Symptoma

Drug-induced Peripheral Neuropathy

Peripheral Neuropathy Secondary to Drugs or Chemicals

Among the 18 patients in the overall group who were eligible to be surveyed (those present for a clinic visit within the past year), 14 reported BIPN, and of these, 10 reported ongoing symptoms at the median follow-up of 24 months. [curetoday.com]

[…] burning, "electric", shooting. difficult to treat with conventional analgesics, other sensory symptoms present. The pathogenesis of NP pain involves which of the following: A. Both peripheral and central sensitization B. Loss of sodium channels C. [quizlet.com]

Patients usually present with muscle weakness, myalgias, and difficulty in walking. [clinicalgate.com]

My Response Presentation/Physical Findings The patient’s presentation is typical of chemotherapy-induced peripheral neuropathy (CIPN) that is characterized by tingling (71%), numbness (58%), and paresthesias or dysesthesias (45%), or spontaneous burning [hematology.org]

  • Intravenous Administration

    Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011; 12: 431-440. 40. [geneesmiddelenbulletin.com]

    Although subcutaneous administration was shown to confer lower rates of neuropathy, randomized trials have shown that intravenous administration has more activity against myeloma. D. All of the above statements are true E. Both A and C are true [quizlet.com]

  • Impulsivity

    They will stimulate the nerve with an electrical impulse and measure how long it takes the impulse to reach a recording instrument at a specific distance from where the nerve was stimulated. [cancersupportivecare.com]

    Thus, the most optimal therapy for DIPN involves drugs like carbamazepine and oxcarbazepine which reduce excitatory impulses via both pathways. All of the following are true regarding oxaliplatin-induced peripheral neuropathy EXCEPT: A. [quizlet.com]

    Treating pain If you have nerve pain, sometimes called neuropathic pain, this can be managed in a number of ways: Drugs Some types of drugs can alter nerve impulses and help relieve nerve pain. [macmillan.org.uk]

  • Peripheral Neuropathy

    Peripheral neuropathy can be caused by medication, and various descriptions have been applied for this condition. [ncbi.nlm.nih.gov]

    TY - JOUR T1 - Drug-induced peripheral neuropathy in a patient with psoriatic arthritis. [unboundmedicine.com]

    A patient with psoriatic arthritis developed a peripheral neuropathy while taking hydroxychloroquine and naproxen. [scholars.northwestern.edu]

  • Dysesthesia

    Patients can present with symmetric, distal, length-dependent, “stocking-glove” distribution of painful paresthesia, dysesthesia, cold sensitivity, allodynia, tingling, and numbness. [clinicalgate.com]

    My Response Presentation/Physical Findings The patient’s presentation is typical of chemotherapy-induced peripheral neuropathy (CIPN) that is characterized by tingling (71%), numbness (58%), and paresthesias or dysesthesias (45%), or spontaneous burning [hematology.org]

    […] syndrome; peripheral reflexes are preserved Dimethylaminopropionitrile (DMAP): Industrial exposure has led to prominent urinary and sexual dysfunction, as well as to distal sensory neuropathy Alcohol: Ataxia and other systemic symptoms may accompany dysesthesia [emedicine.medscape.com]

  • Excitement

    “An exciting aspect of this work is that these are new uses for old drugs. They have been used in humans for over 20 years with no serious side effects and have an excellent safety profile. [fiercebiotech.com]

    Just the presence of new sodium channels and adrenergic receptors cause a state of hyper excitability and pain is mediated abnormally into CNS What causes central neuropathic pain injury causes loss of gaba inhibition as well as enhanced glumatergic activity [quizlet.com]

[…] blood Vitamin B-12 Monoclonal gammopathy of unknown significance Axonal neuropathy Cryoglobins and hepatitis C evaluation Immunofixation (for paraneoplastic neuropathy) Cerebrospinal fluid (CSF) protein level: Usually normal in toxic neuropathy See Workup [emedicine.medscape.com]

Neuropathy is a universal and dose-limiting factor during treatment with vinca alkaloids, but is otherwise a rare complication of drug therapy. [ncbi.nlm.nih.gov]

Eribulin monotherapy versus treatment of physician’s choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study. Lancet 2011; 377: 914-923. 42. [geneesmiddelenbulletin.com]

The patient should receive pyridoxine throughout the treatment to prevent neuropathy. A patient is receiving treatment with oxaliplatin for colorectal cancer. Which of the following statements is/are TRUE regarding this therapy? A. [quizlet.com]

Reversal depends on the severity of the neuropathy, intensity and duration of the treatment and existence of causative cofactors, but generally the prognosis is good. [ncbi.nlm.nih.gov]

What is the Prognosis for Drug-Induced Neuropathy? (Outcomes/Resolutions) The prognosis of Drug-Induced Neuropathy is good with adequate treatment and management of the signs and symptoms. [dovemed.com]

Cisplatin neurotoxicity in the treatment of metastatic germ cell tumour: time course and prognosis. Br J Cancer. 2001; 85: 823-826. 16. D’Addario G, Pintilie M, Leighl NB, Feld R, Cerny T, Shepherd FA. [geneesmiddelenbulletin.com]

Clinical prognosis of patients with diagnosed chronic solvent intoxication. Acta Neurol Scand. 1982 May. 65(5):488-503. [Medline]. Antti-Poika M. Overall prognosis of patients with diagnosed chronic organic solvent intoxication. [emedicine.medscape.com]

Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. Cancer Genet Cytogenet. 2010;198(1):40–6. doi: 10.1016/j.cancergencyto.2009.12.004. [biodatamining.biomedcentral.com]

Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]

Codes with this note are Etiology codes and must be followed by a Manifestation code or codes. [icd.codes]

(Etiology) The cause of Drug-Induced Neuropathy is the use of medications, which can be toxic to the nerves. [dovemed.com]

Only 24% of all peripheral neuropathies are thought to be secondary to drugs. 13 A sizable proportion of neuropathies are undiagnosed as to etiology. [now.aapmr.org]

In some patients, extensive search for an etiology may fail to uncover the exact cause of neuropathy. Many chemicals are known to cause neuropathy in laboratory animals. [emedicine.medscape.com]

Causation and causal inference in epidemiology. Am J Public Health 95 (Suppl 1): S144–50, 2005. Dalakas MC. Peripheral neuropathy and antiretroviral drugs. J Periph N Syst 6:14-20, 2001. Gaist D, Jeppesen U, Anderson M, et al. [now.aapmr.org]

Some of these have been associated with neuropathy in clinical epidemiologic studies, confirming their ability to injure the human peripheral nervous system (PNS). [emedicine.medscape.com]

Molecular epidemiology, cancer-related symptoms, and cytokines pathway. Lancet Oncol. 2008;9(8):777–85. doi: 10.1016/S1470-2045(08)70197-9. PubMed PubMed Central View Article Google Scholar Watkins LR, Maier SF. [biodatamining.biomedcentral.com]

Pathophysiology of peripheral neuropathic pain: immune cells and molecules. Anesth Analg. 2007;105:838-847. 7. Vilholm OJ, Christensen AA, Zedan AH, Itani M. Drug-induced peripheral neuropathy. Basic Clin Pharmacol Toxicol. 2014;115:185-192. 8. [uspharmacist.com]

A better understanding of the pathophysiology of CIPN and genes associated with predisposition ultimately will prove fruitful in the quest to identify predictive or targetable biomarkers for personalized treatment of this prevalent and debilitating symptom [healio.com]

According to traditional Chinese medicine, disruptions in the flow of “vital energy” (qi) throughout the body are the underlying reason behind certain pathophysiologic conditions. [ascopost.com]

Pathophysiology and management. Med Toxicol 1: 421–427 PubMed Google Scholar Lewis W, Dalakas MC (1995) Mitochondrial toxicity of antiviral drugs. [link.springer.com]

Pathophysiology Neuropathy may be categorized by presentation (ie, motor or sensory symptoms), electrodiagnostic features, and neuroanatomical location within the peripheral nerve (ie, demyelinating or axonal, neuronopathy, ion channel neuropathy, neuromuscular [emedicine.medscape.com]

In this MiniReview, the term 'drug-induced peripheral neuropathy' (DIPN) is used with the suggested definition: Damage to nerves of the peripheral nervous system caused by a chemical substance used in the treatment, cure, prevention or diagnosis of a [ncbi.nlm.nih.gov]

Now in its second edition, this popular and essential comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A. [books.google.com]

The patient should receive pyridoxine throughout the treatment to prevent neuropathy. A patient is receiving treatment with oxaliplatin for colorectal cancer. Which of the following statements is/are TRUE regarding this therapy? A. [quizlet.com]

Ways to Prevent or Manage Problems Related to Nerve Changes You may be advised to take these steps: Prevent falls. Have someone help you prevent falls around the house. Move rugs out of your path so you will not trip on them. [cancer.gov]