At 12 months, symptomatic improvement was observed in 18 of 31 patients, 6 of whom remained asymptomatic. Treatment with dofetilide in this study was successful in less than 1 in 5 patients. [ncbi.nlm.nih.gov]

They were monitored intermittently rather than continuously leaving some concern over asymptomatic AF recurrences. [academic.oup.com]

Effect of amiodarone therapy on mortality in patients with left ventricular dysfunction and asymptomatic complex ventricular arrhythmias: Argentine Pilot Study of Sudden Death and Amiodarone (EPAMSA). Am Heart J 1995 ;130: 494 - 500 29. [doi.org]

Unfortunately, atrial fibrillation is common in patients with heart failure and can impair exercise tolerance, exacerbate symptoms, and have hemodynamic and thromboembolic consequences. 1-4 Although digitalis can attenuate the ventricular response in [doi.org]

He experienced an 8-beat run of non-sustained ventricular tachycardia, frequent multifocal PVCs, and ventricular bigeminy. He received magnesium sulfate and potassium chloride supplementation. [ncbi.nlm.nih.gov]

One patient had an allergic reaction during initiation and one patient discontinued the drug during follow-up for symptomatic ventricular bigeminy presumed associated with dofetilide. [academic.oup.com]

In this case, we present a case of trigeminal neuralgia caused by dofetilide. [ncbi.nlm.nih.gov]

In Cox proportional model, female sex, age CONCLUSIONS: Dyslipidemia and LVEF 2017 Wiley Periodicals, Inc. [ncbi.nlm.nih.gov]

Safety assessment included monitoring for the occurrence of excessive QTc interval prolongation and torsade de pointes. [ncbi.nlm.nih.gov]

Table 2 Incidence of excessive QTc interval prolongation/Torsade de pointes Adverse event Study group ( N 127) QTc prolongation, n (%) a 6 (4.7) After first dose 3 (2.4) Subsequent doses 3 (2.4) Torsade de pointes, n (%) 0 (0) b Adverse event Study group [academic.oup.com]

Premature ventricular contractions and right bundle branch block were evident at this dose, without changes in cardiovascular parameters. The mean C(max) values were 3.35 and 60.15 ng mL(-1) at doses of 0.03 and 0.3 mg kg(-1), respectively. [ncbi.nlm.nih.gov]

bundle branch block or incomplete right bundle branch block Resting heart rate 40 or 100 beats per minute (bpm) Pathological Q waves (defined as Q wave 40 msec) Ventricular pre-excitation More than 2 ectopic beats Syncope, palpitations, or unexplained [clinicaltrials.gov]

We report four cases of dofetilide-induced QT prolongation and torsades de pointes. We discuss the risk factors for the development of dofetilide-induced long QT and torsades de pointes and review the current literature. [ncbi.nlm.nih.gov]

Therapy may be initiated at lower dosages due to the risk of torsades de pointes. 1 2 Prescribing Limits Adults Supraventricular Tachyarrhythmias Oral Dosages 500 mcg twice daily have been associated with an increased incidence of torsades de pointes. [drugs.com]

He experienced an 8-beat run of non-sustained ventricular tachycardia, frequent multifocal PVCs, and ventricular bigeminy. He received magnesium sulfate and potassium chloride supplementation. [ncbi.nlm.nih.gov]

One patient had an allergic reaction during initiation and one patient discontinued the drug during follow-up for symptomatic ventricular bigeminy presumed associated with dofetilide. [academic.oup.com]

BACKGROUND: Congenital long QT syndrome type 2 (abnormal hERG potassium channel) patients can develop flat, asymmetric, and notched T waves. Similar observations have been made with a limited number of hERG-blocking drugs. [ncbi.nlm.nih.gov]

Risk factors for adverse events (AEs), defined as any arrhythmia or electrocardiogram change requiring dose reduction or cessation, were identified. RESULTS: Of 329 patients, 227 (69%) received SL and 102 (31%) DF. [ncbi.nlm.nih.gov]