Presentation
It can be divided into 2 forms: primary (when other connective-tissue diseases are not present) and secondary (when other connective-tissue diseases are present). [emedicine.medscape.com]
Duration of symptoms – Symptoms that present within days to weeks are seen more so in AIP or COP. Subacute presentations are seen with RBILD and DIP, with the remaining IIPs being chronic in nature. 3. [cancertherapyadvisor.com]
Advanced disease presents with tachypnoea, tachycardia and low oxygen saturation measured by pulse oximetry (SpO 2 ). Clubbing may be present. [quartz.tg.com.au]
Although some ILDs are acute onset, many people with ILD present late for diagnosis. [independentnurse.co.uk]
Entire Body System
- Congestive Heart Failure
Cancer in some cases spreads throughout the lymph system in the lungs and appears as interstitial disease Congestive heart failure, renal failure both can present with similar findings due to excess fluid in the spongy tissue of the lung Examples of idiopathic [medicinenet.com]
People with congestive heart failure (CHF) often have pulmonary edema. CHF occurs when the heart cannot pump blood effectively. [healthline.com]
If dyspnea and/or pleuritic chest pain develop, the prudent clinician will order X-rays to rule out congestive heart failure, infectious disease, or malignancy. 3,4 Drugs and biologics can cause different types of damage: bronchiolitis obliterans organizing [pharmacytimes.com]
Drug-induced ILD was essentially defined by the exclusion of other diseases such as pulmonary infection, congestive heart failure and lymphangitic carcinomatosis. [academic.oup.com]
Respiratoric
- Pertussis
Pertussis. Exposure to an inhaled allergen (hypersensitivity pneumonitis) - eg, humidifier lung, farmer's lung, bird fancier's lung. [patient.info]
Cardiovascular
- Heart Disease
Regardless of the cause of illness and special treatment, the following applies: Nicotine (smoking) must stop Other concurrent diseases must be treated as well as possible, including: Stomach acid Reflux Heart disease Obesity must be reduced It is essential [bindevevssykdommer.no]
[…] failure, with the heart having difficulty pumping blood to the rest of the body) Heart disease Lung cancer: Pulmonary fibrosis is associated with an increased risk of developing lung cancer Blood clots in the legs which can travel to the lungs (pulmonary [verywell.com]
Get Your Free Guide Treatment Treatment of interstitial lung disease is aimed at relieving symptoms and preventing complications, such as high blood pressure and heart disease. [asbestos.com]
Cardiopulmonary exercise testing can be used to assess severity of disease and to exclude an alternative diagnosis, such as heart failure. [quartz.tg.com.au]
I thought about my heart disease, but my cardiologist sent me to have a pulmonary scan with low radiation. The result mentioned only the enlarged heart. I cannot do an MRI because of my pacemaker. [my.clevelandclinic.org]
- Irregular Heart Rhythm
heart rhythm) statins (used to lower cholesterol levels) antibiotics It may also stem from the inhalation of substances, such as asbestos silica chemicals animal proteins mold smoke Interstitial lung disease related to the inhalation of cigarette smoke [radiologyinfo.org]
Musculoskeletal
- Myalgia
If the patient also has prominent extrapulmonary symptoms, such as myalgia, arthralgia, sclerodactyly, gastroesophageal reflux, or Raynaud phenomenon, ILD resulting from underlying connective tissue disease may be present ( Table 24-2 ). [clinicalgate.com]
[…] progress within the lungs, patient might have: Diffculity in breathing (Dyspnea) An unproductive cough that is persistent Shortness of breath (especially when engaging in activities such as walking) Greater levels of fatigue low-grade fevers Muscular pain (myalgias [physio-pedia.com]
HP Occupational ILD Abnormal GER, GERD, dysphagia CTD (especially scleroderma), IPF Sicca symptoms Sjögren’s disease Raynaud’s phenomenon CTD Arthralgias, arthritis CTD, sarcoidosis Myalgias, muscle weakness DM-PM Morning stiffness RA, CTD Age >70 years [transrespmed.springeropen.com]
Skin
- Skin Ulcer
Endobronchial biopsy may provide useful information if endobronchial abnormalities are present (e.g. superficial nodules, mucosal ulceration). [transrespmed.springeropen.com]
Neurologic
- Dizziness
The usual side effects of minocycline are: lightheadedness, dizziness, or vertigo and pigmentation. [clinicaltrials.gov]
When we think about adverse drug reactions (ADRs), we often think about the common (drowsiness, dizziness, rash) or the unusual and noteworthy (graying hair returning to its original color, or sensations of bugs crawling on skin). [pharmacytimes.com]
- Vertigo
The usual side effects of minocycline are: lightheadedness, dizziness, or vertigo and pigmentation. [clinicaltrials.gov]
Workup
[…] initially with exertion and as the disease progresses, then at rest) cough fatigue Physical exam rales on pulmonary auscultation digital clubbing cyanosis in advanced disease Imaging Chest radiography indication typically initial imaging option in the workup [medbullets.com]
[…] email protected] Received date: March 02, 2014; Accepted date: April 24, 2014; Published date: April 26, 2014 Citation: Chen YM, Luo YH (2015) Interstitial Lung Disease Induced by Targeted Therapy for Non-Small Cell Lung Cancer: A Review of Diagnosis, Workup [omicsonline.org]
Microbiology
- Chlamydia
These infections may include: Pneumonia Tuberculosis Chlamydia trachomatis Respiratory syncytial virus Familial Familial pulmonary fibrosis, also known as familial interstitial pneumonia, accounts for a small percentage of patients that have idiopathic [news-medical.net]
Treatment
Clinical scenarios connect to specific diseases so you can better understand the disease and the treatment modalities used. Unique! [books.google.de]
Antifibrotic treatment In SSc, no antifibrotic drug has shown a real efficacy in prevention and treatment of fibrosis. [err.ersjournals.com]
Treatment The treatment of ILD depends on the degree of inflammation and scarring. [cumc.columbia.edu]
Radiation treatment: Lung damage can occur following radiation treatment. Such damage infrequently occurs after treatment of breast or lung cancer. Acid reflux: Individuals with pulmonary fibrosis often have acid reflux. [mesotheliomaweb.org]
Prognosis
Prognosis. In the case of pneumonitis with a good response to treatment, the prognosis is favorable. The prognosis for fibrosis is variable. [archbronconeumol.org]
The prognosis of pulmonary fibrosis also depends on the particular cause. [verywell.com]
(Outcomes/Resolutions) Prognosis of Radiation-Induced Pulmonary Fibrosis depends upon the extent of scarring in the lungs and resulting symptoms. [dovemed.com]
Prognosis Natural history of ILD Most forms of ILDs are progressive in nature. There is no permanent cure. Patient’s condition is likely to deteriorate with time. [jindalchest.com]
Prognosis Prognosis is good with early diagnosis and management. Late-diagnosed chronic pneumonitis may lead to progressive, irreversible lung disease. [patient.info]
Etiology
Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]
The histopathological features of DI-ILD are generally consistent, rather than suggestive or specific to the drug etiology. Thus, the diagnosis of DI-ILD is mainly made by the meticulous exclusion of all other possible causes. [ncbi.nlm.nih.gov]
While there are multiple methods by which to classify these diseases, one option is to classify by their etiologies. There are seven categories that are frequently used: 1. [cancertherapyadvisor.com]
A number of interstitial lung diseases of unknown etiology have characteristic histology, clinical features, or presentation and thus are considered unique diseases, including In up to 30% of patients who have interstitial lung diseases with no clear [merckmanuals.com]
Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features. Definition (MSHCZE) Různorodá skupina plicních onemocnění, která ovlivňují plicní parenchym. [fpnotebook.com]
Epidemiology
CDC has initiated a series of toxicologic studies and is considering additional epidemiologic investigation within the flocking industry. [cdc.gov]
Epidemiology It is common, if all causes of pneumonitis are considered. [patient.info]
The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 1994;150:967-972. 7. Thomeer M, Costabel U, Rizzato G, et al. Comparison of registries of interstitial lung diseases in three European countries. [pharmacytimes.com]
However, the difference remains unexplained, leaving important epidemiological and mechanistic questions. [nature.com]
[…] unproductive cough that is persistent Shortness of breath (especially when engaging in activities such as walking) Greater levels of fatigue low-grade fevers Muscular pain (myalgias) Joint pain (arthralgias) Unexplained weight loss Clubbing in fingers and toes Epidemiology [physio-pedia.com]
Pathophysiology
Overview boxes summarize the clinical manifestations caused by the pathophysiologic mechanisms of each disorder. [books.google.de]
Further studies are required to understand the role of chemical mediators in patients presenting with PF, so that theraputic interventions can be progressed in years to come to limit the burden of this prevalent health condition. [6] Pathophysiology The [physio-pedia.com]
A delayed-type hypersensitivity reaction involving immunological and non-immunological mechanisms has been proposed as a possible pathophysiological mechanism [ 45 ]. [annonc.oxfordjournals.org]
Indeed, there can be considerable inter-individual variability in genetic abnormalities that have predisposed an individual to develop the disease, in pathophysiologic characteristics of the disease process, and in responses to specific drugs. [transrespmed.springeropen.com]
Prevention
If you have noticed symptoms of interstitial lung disease, you should talk to medical professional as soon as possible to prevent further damage. [centralarkansaslung.com]
This prevents the alveoli from expanding and contracting well during breathing. [verywell.com]
Prevention Since the late 1970s, many regulations have been enacted to protect workers from asbestos exposure. Reducing or eliminating asbestos exposure is the best way to prevent asbestosis. [asbestos.com]
Getting a flu shot every year can help prevent both the flu and pneumonia. In addition, pneumococcal bacteria can cause minor problems such as ear infections. [cedars-sinai.edu]