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Doxycycline


Presentation

  • Patients typically present in the first two decades of life with keratotic, greasy papules in a seborrheic distribution. Segmental Darier disease is a variant with localized disease that follows Blaschko lines.[ncbi.nlm.nih.gov]
  • Herein is presented an ambulatory 19-year-old male subject with a painful lymphatic malformation of the distal femur characterized by a serpiginous intraosseous and extraosseous extent.[ncbi.nlm.nih.gov]
  • Abstract The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory mechanisms in biological systems.[ncbi.nlm.nih.gov]
  • She had consequently finished a 10-day course of doxycycline therapy, with her last dose five days before presentation.[ncbi.nlm.nih.gov]
  • An HIV-infected male patient who had sex with men and with a penicillin allergy presented with liver dysfunction due to secondary syphilis and was successfully treated with doxycycline.[ncbi.nlm.nih.gov]
Camping
  • In Neuro2a cells with endogenous expression of PAC1 and its ligands, doxycycline not only promoted the proliferation of Neuro2a cells but also protected the cells from scopolamine induced apoptosis, which was inhibited by cAMP-PKA signal pathway inhibitor[ncbi.nlm.nih.gov]
  • Herbert packs Doxycycline, a Malaria medication.jpg 3 008 2 000; 308 KB US Navy 081114-N-7526R-098 Hospitalman Knasi Kusi separates Doxycycline Hyclate malaria medication into weekly doses in the pharmacy at Seth Michaud emergency medical facility at Camp[commons.wikimedia.org]
  • Camps, M., G. Arrizabalaga, and J. Boothroyd. 2002. An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii. Mol. Microbiol. 43 : 1309 -1318. Desjardins, R. E., C. J. Canfield, J. D. Haynes, and J. D.[doi.org]
  • The passage of water out of the ducts is thought to be mediated largely by cyclic adenosine-monophosphate (cAMP), the synthesis of which is stimulated by ADH, which increases the permeability of the luminal cell membrane to water.[inchem.org]
Intravenous Administration
  • Fatal liver disease after intravenous administration of tetracycline in high dosage. NEJM 1963;269(19):999-1004. back to table[fda.gov]
Lymphedema
  • Morbihan disease (MD) is rosacea-like disease characterized by persistent lymphedema on the upper half of the face. Currently, there is no established standard treatment for MD.[ncbi.nlm.nih.gov]
Nausea
  • A 33-year-old woman was admitted to the emergency room complaining of nausea and abdominal pain after the use of doxycycline 500 mg and ornidazole 500 mg twice daily for three days for a vaginal infection.[ncbi.nlm.nih.gov]
  • […] such as nausea, vomiting, something stuck in my throat, dizziness,headache,loss of appetite.[everydayhealth.com]
  • Side Effects Upset stomach, nausea, diarrhea, or mild headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.[myhealth.alberta.ca]
  • A 21-year-old, otherwise healthy female presented with severe abdominal discomfort associated with nausea and vomiting. She was hemodynamically stable with normal vital signs. Physical exam revealed a soft but tender to palpation epigastric area.[ncbi.nlm.nih.gov]
  • […] hard to take Dosage: 100 mg Twice daily Cost: 25 monthly May 13, 2017 (Started Dec 07, 2015) Effectiveness Major (for sinus infection) Effectiveness Major (for upper respiratory infection) Side effects Mild (skin sensitivity to sun (photosensitivity), nausea[patientslikeme.com]
Abdominal Pain
  • We encountered 2 patients who underwent esophagogastroduodenoscopy for epigastric abdominal pain, which showed gastric mucosal erosions covered with adherent exudate.[ncbi.nlm.nih.gov]
  • A 33-year-old woman was admitted to the emergency room complaining of nausea and abdominal pain after the use of doxycycline 500 mg and ornidazole 500 mg twice daily for three days for a vaginal infection.[ncbi.nlm.nih.gov]
  • pain 104/4020 (2.6%) 125/2185 (5.7%) Dyspepsia 5/4020 (0.1%) 61/2185 (2.8%) Vomiting 33/4020 (0.8%) 22/2185 (1.0%) Rash 38/1620 (2.3%) 19/558 (3.4%) Itching 41/1620 (2.5%) 16/558 (2.9%) Erythema — 31/558 (5.6%) Table 1 Proportion of travelers experiencing[doi.org]
  • Side effects were reported in 17 patients (47.2%), mainly abdominal pain (11/30.5%), nausea (seven/19.4%) and vomiting (five/13.9%).[dx.doi.org]
Eczema
  • Cutaneous D016410 EFO:0002913 Cutaneous T-cell lymphoma 0 ClinicalTrials Neoplasms D009369 EFO:0000616 neoplasm 3 ClinicalTrials ClinicalTrials Skin Diseases D012871 EFO:0000701 skin disease 2 ClinicalTrials Dermatitis, Atopic D003876 EFO:0000274 atopic eczema[ebi.ac.uk]

Workup

Hypertriglyceridemia
  • Though DIP is a rare etiology of acute pancreatitis compared to other common etiologies like alcohol, gallstones, hypercalcemia, hypertriglyceridemia, infection, trauma or medical procedures like endoscopic retrograde cholangiopancreatography (ERCP),[ncbi.nlm.nih.gov]

Treatment

  • There were 114 treatments performed, averaging 2.8 treatments (range, 1-8 treatments) per patient. Average follow-up time was 10 months (range, 1-59 months).[ncbi.nlm.nih.gov]
  • For detailed recommendations on treatment, consult the 2006 guidelines for treatment developed by the Infectious Diseases Society of America (IDSA) ( ).[web.archive.org]
  • The treatment was directly observed.[doi.org]
  • A retrospective study was conducted to evaluate the effectiveness of doxycycline for the treatment of patients with different stages of syphilis. Patients who received doxycycline treatment between June 2011 and June 2014 were involved.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Gallbladder carcinoma is the most common and aggressive malignancy of the biliary tree and highly expresses CD147, which is closely related to disease prognosis in a variety of human cancers.[ncbi.nlm.nih.gov]
  • Rapidly effective regimes such as CyBorD are unable to overcome poor prognosis in very advanced AL amyloidosis (Venner et al and Palladini et al Leukemia 2014 ).[bloodjournal.org]
  • Prognosis The prognosis after treatment of Lyme disease is generally very good. The majority of people are treated with antibiotics and return to their normal health.[hopkinsarthritis.org]
  • C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:250-5. 31. Man P, Connett JE, Anthonisen NR, Wise RA, Tashkin DP, Sin DD.[web.archive.org]
  • Spyropoulou, Antonis Tsimponis and Efterpi Demiri , Can Acne Affect Prognosis of Breast Augmentation? , Plastic and Reconstructive Surgery - Global Open , 4 , 6 , (e754) , (2016) .[doi.org]

Etiology

  • Though DIP is a rare etiology of acute pancreatitis compared to other common etiologies like alcohol, gallstones, hypercalcemia, hypertriglyceridemia, infection, trauma or medical procedures like endoscopic retrograde cholangiopancreatography (ERCP),[ncbi.nlm.nih.gov]
  • The patient's esophageal ulcer resolved with the aid of dietary changes and a prescription of rabeprazole, a proton pump inhibitor. and The etiology of doxycycline-induced esophageal ulceration is complex, and proper diagnosis is essential for its resolution[ncbi.nlm.nih.gov]
  • Drugs are related to the etiology of acute pancreatitis in approximately 1.4-2.0% of cases. Although antibiotics constitute a small number of the drugs suspected, tetracycline is the most encountered antibiotic among those drugs.[ncbi.nlm.nih.gov]
  • […] agents using real-time PCR in pediatric inpatients with community-acquired pneumonia, J Infect Chemother, 2012 in press 9 Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections,[doi.org]
  • The etiology is unknown at present.[inchem.org]

Epidemiology

  • Author information 1 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, 3053, VIC, Australia. 2 Melbourne Sexual Health Centre, Alfred Health, 580 Swanston St, Carlton, 3053,[ncbi.nlm.nih.gov]
  • Mahidol University, Bangkok, Thailand; ‡Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne; §Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne, Parkville; and ¶Centre for Epidemiology[ncbi.nlm.nih.gov]
  • Serum concentrations were compared to minimum inhibitory concentrations (MIC) and epidemiological cut-off values (ECOFFs) for relevant pathogens.[ncbi.nlm.nih.gov]
  • All NPSs were sent to the Laboratory of Molecular Epidemiology for Infectious Agents at Kitasato University. No patients with an underlying disease were enrolled in this study.[doi.org]
  • (R.C.F.); the Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (K.F.); Northern Westchester Hospital Center, Mt. Kisco, N.Y.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • In addition, tetracyclines inhibit matrix metalloproteases (MMPs), a family of zinc-dependent proteases that contribute to tissue remodeling, inflammation, and angiogenesis and are overexpressed in certain pathophysiologies such as diabetic foot ulcers[ncbi.nlm.nih.gov]
  • It combines occlusive properties with DOX sclerosing and MMP inhibition properties, respectively known to prevent recanalization process and to counteract the underlying pathophysiology of vessel wall degradation and aneurysm progression.[ncbi.nlm.nih.gov]
  • It achieves similar concentration in lungs and plasma. [27], [28] Airway limitation and airway inflammation are separate and independent factors in pathophysiology of COPD.[web.archive.org]
  • The pathophysiology of acne and rationale for using antibiotics There are a number of pathophysiologic components to acne, including sebaceous gland hyperplasia with seborrhoea; altered follicular growth and differentiation; microbial colonization; and[web.archive.org]
  • By distinguishing subsets of Lyme disease, such as PTLDS, our research program is illuminating the pathophysiology of the illness to improve diagnostics, treatments, and quality of life for[hopkinsarthritis.org]

Prevention

  • Efficacy of antibiotic prophylaxis for prevention of Lyme disease. J Gen Intern Med 1996;11:329-333. [ISI] [Medline] Magid D, Schwartz B, Craft J, Schwartz JS. Prevention of Lyme disease after tick bites: a cost-effectiveness analysis.[web.archive.org]
  • Drug induced oesophageal disease is a preventable self-limiting condition. Proper advice regarding medication ingestion is essential for prevention.[ncbi.nlm.nih.gov]
  • Moreover, the inhibition of aneurysmal wall degradation via matrix metalloproteinases (MMPs) may further prevent aneurysm progression.[ncbi.nlm.nih.gov]
  • It may also be used to treat Lyme disease or to prevent Lyme disease in certain people who have been bitten by a tick. It may also be used to prevent infection in people who were sexually attacked.[nlm.nih.gov]
  • CONCLUSION: Evidence base must be improved for giving advice on appropriate prevention measures to travelers taking doxycycline and having a risk of significant sun exposure. 2017 S. Karger AG, Basel.[ncbi.nlm.nih.gov]

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