I presented evidence that droperidol is a cost-effective antiemetic and its safety profile when used in antiemetic doses is excellent. [journals.lww.com]

The present study was designed to assess the antiemetic effectiveness of droperidol in patients using an intravenous PCA during the first 24 hours after surgery. [ekja.org]

The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. [scielo.br]

Warnings/Precautions: Perform ECG prior to administration to determine if prolonged QT interval present; if prolonged, do not administer unless treatment outweighs risks; if treating, monitor for arrhythmias: perform ECG prior to treatment and 2–3hrs [clinicaladvisor.com]

• Intravenous Administration

  Cardiac dysrhythmias associated with the intravenous administration of ondansetron and metoclopramide. Anesth Analg 1997; 84: 1380-1 13. Bosek V, Hu P, Robinson LA. Acute myocardial ischemia after administration of ondansetron hydrochloride. [journals.lww.com]

  Article First Online: 01 July 1965 163 Downloads 6 Citations Summary The intravenous administration by a number of different techniques of fentanyl and droperidol in a proportion of 1 50 has been described Clinical experiences indicate that to avoid marked [link.springer.com]

  For intravenous administration, droperidol may be diluted in 250 mL of normal saline, 5% glucose, or lactated Ringers solution. Droperidol injection should be stored at 20 to 25 degrees C (68 to 77 degrees F) and protected from light. [drugs.com]

• Sore Throat

  throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle [medical-dictionary.thefreedictionary.com]

• Hoarseness

  […] related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness [drugs.com]

  Symptoms of laryngeal origin (eg, dyspnea, cough, hoarseness) that have not responded to 8 week PPI trial c. [studyres.com]

• Throat Irritation

  Common Dosages □ Docusate sodium lOOmg PO BID □ Docusate calcium 240mg PO BID Adverse Effects & Contraindications □ Adverse effects rare. □ Occasionally rash, cramping, nausea, diarrhea, throat irritation or bitter taste may occur. [archive.org]

• Epigastric Pain

  hypertension, hypotension, vasodilation, arrhythmias, atrial fibrillation EENT: cataracts, blurred vision, eye irritation, sore throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence, increased salivation [medical-dictionary.thefreedictionary.com]

  Maximum 16mg/day Adverse Effects & Contraindications □ Adverse effects include distension, constipation, drowsiness, dizziness, fatigue, dry mouth, nausea and vomiting, and epigastric pain □ Overuse reported to result in CNS depression and paralytic ileus [archive.org]

• Fecal Incontinence

  incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising, rash [medical-dictionary.thefreedictionary.com]

• Abdominal Bloating

  Adverse Effects & Contraindications □ Side effects include nausea and vomiting, abdominal bloating and cramps, flatulence, eczema, and urticaria. □ Fluid and electrolyte changes and cardiac dysrhythmia are possible. □ CONTRAINDICATED in bowel obstruction [archive.org]

• Toothache

  […] increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising, rash, urticaria, facial sweating, diaphoresis, pruritus, flushing Other: toothache [medical-dictionary.thefreedictionary.com]

• Torticollis

  Observe carefully and report promptly to physician early signs of acute dystonia: Facial grimacing, restlessness, tremors, torticollis, oculogyric crisis. Extrapyramidal symptoms may occur within 24–48 h postoperatively. [robholland.com]

• Eye Irritation

  seizures, neuroleptic malignant syndrome CV: chest pain, hypertension, hypotension, vasodilation, arrhythmias, atrial fibrillation EENT: cataracts, blurred vision, eye irritation, sore throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating [medical-dictionary.thefreedictionary.com]

• Increased Libido

  […] salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising, rash, urticaria, facial sweating [medical-dictionary.thefreedictionary.com]

• Facial Grimacing

  Observe carefully and report promptly to physician early signs of acute dystonia: Facial grimacing, restlessness, tremors, torticollis, oculogyric crisis. Extrapyramidal symptoms may occur within 24–48 h postoperatively. [robholland.com]

• Incontinence

  […] malignant syndrome CV: chest pain, hypertension, hypotension, vasodilation, arrhythmias, atrial fibrillation EENT: cataracts, blurred vision, eye irritation, sore throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence [medical-dictionary.thefreedictionary.com]

  Incontinence Enablex darifenacin 7.5mg Not appro ved PAP Genitourin ary Tract Incontinence Toviaz fesoterodine extendedrelease 4, 8mg Appr oved Central Pharma cy Genitourin ary Tract ved Not appro ved Appr oved PAP Retail Networ k Retail Networ k PAP [studyres.com]

• Hot Flushes

  (Trials: MRC, SHEP, ALLHAT, INSIGHT and HOT-felodipine). [archive.org]

• Hematuria

  […] and Micro hematuria: o IVP (Priority)(or CT scan abdominal /pelvis with contrast), microscopic urinalysis (at least 2) documenting abnormal # of blood cells and absence of active infection o Urine Cytology  Urinary Frequency:  UA  Urine Culture  [studyres.com]

• Oliguria

  […] ratio threshold Patients taking drug having adverse event Patients taking drug not having adverse event Patients not taking drug having adverse event Patients not taking drug not having adverse event Acute kidney injury 192.08 55.80 56 281 49627 3335895 Oliguria [drugcentral.org]

• Dysarthria

  Adverse reactions CNS: weakness, dysarthria, dysphonia, dizziness, extrapyramidal reactions, headache, postoperative hallucinatory episodes with transient depression, tremor, irritability, paresthesia, aggression, vertigo, ataxia, loss of consciousness [medical-dictionary.thefreedictionary.com]

  Adverse Effects □ Acute toxicity is associated with delirium, nystagmus, ataxia, incoordination, dysarthria and hand tremors. □ Hypersensitivity reaction is most often associated with skin rash but can rarely be associated with hepatic failure, Stevens-Johnsons [archive.org]

• Altered Mental Status

  mental status, stupor, coma, hypertension, tachycardia, pallor, or diaphoresis. [medical-dictionary.thefreedictionary.com]

• Indifference to Pain

  Principally used in fixed combination with the potent narcotic analgesic fentanyl (Innovar) to produce neuroleptanalgesia (quiescence, reduced motor activity, and indifference to pain and environmental stimuli) to permit carrying out a variety of diagnostic [robholland.com]

• Grunting

  He remained fully conscious, was able to breathe deeply and move his unanesthetized extremities on command, but was totally unable to speak, uttering only a grunt when questioned. [miami.pure.elsevier.com]

• Tingling

  […] trial of appropriate conservative therapy o Rest and wrist splinting for at least 1 month Patients with chronic pain without new focal symptoms/signs: o Fibromyalgia o Complex Regional Pain Syndrome Reason for Referral: □ □ □ □ Numbness/Paresthesias/Tingling [studyres.com]

treatment with drugs that may cause electrolyte imbalance. [prnewswire.com]

Moreover, no adverse hemodynamic events were reported in the aforementioned studies evaluating ED treatment of headache. [epmonthly.com]

For patients in whom the potential benefit of [droperidol] treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2-3 hours after completing treatment to monitor [apsf.org]

The etiology of the condition is discussed. [miami.pure.elsevier.com]

This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed. [tocris.com]

Despite the diverse etiologies of these symptoms, ED physicians usually prescribe medication for relief initially. [tcmjmed.com]

Practical Tips □ Establishing the etiology of thrombocytopenia is imperative prior to platelet transfusion (see adverse events and contra-indications). □ One standard adult dose should raise the platelet count of a 70kg adult by 2.5- 5xl0 9 /L in the [archive.org]

Leal Horta a Bernardo Lessa Horta b Guilherme Antônio Moreira de Barros c Ana Paula Behrensdorf d Ingrid Severo d Mariana Antunes Nunes d Roberta Boabaid d André Real d a Anesthesiology, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil b Epidemiology [scielo.br]

[…] compression, we made a distinction between its incidence before birth (initial hypotension), treated with metaraminol only if persisting after improving the manual displacement, and hypotension after child birth (final hypotension), which has the same pathophysiology [scielo.br]

Hypersensitivity to dopamine agonists in patients with migraines indicates that dopamine may play a role in the pathophysiology of migraine [15]. Therefore, dopamine receptor antagonists have been considered a choice for the treatment of migraine. [tcmjmed.com]

Remember back to the days of pre-clinical years, while we are scrambling to learn the pathophysiology of diseases, the fundamentals of pharmacology is often less emphasized. [archive.org]

Conclusion(s): Prophylactic IV single-dose droperidol, 0.25 to 1 mg, prevents PONV symptoms independent of the dose but increases the risk of postoperative restlessness. [journals.lww.com]

and for the prevention of nausea and vomiting during postoperative patient‐controlled analgesia (PCA) in adults. [onlinelibrary.wiley.com]

Kovac Al (2000) Prevention and treatment of postoperative nausea and vomiting. Drugs 59:213–243 PubMed CrossRef Google Scholar 19. [link.springer.com]

[…] alerts in My Account The alert will be sent to: × Top On December 5, 2001, the US Food and Drug Administration (FDA) issued a new “black box” warning on droperidol (Akorn Pharmaceuticals, Buffalo Grove, IL), a popular antiemetic for the treatment and/or prevention [anesthesiology.pubs.asahq.org]