A 4-month-old male infant with Serratia marcescens septic shock, multiple organ dysfunction syndrome (MODS), and consumptive coagulopathy was admitted. [ncbi.nlm.nih.gov]

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003 ; 101: 3765 – 77. Google Scholar Medline ISI 5. Levi, M., ten Cate, H., van der Poll, T., van Deventer, S.J.. [journals.sagepub.com]

Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med. 2001 ; 29 : S99 –106. 14 Jacobi J. Pathophysiology of sepsis. [academic.oup.com]

Efficacy of therapy with recombinant human activated protein C of critically ill surgical patients with infection complicated by septic shock and multiple organ dysfunction syndrome. Surg Infect (Larchmt) 2011 ;12: 443 - 449 19. [nejm.org]

Use appropriate aseptic technique during the preparation of Xigris for intravenous administration. Calculate the approximate amount of Xigris needed based upon the patient's actual body weight and duration of infusion period. [drugs.com]

Use appropriate aseptic technique during the preparation of Xigris for intravenous administration. Calculate the approximate amount of Xigris needed based upon the patient's actual body weight and duration of infusion period. [drugs.com]

Peripheral limb cyanosis was markedly decreased, with pink, warm extremities. In addition, the patient's clinical laboratory test values improved after administration of drotrecogin alfa. [ncbi.nlm.nih.gov]

Peripheral limb cyanosis was markedly decreased, with pink, warm extremities. In addition, the patient’s clinical laboratory test values improved after administration of drotrecogin alfa. [ajhp.org]

Slowly withdraw calculated dose from vial, add to infusion bag of NS by directing stream to side of bag to minimize agitation, then gently invert to mix. Final concentration should be 100–200 mcg/mL. [robholland.com]

When adding the drug, direct stream to side of bag to minimize agitation of the solution. • Gently invert infusion bag to obtain a homogenous solution. [glowm.com]

When injecting the Xigris into the infusion bag, direct the stream to the side of the bag to minimize the agitation of the solution. Gently invert the infusion bag to obtain a homogeneous solution. [drugs.com]