyde dehydrogenase from converting acetaldehyde into acetic acid, leading to a buildup of acetaldehyde levels in the blood.[medicinenet.com]
  • The reaction has been variously termed a disulfiram-like reaction , alcohol intolerance , and acetaldehyde syndrome . [3] The prototypical drug of this group is disulfiram (brand name Antabuse), which acts as an acetaldehyde dehydrogenase inhibitor , preventing[en.wikipedia.org]

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