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Dridol - Teratogenic Agent

Droperidol


Presentation

  • I presented evidence that droperidol is a cost-effective antiemetic and its safety profile when used in antiemetic doses is excellent.[journals.lww.com]
  • The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined.[scielo.br]
  • The present study was designed to assess the antiemetic effectiveness of droperidol in patients using an intravenous PCA during the first 24 hours after surgery.[ekja.org]
  • Warnings/Precautions: Perform ECG prior to administration to determine if prolonged QT interval present; if prolonged, do not administer unless treatment outweighs risks; if treating, monitor for arrhythmias: perform ECG prior to treatment and 2–3hrs[empr.com]
Intravenous Administration
  • Article First Online: 01 July 1965 163 Downloads 6 Citations Summary The intravenous administration by a number of different techniques of fentanyl and droperidol in a proportion of 1 50 has been described Clinical experiences indicate that to avoid marked[link.springer.com]
  • Cardiac dysrhythmias associated with the intravenous administration of ondansetron and metoclopramide. Anesth Analg 1997; 84: 1380-1 13. Bosek V, Hu P, Robinson LA. Acute myocardial ischemia after administration of ondansetron hydrochloride.[journals.lww.com]
  • For intravenous administration, droperidol may be diluted in 250 mL of normal saline, 5% glucose, or lactated Ringers solution. Droperidol injection should be stored at 20 to 25 degrees C (68 to 77 degrees F) and protected from light.[drugs.com]
Sore Throat
  • throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle[medical-dictionary.thefreedictionary.com]
Respiratory Insufficiency
  • insufficiency, prostatic hypertrophy, angle-closure glaucoma, CNS depression, CNS tumors, intestinal obstruction, bone marrow depression • elderly patients • pregnant or breastfeeding patients • children younger than age 2.[medical-dictionary.thefreedictionary.com]
Pharyngitis
  • […] extrapyramidal symptoms, neuroleptic malignant syndrome, confusion, nervousness, paresthesia, somnolence, tremor, akathisia, oculogyric crisis, unexplained fever, alteration of consciousness, autonomic instability [ Ref ] Respiratory Frequency not reported : pharyngitis[drugs.com]
Abdominal Cramps
  • cramps, bloating, epigastric pain, fecal incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory:[medical-dictionary.thefreedictionary.com]
Fecal Incontinence
  • incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising, rash[medical-dictionary.thefreedictionary.com]
Epigastric Pain
  • pain, fecal incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising[medical-dictionary.thefreedictionary.com]
Dysphagia
  • […] hypertension, hypotension, vasodilation, arrhythmias, atrial fibrillation EENT: cataracts, blurred vision, eye irritation, sore throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence, increased salivation, dysphagia[medical-dictionary.thefreedictionary.com]
Toothache
  • […] increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising, rash, urticaria, facial sweating, diaphoresis, pruritus, flushing Other: toothache[medical-dictionary.thefreedictionary.com]
Eye Irritation
  • […] tremor, irritability, paresthesia, aggression, vertigo, ataxia, loss of consciousness, seizures, neuroleptic malignant syndrome CV: chest pain, hypertension, hypotension, vasodilation, arrhythmias, atrial fibrillation EENT: cataracts, blurred vision, eye[medical-dictionary.thefreedictionary.com]
Arthritis
  • […] nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence, increased salivation, dysphagia GU: urinary frequency, increased libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis[medical-dictionary.thefreedictionary.com]
Torticollis
  • Observe carefully and report promptly to physician early signs of acute dystonia: Facial grimacing, restlessness, tremors, torticollis, oculogyric crisis. Extrapyramidal symptoms may occur within 24–48 h postoperatively.[robholland.com]
Facial Grimacing
  • Observe carefully and report promptly to physician early signs of acute dystonia: Facial grimacing, restlessness, tremors, torticollis, oculogyric crisis. Extrapyramidal symptoms may occur within 24–48 h postoperatively.[robholland.com]
Increased Libido
  • libido Hepatic: cholestatic jaundice Metabolic: dehydration Musculoskeletal: muscle cramps, arthritis, bone fractures Respiratory: bronchitis, dyspnea Skin: bruising, rash, urticaria, facial sweating, diaphoresis, pruritus, flushing Other: toothache,[medical-dictionary.thefreedictionary.com]
Incontinence
  • […] malignant syndrome CV: chest pain, hypertension, hypotension, vasodilation, arrhythmias, atrial fibrillation EENT: cataracts, blurred vision, eye irritation, sore throat GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, epigastric pain, fecal incontinence[medical-dictionary.thefreedictionary.com]
Oliguria
  • […] ratio threshold Patients taking drug having adverse event Patients taking drug not having adverse event Patients not taking drug having adverse event Patients not taking drug not having adverse event Acute kidney injury 192.08 55.80 56 281 49627 3335895 Oliguria[drugcentral.org]
Paresthesia
  • Adverse reactions CNS: weakness, dysarthria, dysphonia, dizziness, extrapyramidal reactions, headache, postoperative hallucinatory episodes with transient depression, tremor, irritability, paresthesia, aggression, vertigo, ataxia, loss of consciousness[medical-dictionary.thefreedictionary.com]
  • […] reported in patients during epidural anesthesia. [ Ref ] Frequency not reported : Dysphoria, drowsiness, restlessness, hyperactivity, anxiety, hallucinations, dizziness, extrapyramidal symptoms, neuroleptic malignant syndrome, confusion, nervousness, paresthesia[drugs.com]
Dysarthria
  • Adverse reactions CNS: weakness, dysarthria, dysphonia, dizziness, extrapyramidal reactions, headache, postoperative hallucinatory episodes with transient depression, tremor, irritability, paresthesia, aggression, vertigo, ataxia, loss of consciousness[medical-dictionary.thefreedictionary.com]
Difficulty Concentrating
  • The study was prematurely terminated due to adverse events (restlessness, anxiety, and difficulty concentrating) seen in the larger doses. In addition the study was underpowered to detect the primary outcome.[journals.lww.com]
Indifference to Pain
  • Principally used in fixed combination with the potent narcotic analgesic fentanyl (Innovar) to produce neuroleptanalgesia (quiescence, reduced motor activity, and indifference to pain and environmental stimuli) to permit carrying out a variety of diagnostic[robholland.com]

Treatment

  • treatment with drugs that may cause electrolyte imbalance.[prnewswire.com]
  • Moreover, no adverse hemodynamic events were reported in the aforementioned studies evaluating ED treatment of headache.[epmonthly.com]
  • For patients in whom the potential benefit of [droperidol] treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2-3 hours after completing treatment to monitor[apsf.org]

Etiology

  • The etiology of the condition is discussed.[miami.pure.elsevier.com]
  • This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.[tocris.com]
  • Despite the diverse etiologies of these symptoms, ED physicians usually prescribe medication for relief initially.[tcmjmed.com]

Epidemiology

  • Leal Horta a Bernardo Lessa Horta b Guilherme Antônio Moreira de Barros c Ana Paula Behrensdorf d Ingrid Severo d Mariana Antunes Nunes d Roberta Boabaid d André Real d a Anesthesiology, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil b Epidemiology[scielo.br]
Sex distribution
Age distribution

Pathophysiology

  • […] compression, we made a distinction between its incidence before birth (initial hypotension), treated with metaraminol only if persisting after improving the manual displacement, and hypotension after child birth (final hypotension), which has the same pathophysiology[scielo.br]
  • Hypersensitivity to dopamine agonists in patients with migraines indicates that dopamine may play a role in the pathophysiology of migraine [15]. Therefore, dopamine receptor antagonists have been considered a choice for the treatment of migraine.[tcmjmed.com]

Prevention

  • Conclusion(s): Prophylactic IV single-dose droperidol, 0.25 to 1 mg, prevents PONV symptoms independent of the dose but increases the risk of postoperative restlessness.[journals.lww.com]
  • ) and for the prevention of nausea and vomiting during postoperative patient‐controlled analgesia (PCA) in adults.[onlinelibrary.wiley.com]
  • ) over several decades and, more recently, for the prevention of opioid-induced PONV during patient-controlled analgesia (PCA) in adults.[ncbi.nlm.nih.gov]
  • Kovac Al (2000) Prevention and treatment of postoperative nausea and vomiting. Drugs 59:213–243 PubMed CrossRef Google Scholar 19.[link.springer.com]
  • […] alerts in My Account The alert will be sent to: Top On December 5, 2001, the US Food and Drug Administration (FDA) issued a new “black box” warning on droperidol (Akorn Pharmaceuticals, Buffalo Grove, IL), a popular antiemetic for the treatment and/or prevention[anesthesiology.pubs.asahq.org]

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