Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011; 12: 431-440. 40. [geneesmiddelenbulletin.com]

Although subcutaneous administration was shown to confer lower rates of neuropathy, randomized trials have shown that intravenous administration has more activity against myeloma. D. All of the above statements are true E. Both A and C are true [quizlet.com]

They will stimulate the nerve with an electrical impulse and measure how long it takes the impulse to reach a recording instrument at a specific distance from where the nerve was stimulated. [cancersupportivecare.com]

Thus, the most optimal therapy for DIPN involves drugs like carbamazepine and oxcarbazepine which reduce excitatory impulses via both pathways. All of the following are true regarding oxaliplatin-induced peripheral neuropathy EXCEPT: A. [quizlet.com]

Treating pain If you have nerve pain, sometimes called neuropathic pain, this can be managed in a number of ways: Drugs Some types of drugs can alter nerve impulses and help relieve nerve pain. [macmillan.org.uk]

Peripheral neuropathy can be caused by medication, and various descriptions have been applied for this condition. [ncbi.nlm.nih.gov]

TY - JOUR T1 - Drug-induced peripheral neuropathy in a patient with psoriatic arthritis. [unboundmedicine.com]

A patient with psoriatic arthritis developed a peripheral neuropathy while taking hydroxychloroquine and naproxen. [scholars.northwestern.edu]

Patients can present with symmetric, distal, length-dependent, “stocking-glove” distribution of painful paresthesia, dysesthesia, cold sensitivity, allodynia, tingling, and numbness. [clinicalgate.com]

My Response Presentation/Physical Findings The patient’s presentation is typical of chemotherapy-induced peripheral neuropathy (CIPN) that is characterized by tingling (71%), numbness (58%), and paresthesias or dysesthesias (45%), or spontaneous burning [hematology.org]

[…] syndrome; peripheral reflexes are preserved Dimethylaminopropionitrile (DMAP): Industrial exposure has led to prominent urinary and sexual dysfunction, as well as to distal sensory neuropathy Alcohol: Ataxia and other systemic symptoms may accompany dysesthesia [emedicine.medscape.com]

“An exciting aspect of this work is that these are new uses for old drugs. They have been used in humans for over 20 years with no serious side effects and have an excellent safety profile. [fiercebiotech.com]

Just the presence of new sodium channels and adrenergic receptors cause a state of hyper excitability and pain is mediated abnormally into CNS What causes central neuropathic pain injury causes loss of gaba inhibition as well as enhanced glumatergic activity [quizlet.com]

Monitoring the safety of quadrivalent human papillomavirus vaccine: findings from the Vaccine Safety Datalink. Vaccine 2011; 29: 8279-8284. *The literature refers to the Dutch text [geneesmiddelenbulletin.com]