Presentation
[…] degeneration (parkinsonian presentation) olivopontocerebellar atrophy (ataxic presentation) Shy-Drager syndrome (autonomic presentation) While at initial presentation a patient may have a rather pure phenotype, as the condition progresses other symptoms [pdcenter.neurology.ucsf.edu]
While both recreational and prescription drugs can cause brain damage which can in turn exacerbate the symptoms of AD without being causative it is important to note that chemical-induced dementia (a.k.a., drug-induced dementia) often presents with a [neurotoxicants.com]
Furthermore, the criteria for diagnosis of dementia were inspired by the clinical presentation of Alzheimer's disease and are poorly adapted to the diagnosis of other dementias. [en.wikipedia.org]
Here’s the scenario: An 81 year old male presents with worsening confusion over the period of about 3-6 months. The primary provider is considering an Rx for Aricept as she feels that this is Alzheimer’s dementia. [meded101.com]
The following features may be present: Usually acute or subacute presentation. Fluctuating course. Consciousness is clouded/impaired cognition/disorientation. Poor concentration. Memory deficits - predominantly poor short-term memory. [patient.info]
Eyes
- Visual Impairment
Charles Bonnet syndrome Some people with visual impairment may experience temporary visual hallucinations. [nhs.uk]
- Visual Impairment
Charles Bonnet syndrome Some people with visual impairment may experience temporary visual hallucinations. [nhs.uk]
Musculoskeletal
- Muscle Weakness
Common side effects of systemic steroids include: Weight gain Sudden mood swings Muscle weakness Blurred vision Increased growth of body hair Easy bruising Lower resistance to infection Water retention and swelling, including a swollen, "puffy" face Acne [jonbarron.org]
Psychiatrical
- Delusion
F19.121 …… delirium F19.122 …… with perceptual disturbances F19.129 …… unspecified F19.14 …… with psychoactive substance-induced mood disorder F19.15 Other psychoactive substance abuse with psychoactive substance-induced psychotic disorder F19.150 …… with delusions [icd10data.com]
Treatment with cholinesterase inhibitors may reduce delusions, apathy, agitation and hallucinations (McKeith et al, 2000). A severe extrapyramidal reaction to antipsychotic medication is another feature of this disease. [pdcenter.neurology.ucsf.edu]
Delusions are unshakable beliefs that are out of context with a person’s social and cultural background. [aafp.org]
In some cases, a person with dementia may see or hear things that are not (hallucinations and delusions). They may get very agitated, may withdraw from other people. [drugs.com]
Delusions, suspicion, paranoia, and hallucinations may occur later in the disease. Sleep disturbances may occur, including insomnia and sleep interruptions. [medical-dictionary.thefreedictionary.com]
- Behavior Disorder
Haloperidol has been used with acceptable side effects in the management of behavior disorders of dementia. [aafp.org]
ICD-10-CM Codes › F01-F99 Mental, Behavioral and Neurodevelopmental disorders › F10-F19 Mental and behavioral disorders due to psychoactive substance use › Includes Includes Help "Includes" further defines, or give examples of, the content of the code [icd10data.com]
- Aggressive Behavior
[…] result in aggressive behavior. [aafp.org]
Urogenital
- Incontinence
Incontinence drugs (Anticholinergics) Why they are prescribed: These medications are used to relieve symptoms of overactive bladder and reduce episodes of urge incontinence, an urge to urinate so sudden and strong that you often can't get to a bathroom [aarp.org]
Some examples include: widely used antihistamines such as diphenhydramine (Benedryl); a drug widely used for treating urinary incontinence, tolteridine (Detrol); a nausea treatment drug, metoclopramide (Reglan); and drugs in the benzodiazepine category [commondreams.org]
April 20, 2016 -- Older people who take certain medicines to treat conditions like urinary incontinence, depression, asthma, allergies, and sleeping problems should be warned that their use may bring a higher risk of dementia, scientists say. [webmd.com]
A person with this condition also may experiences motor weakness, urinary incontinence, and irregular muscle coordination (ataxia), and may develop hypertension, diabetes, or vascular disease. [healthcommunities.com]
Bladder Drugs (Urinary Incontinence) In the ACT study the most common anticholinergic drug in the class of meds for overactive bladder was oxybutynin (Ditropan). [peoplespharmacy.com]
- Urinary Incontinence
Some examples include: widely used antihistamines such as diphenhydramine (Benedryl); a drug widely used for treating urinary incontinence, tolteridine (Detrol); a nausea treatment drug, metoclopramide (Reglan); and drugs in the benzodiazepine category [commondreams.org]
April 20, 2016 -- Older people who take certain medicines to treat conditions like urinary incontinence, depression, asthma, allergies, and sleeping problems should be warned that their use may bring a higher risk of dementia, scientists say. [webmd.com]
A person with this condition also may experiences motor weakness, urinary incontinence, and irregular muscle coordination (ataxia), and may develop hypertension, diabetes, or vascular disease. [healthcommunities.com]
Check with your doctor or other health professional to see if your urinary incontinence symptoms might stem from another condition (such as a bladder infection or another form of incontinence) or a medication (such as a blood pressure drug, diuretic or [aarp.org]
It’s harder to find alternative medications for urinary incontinence, but some behavioral changes can reduce this problem. [sop.washington.edu]
- Urinary Retention
Dry mouth, dry eyes, constipation, or urinary retention may occur. The toxic effects of anticholinergic medications on the brain include confusion, memory disturbance, agitation, and even delirium. [brightfocus.org]
Others : Urinary retention. Faecal impaction. Multiple aetiology. Unknown aetiology. The most common causes are medical conditions such as infections, medications or drug withdrawal. [patient.info]
Neurologic
- Cognitive Impairment
Drugs that can cause cognitive impairment Drug-induced cognitive impairment is most commonly linked to benzodiazepines, opiates, tricyclic antidepressants and anticonvulsants (drugs used to treat and prevent seizures). [worstpills.org]
This subjective cognitive decline is associated with an increased risk of progression to mild cognitive impairment (MCI) and dementia (Jessen et al., 2014). [asha.org]
"After beginning new drugs, doctors, patients and their families should watch for subtle changes in cognition and assume changes may be caused by drug therapy. People already suffering from some cognitive impairment are most susceptible." [commondreams.org]
There are medications, and combinations of medications, that can cause cognitive impairment, leading to symptoms that may seem like dementia, but these symptoms typically go away when the medication, or combination, is removed. [everydayhealth.com]
Abstract Many drugs have been reported to induce not only delirium but also cognitive impairment. [ncbi.nlm.nih.gov]
- Confusion
Subtypes of delirium [ 4 ] Hypoactive subtype - apathy and quiet confusion are present and easily missed. This type can be confused with depression. [patient.info]
However, medications can definitely cause delirium, which is often confused with dementia. Delirium is a confused state that is reversible once the cause is treated. [caring.com]
Confusion also takes several months to clear up. As confusion clears, the severe memory problems associated with Korsakoff syndrome may become more noticeable. [alz.org]
Here’s the scenario: An 81 year old male presents with worsening confusion over the period of about 3-6 months. The primary provider is considering an Rx for Aricept as she feels that this is Alzheimer’s dementia. [meded101.com]
Inouye also developed what’s called the Confusion Assessment Method or CAM, a widely-used means of identifying delirium). [medshadow.org]
- Insomnia
(acid reflux) Sominex (for insomnia) Tagamet (acid reflux) Tylenol PM (for pain and insomnia) Unisom (for insomnia) Zantac (acid reflux) A large study found that seniors who take OTC medications like Benadryl are at significantly increased risk for developing [bebrainfit.com]
Benzodiazepines -- marketed under such names as as Xanax, Valium, Ativan and Klonopin -- are widely used to treat insomnia, agitation and anxiety, all of which can be early signs of impending Alzheimer's disease in the elderly. [latimes.com]
Anxiety and Insomnia Medications Benzodiazepines, a class of medications used to treat anxiety or insomnia, comprise another group that has been linked with cognitive difficulties. [brightfocus.org]
Because benzodiazepines have a sedative effect, they are sometimes used to treat insomnia and the anxiety that can accompany depression. [aarp.org]
There is a strong and possibly irreversible link between Alzheimer’s disease and many commonly used medications for insomnia, allergies, and depression, according to a large recent JAMA Internal Medicine study. [dddmag.com]
- Seizure
Benzodiazepines are used for treating insomnia, anxiety, alcohol withdrawal, seizures, and several other conditions. They have an extensive duration of action in the body, and the elderly have increased sensitivity to their side effects. [rxeconsult.com]
Antiseizure drugs Why they are prescribed: Long used to treat seizures, these medications are increasingly prescribed for nerve pain, bipolar disorder, mood disorders and mania. [aarp.org]
Drugs that can cause cognitive impairment Drug-induced cognitive impairment is most commonly linked to benzodiazepines, opiates, tricyclic antidepressants and anticonvulsants (drugs used to treat and prevent seizures). [worstpills.org]
Lithium and antidepressants like sertraline, fluoxetine Tricyclic antidepressants like imipramine Monoamine oxidase inhibitors (MAOIs) like phenelzine Medications for medical conditions Prochlorperazine Metoclopramide Valproate or other drugs used for seizures [carelinx.com]
Alcoholism can lead to vitamin B1 (thiamine) deficiency, seizures, and head injuries that produce dementia. Chronic drug abuse also can cause symptoms of dementia. [healthcommunities.com]
- Ataxia
[…] is now understood to play a role in the pathogenesis of a wide range of seemingly unrelated disorders such as schizophrenia, bipolar disease, dementia, Alzheimer’s disease, epilepsy, migraine headaches, strokes, neuropathic pain, Parkinson’s disease, ataxia [elderadvocates.ca]
This disease also may cause heart problems, tremors, loss of muscle coordination (ataxia), paralysis, and blindness and damage is irreversible. [healthcommunities.com]
Ataxia or peripheral sensory polyneuropathy (not attributed to other causes). Beyond 60 days of abstinence, the cognitive impairment stabilizes or improves. [en.wikipedia.org]
One or more of the following: ataxia, apraxia, agnosia, or executive function deficits 3. Significant impairment in social or occupational functioning and decline from prior functioning 4. [taylorstudymethod.com]
Clinically, it presents with bradykinesia cerebellar ataxia autonomic dysfunction pyramidal signs The term "multiple system atrophy" encompasses the three presentations of the illness that have overlapping clinical and pathological findings: striatonigral [pdcenter.neurology.ucsf.edu]
Workup
Experts recommend that a medical workup for memory loss or other cognitive changes always include questions about an individual's alcohol use. [alz.org]
Treatment
Confusion and lack of understanding Trouble generating abstract thought Disturbances or difficulty with memory Disorientation Lethargy Depression Fatigue Hallucinations Treatments One of the most important forms of early treatment is preventing the severity [dementia.org]
This approach to treatment can really make a difference. [gomentor.com]
Dementia, myoclonus, peripheral neuropathy, and lipid-like material in skin biopsy during psychotropic drug treatment. [link.springer.com]
Treatment for this condition is the same as for PD. [pdcenter.neurology.ucsf.edu]
However, these drugs should not be considered first-line agents in the treatment of psychosis but rather adjunctive treatment. [aafp.org]
Prognosis
The further dementia progresses, the less likely it is to be treatable with a favorable prognosis. Do something about it: call the number at the top of your screen now for an immediate consultation. [recoveryfirst.org]
Patients with malignancy or HIV also have a worse prognosis. [ 4 ] Prevention [ 1 ] Awareness of high-risk patients and subsequent close observation for delirium with prompt assessment and management can potentially reduce morbidity and mortality. [patient.info]
Researchers are studying proteins in the spinal fluid to see if certain patterns can detect specific causes of dementia, or can predict the outlook (prognosis). Expected Duration In most cases, dementia gets worse and cannot be cured. [drugs.com]
Prognosis and Patient Counseling. Prognosis for drug-induced lupus is good. Symptoms usually will resolve with days or weeks of discontinuation of the medication. Antibodies may persist for longer periods. VI. Patient Safety and Quality Measures A. [clinicaladvisor.com]
Treatment of Alcohol Induced Persistent Dementia The prognosis for alcohol induced dementia depends a great deal on how early the condition is caught. [alcoholrehab.com]
Etiology
It is so tempting to use the popularized, but rather squishy label of AD (of unknown etiology) rather than to educate ourselves about the possibility of drug- or vaccine-induced dementia. [thepeoplesvoice.org]
There is evidence from the history, physical examination, or laboratory findings that the deficits are etiologically related to the persisting effects of substance use (e.g., a drug of abuse, a medication). [behavenet.com]
Recently Alzheimer’s support groups all around the nation have been marketing a documentary about country singer Glen Campbell who has recently been diagnosed with Alzheimer’s disease (of unknown etiology) despite the obvious fact that Campbell was [ppjg.me]
Big Pharma has found that the promotion and de-stigmatization of so-called “mental illnesses of unknown etiology” is a great tool for marketing their drugs. [duluthreader.com]
Epidemiology
Expanding upon this same theme, Drug-Induced Dementia: A Perfect Crime presents a methodical analysis of the scientific and epidemiological evidence which confirms psychopharmaceuticals as a cause of brain damage and premature death. [authorhouse.com]
Expanding upon this same theme, Drug-Induced Dementia: a perfect crime presents a methodical analysis of the scientific and epidemiological evidence which confirms psychopharmaceuticals as a cause of brain damage and premature death. [beyondmeds.com]
[…] far more common that the dementia will reveal itself anywhere from age 50 to 70. [7] The onset and the severity of this type of dementia is directly correlated to the amount of alcohol that a person consumes over their lifetime. [ citation needed ] Epidemiological [en.wikipedia.org]
Pharm World Sci 24(2): 46 CrossRef CAS PubMed Google Scholar Handler SM, Wright RM, Ruby CM, Hanlon JT (2006) Epidemiology of medication-related adverse events in nursing homes. [link.springer.com]
Pathophysiology
The pathophysiology of memory loss associated with anticholinergic drugs was strengthened by the emergence of the cholinergic hypothesis of memory and by the demonstration that memory is adversely affected by the injection of scopolamine, but that these [medlink.com]
Pathophysiology [ edit ] Alcohol has a direct effect on brain cells in the front part of the brain, resulting in poor judgment, difficulty making decisions, and lack of insight. [en.wikipedia.org]
Considering that several studies link energy impairment to neuronal death, neurodegeneration and disease, this review article discusses energy impairment as a mechanism underlying the pathophysiology of some psychiatric disorders, like (psychotropic drug-treated [thepeoplesvoice.org]
Prevention
Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. [books.google.com]
Unfortunately, medication-induced dementia is hard to detect and even harder to prevent. [dementia.org]
[…] not recognized preventive care will not be offered. [ppjg.me]
Drug-induced dementia can be prevented by avoiding polypharmacy and adhering to the saying 'start low and go slow'. Early diagnosis of drug-induced dementia and withdrawal of the offending drug is essential to improve cognitive function. [ncbi.nlm.nih.gov]