The patient presented to the emergency department soon thereafter with worsening eruption, fever, rigors, facial edema, and lymphadenopathy. Methylprednisolone was initiated. [ncbi.nlm.nih.gov]

The patients present with high fever, enlargement of the liver, spleen, and several peripheral lymph nodes. Enlargement of the liver, spleen, and several peripheral lymph nodes. [pathopedia-india.com]

Here we present a case of a 36-year-old African-American male who presented with symptoms mimicking sepsis with an associated skin eruption that was diagnosed as DRESS. dermatology neurology (drugs and medicines) immunology medical management Statistics [casereports.bmj.com]

• Inguinal Lymphadenopathy

  Five weeks later he developed features of DRESS syndrome including facial and peri-orbital oedema, generalized erythematous, maculo-papular rash, conjunctivitis, inguinal lymphadenopathy, leucocytosis, eosinophilia and elevated liver enzymes. [scopemed.org]

• Photopsia

  A few hours later, he presented with sudden acute vision loss and photopsiae, lasting for 10 min and without neurological or ophthalmological clinical findings (a CT of the brain was normal). [nature.com]

• Insect Bite

  There were no stigmata of insect bite. He had no previous history of allergy or any recent history of taking any other drug. There was no significant family history. [idoj.in]

  Furthermore, no history of animal/insect bites was detected. The first modality to treat DRESS syndrome is discontinuing the causative drug. [clinicaldermatology.eu]

• Long Arm

  2014/5/6/120/146189 Sir, Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by reciprocal translocation between the long arms of chromosomes 9 and 22 generating the Philadelphia chromosome, that leads to the formation of Bcr-Abl [idoj.in]

• Psychiatric Symptoms

  Limbic encephalitis (LE) is a rare disorder characterized by cognitive dysfunction with memory disturbance, seizures and psychiatric symptoms. [ncbi.nlm.nih.gov]

Despite an exhaustive workup noted above and consultation with dermatology, infectious disease, ophthalmology, pulmonary and burn specialists, no clear etiology was identified. [jmedicalcasereports.biomedcentral.com]

This risk should be integrated in the risk-benefit balance evaluation of patient treatment, and the occurrence of a rash should lead to prompt and permanent treatment discontinuation with careful follow-up. [ncbi.nlm.nih.gov]

Treatment and prognosis The prognosis can be variable but can carry a mortality of up to ~10% in patients with multi-organ involvement. Withdrawal of the causative drug and steroid therapy as traditionally been a mainstay of treatment. [radiopaedia.org]

AIM: We investigate clinical and pathological features and prognosis of DRESS and hope this study will provide data concerning this disorder in Taiwan. [ncbi.nlm.nih.gov]

The prognosis is severe; drug discontinuation is sometimes not enough and so far the proposed therapies are not always valid. [unipa.pure.elsevier.com]

The prognosis of SS is poor with the mean survival being 2 to 4 years and 5-year survival of 25%. [clevelandclinicmeded.com]

Prognosis• Mortality rate 10 %• Most common from liver failure [slideshare.net]

Inpatient vancomycin use is increasing and appears to be emerging as an important etiology of DRESS syndrome. This study highlights the importance of vancomycin as a cause of DRESS syndrome. [ncbi.nlm.nih.gov]

Hypereosinophilia is a systemic condition that has several possible etiologies: allergies, medications, infectious, autoimmune or other systemic diseases, and finally idiopathic forms. [unipa.pure.elsevier.com]

A clear etiology for the cause in our patient and for DRESS patients in general remains elusive. [omicsonline.org]

Despite an exhaustive workup noted above and consultation with dermatology, infectious disease, ophthalmology, pulmonary and burn specialists, no clear etiology was identified. [jmedicalcasereports.biomedcentral.com]

Scope of The Presentation• Overview of SCARs• Definition of DRESS/DIHS• Epidemiology• Clinical Manifestations & Common Culprit Drugs• Pathogenesis• Diagnosis• Conclusion 3. [slideshare.net]

Aims: To study the clinical and epidemiological aspects of DRESS and to identify the precipitating drugs. [ijdvl.com]

Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains [published online ahead of print October 19, 2012]. [clevelandclinicmeded.com]

The pathophysiology of DRESS syndrome is not well known. [radiopaedia.org]

Pathophysiology The pathogenesis of DRESS is thought to be multifactorial and to include both immunologic and nonimmunologic factors. [clevelandclinicmeded.com]

The pathophysiology of DRESS syndrome is unclear. [synapse.koreamed.org]

While there is a slight predilection towards females versus males (male/female ratio of 0.80), there is an increased incidence in children versus adults. 8 Pathophysiology While the pathophysiology is still being investigated, the current theory is that [emdocs.net]

The pathophysiology of DRESS has not been fully elucidated. Both immunological and non-immunological mechanisms were discussed (8-10). [latunisiemedicale.com]

In the absence of a well-established therapy, primary and secondary prevention have a key role in the management of DRESS syndrome. Copyright 2003 S. Karger AG, Basel [ncbi.nlm.nih.gov]

Its diagnosis requires the application of a complex diagnostic algorithm and immediate identification to prevent inauspicious evolution. [unipa.pure.elsevier.com]

Hepatology General Surgery Gynecology Hematology/Oncology Hospice and Palliative Medicine Infectious Disease Inpatient Medicine Nephrology/Hypertension Neurology Obstetrics Ophthalmology Orthopedics Pediatrics Pharmacology / Meds Physical Examination Preventive [fpfacultynotes.wordpress.com]

Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management. CNS Drugs. 2002; 16 (3): 197-205[ PubMed ] 5. Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS syndrome: a literature review. [comprped.com]