Conclusions DDD can have varied presentations and remains camouflaged. [cureus.com]

Interestingly, most cases of follicular DDD present around childhood and puberty while classic DDD commonly presents after puberty. [karger.com]

Outline the typical presentation of a patient with Dowling-Degos disease. Review treatment and psychosocial considerations for patients with Dowling-Degos disease. [statpearls.com]

Relevance of psychiatry in dermatology: Present concepts. Indian J Psychiatry. 2010 Jul;52(3):270-5. [PMC free article: PMC2990831] [PubMed: 21180416] [ncbi.nlm.nih.gov]

DSH and DUH present with macules only and are characterized by the absence of papules, thereby allowing differentiation from DDD. [ijdvl.com]

• Papule

  Cutaneous examination revealed multiple hyperpigmented macules and papules over the face, neck and trunk. Lower trunk revealed numerous hypopigmented macules and papules. Hands, feet, mucosae, nails and hair were spared. [ijdvl.com]

  The first is classic DDD with typical histologic characters and the generalized DDD with generalized hypopigmented papules [16]. [cureus.com]

  A 37-year-old Thai man presented with slowly progressive hyperpigmented comedone-like papules on the face, neck, axillae, upper trunk, and buttocks with perioral pitted scars. [karger.com]

  " and "black papules" that closely resemble the dark dots and the diffuse seborrheic keratoses of the flexures of DDD. [jamanetwork.com]

  They include the following: Reticulate acropigmentation of Kitamura Manifests as atrophic hyperpigmented papules that coalesce into a reticulated pattern. [statpearls.com]

• Hypopigmented Macule

  To conclude, DDD can present with hypopigmented macules and papules along with hyperpigmented lesions (as noted in our case) or rarely, with hypopigmented lesions only. [ijdvl.com]

  The British journal of dermatology. 2010 Jul [PubMed PMID: 20222933] [7] Pickup TL,Mutasim DF, Dowling-Degos disease presenting as hypopigmented macules. [statpearls.com]

  Dowling-Degos disease presenting as hypopigmented macules. J Am Acad Dermatol. 2011 Jun;64(6):1224-5. [PubMed: 21571208] 8. Yun JH, Kim JH, Choi JS, Roh JY, Lee JR. Treatment of Dowling-Degos disease with fractional Er:YAG laser. [ncbi.nlm.nih.gov]

  These patients may have intermingled hypopigmented macules and for this reason there is clinical overlap with dyschromatosis universalis hereditaria (DUH) [6, 35]. [escholarship.org]

  Other findings in DDD include hypopigmented macules and papules, comedones-like lesions, fingernail dystrophy, pitted perioral scars, chloracne-like presentation, Galli-Galli disease, and overlap with reticulate acropigmentation of Kitamura (RAPK) [10 [cureus.com]

• Keratosis

  Seborrhoeic keratosis — in Dowling-Degos disease, epithelial strands extend from the epidermis and hair follicles. The clinical presentation is very helpful in differentiating these conditions. [dermnetnz.org]

  The epidermis often contains small keratin-containing cysts, which may be numerous and mimic the appearance of an adenoid seborrheic keratosis (Figure 4). [escholarship.org]

  The association of DDD and seborrhoeic keratosis has also been previously reported, and follicular keratinization might be the common pathological mechanism[14]. [mednexus.org]

• Eruptions

  The initial facial eruption supports the classification of Haber's disease as a separate entity from DDD. [12][13] Neurofibromatosis type 1 Exhibits axillary and inguinal freckling that mirrors the reticulated hyperpigmentation of DDD but becomes easily [statpearls.com]

• Macula

  Caraballo Medicine 2004 Dowling-Degos disease is a rare benign genodermatosis characterized by the presence of hyperpigmented reticulate maculas in the body flexural areas and it shows variable penetrance. 5 PDF Related Papers Showing 1 through 3 of 0 [semanticscholar.org]

• Facial Scar

  Specifically, there was no evidence of hidradenitis suppurativa, seborrheic keratoses, comedo-like lesions, hyperkeratotic follicular lesions, epidermoid cysts, pitted acne-like facial scars, or keratoacanthomas. [escholarship.org]

Hyperpigmentation is often recalcitrant to treatment, as evidenced by the varying success of topical and laser therapies. [statpearls.com]

DDD is known to be resistant to treatment, and no standard treatment has been established [3]. [karger.com]

Treatment options are discussed and the available literature is reviewed. [pesquisa.bvsalud.org]

The patient was treated with systemic and topical antibiotics as an acute treatment for the ruptured, infected cyst. [odermatol.com]

Mutations in genes involved in melanosome trafficking and melanocyte and keratinocyte proliferation, differentiation, and cellular communications have all been implicated as etiologies. [statpearls.com]

In this review, we summarize features of DDD, emphasizing advances in genetics research and looking to the future for further understanding of its etiology and the development of therapeutic methods. [mednexus.org]

We report epidemiological and clinical characteristics for a cohort of 15 patients with DDD, concomitantly affected by HS, who attended the Dermatology Services of Alicante Hospital and Sabadell Hospital between 2015 and 2017. [medicaljournals.se]

POFUT1 and POGLUT1 mutations have been linked to a variant form of DDD that commonly involves non-flexural sites, while PSENEN mutations have been attributed to a variant of DDD associated with hidradenitis suppurativa.[3],[4] Epidemiology Since DDD was [statpearls.com]

Recent genetic studies speculate a shared pathophysiologic mechanism of DDD and HS. © 2021 The Author(s). Published by S. [karger.com]

DDD has no racial or gender predilection, and lesions typically present in the third to fourth decade of life.[5] Pathophysiology Given that DDD is a disorder of hyperpigmentation, the main pathophysiology behind the disease fittingly involves melanosomal [statpearls.com]