Conclusions DDD can have varied presentations and remains camouflaged. [cureus.com]

Interestingly, most cases of follicular DDD present around childhood and puberty while classic DDD commonly presents after puberty. [karger.com]

Outline the typical presentation of a patient with Dowling-Degos disease. Review treatment and psychosocial considerations for patients with Dowling-Degos disease. [statpearls.com]

Relevance of psychiatry in dermatology: Present concepts. Indian J Psychiatry. 2010 Jul;52(3):270-5. [PMC free article: PMC2990831] [PubMed: 21180416] [ncbi.nlm.nih.gov]

Overlying mild hyperkeratosis is commonly present. Thinning of the suprapapillary epithelium is regularly present. [escholarship.org]

• Eruptions

  The eruption first started over the face, gradually progressed to involve the chest and back. [ijdvl.com]

  The initial facial eruption supports the classification of Haber's disease as a separate entity from DDD. [12][13] Neurofibromatosis type 1 Exhibits axillary and inguinal freckling that mirrors the reticulated hyperpigmentation of DDD but becomes easily [statpearls.com]

  Atypical Variant of Galli-Galli Disease (Grover-Like Eruption With Lentiginous Freckling) in a Liver Transplant Patient. Am J Dermatopathol. 2011 Jan 19. [QxMD MEDLINE Link]. Müller CS, Tremezaygues L, Pföhler C, Vogt T. [emedicine.medscape.com]

• Sweating

  These feelings can be triggered by UV light, sweating, or friction on the skin. [medlineplus.gov]

• Blister

  Because mutations in keratin 5 can cause epidermolysis bullosa of the simplex type (EBS), it is important to understand why there is no blistering in patients with DDD. [escholarship.org]

• Confusion

  Changing a concept--controversy on the confusing spectrum of the reticulate pigmented disorders of the skin. J Cutan Pathol. 2009 Jan. 36(1):44-8. [QxMD MEDLINE Link]. El Shabrawi-Caelen L, Rütten A, Kerl H. [emedicine.medscape.com]

  Changing a concept--controversy on the confusing spectrum of the reticulate pigmented disorders of the skin. J Cutan Pathol, 2009. 36(1): p. 44-8. [PubMed] 30. Al Hawsawi, K., Al Aboud K, Alfadley A, Al Aboud D. [escholarship.org]

Hyperpigmentation is often recalcitrant to treatment, as evidenced by the varying success of topical and laser therapies. [statpearls.com]

DDD is known to be resistant to treatment, and no standard treatment has been established [3]. [karger.com]

A case report of combined treatment using tissue expansion, radical excision, and isotretinoin. [link.springer.com]

The patient was treated with systemic and topical antibiotics as an acute treatment for the ruptured, infected cyst. [odermatol.com]

The clinical and histopathological changes were memorably summarized by Wilson-Jones and Grice as ′demonstrating dusky dappled disfigurements and dark dot depressions and disclosing digitate downgrowths delving dermally′. [1] Because of its favorable prognosis [ijdvl.com]

A Chinese newborn with reticulate pigmented anomaly of the flexures was recently described. [25] Prognosis Dowling-Degos disease (reticulate pigmented anomaly) is slowly progressive but not life threatening. [emedicine.medscape.com]

Mutations in genes involved in melanosome trafficking and melanocyte and keratinocyte proliferation, differentiation, and cellular communications have all been implicated as etiologies. [statpearls.com]

We report epidemiological and clinical characteristics for a cohort of 15 patients with DDD, concomitantly affected by HS, who attended the Dermatology Services of Alicante Hospital and Sabadell Hospital between 2015 and 2017. [medicaljournals.se]

POFUT1 and POGLUT1 mutations have been linked to a variant form of DDD that commonly involves non-flexural sites, while PSENEN mutations have been attributed to a variant of DDD associated with hidradenitis suppurativa.[3],[4] Epidemiology Since DDD was [statpearls.com]

Epidemiology Frequency Dowling-Degos disease (reticulate pigmented anomaly) is a rare condition worldwide. Sex Dowling-Degos disease (reticulate pigmented anomaly) affects both sexes. [emedicine.medscape.com]

DDD has no racial or gender predilection, and lesions typically present in the third to fourth decade of life.[5] Pathophysiology Given that DDD is a disorder of hyperpigmentation, the main pathophysiology behind the disease fittingly involves melanosomal [statpearls.com]

Recent genetic studies speculate a shared pathophysiologic mechanism of DDD and HS. © 2021 The Author(s). Published by S. [karger.com]