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Drug-induced Dementia

Dementia Drug Induced


Presentation

  • ., drug-induced dementia) often presents with a pattern of neuropsychological deficits that are different than those seen in AD including a lack of clinical progression of the dementia following cessation of exposure.[neurotoxicants.com]
  • Here’s the scenario: An 81 year old male presents with worsening confusion over the period of about 3-6 months. The primary provider is considering an Rx for Aricept as she feels that this is Alzheimer’s dementia.[meded101.com]
  • Expanding upon this same theme, Drug-Induced Dementia: A Perfect Crime presents a methodical analysis of the scientific and epidemiological evidence which confirms psychopharmaceuticals as a cause of brain damage and premature death.[amazon.com]
  • When someone dies from a common disease process such as heart disease, it is unlikely that the treating physician considers prescription drugs (from past or present treatment) as a possible cause.[questia.com]
  • Drug-disease interaction, such as in patients with dementia where a risk of delirium is present, is enhanced due to diminished "cognitive reserve." Dementia is the most severe form of cognitive deficit and is sometimes referred to as brain failure.[medlink.com]
Chronic Fatigue Syndrome
  • fatigue syndrome, fibromyalgia, retinitis pigmentosa, diabetes, hepatitis C, and primary biliary cirrhosis.[elderadvocates.ca]
Denial
  • Do expect denials, dismissals, distractions, discrediting and then the delaying of real legitimate explorations of the real scientific evidence that exposes its subterfuge in the name of maintaining large profits for their stakeholders.[thepeoplesvoice.org]
  • Do, however, expect denials, dismissals, distractions, delays and ad hominem attacks against the whistle-blowers rather than honest mea culpas.[ppjg.me]
Confusion
  • Here’s the scenario: An 81 year old male presents with worsening confusion over the period of about 3-6 months. The primary provider is considering an Rx for Aricept as she feels that this is Alzheimer’s dementia.[meded101.com]
  • Their memory loss, confusion, and delirium are caused by prescription drugs! And so are many of their other problems. This is not just speculation on my part. It’s fully documented in the medical journals.[iprogressivemed.com]
  • Confusion and lack of understanding Trouble generating abstract thought Disturbances or difficulty with memory Disorientation Lethargy Depression Fatigue Hallucinations Treatments One of the most important forms of early treatment is preventing the severity[dementia.org]
  • Subtypes of delirium [ 4 ] Hypoactive subtype - apathy and quiet confusion are present and easily missed. This type can be confused with depression.[patient.info]
  • However, medications can definitely cause delirium, which is often confused with dementia. Delirium is a confused state that is reversible once the cause is treated.[caring.com]
Agitated Delirium
  • Antianxiety drugs (Benzodiazepines) Why they are prescribed: Benzodiazepines are used to treat a variety of anxiety disorders, agitation, delirium and muscle spasms, and to prevent seizures.[aarp.org]
Unable to Walk
  • Not surprisingly, Dad had a significant adverse reaction to the medication. 18 hours after walking into the ER and discussing his condition coherently with hospital personnel; Dad was listless, agitated and unable to walk.[keepinmindinc.com]
Perseveration
  • Grace Jackson has faced this dilemma with courage and perseverance, bringing us a work of great scholarly magnitude.[questia.com]

Workup

  • Experts recommend that a medical workup for memory loss or other cognitive changes always include questions about an individual's alcohol use.[alz.org]
Microalbuminuria
  • الصفحة 237 - Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc committee of the Council on Diabetes Mellitus of the National[books.google.com]

Treatment

  • Confusion and lack of understanding Trouble generating abstract thought Disturbances or difficulty with memory Disorientation Lethargy Depression Fatigue Hallucinations Treatments One of the most important forms of early treatment is preventing the severity[dementia.org]
  • Dementia, myoclonus, peripheral neuropathy, and lipid-like material in skin biopsy during psychotropic drug treatment.[link.springer.com]
  • When someone dies from a common disease process such as heart disease, it is unlikely that the treating physician considers prescription drugs (from past or present treatment) as a possible cause.[questia.com]
  • […] the number of drugs prescribed; (ii) using shorter-acting preparations; (iii) avoiding agents that cross the blood-brain barrier where possible; (iv) evaluating renal and hepatic function regularly; and (v) briefly assessing cognitive function before treatment[ncbi.nlm.nih.gov]
  • Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2000;283: 1967-1975. ‏[books.google.com]

Prognosis

  • The further dementia progresses, the less likely it is to be treatable with a favorable prognosis. Do something about it: call the number at the top of your screen now for an immediate consultation.[recoveryfirst.org]
  • Patients with malignancy or HIV also have a worse prognosis. [ 4 ] Prevention [ 1 ] Awareness of high-risk patients and subsequent close observation for delirium with prompt assessment and management can potentially reduce morbidity and mortality.[patient.info]
  • Researchers are studying proteins in the spinal fluid to see if certain patterns can detect specific causes of dementia, or can predict the outlook (prognosis). Expected Duration In most cases, dementia gets worse and cannot be cured.[drugs.com]
  • Prognosis and Patient Counseling. Prognosis for drug-induced lupus is good. Symptoms usually will resolve with days or weeks of discontinuation of the medication. Antibodies may persist for longer periods. VI. Patient Safety and Quality Measures A.[clinicaladvisor.com]
  • Treatment of Alcohol Induced Persistent Dementia The prognosis for alcohol induced dementia depends a great deal on how early the condition is caught.[alcoholrehab.com]

Etiology

  • It is so tempting to use the popularized, but rather squishy label of AD (of unknown etiology) rather than to educate ourselves about the possibility of drug- or vaccine-induced dementia.[thepeoplesvoice.org]
  • […] about country singer Glen Campbell who has recently been diagnosed with Alzheimer’s disease (of unknown etiology) despite the obvious fact that Campbell was infamous for his chronic heavy use of brain-damaging, dementia-inducing, addictive, and very[ppjg.me]
  • Big Pharma has found that the promotion and de-stigmatization of so-called “mental illnesses of unknown etiology” is a great tool for marketing their drugs. () Recently Alzheimer’s support groups all around the nation have been marketing a documentary[duluthreader.com]
  • There is evidence from the history, physical examination, or laboratory findings that the deficits are etiologically related to the persisting effects of substance use (e.g., a drug of abuse, a medication).[behavenet.com]

Epidemiology

  • Expanding upon this same theme, Drug-Induced Dementia: A Perfect Crime presents a methodical analysis of the scientific and epidemiological evidence which confirms psychopharmaceuticals as a cause of brain damage and premature death.[authorhouse.com]
  • Expanding upon this same theme, Drug-Induced Dementia: a perfect crime presents a methodical analysis of the scientific and epidemiological evidence which confirms psychopharmaceuticals as a cause of brain damage and premature death.[beyondmeds.com]
  • […] far more common that the dementia will reveal itself anywhere from age 50 to 70. [7] The onset and the severity of this type of dementia is directly correlated to the amount of alcohol that a person consumes over their lifetime. [ citation needed ] Epidemiological[en.wikipedia.org]
  • School of Medicine, adjunct associate professor of health services at the UW School of Public Health, and affiliate investigator at GHRI; Sascha Dublin, MD, PhD, a Group Health physician, GHRI associate investigator, and affiliate associate professor of epidemiology[sop.washington.edu]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of memory loss associated with anticholinergic drugs was strengthened by the emergence of the cholinergic hypothesis of memory and by the demonstration that memory is adversely affected by the injection of scopolamine, but that these[medlink.com]
  • Considering that several studies link energy impairment to neuronal death, neurodegeneration and disease, this review article discusses energy impairment as a mechanism underlying the pathophysiology of some psychiatric disorders, like (psychotropic drug-treated[thepeoplesvoice.org]
  • Considering that several studies link energy impairment to neuronal death, neurodegeneration and disease, this review article discusses energy impairment as a mechanism underlying the pathophysiology of some psychiatric disorders , like (psychotropic[globalresearch.ca]
  • Pathophysiology [ edit ] Alcohol has a direct effect on brain cells in the front part of the brain, resulting in poor judgment, difficulty making decisions, and lack of insight.[en.wikipedia.org]

Prevention

  • Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. ‏[books.google.com]
  • Unfortunately, medication-induced dementia is hard to detect and even harder to prevent.[dementia.org]
  • […] not recognized preventive care will not be offered.[ppjg.me]
  • The findings suggest that interventions focusing on adverse drug effects have the greatest potential for preventing delirium.[ncbi.nlm.nih.gov]

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