Clinical description The disease presents with anemia linked to hemolysis, and physical examination may show an enlarged spleen. [orpha.net]

Microangiopathic hemolytic anemia - most often present with schistocytes (RBC fragments) but may have spherocytes as well. [pedclerk.bsd.uchicago.edu]

Case Report A 24-year-old Ethiopian female, previously healthy, presented to our Accident and Emergency Department with fatigue, intermittent fever and abdominal pain lasting 1-month. [jahjournal.org]

• Hodgkin Lymphoma

  lymphomas (NHLs), Castleman disease Autoimmune disorders: SLE, rheumatoid arthritis (RA), ulcerative colitis (UC) Immune checkpoint inhibitors (e.g., pembrolizumab and nivolumab ) Viral: Epstein-Barr virus (EBV) or influenza Bacterial: brucellosis Solid [unboundmedicine.com]

  Use of Rituximab in Autoimmune Hemolytic Anemia Associated with Non-Hodgkin Lymphomas. Hindawi Publishing Corporation Advances in Hematology. 2011; htt1-4 https://doi.org/10.1155/2011/960137. 53. [revistahematologia.com.ar]

  Lymphoproliferative disorders (e.g., chronic lymphocytic leukemia, non-Hodgkin's lymphoma) may produce warm or cold autoantibodies. [aafp.org]

• Swelling

  In very advanced cases, swelling of the ankles and other evidence of heart failure may appear. Common Causes of Anemia. [medical-dictionary.thefreedictionary.com]

• Splenomegaly

  The red blood cells trapped in the spleen cause the spleen to enlarge, leading to the splenomegaly often seen in these patients. There are two models for this: the hapten model and the autoantibody model. [en.wikipedia.org]

  The clinical history is determined by the degree of anemia induced by the hemolysis, which may include fatigue, dyspnea or abdominal fullness from splenomegaly. [clinicaladvisor.com]

  […] hemolytic anemia cold agglutinin disease acrocyanosis (different from Raynaud) painful and blue toes/fingers in the cold “colder” parts of the body symptoms resolve upon warming that part of the body acute hemolytic anemia with the cold Physical exam splenomegaly [medbullets.com]

  Your symptoms may include: Jaundice, yellowing of the skin Dark (tea or cola colored) urine Pallor, pale coloring of the skin Fatigue, tiredness Dizziness Elevated heart rate Shortness of breath Splenomegaly, enlarged spleen Diagnosis Diagnosis of drug-induced [verywell.com]

  Mild splenomegaly is typical. Cold agglutinin disease manifests as an acute or chronic hemolytic anemia. Other cryopathic symptoms or signs may be present (eg, acrocyanoses, Raynaud syndrome, cold-associated occlusive changes). [merckmanuals.com]

• Kidney Failure

  Other tests – Tests to check for kidney failure, lead poisoning, and vitamin deficiencies are also performed because they are also common causes of anemia. The sooner your doctor is able to establish a diagnosis, the better your outcomes. [consumerhealthdigest.com]

Hemolytic Anemia Workup. Medscape Reference. Available online at http://emedicine.medscape.com/article/201066-workup#c13. Accessed October 2015. (March 21, 2014) National Heart, Lung and Blood Institute. Types of Hemolytic Anemia. [labtestsonline.it]

In the workup of HA, a careful drug history must be taken, and if suspected, a search for drug-induced antibodies should be made by a reference laboratory with expertise in this area. A U.S. [hematologyandoncology.net]

A serological workup to investigate the presence of RBC alloantibodies includes testing the patient’s serum with a selected panel of previously phenotyped reagent RBCs. [dovepress.com]

However, steroid therapy is an option when hemolysis fails to respond to anti-TB treatment. [jahjournal.org]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Polyclonal antibodies seen in infections are self-resolving and require only supportive treatment. Treatment of the underlying infection may expedite the recovery. [clinicaladvisor.com]

Prognosis The prognosis is good if the causative drug is identified and the patient stops taking it. Death is a rare outcome, but has been reported particularly in children with AIHA caused by cefotetan and ceftriaxone. [orpha.net]

Prevention, and Complications Prognosis mortality rate 10% for most patients, prognosis is good Prevention for cold agglutinin disease keep warm Complications warm agglutinin lymphoproliferative disease venous thromboembolism cold agglutinin peripheral [medbullets.com]

[…] dermatomyositis, myasthenia gravis, pemphigus, pemphigoid, membranous glomerulonephritis, autoimmune hepatitis, autoimmune thyroiditis, autoimmune haemolytic anaemia, Sjögren’s syndrome, and scleroderma.” 1 Conclusion Although DILE has a more favorable prognosis [pharmacytimes.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]

Etiology To date about 100 drugs have been implicated in drug-induced AIHA, including: cephalosporins (primarily cefotetan and ceftriaxone), levodopa, methyldopa, penicillin and its derivatives, quinidine and some nonsteroidal anti-inflammatory drugs. [orpha.net]

Summary Epidemiology Drug-induced AIHA is rare; annual incidence is estimated at about 1/1,000,000. It is more common in adults and is very rare in children, although some fatal cases in children have been reported. [orpha.net]

Introduction Extrinsic hemolytic anemia caused by antibodies type II hypersensitivity Epidemiology peak incidence in 50s-80s Presentation Symptoms warm agglutinin disease chronic hemolytic anemia cold agglutinin disease acrocyanosis (different from Raynaud [medbullets.com]

[…] cold hemoglobinuria (PCH) Mixed AIHA (antibodies bind from 4°C to 37°C): a range of autoantibody thermal amplitudes that has features of both warm and cold AIHA Drug-induced AIHA: related to drug exposure; similar to warm AIHA and mainly IgG mediated Epidemiology [unboundmedicine.com]

Etiology and Pathophysiology Mechanisms of RBC destruction ( 1, 2, 3 ) IgG, IgM, or IgA isotypes target RBC antigens, causing either direct opsonization and/or triggering of complement fixation. [unboundmedicine.com]

Pharmacotherapy: A Pathophysiologic Approach. 7th ed. United States: The McGraw-Hill Companies, Inc; 2008: 1439-1440. Borchers AT, Keen CL, Gershwin ME. Drug-induced lupus. Ann N Y Acad Sci 2007 Jun; 1108; 166-82. [pharmacytimes.com]

Pathophysiology and Primary AIHA In AIHA the hemolysis is mainly extravascular, with sequestration mainly occurring in the liver and the spleen. [pedclerk.bsd.uchicago.edu]

Cases of AIHA have also been classified by the presence or absence of various pathophysiologically associated underlying conditions. [dovepress.com]

Pathophysiology There are two mechanisms of hemolysis. Intravascular hemolysis is the destruction of red blood cells in the circulation with the release of cell contents into the plasma. [aafp.org]

/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis of Alcohol 0% Unclassified 100% Health Topic [codelay.com]

(ChemotherapyAdvisor) – Several studies demonstrate the role of aspirin in cancer prevention, according to the authors of a recently published review article. [cancertherapyadvisor.com]

Now in its second edition, this popular and essential comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A. [books.google.com]

and Complications Prognosis mortality rate 10% for most patients, prognosis is good Prevention for cold agglutinin disease keep warm Complications warm agglutinin lymphoproliferative disease venous thromboembolism cold agglutinin peripheral gangrene [medbullets.com]

Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. ‎ Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. ‎ [books.google.es]