We present a case of DILE presenting with cardiac tamponade associated with infliximab use that resolved with discontinuation of the medication and administration of high-dose steroids. [ncbi.nlm.nih.gov]

CASE REPORT Case 1: A 54-year-old male patient with hypertension, taking hydralazine for four years, had been presenting with been presenting erythematous, scaly and edematous papules on the trunk, back, upper limbs and sun-exposed areas for the last [scielo.br]

• Follicular Hyperkeratosis

  Histopathology: follicular hyperkeratosis, vacuolization of the basal layer of the epidermal and follicular epithelium, superficial perivascular mononuclear infi ltrate and melanophages in the papillary dermis DISCUSSION Drugs associated with induction [scielo.br]

• Incontinence

  Histopathology: hyperkeratosis, thinning of the epidermis, vacuolar degeneration of the basal layer (A – white arrow), keratinocyte apoptosis, pigmentary incontinence, perivascular and periadnexal infi ltrate. [scielo.br]

  Histopathology: hyperkeratosis, thinning of the epidermis, vacuolar degeneration of the basal layer (A - white arrow), keratinocyte apoptosis, pigmentary incontinence, perivascular and periadnexal infi ltrate. [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus (SLE) Workup. (19 September 2016 updated.) Available online at http://emedicine.medscape.com/article/332244-workup. Accessed March 27, 2017. Fonti utilizzate nelle precedenti revisioni (2003 August). [labtestsonline.it]

[…] of patients on hydralazine therapy have a positive ANA yet do not have SLE. 20 On the other hand, in patients who report common symptoms while receiving hydralazine, close monitoring and subsequent ANA levels plus antihistone antibodies and other lab workup [consultant360.com]

Associated with antiphospholipid antibodies (cerebrovascular disease, seizures, chorea) and NMDA-receptor antibodies (neurocognitive defects). [2,11] Treatment - workup and treatment should be similar to that in non-SLE patients presenting with the same [straighthealthcare.com]

SLE: Joint radiography Chest radiography and chest CT scanning Echocardiography Brain MRI/MRA Cardiac MRI Procedures Procedures that may be performed in patients with suspected SLE include the following: Arthrocentesis Lumbar puncture Renal biopsy See Workup [emedicine.medscape.com]

Herein we report the first case of DILE in a 68-year-old woman who presented with arthralgia, myalgia and prolonged thrombocytopenia after receiving capecitabine and bevacizumab combination treatment as palliative treatment for metastatic colon cancer [ncbi.nlm.nih.gov]

Clinical results have been published more fully by McEntegert et al. 12 Table 1 Proportion of patients continuing treatment over the five years DRUG TOXICITY Side effects were common, although not all resulted in withdrawal from treatment (table 2 ). [ard.bmj.com]

Prognosis Special patient groups [amboss.com]

Outlook (Prognosis) Most of the time, drug-induced lupus erythematosus is as severe as SLE. The symptoms often go away within a few days to weeks after stopping the medicine you were taking. Avoid taking the drug that caused the reaction in future. [lutheranhealthcare.org]

Prognosis The prognosis has improved with earlier recognition and improved management. The five-year survival rate is over 90%. [patient.info]

Prognosis and Patient Counseling. Prognosis for drug-induced lupus is good. Symptoms usually will resolve with days or weeks of discontinuation of the medication. Antibodies may persist for longer periods. VI. Patient Safety and Quality Measures A. [clinicaladvisor.com]

Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]

When confronted with sterile exudative effusions, clinicians should strongly consider non-infectious etiologies. [ncbi.nlm.nih.gov]

[…] individuals display all of these problems Chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes; it is of unknown etiology [icd9data.com]

The exact cause is still unknown, but a genetic predisposition, as well as hormonal and immunological influences, are considered likely etiological factors. [amboss.com]

] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Lopez P, Mozo Gutierrez C, Suarez A (2003) Epidemiology of systemic lupus erythematosus in a northern Spanish population: gender and age influence on immunological features. [link.springer.com]

Furthermore, DILE can be differentiated from SLE by epidemiological factors. SLE tends to occur in young African-American females, while DILE is most commonly a disease of elderly Caucasians with no sexual predilection. [ncbi.nlm.nih.gov]

Epidemiología – Epidemiology is the study and analysis of the patterns, causes, and effects of health and disease conditions in defined populations. [wikivisually.com]

Bernatsky, et al, A population-based assessment of systemic lupus erythematosus incidence and prevalence—results and implications of using administrative data for epidemiological studies. Rheumatology 2007 46(12):1814-1818. 18. Glinda S. [passeportsante.net]

Pathophysiology The pathophysiology of DILE is not well known. [ncbi.nlm.nih.gov]

Additional research efforts are necessary to get a better understanding of the pathophysiology and pharmacogenetics of DILE. follow @RheumAdvisor References Ho CH, Chauhan K. Lupus erythematosus, drug-induced. StatPearls [Internet]. [rheumatologyadvisor.com]

TNF α) (etanercept, infliximab, adalimubab) 13 Valproate Voriconazole Drugs that cause flares of SLE are as follows: Cimetidine Hydralazine Hydrochlorothiazide Mesantoin P -Aminobenzoic acid (PABA) Penicillin Phenylbutazone Sulfonamides Terbinafine 14 Pathophysiology [oralmaxillo-facialsurgery.blogspot.com]

SUMMARY OF KEY PARAMETERS OF SYSTEMIC LUPUS ERYTHEMATOSUS MARKET, THROUGH 2018 CHAPTER 3 - OVERVIEW SIGNS AND SYMPTOMS TYPES OF LUPUS SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) CUTANEOUS LUPUS ERYTHEMATOSUS (CLE) DRUG-INDUCED LUPUS NEONATAL LUPUS ERYTHEMATOSUS PATHOPHYSIOLOGY [gii.co.jp]

See also the following Medscape articles: Pathophysiology SLE is an autoimmune disorder characterized by multisystem inflammation with the generation of autoantibodies. [emedicine.medscape.com]

The goals of the treatment plan are to Prevent flares Treat flares when they occur Reduce organ damage and other problems Treatments may include drugs to Reduce swelling and pain Prevent or reduce flares Help the immune system Reduce or prevent damage [icdlist.com]

List Of Drugs And Associated Risk Of Drug Induced Lupus Antiarrhythmics Drugs to prevent harmful heart arrhythmias Procainamide (Pronestyl). Risk: high Quinidine (Quinaglute). Risk: moderate Disopyramide (Norpace). [womens-health-advice.com]

Centers for Disease Control and Prevention. Systemic lupus erythematosus (SLE or lupus). Available online at http://www.cdc.gov/arthritis/basics/lupus.htm. Accessed March 2014. MedlinePlus. Lupus. [labtestsonline.it]

Moreover, the effect seemed independent of immune suppression, implying that Plaquenil can directly act to prevent the blood clots. [medicinenet.com]

Can lupus be prevented or avoided? You cannot avoid lupus since the cause of it is unknown. However, you may be able to help prevent flares. [familydoctor.org]