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Dowling-Degos Disease
Dowling Degos Disease

Presentation

Overlying mild hyperkeratosis is commonly present. Thinning of the suprapapillary epithelium is regularly present. [escholarship.org]

We present the case of a 51 year-old man with macrocomedo-like lesions, pitted scars, cysts, hyperpigmented macules in his back, chest, axillae, neck, groin and face. [pubmed.ncbi.nlm.nih.gov]

In this paper the authors present a study of seven cases of DDD, 1 man and 6 women, 30-56 years of age, observed in 7 years. [moh-it.pure.elsevier.com]

Disease Associated With Hidradenitis Enfermedad de Dowling-Degos Medicine 2015 A case of DDD associated with hidradenitis suppurativa (HS) in a 43-year-old Spanish woman, thought to be a rare autosomal dominant genodermatosis with variable penetrance, is presented [semanticscholar.org]

New insights into the diagnosis of hidradenitis suppurativa: Clinical presentations and phenotypes. J Am Acad Dermatol 2015; 73: S23–26. View article Google Scholar Agut-Busquet E, Romaní J, Ribera M, Luelmo J. [medicaljournals.se]

Treatment

As Dowling-Degos is a genetic disease there is no curative treatment. [dermnetnz.org]

Biologic treatment is available for patients who fail to respond. Due to the increased risk of skin malignancies, long-term follow-up of patients with DDD and HS is crucial. [medicaljournals.se]

Treatment No therapy has been established as effective. Previous reports indicate that topical steroids, hydroquinone, and oral retinoids are not effective. [escholarship.org]

Epidemiology

We report epidemiological and clinical characteristics for a cohort of 15 patients with DDD, concomitantly affected by HS, who attended the Dermatology Services of Alicante Hospital and Sabadell Hospital between 2015 and 2017. [medicaljournals.se]

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