These incidents usually occur during the first 6 months of treatment and are preceded by nonspecific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, vomiting, and even loss of seizure control. [emedicine.medscape.com]

Initially, anorexia, nausea, and malaise may occur, followed by pruritus in some but not all patients. [clinicalgate.com]

Some of the common symptoms are: nausea vomiting headache anorexia jaundice clay color stools dark urine hepatomegaly Diagnosis Diagnosis is typically made through a physical exam along with a patient history to identify any possible hepatotoxins. [medical-dictionary.thefreedictionary.com]

urine Diarrhea Fatigue Fever Headache Jaundice Loss of appetite Nausea and vomiting Rash White or clay-colored stools Exams and Tests You will have blood tests to check liver function. [mountsinai.org]

Later, overt evidence of liver damage, such as jaundice, dark urine and an enlarged and tender liver, may develop. Two general pathogenic mechanisms are recognised: Predictable or direct: usually promptly follows an exposure to a new medication. [patient.info]

Patients should be advised to promptly report any new onset symptoms such as yellowing of their eyes, abdominal pain / discomfort, nausea / vomiting, itching, or dark urine. [utahgastroblog.com]

Symptoms of liver damage include 5, 18 : Dark Urine. Fever. Pain in the abdomen. Nausea. Vomiting. Headache. Diarrhea. White stools. Rash. Build-up of fluid in the abdominal cavity. Jaundice (yellowing of eyes and skin). Enlarged liver. Fatigue. [drugabuse.com]

The prevalences of HLA-DR2, DR6, and B8 were similar in the 71 patients and in controls. [ncbi.nlm.nih.gov]

In a study of DILI associated with a range of different drugs, a small but not statistically significant increase in incidence in frequency of both HLA-DR2 and another serotype, HLA-DR6, was seen [ 12 ]. [genomemedicine.biomedcentral.com]

Abstract Possible associations between particular human leucocyte antigen molecules and immunoallergic hepatitis have been suggested previously (HLA-A11 in halothane hepatitis, HLA-DR6 and DR2 in nitrofurantoin hepatitis, HLA-B8 in clometacin hepatitis [ncbi.nlm.nih.gov]