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Ductal Breast Carcinoma


Presentation

  • High-grade DCIS, which also has comedo necrosis, presents with linear-branching microcalcifications. On the other hand, low-grade DCIS usually presents with fine granular microcalcifications. Bilateral mammography is indicated.[lecturio.com]
  • The present study aimed to evaluate the classic and non-classic characteristics of MBC and its differences with IDC. The present review study incorporates 22 years of practical experience from a breast disease research center-based series of cases.[ncbi.nlm.nih.gov]
  • The suspicious calcifications present in and outside the mass is a finding associated with histologically high grade tumors.[ijri.org]
  • We present the case of a 52 years woman, presented to us for an upper-outer breast lump. Breast imaging concluded to tow contiguous lesions, one of them was suspicious. She had a conservative surgery.[panafrican-med-journal.com]
  • Both may have rounded non-branching ducts with a single layer of cells, lacking myoepithelial cells Infiltrating Ductal Carcinoma Radial Scar Cells may show various levels of atypia Cytologically bland cells No myoepithelial cells Myoepithelial cells present[surgpathcriteria.stanford.edu]
Weakness
  • The exceptions were cases B638 and B413, which showed weak to moderate levels of expression by microarray. Although B638 did not show any staining for E-cadherin by immunohistochemistry, B413 showed diminished but positive membranous staining.[cancerres.aacrjournals.org]
Heart Failure
Vascular Disease
  • diseases, or a previous history of chest irradiation therapy.[lecturio.com]
Fear
  • “I went into a state of shock and fear,” Ms. Taylor said. She had the surgery. She regrets it. “It takes away your feeling of attractiveness,” she said. “Compared to women who really have cancer, it is nothing.[nytimes.com]
Confusion
  • Many were confused as to whether it was actually cancerous or not. Most wanted more information about DCIS and many felt unprepared for the diagnosis because they'd had no symptoms.[healthtalk.org]

Workup

  • Ultimately, there still remains a lack of uniformity in workup and management across all specialists [ 9 ].[ajronline.org]
Polyps
  • D.C.I.S. has long been regarded as a precursor to potentially deadly invasive cancers, analogous to colon polyps that can turn into colon cancer, said Dr. Steven A.[nytimes.com]

Treatment

  • Learn more about treatments for DCIS. Learn about the risk of invasive breast cancer after treatment for DCIS. Learn more about emerging areas in the treatment of DCIS.[ww5.komen.org]
  • treatment is unnecessary for most patients.[nytimes.com]
  • Treatment for DCIS Most women who are diagnosed with DCIS will be recommended treatment. This is because it is not possible to predict which women may go on to develop invasive breast cancer.[bcna.org.au]
  • The results from these trials will help to determine the best treatment options for women with low-grade DCIS.[breast-cancer.canceraustralia.gov.au]
  • Each treatment has advantages and disadvantages. 1.[bci.org.au]

Prognosis

  • Tubular breast cancer has an excellent prognosis.[hopkinsmedicine.org]
  • prognosis - Cribriform carcinoma: younger age, good prognosis.[atlasgeneticsoncology.org]
  • Prognosis With treatment, prognosis for DCIS is usually excellent. Surgery Surgery is the first step to treat DCIS. It removes the abnormal tissue from the breast.[ww5.komen.org]
  • Prognosis Doctors use the term prognosis to talk about your future outlook and survival.[verywellhealth.com]
  • Prognosis of medullary breast cancer: analysis of 13 International Breast Cancer Study Group (IBCSG) trials.[ncbi.nlm.nih.gov]

Etiology

  • Beyond their etiologic importance these results also have clinical significance because CHRT use increased steadily in the United States from the 1970s to the 1990s 8 - 12 and because ILC and IDC have different clinical features.[jamanetwork.com]
  • Breast Cancer: Epidemiology and Etiology. Cell Biochem Biophys. 2015; 72 :333–8. doi: 10.1007/s12013-014-0459-6. [ PubMed ] [ CrossRef ] [ Google Scholar ] 6. Verma R, Bowen RL, Slater SE, Mihaimeed F, Jones JL.[ncbi.nlm.nih.gov]
  • Etiology The etiology is multifactorial with three major contributors to the development of breast cancer: 1) genetic factors, 2) hormonal influences and 3) environmental factors.[atlasgeneticsoncology.org]
  • Distinct incidence patterns among in situ and invasive breast carcinomas, with possible etiologic implications. Breast Cancer Res Treat 2004; 88:149–159 [Google Scholar] 37. Kerlikowske K, Barclay J, Grady D, Sickles EA, Ernster V.[ajronline.org]

Epidemiology

  • Design Descriptive epidemiologic study.[jamanetwork.com]
  • There is also evidence from epidemiological studies that there is an inherited predisposition to DCIS.[breast-cancer-research.biomedcentral.com]
  • ., of the Women’s College Hospital, Toronto, and his colleagues used data from NCI’s Surveillance, Epidemiology and End Results (SEER) program to estimate the death rate from breast cancer among women diagnosed with DCIS.[cancer.gov]
  • Materials and methods: Patients with nonmetastatic breast cancer who underwent surgery in 2010–2014 were included from the Surveillance, Epidemiology, and End Results program.[dovepress.com]
  • Epidemiology of Non-Invasive Breast Cancer It is the most common type of non-invasive breast cancer. About 60,000 cases of DCIS are diagnosed in the United States each year.[lecturio.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of Non-Invasive Breast Cancer Ductal carcinoma in situ arises from the ductal epithelium. Due to poorly understood reasons, the ductal epithelium can undergo hyperplasia.[lecturio.com]

Prevention

  • Women should talk with their doctor about specific preventive measures they can take.[pennmedicine.org]
  • Accordingly, tamoxifen was used for primary and secondary prevention of DCIS.[lecturio.com]
  • In addition, treating these lesions may help prevent a recurrence in the breast but does not appear to decrease the already-low risk of dying from the disease, even after 20 years of follow-up.[cancer.gov]
  • Treatment for DCIS aims to help prevent invasive breast cancer from developing and DCIS from coming back in the breast. DCIS can be treated successfully and most women diagnosed and treated for DCIS will not later develop invasive breast cancer.[breast-cancer.canceraustralia.gov.au]
  • It may also be given after surgery to prevent cancer cells from returning. Radiation : Radiation treatments are given after surgery and chemotherapy to prevent cancer cells from returning.[verywellhealth.com]

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