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Duodenal and-or Jejunal Atresia


Presentation

  • Distal ileal atresia may present after 24-48 hours. An abdominal radiograph is important in the diagnosis of these conditions. In duodenal atresia, a double bubble is typically present.[cancertherapyadvisor.com]
  • When a neonate presents with a bowel obstruction, locating the site of the lesion becomes most important in the sequence of clinical investigation and management.[mhmedical.com]
  • The mean age at presentation to the surgeon was 10.3 days (range 2-43 days) for JIA and 10.6 days (range 1-35 days) for DA. Average weight at presentation was 2.2 kg for JIA and 2.4 kg for DA.[njcponline.com]
  • We herein present 3 cases of dual intestinal type I atresia located in both the small intestine and colon.[bmcgastroenterol.biomedcentral.com]
Sepsis
  • Causes of death were: Sepsis with disseminated intravascular coagulation (1), sepsis from anastomotic leakage (1), septic shock (1), anesthesia-related (1), undetermined (1). Two of the mortalities (40%) had re-operation for anastomotic leak.[njcponline.com]

Treatment

  • Treatment will include surgery to repair the intestine and supportive care. Nutrition Support Nutrition normally enters the body through the intestines.[wmhs.com]
  • […] of duodenal obstruction duodenal atresia, duodenal web or stenosis, annular pancreas, malrotation of the bowel with a midgut volvulus , or Ladd's bands Fetal ultrasound may show polyhydramnios Differential Pyloric stenosis, tracheoesophageal fistula Treatment[step2.medbullets.com]
  • The team at our Prenatal Diagnosis and Treatment program can work with you to get ready for your baby’s birth and the treatment they will need early in life.[seattlechildrens.org]
  • Surgical treatment is ultimately necessary to reestablish intestinal continuity.[cancertherapyadvisor.com]
  • Treatments vary, depending on the location of the blockage. Most babies with intestinal atresia need surgery during the first 24 to 48 hours of life.[rileychildrens.org]

Prognosis

  • , Prevention, and Complications Prognosis full recovery is expected after surgical correction Prevention no preventive measures are available at this time Complications without treatment, condition is lethal Please rate topic.[step2.medbullets.com]
  • This classification generally guides prognosis and therapy (see the image below). Classification of jejunoileal atresias.[emedicine.medscape.com]
  • The prognosis of colonic atresia is usually good [17]. The prognosis of intestinal atresia is better in developed countries (Table 4) that in developing countries where there are survival rates barely reaching 50% [9, 72].[ispub.com]

Etiology

  • Therefore, the most likely etiology for duodenal atresia is failure of luminal recanalization after the cord stage.[mhmedical.com]
  • […] in·tes·ti·nal a·tre·si·a an obliteration of the lumen of the small intestine, with the ileum involved in 50% of cases and the jejunum and duodenum next in frequency; most frequent cause of intestinal obstruction in the newborn; etiology may be related[medical-dictionary.thefreedictionary.com]
  • Etiology Multiple theories regarding the etiology of jejunoileal atresia have been studied in many animal models (eg, puppies, ewes, rabbits, and chick embryos). [22, 23, 24, 25, 26] Murine studies suggest that some forms of atresia may be hereditary[emedicine.medscape.com]
  • The etiology is thought to be from an in-utero ischemic event.[radiopaedia.org]

Epidemiology

  • References: [1] [2] Epidemiological data refers to the US, unless otherwise specified.[amboss.com]
  • […] during weeks 8-10 of development Results in stenosis of the duodenal passageway between the stomach and intestinal tract leads to gastric outlet syndrome Associated with Down syndrome (20-30% of DS cases) and other birth defects as with biliary atresia Epidemiology[step2.medbullets.com]
  • Epidemiology. vol. 14. 2003. pp. 349. Copyright 2017, 2013 Decision Support in Medicine, LLC. All rights reserved. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC.[cancertherapyadvisor.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Duodenal atresia occurs when recanalization of the closed duodenum fails to occur or occurs only partially during the embryonic period (usually between the 8 th –10 th week of gestation).[amboss.com]
  • Pathophysiology Accumulation of ingested food, gas, and intestinalsecretions proximal to the point of obstruction,leading to distention of the bowel. As the bowel dilates, intestinal absorption decreasesand secretion of fluid and electrolytes increases[slideshare.net]
  • Comparative outcomes in intestinal atresia: clinical outcome and pathophysiology analysis. Pediatr Surg Int 2011; 27: 437–442. 19. Chadha R, Sharma A, Roychoudhury S, Bagga D.[ispub.com]

Prevention

  • , and Complications Prognosis full recovery is expected after surgical correction Prevention no preventive measures are available at this time Complications without treatment, condition is lethal Please rate topic.[step2.medbullets.com]
  • Prevention There are no current guidelines to prevent intestinal atresia. There may be a link between atresia and smoking and cocaine during pregnancy. Congenital duodenal obstruction. EBSCO DynaMed Plus website. Available at: .[wmhs.com]
  • Food is blocked from passing through the intestine , which prevents normal feeding and intestinal function. Intestinal atresia and stenosis usually involve the small intestine, but can affect any part of the gastrointestinal tract.[chp.edu]
  • IA prevents food and poop (stool) from moving through your child’s body. It is most common in the small bowel . But it also can affect the large bowel . Doctors sometimes describe IA by naming the part of the bowel it affects.[seattlechildrens.org]
  • How can intestinal atresia be prevented? Prevention is through avoidance of medications and substances thought to be associated with fetal vasoconstriction. Werler, MM,, Sheehan, JE,, Mitchell, AA.[cancertherapyadvisor.com]

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