It is characterized by rash, fever, and internal organ involvement. It may present in different clinical forms. We present a case of acute generalized exanthematous pustulosis occurring as a manifestation of AHS. [ncbi.nlm.nih.gov]

Within 24 hours his fever resolved. Over the following week his liver enzymes, C reactive protein concentration, and skin returned to normal. [bmj.com]

This syndrome is a severe, idiosyncratic multi-system reaction defined by the clinical triad of fever, rash and internal organ involvement (e.g. hepatitis, myocarditis, nephritis or pneumonitis), which may occur 1 - 8 weeks after medicine exposure.1 Fever [medsafe.govt.nz]

The most common presentations in patients with DHS are fever, which ranges from 38 C to 40 C and occurs in 85% of cases, malaise, pharyngitis, and cervical lymphadenopathy. [mdedge.com]

As with serum sickness, the rash is usually preceded by a prodromal phase consisting of fever, malaise, and lymphadenopathy. Viral infections must be ruled out, as they can mimic SSLR. [uspharmacist.com]

The syndrome may be mild (with arthralgias, fever, and rash) or fairly dramatic (with serositis, high fevers, and malaise), but it tends to spare the kidneys and CNS. The antinuclear antibody test is positive. [msdmanuals.com]

Those affected individuals develop rashes, fever, gastrointestinal symptoms, lethargy, malaise, arthralgia, myalgia or respiratory symptoms in the first weeks after initiation of the intake of the drug. [intechopen.com]

Opioid-intoxication, as for example a morphine overdose leads to unconsciousness, hypoventilation and miosis. The probability of an ADE differs from substance to substance. [intechopen.com]

Alf Björnberg and Rolf Holst, GENERALIZED LYMPHADENOPATHY AS A DRUG REACTION TO HYDANTOIN, Acta Neurologica Scandinavica, 43, 3, (399-402), (2009). [doi.org]

Allergic reactions can range from the mild (sneezing and runny nose, or a few hives) to the severe (anaphylaxis or cardiopulmonary arrest). [brighamandwomens.org]

Allergic rhinitis: Release of the above mediators in the upper respiratory tract can result in sneezing, itching, nasal congestion, rhinorrhea, and itchy or watery eyes. [emedicine.medscape.com]

Two weeks following therapy, the patient developed fever, skin rash, nausea, and headache. The next day, the patient became anuric. There was no family history of renal or hepatic disease. [mdedge.com]

No nausea and vomiting, loss of appetite three days before entering the hospital. Patients gained weight in the last six months but previously experienced a weight loss of about 5-10 kg in five years. Normal urination and defecation. [omicsonline.org]

Wait about an hour before lying down Patients should protect skin and nails from sun exposure, as it is photosensitising and can cause unexpected sunburn It can cause nausea, vomiting and diarrhoea; it is better tolerated when taken after food than on [dermnetnz.org]

These conditions include: Serum sickness, which may cause fever, joint pain, rash, swelling and nausea Drug-induced anemia, a reduction in red blood cells, which can cause fatigue, irregular heartbeats, shortness of breath and other symptoms Drug rash [mayoclinic.org]

A pearl is patients may present with only recurrent episodes of abdominal pain with GI distress (n/v/d) secondary to gut edema. [imrespdx.com]

pain, diarrhea, hepatomegaly, splenomegaly Skin rash (maculopapular rash, bullous, wheal and flare, plaque, patch, target lesion) Internal organ involvement (liver - elevated alanine aminotransferase levels, kidney, lung); also brain ( Turk J Pediatr [pathologyoutlines.com]

Drug-induced liver damage Typical externally evident signs of severe liver damage include fatigue, weakness, abdominal pain, nausea, dark urine, jaundice, pruritus, and fever. [ncbi.nlm.nih.gov]

Doxycycline is also effective at controlling non-infectious, inflammatory skin and mucosal diseases, including: Acne Rosacea Perioral dermatitis Hidradenitis suppurativa Recurrent aphthous stomatitis Bullous pemphigoid Granulomatous disorders such as [dermnetnz.org]

Diagnosis of AIN should be considered in any case of rapidly progressive renal failure occurring during drug therapy, especially when fever, skin rash, arthralgias, macroscopic hematuria, and blood or urinary eosinophilia are present. [ncbi.nlm.nih.gov]

The syndrome may be mild (with arthralgias, fever, and rash) or fairly dramatic (with serositis, high fevers, and malaise), but it tends to spare the kidneys and CNS. The antinuclear antibody test is positive. [msdmanuals.com]

Additionally, hypotension, bleeding, interstitial nephritis, arthralgia, arthritis, myositis, thyroiditis, pneumonitis, respiratory distress syndrome, pericarditis, myocarditis, pancreatitis, colitis, orchitis, encephalitis, and aseptic meningitis have [mdedge.com]

It is characterized not only by cutaneous exanthema, but also by organ involvement, for example hepatitis, arthralgia and lymphadenopathy [13]. [intechopen.com]

The present study aimed to investigate the relationship between NH and chronic urticaria, rhinitis/rhinosinusitis, and asthma in an effort to identify NH phenotypes. [ncbi.nlm.nih.gov]

Since then, many different types of exanthemas from the mild macular-papular forms to the severe life-threatening bullous exanthemas such as toxic epidermal necrolysis have been observed from numerous drugs. [ncbi.nlm.nih.gov]

Activation of T cells with a particular function seems to lead to a specific clinical picture (for example, bullous or pustular exanthema). [annals.org]

This is a case of a young person who initially presented with a dramatic episode of unilateral arm swelling after injuring a finger, with subsequent episodes of recurrent localized edema without pruritus throughout their body, including episodes of gut [imrespdx.com]

ampicillin sulbactam 4 g/d 0.5 g/d, ciprofloxacin 750 mg/d, fluconazole 200 mg/d) – growth factors such as filgrastim DILI – H1 blockers for pruritus DRESS (type IVb) – antipyretic drugs for fever – H1 blockers for pruritus – glucocorticoids, plasmapheresis [ncbi.nlm.nih.gov]

Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006 Aug 26. 368(9537):733-43. [Medline]. [emedicine.medscape.com]

[…] eosinophilia and systemic symptoms (DRESS) Stevens-Johnson syndrome / Lyell syndrome (synonym: toxic epidermal necrolysis) (SJS/TEN) drug-induced liver injury (DILI) drug-induced renal injury (DIRI) Contact allergies of the skin, usually consisting of contact eczema [ncbi.nlm.nih.gov]

The present study aimed to investigate the relationship between NH and chronic urticaria, rhinitis/rhinosinusitis, and asthma in an effort to identify NH phenotypes. [ncbi.nlm.nih.gov]

Molecular genetic mechanisms of chronic urticaria. Allergy Asthma Immunol Res 2014;6:13–21. 50. Sanak M, Pierzchalska M, Bazan-Socha S, Szczeklik A. [kjim.org]

Forty-one patients were excluded: 27 because of a clinical history incompatible with a drug hypersensitivity reaction, 6 because of HIV, 2 because of chronic urticaria, 4 because of food or latex allergy, and 2 because of severe cutaneous reactions. [jamanetwork.com]

urticaria refractory to high dose treatment with H1 antihistamines (ref60) and is now FDA approved for refractory chronic urticaria. [emedicine.medscape.com]

Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, Kuroda K, Nunomura S, Hayama K, Terui T, Ra C, Okayama Y: Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria [doi.org]

Diagnosis of AIN should be considered in any case of rapidly progressive renal failure occurring during drug therapy, especially when fever, skin rash, arthralgias, macroscopic hematuria, and blood or urinary eosinophilia are present. [ncbi.nlm.nih.gov]

Two weeks following therapy, the patient developed fever, skin rash, nausea, and headache. The next day, the patient became anuric. There was no family history of renal or hepatic disease. [mdedge.com]

[…] blood pressure Lung disease, causing shortness of breath and cough (interstitial pneumonitis, pleuritis, pneumonia and acute respiratory distress syndrome) Neurological involvement, which may lead to meningitis and, encephalitis, polyneuritis, causing headache [dermnetnz.org]