Symptoma

Drug Rash with Eosinophilia and Systemic Symptoms

DRESS syndrome

The patient presented to the emergency department soon thereafter with worsening eruption, fever, rigors, facial edema, and lymphadenopathy. Methylprednisolone was initiated. [ncbi.nlm.nih.gov]

The patients present with high fever, enlargement of the liver, spleen, and several peripheral lymph nodes. Enlargement of the liver, spleen, and several peripheral lymph nodes. [pathopedia-india.com]

  • Constitutional Symptom

    Lymphadenopathy, haematological abnormalities and constitutional symptoms are among the non-specific manifestations seen in drug rash with eosinophilia and systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse drug reaction. [ncbi.nlm.nih.gov]

  • Inguinal Lymphadenopathy

    Five weeks later he developed features of DRESS syndrome including facial and peri-orbital oedema, generalized erythematous, maculo-papular rash, conjunctivitis, inguinal lymphadenopathy, leucocytosis, eosinophilia and elevated liver enzymes. [scopemed.org]

  • Pleural Effusion

    Chest radiograph [Figure 2] showed bilateral haziness, right more than left, which was pleural effusion as shown by ultrasound of the chest. ATT was stopped, and she was put on intravenous broad spectrum antibiotics. [mjdrdypu.org]

  • Long Arm

    Available from: Sir, Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by reciprocal translocation between the long arms of chromosomes 9 and 22 generating the Philadelphia chromosome, that leads to the formation of Bcr-Abl [idoj.in]

  • Papular Rash

    Key words: DRESS syndrome, Maculo-papular rash, Eosinophilia, Phenytoin, Systemic corticosteroids, Naranjo ADR probability scale. Advertisement American Journal of Research in Medical Sciences SUBMIT YOUR ARTICLE NOW [scopemed.org]

    Keywords DRESS syndrome, Maculo-papular rash, Eosinophilia, Phenytoin, Systemic corticosteroids, Naranjo ADR probability scale References Camous X, Calbo S, Picard D, Musette P. [ijbcp.com]

  • Insect Bite

    There were no stigmata of insect bite. He had no previous history of allergy or any recent history of taking any other drug. There was no significant family history. [idoj.in]

    Furthermore, no history of animal/insect bites was detected. The first modality to treat DRESS syndrome is discontinuing the causative drug. [clinicaldermatology.eu]

Despite an exhaustive workup noted above and consultation with dermatology, infectious disease, ophthalmology, pulmonary and burn specialists, no clear etiology was identified. [jmedicalcasereports.biomedcentral.com]

  • Gram-Positive Bacteria

    Linezolid is a recent addition to the antibiotic armamentarium against Gram-positive bacteria, including multiresistant staphylococci and enterococci. Linezolid is relatively well tolerated and is not believed to be nephrotoxic. [ncbi.nlm.nih.gov]

  • Pleural Effusion

    Chest radiograph [Figure 2] showed bilateral haziness, right more than left, which was pleural effusion as shown by ultrasound of the chest. ATT was stopped, and she was put on intravenous broad spectrum antibiotics. [mjdrdypu.org]

This risk should be integrated in the risk-benefit balance evaluation of patient treatment, and the occurrence of a rash should lead to prompt and permanent treatment discontinuation with careful follow-up. [ncbi.nlm.nih.gov]

AIM: We investigate clinical and pathological features and prognosis of DRESS and hope this study will provide data concerning this disorder in Taiwan. [ncbi.nlm.nih.gov]

Treatment and prognosis The prognosis can be variable but can carry a mortality of up to 10% in patients with multi-organ involvement. Withdrawal of the causative drug and steroid therapy as traditionally been a mainstay of treatment. [radiopaedia.org]

The prognosis is severe; drug discontinuation is sometimes not enough and so far the proposed therapies are not always valid. [unipa.pure.elsevier.com]

The prognosis of SS is poor with the mean survival being 2 to 4 years and 5-year survival of 25%. [clevelandclinicmeded.com]

Prognosis• Mortality rate 10 %• Most common from liver failure [slideshare.net]

Inpatient vancomycin use is increasing and appears to be emerging as an important etiology of DRESS syndrome. This study highlights the importance of vancomycin as a cause of DRESS syndrome. [ncbi.nlm.nih.gov]

Hypereosinophilia is a systemic condition that has several possible etiologies: allergies, medications, infectious, autoimmune or other systemic diseases, and finally idiopathic forms. [unipa.pure.elsevier.com]

Despite an exhaustive workup noted above and consultation with dermatology, infectious disease, ophthalmology, pulmonary and burn specialists, no clear etiology was identified. [jmedicalcasereports.biomedcentral.com]

A clear etiology for the cause in our patient and for DRESS patients in general remains elusive. [omicsonline.org]

Aims: To study the clinical and epidemiological aspects of DRESS and to identify the precipitating drugs. [ijdvl.com]

Scope of The Presentation• Overview of SCARs• Definition of DRESS/DIHS• Epidemiology• Clinical Manifestations & Common Culprit Drugs• Pathogenesis• Diagnosis• Conclusion 3. [slideshare.net]

Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains [published online ahead of print October 19, 2012]. [clevelandclinicmeded.com]

The pathophysiology of DRESS syndrome is not well known. [radiopaedia.org]

The pathophysiology of DRESS syndrome is unclear. [synapse.koreamed.org]

Pathophysiology The pathogenesis of DRESS is thought to be multifactorial and to include both immunologic and nonimmunologic factors. [clevelandclinicmeded.com]

The pathophysiology of DRESS syndrome has not been fully elucidated. [jmedicalcasereports.biomedcentral.com]

While there is a slight predilection towards females versus males (male/female ratio of 0.80), there is an increased incidence in children versus adults. 8 Pathophysiology While the pathophysiology is still being investigated, the current theory is that [emdocs.net]

In the absence of a well-established therapy, primary and secondary prevention have a key role in the management of DRESS syndrome. Copyright 2003 S. Karger AG, Basel [ncbi.nlm.nih.gov]

Hepatology General Surgery Gynecology Hematology/Oncology Hospice and Palliative Medicine Infectious Disease Inpatient Medicine Nephrology/Hypertension Neurology Obstetrics Ophthalmology Orthopedics Pediatrics Pharmacology / Meds Physical Examination Preventive [fpfacultynotes.wordpress.com]

Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management. CNS Drugs. 2002; 16 (3): 197-205[ PubMed ] 5. Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS syndrome: a literature review. [comprped.com]

Its diagnosis requires the application of a complex diagnostic algorithm and immediate identification to prevent inauspicious evolution. [unipa.pure.elsevier.com]