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Drug-induced Cardiomyopathy

Dilated Cardiomyopathy Secondary to Drug


Presentation

  • From the initial two presentations it was thought to be and managed as a chest infection, and a perfusion ventilation scan was done to rule out pulmonary embolism.[casereports.bmj.com]
  • Congestive heart failure (CHF) was not present before BMT. Right heart pressures were monitored by a pulmonary arterial balloon catheter system (Swan-Ganz catheter). After BMT, she had severe CHF, which was controlled using pimobendan and amrinone.[ncbi.nlm.nih.gov]
  • Evidence of septic emboli may be present if endocarditis is present. The radiograph may be normal in many cases.[emedicine.medscape.com]
  • Eight weeks prior to presentation he had an influenza-like illness. He presented with a 2-week history of shortness of breath, ankle swelling and orthopnoea.[nzma.org.nz]
Congestive Heart Failure
  • Congestive heart failure (CHF) was not present before BMT. Right heart pressures were monitored by a pulmonary arterial balloon catheter system (Swan-Ganz catheter). After BMT, she had severe CHF, which was controlled using pimobendan and amrinone.[ncbi.nlm.nih.gov]
  • Symptoms of chronic congestive heart failure usually are absent, but a history of prior congestive heart failure related to cocaine use may be present.[emedicine.medscape.com]
  • heart failure (chf) with cardiomyopathy Congestive heart failure due to cardiomyopathy Congestive obstructive cardiomyopathy Dilated cardiomyopathy Dystrophic cardiomyopathy Endomyocardial disease Familial cardiomyopathy Familial restrictive cardiomyopathy[icd9data.com]
  • heart failure, and even shock.[hopkinsmedicine.org]
  • Congestive heart failure due to dilated cardiomyopathy is an unusual cause of shortness of breath in young patients.[nzma.org.nz]
Rhinitis
  • […] constipation, cough increased, dizziness, dyspepsia, dyspnea, flu syndrome, gastroenteritis, gastrointestinal disorder, hyperlipemia, hypertonia, infection, liver function tests abnormal, migraine, nausea, neck pain, pain, pharyngitis, rectal disorder, rhinitis[medhelp.org]
Constipation
  • Trihexyphenidyl Side effect control 1.Pantoprazole anxiety, arthralgia, asthenia, back pain, bronchitis, chest pain, constipation, cough increased, dizziness, dyspepsia, dyspnea, flu syndrome, gastroenteritis, gastrointestinal disorder, hyperlipemia,[medhelp.org]
Dyspepsia
  • Trihexyphenidyl Side effect control 1.Pantoprazole anxiety, arthralgia, asthenia, back pain, bronchitis, chest pain, constipation, cough increased, dizziness, dyspepsia, dyspnea, flu syndrome, gastroenteritis, gastrointestinal disorder, hyperlipemia,[medhelp.org]
Heart Disease
  • Mainly based on some drugs such as the above-mentioned antineoplastic drugs, antipsychotic or antidepressants before no evidence of heart disease, medication after arrhythmia, heart enlargement, signs of cardiac dysfunction, and can not use other heart[healthfrom.com]
  • Understand Your Risk for Cardiomyopathy Symptoms and Diagnosis of Cardiomyopathy Prevention and Treatment of Cardiomyopathy Cardiomyopathy in Children Learn more: Family History and Heart Disease Alcohol and Heart Disease Cocaine, Marijuana and Other[heart.org]
  • Familial and senile amyloid heart disease are related to the overproduction of transthyretin. Myocardial amyloid heart disease is confirmed by EMB.[clevelandclinicmeded.com]
  • In the clinical setting, TIC is usually seen in patients with no previous structural heart disease, although it may be responsible for ventricular dysfunction aggravation in those with underlying heart disease (2).[escardio.org]
  • Usual causes are conditions such as coronary heart disease, hypertension, valvular heart disease, atrial arrhythmias, and/or noncardiac conditions (including renal dysfunction, diabetes, anemia) [3].[oatext.com]
Tachycardia
  • ( Torsion type VT). (2) tricyclic antidepressants: adverse effects on cardiovascular, including myocardial inhibition, orthostatic hypotension, sinus tachycardia, atrioventricular block, etc., because the drug can inhibit cytochrome P450, Combined with[healthfrom.com]
  • Table 1 : Described arrhythmias associated with tachycardiomyopathy Supraventricular causes Atrial tachycardia Atrial flutter Atrual fibrillation Atrioventricular nodal reentry tachycardia Atrioventricular tachycardia Permanent junctional reciprocating[escardio.org]
  • Other causes include prolonged tachycardia, toxoplasmosis, thyrotoxicosis, and beriberi.[merckmanuals.com]
  • […] to glycogen storage disease Restrictive cardiomyopathy with endomyocardial fibrosis Restrictive cardiomyopathy without endomyocardial fibrosis Reversible myocardial perfusion defect Secondary restrictive cardiomyopathy Specific heart muscle disorder Tachycardia-induced[icd9data.com]
  • Electrocardiogram showed sinus tachycardia at rate 130/min and QTc was prolonged at 488ms (Figure 1).[bjmp.org]
Cardiomegaly
  • Cardiomyopathy Cardiomegaly 1040g with hypertrophic and dilated ventricles 'Hypertensive change of coronary arteries and myocardium Morbid obesity BMI 50 Organomegaly Cardiomegaly Hepatosplenomegaly with fatty change of live Based on anatomic findings[medhelp.org]
  • Chest x-ray shows cardiomegaly, usually of all chambers. Pleural effusion, particularly on the right, often accompanies increased pulmonary venous pressure and interstitial edema.[merckmanuals.com]
  • His chest radiograph showed cardiomegaly [Fig 1]. There are no acute ischemic changes in his ECG apart for sinus tachycardia. His white cell was 14.3 x 10 9 /L, c- reactive protein 0.79 mg/dL.[ispub.com]
  • Significant resolution of cardiomegaly is apparent. III- Treatment Heart rate normalisation, either with rate or rhythm control, is the cornerstone of therapy in TIC. Most of the data available come from patients with atrial fibrillation.[escardio.org]
  • Imaging Studies In cases of cardiomyopathy, the chest radiograph usually shows evidence of cardiomegaly and congestive heart failure. Evidence of septic emboli may be present if endocarditis is present. The radiograph may be normal in many cases.[emedicine.medscape.com]
Arthralgia
  • Trihexyphenidyl Side effect control 1.Pantoprazole anxiety, arthralgia, asthenia, back pain, bronchitis, chest pain, constipation, cough increased, dizziness, dyspepsia, dyspnea, flu syndrome, gastroenteritis, gastrointestinal disorder, hyperlipemia,[medhelp.org]
Dysesthesia
  • Omeprazole Nervous System/Psychiatric Psychic disturbances including depression, agitation, aggression, hallucinations, confusion, insomnia, nervousness, tremors, apathy, somnolence, anxiety, dream abnormalities; vertigo; paresthesia; and hemifacial dysesthesia[medhelp.org]
Apathy
  • Omeprazole Nervous System/Psychiatric Psychic disturbances including depression, agitation, aggression, hallucinations, confusion, insomnia, nervousness, tremors, apathy, somnolence, anxiety, dream abnormalities; vertigo; paresthesia; and hemifacial dysesthesia[medhelp.org]
Somnolence
  • Omeprazole Nervous System/Psychiatric Psychic disturbances including depression, agitation, aggression, hallucinations, confusion, insomnia, nervousness, tremors, apathy, somnolence, anxiety, dream abnormalities; vertigo; paresthesia; and hemifacial dysesthesia[medhelp.org]
Insomnia
  • Omeprazole Nervous System/Psychiatric Psychic disturbances including depression, agitation, aggression, hallucinations, confusion, insomnia, nervousness, tremors, apathy, somnolence, anxiety, dream abnormalities; vertigo; paresthesia; and hemifacial dysesthesia[medhelp.org]
Unable to Walk
  • He was rushed to hosp 9 yrs ago unable to walk or talk eyes rolling upwards and salivating heavily. No dr admit to anything, his social worker disappeared. 3 solicitors would not take on the case. it is all wrong. system corrupt.[medhelp.org]

Workup

  • An extensive infectious and rheumatologic workup was negative.[oatext.com]
Pericardial Effusion
  • It was associated with development of a large pericardial effusion and low output heart failure.[romj.org]
Myocardial Fibrosis
  • The dominant lesion found in our cases was myocardial fibrosis. The collagen fibrillogenesis process may be due on one hand to myocardial hypoxia and on the other hand to the presence of large numbers of fibroblasts.[romj.org]
  • The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function.[clevelandclinicmeded.com]

Treatment

  • CQ-induced or HCQinduced autophagic vacuolar cardiomyopathy is not universally fatal, but successful treatment requires early detection.[ohsu.pure.elsevier.com]
  • Treatment Treatment of drug - induced cardiomyopathy Department of Internal Medicine: Department of Internal Medicine Treatment: drug treatment supportive treatment Treatment cycle: 1-3 months Cure rate: 70% Commonly used drugs: injection with levocaine[healthfrom.com]
  • Keywords Acrolein, Cardiomyocytes, Nitrogen Mustards, Poly (ADP-ribose) Polymerase Abstract Drug-induced cardiotoxicity has resulted in a thorough evaluation of patient doses, treatments, and rehabilitation.[scholarcommons.usf.edu]
  • Patients whose dilated cardiomyopathy is well-compensated with treatment may be stable for many years.[merckmanuals.com]
  • This can be a long-term treatment or a short-term treatment for people who are waiting for a heart transplant. Implantable cardioverter defibrillator (ICD). This device keeps track of your heart rate.[mskcc.org]

Prognosis

  • (B) prognosis The disease if the timely diagnosis, disable allergens and the use of symptomatic treatment, the general prognosis is good, most patients can be completely back to normal.[healthfrom.com]
  • Prognosis and Recurrence The long-term prognosis for patients with stress cardiomyopathy appears to be excellent. The heart returns to normal within a few weeks with no permanent damage.[hopkinsmedicine.org]
  • Prognosis Prognosis of dilated cardiomyopathy generally has been poor, although prognosis has improved with current management regimens (eg, use of beta-blockers, angiotensin-converting enzyme [ACE] inhibitors, mineralocorticoid receptor antagonists,[merckmanuals.com]
  • Prognosis and Treatment If a person who has been diagnosed with alcohol cardiomyopathy has severe heart damage, the prognosis for the condition tends to be poor.[dualdiagnosis.org]
  • Identification of these areas and restoration of their perfusion through revascularization might improve the ejection fraction and long-term prognosis.[clevelandclinicmeded.com]

Etiology

  • Introduction Etiology Prevention Complication Symptom Examine Diagnosis Treatment Basic Nursing Introduction Brief introduction of drug - induced cardiomyopathy Drug-induced cardiomyopathy Patients receiving certain medications, due to the toxic effects[healthfrom.com]
  • Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • Patient History A cocaine-related etiology for cardiomyopathy should be suspected in any patient with a history of cocaine use, particularly binge use, and heart failure, without another established etiology for the heart failure, such as coronary artery[emedicine.medscape.com]
  • After an extensive negative workup, the underlying etiology of the cardiomyopathy was postulated to be due to Anabolic Androgenic Steroids abuse.[oatext.com]
  • May 23, 2011 Coding for Cardiomyopathy For The Record Vol. 23 No. 10 P. 27 Cardiomyopathy is a progressive disease of the heart muscle with no known etiology. The condition makes it difficult for the heart to pump blood throughout the body.[fortherecordmag.com]

Epidemiology

  • Epidemiology The 2005 National Survey on Drug Use and Health [4] reported that approximately 33.7 million Americans aged 12 years and older (13.8% of Americans in that age group) had tried cocaine at least once.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Knowledge of structural changes in myocardial cells and the myocardium as a whole could explain the pathophysiology of the disease and allow a correct therapeutic approach.[romj.org]
  • Pathophysiology Dilated cardiomyopathy represents the final common morphologic outcome of various biologic insults. The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function.[clevelandclinicmeded.com]
  • Pathophysiology As a primary myocardial disorder, the myocardial dysfunction of dilated cardiomyopathy occurs in the absence of other disorders that can cause dilated myocardium, such as severe occlusive coronary artery disease or conditions that involve[merckmanuals.com]
  • Cocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options. Am J Cardiovasc Drugs. 2009;9:177-196. 19. Schwartz B, Rezkalla S, Kloner RA. Cardiovascular effects of cocaine. Circulation. 2010;122:2558-2569. 20.[uspharmacist.com]
  • I - Pathophysiology The normal heart rate in humans is between 55 and 95 beats per minute (3). The sustained heart rate limit above which TIC will appear is not well established.[escardio.org]

Prevention

  • Prevention Prevention of drug - induced cardiomyopathy 1. For patients with allergic constitution, especially in the past have allergies to drugs, should be carefully selected medication. 2.[healthfrom.com]
  • Now in its second edition, this popular and essential comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A.[books.google.com]
  • Prevention The best way to prevent cardiomyopathy is to prevent the diseases that cause it. Know your risk factors for coronary artery disease. Modify those risks early in life.[drugs.com]
  • Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted[acc.org]
  • To develop a drug that prevents this toxicity, we established a doxorubicin-induced cardiomyopathy model in zebrafish that recapitulates the cardiomyocyte apoptosis and contractility decline observed in patients.[stm.sciencemag.org]

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