Both the cases presented indicate that drotrecogin alfa (activated) interrupts the developmental cascade of severe sepsis. [ncbi.nlm.nih.gov]

[…] that less severely ill patients were enrolled in the present study. [nejm.org]

• Polyneuropathy

  • Glycemia control: hyperglycemia associated with insulin resistance is common in critically ill children and may lead to severe infections, polyneuropathy, multiple organ failure and death. [tandfonline.com]

All other treatments were at the discretion of treating clinicians. [nejm.org]

Neilson AR, Burchardi H, Chinn C, et al. 2003 Cost-effectiveness of drotrecogin alfa (activated) for the treatment of severe sepsis in Germany. [cambridge.org]

Neither self-reported race nor genetically determined continent of origin impacted the overall DrotAA treatment effect or the IRP*Treatment interactions in conditional logistic regression models. [annalsofintensivecare.springeropen.com]

Patients with severe infections may be unable to activate protein C and those with low concentrations of protein C have a poor prognosis. [nps.org.au]

The APACHE II score was developed by Knaus et al. (41) to graduate critically ill patients’ prognosis. [signavitae.com]

The trial excluded patients who were considered to be at a high risk of bleeding (e.g., hemorrhagic stroke, major trauma, thrombocytopenia, and recent thrombolytic, antiplatelet, or anticoagulant therapy) or patients with a futile prognosis. [clevelandclinicmeded.com]

Among pediatric patients with MEN (42 of 50 (84%) had a culture result available), the most common etiologic pathogens were N. meningitidis (31 of 42; 74%) and Group B streptococci (7 of 42; 17%). [ccforum.biomedcentral.com]

McCabe WR, Jackson GG. 1962 Gram negative bacteremia I: Etiology an ecology. Arch Intern Med. 110 : 847 – 855. McNelis J, Marini C, Kalimi R, et al. 2001 A comparison of predictive outcomes of APACHE II and SAPS II in a surgical intensive care unit. [journals.cambridge.org]

Bacteremia in transplant recipients: a prospective study of demographics, etiologic agents, risk factors, and outcomes. Am J Infect Control 1992; 20 ( 5): 239. 3. Singh N, Gayowski T, Wagener MM, et al. [journals.lww.com]

In this article, I will briefly summarize the events leading to the development of drotrecogin alfa (activated) including aspects of sepsis epidemiology and pathophysiology and the results of early animal and clinical studies. [eurekaselect.com]

EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004;30:580-588 6. Sands KE, Bates DW, Lanken PN, et al. Epidemiology of sepsis syndrome in 8 academic medical centers. [nejm.org]

In this article, I will briefly summarize the events leading to the development of drotrecogin alfa (activated) including aspects of sepsis epidemiology and pathophysiology and the results of early animal and clinical studies. [eurekaselect.com]

Specifically, APC works by preventing clot formation and helping to dissolve existing clots. It also appears to have some anti-inflammatory effects. [medsafe.govt.nz]

Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis. [emedicinehealth.com]

These findings are in line with the previously formulated suggestion that DrotAA alone is as effective as heparin in the prevention of coagulation in the extracorporeal circuit. [ncbi.nlm.nih.gov]