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Dyskeratosis Congenita
Zinsser-Engman-Cole Syndrome

Dyskeratosis congenita is a general term for genetic disorders that lead to excess skin pigmentation, nail dystrophy and mucosal leukoplakia. Patients suffer and may die from distinct grades of bone marrow failure.

Presentation

To date, mutations affecting ten different genes have been identified as possible DC triggers. However, each one of these genes may show a variety of different mutations that may yield distinct degrees of protein dysfunction. In this context, more than 50 mutations have been described for the DKC1 gene. Also, environmental factors seem to influence symptom onset and severity and even members of the same family, parents that inherited a determined genetic disorder to their children, may not necessarily present the same clinical picture. Even though the exact mechanisms behind such phenomena are not completely understood, these are the reasons for the heterogeneity in age of DC symptom onset, symptom progress, affected tissues and severity of pathological conditions.

Early symptom onset is generally associated with rapid and severe disease progress. Indeed, symptoms do usually not manifest until childhood or adolescence except in cases of the very severe Hoyeraal-Hreidarsson syndrome and Revesz syndrome. Mild cases may even progress asymptomatically until well into adulthood and manifest in form of one single symptom then [10]. These patients may, however, develop malignant neoplasms. TERC, TERT and TINF2 mutations tend to cause these less severe forms of the disease.

The classical symptom triad for DC is often triggered by DKC1 mutations and is characterized by excess skin pigmentation, nail dystrophy and mucosal leukoplakia. These symptoms usually manifest before the age of ten and are most likely followed by bone marrow failure in between ten more years. About 90% of these patients develop bone marrow failure before becoming 30 years old. Malignant neoplasms are less frequently observed here than in those patients suffering from mild forms of DC.

In detail, the following symptoms may be observed:

  • Reticulate hyperpigmentation, particularly affecting face, neck and shoulders, possibly associated with skin atrophy.
  • Nail hypoplasia, contortion and nail loss. Fingernails are often affected before toenails.
  • Oral leukoplakia that manifests in form of white patches that cover the oral mucosa.
  • Bone marrow failure resulting in different degrees of pancytopenia [11]. Fatigue, weakness, dyspnea, cyanosis, dizziness and headaches may indicate anemia. Thrombocytopenia may provoke a hemorrhagic diathesis. Such patients frequently report bleeding gums and epistaxis. Recurring infections may be the first sign of leukopenia.
  • Malignant neoplasms, most frequently head and neck squamous cell carcinoma, leukemia and lung cancer. Leukoplakia is considered a precancerous condition and may precede malignant degeneration. Cancer is usually detected in patients aged 30 and older and thus is not typical for more severe forms of DC.
  • Pulmonary fibrosis.
  • A wide variety of dermatological, ophthalmologic, urological and neuropsychiatric symptoms may also be detected in DC patients [12] [13]. Compared with the aforementioned symptoms, their overall prevalence is rather low.

Entire Body System

  • Anemia

    Of all the congenital bone marrow failure syndromes, two of them-Fanconi anemia and dyskeratosis congenita-represent a real challenge in terms of conditioning for HCT and require special attention. [ncbi.nlm.nih.gov]

    Aplastic anemia Aplastic anemia results in progressive bone marrow failure due to the loss of mature blood cells. [cygenia.com]

  • Nail Abnormality

    The most common nail abnormalities are longitudinal ridges, pterygium, or atrophic / absent nails. [visualdx.com]

    The classic triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia is diagnostic of DC, but substantial clinical heterogeneity exists; the clinically severe variant Hoyeraal Hreidarsson syndrome (HH) also includes cerebellar hypoplasia [ncbi.nlm.nih.gov]

    The nails also have fissures or don’t grow properly. Finally, thick, white and mucous-filled patches affect the mouth. Other complications can occur over time from bone marrow failure, or other organ abnormalities. [nicklauschildrens.org]

    Affected individuals are therefore boys who display, at the latest at the age of 10, skin, phanerian and mucosal abnormalities: reticular patterns on the skin, melanodermia, nail abnormalities (striated patterns, deformed nails, reduction in size or even [afdc.asso.fr]

Jaw & Teeth

  • Dental Caries

    Further examination revealed dystrophic nails, numerous dental caries, and blepharitis. Chromosomal analysis on leukocytes showed significant telomere shortening consistent with DC. [ncbi.nlm.nih.gov]

    caries/loss 16.9 Oesophageal stricture 16.9 Premature hair loss /greying/sparse eyelashes 16.1 Hyperhiderosis 15.3 Malignancy 9.8 Intrauterine growth retardation 7.6 Liver disease/peptic ulceration/enteropathy 7.3 Ataxia/cerebellar hypoplasia 6.8 Hypogonadism [europeanmedical.info]

    caries, esophageal webs, genitourinary defects, restrictive pulmonary disorder Rarely associated with usual interstitial pneumonia causing death from respiratory failure ( Mayo Clin Proc 2005;80:817 ) Although probably an inherited DNA repair defect [pathologyoutlines.com]

Cardiovascular

  • Acrocyanosis

    Hyperhidrosis of palms and soles, blister formation, acrocyanosis, hair loss (scalp), and early tooth loss also occur. Pneumonia and sinusitis, likely due to defective humoral immune system (dysgammaglobulinemias), are common. [visualdx.com]

Musculoskeletal

  • Osteoporosis

    Other findings include carious teeth, premature graying of hair, and osteoporosis. Approximately 50% of patients develop pancytopenia. [ncbi.nlm.nih.gov]

    Other clinical manifestations may include epiphora, lung fibrosis, liver cirrhosis, osteoporosis, and a predisposition to develop a variety of malignancies. [eurekaselect.com]

    Other disease manifestations can include epiphora (excessive tear production), intellectual disability, pulmonary fibrosis, abnormal pulmonary vasculature, tooth loss or decay, premature hair loss or greying, liver disease, osteoporosis, and deafness. [dnatesting.uchicago.edu]

    Other clinical symptoms of the disease can be : Growth retardation Early loss of hair or appearance of grey hair Abnormally abundant tears (epiphora) Dental abnormalities Early osteoporosis Liver cirrhosis Œsophageal strictures Neurological disorders [afdc.asso.fr]

Eyes

  • Lacrimation

    Ophthalmologic manifestations include blepharitis, conjunctivitis, obliteration of the lacrimal puncta, nasolacrimal duct obstruction, ectropion, and loss of eyelashes. [ncbi.nlm.nih.gov]

    Lacrimal duct stenosis or atresia is present in up to 80% of patients and leads to continuous epiphora. Up to 90% of patients suffer from bone marrow failure; rarely the diagnosis of aplastic anemia precedes the diagnosis of dyskeratosis congenita. [accessanesthesiology.mhmedical.com]

    Other clinical manifestations may include continuous lacrimation due to atresia of the lacrimal ducts, lung fibrosis, liver cirrhosis, osteoporosis and various neurological abnormalities including mental retardation and basal ganglia calcification (Chan [link.springer.com]

    The condition also may cause lacrimal duct atresia with excessive tearing, and bone marrow failure with consequent anemia, thrombocytopenia, or pancytopenia. [visualdx.com]

  • Blepharitis

    Ophthalmologic manifestations include blepharitis, conjunctivitis, obliteration of the lacrimal puncta, nasolacrimal duct obstruction, ectropion, and loss of eyelashes. [ncbi.nlm.nih.gov]

    Keratinization of the lid margins, absent lacrimal puncta, trichiasis, cicatrizing conjunctivitis, entropion, ectropion, blepharitis, sparse eyelashes, and symblephara are important features. [disorders.eyes.arizona.edu]

Skin

  • Hyperpigmentation

    Dyskeratosis congenita: nail dystrophy dyskeratosis congenita A rare X-linked or autosomal dominant disease characterized by dystrophic formation of the nails, oral leukoplakia, and hyperpigmentation of the skin. [medical-dictionary.thefreedictionary.com]

    Dyskeratosis congenita is a genodermatosis characterized by hyperpigmentation of the skin, dystrophy of the nails, leukoplakia of mucous membranes, and progressive pancytopenia. Zinsser-Cole-Engman Syndrome; Dyskeratosis Congenita Scoggins type. [accessanesthesiology.mhmedical.com]

    Medical history included a macular hyperpigmentation on the neck, present since the age of 8 years. At age 20 years, the hyperpigmentation had extended to involve the trunk, arms, and [jamanetwork.com]

    Naegeli(-Franceschetti-Jadassohn) syndrome and Dermatopathia Pigmentosa Reticularis are allelic disorders, both characterized by a congenital generalized reticulate hyperpigmentation, palmoplantar hyperkeratosis and other ectodermal symptoms. [ncbi.nlm.nih.gov]

  • Alopecia

    There was a significant alopecia of scalp over the past year. Blood picture, however, was satisfactory. 4. [hindawi.com]

    […] developmental delay, short stature, microcephaly, blepharitis, epiphora, periodontal disease, taurodontism, decreased teeth/root ratio, esophageal stenosis, urethral stenosis, osteoporosis, avascular necrosis of femur and/or humerus, premature hair greying/alopecia [orpha.net]

    The patient had diffuse alopecia over the scalp. The nails were brittle with vertical ridges [Figure 4]. There was no abdominal organomegaly or free fluid. [e-ijd.org]

  • Skin Disease

    X-Linked Skin Abnormalities Skin Diseases, Genetic Ohjaustermit Syndrome, Zinsser-Cole-Engman Zinsser Cole Engman Syndrome Zinsser-Cole-Engman Syndrome Käyttöhuomautus A predominantly X-linked recessive syndrome characterized by a triad of reticular [finto.fi]

    Congenital diseases of the skin. [pascal-francis.inist.fr]

    Our preliminary evaluation of its measurement properties suggests that it is a reliable and valid measure of the effects of skin disease on the quality of life in Korean patients. [kiss.kstudy.com]

    カテゴリ 先天奇形 階層分類 ヒト疾患 [BR: jp08402 ] 先天奇形 皮膚の先天奇形 H00691 水疱型先天性魚鱗癬様紅皮症 ICD-11 による疾患分類 [BR: jp08403 ] 14 Diseases of the skin Genetic and developmental disorders affecting the skin Genetic syndromes affecting the skin EC20 Genetic disorders of keratinisation [kegg.jp]

    diseases See the DermNet NZ bookstore. [dermnetnz.org]

  • Skin Lesion

    Case 2 A 30 year old male, admitted under orthopedics for chronic hip pain, was referred to the dermatology department for his skin lesions. Skin lesions began appearing since the age of 10. [ibimapublishing.com]

    In this article, we present a young male with a diagnosis of dyskeratosis congenita who had reticulated hyperpigmented skin lesions on the neck, shoulders and upper eyelids, bilateral punctal and canalicular obstruction, and dystrophic nails. [oftalmoloji.org]

    There were hypopigmented skin lesions in the whole body. The skin was dry and the nails were dystrophic. His axillary and pubic hair was normal but facial hair was scarce. He had alopecia in 1/3 of outer eyebrow (Omnibus sign) and saddle nose. [endocrine-abstracts.org]

    Similar skin lesions were also present in many of his family members as shown in the pedigree. This triad of skin, mucosa, and nail changes is classical of DC. The pattern of transmission was autosomal dominant. [japi.org]

    Skin lesions in Bloom’s, Kindler’s and Rothmund-Thomson syndromes may be similar to that seen in DKC, but are more sun sensitive and also differ in associated features [ 1 ]. [ncbi.nlm.nih.gov]

  • Hypopigmented Macule

    The hypopigmented macules showed no discernible erythema upon rubbing or the local application of heat. The naevus anaemicus-like macules may be a relatively common but under-recognized feature in DC. [ncbi.nlm.nih.gov]

    (c and d) Picture showing hypopigmented macules with reticular hyperpigmentation on the trunk and upper limb Click here to view Retrospective history revealed significant weight loss in the last 6 months but was not investigated. [meajo.org]

    Case presentation Herein, we report a 31-year-old male with history of recurrent febrile episodes who was found to have reticulate skin pigmentation interspersed with hypopigmented macules involving the face, neck and extremities, hyperkeratosis of palms [bmcmedgenet.biomedcentral.com]

    On examination, numerous discrete to coalesced hypopigmented dry atrophic macules with mottled appearance were noted all over the body. [ibimapublishing.com]

Workup

While the classical symptom triad of excess skin pigmentation, nail dystrophy and mucosal leukoplakia may directly prompt the tentative diagnosis of DC, symptoms resulting from bone marrow failure require a more thorough workup. Blood samples need to be analyzed and will typically show pancytopenia, but in many cases only one or two of anemia, thrombocytopenia and leukopenia will be detected. Bone marrow biopsies may reveal aplastic anemia.

Spirometric tests and diagnostic imaging of the lungs is indicated to assess lung function and to detect possible lung cancer. Further images may be helpful to confirm or rule out the presence of malignant neoplasms in other tissues.

Additional diagnostic measures need to be adjusted to the individual case. If mucosal leukoplakia is present but hyperpigmentation and nail dystrophy are not, histopathologic analysis of a corresponding biopsy provide information regarding the nature of mucosal alterations. This applies similarly to dermatological findings. Ophthalmologic, urological and neuropsychiatric symptoms require their own workup.

Genetic testing and confirmation of known mutations may be diagnostic, but about one in three patients does not present any of the aforementioned gene disorders. Thus, failure to detect any genetic defect does not rule out DC [13]. Flow fluorescence in situ hybridization may be used on subsets of leukocytes, particularly on lymphocytes, to measure telomere length and to detect abnormally short telomeres [14].

Treatment

DC therapy consists in delay of bone marrow failure, palliative treatment of present symptoms and life style adaptions to avoid disease progress. There is no cure for DC.

Bone marrow failure may initially be treated with androgens like oxymetholone [15]. Such treatment may improve anemia and possibly thrombocytopenia. However, long-term effects are not to be expected.

Because androgen therapy in pediatric patients may accelerate growth, corticosteroids may supplement the former. Not only do corticosteroids reduce growth acceleration, they may also serve to counteract the hemorrhagic diathesis caused by thrombocytopenia.

Hematopoietic growth hormones such as granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor may be administered to stimulate proliferation of neutrophil precursors. As is the case for androgen therapy, effects are usually transient.

Bone marrow or stem cell transplantation may eventually cure aplastic anemia but not premature cell aging in other tissues [16]. Success of transplantations may depend on immunosuppressive therapy, but DC patients are very sensitive towards chemotherapy and irradiation. Busulfan and melphalan should be avoided. Potentially lethal pulmonary complications may occur after stem cell transplantation which is why this therapeutic measure should be reserved for patients mainly suffering from bone marrow failure.

If DC patients develop malignant neoplasms, they should be surgically removed if at all possible. As has been mentioned above, chemotherapy and irradiation are not suitable therapeutic options.

Additionally, any habits that accelerate aging should strictly be avoided. Tobacco and alcohol are not to be consumed by DC patients. Skin care and an adequate oral hygiene are very important measures to prevent skin lesions, tooth loss and even certain malignancies.

Prognosis

The prognosis associated with DC is poor and life expectancy is less than 30 years. Only palliative therapy may be provided, although bone marrow and stem cell transplantations may cure aplastic anemia. Nevertheless, about 70% of DC patients eventually die from bone marrow failure and consequences. Gene mutations triggering DC affect all organ systems and predispose for infections, hemorrhages and malignant degeneration of rapidly dividing cell types.

It has been suggested that prognosis is somewhat better in DC forms triggered by mutations that are inherited with an autosomal dominant traits.

Etiology

X-linked inheritance has been shown for mutations in DKC1, a gene encoding for the nucleolar protein dyskerin. Such mutations account for about half of all DC cases [1].

Less frequently observed are gene defects affecting TERC (telomerase RNA component), TERT (telomerase reverse transcriptase) and TINF2 whose gene products are required for telomere replication, catalytic activity of telomerases and telomere protection, respectively, and that are inherited with an autosomal dominant trait.

TERT mutations may also be inherited in an autosomal recessive manner and this applies for additional proteins, too [4].

Epidemiology

While DKC1 mutations account for the majority of DC cases, there are several other genes whose gene products interfere with telomerase function and telomere replication. Penetrance varies and environmental factors significantly affect symptom onset and severity. Thus, DC is a very heterogenous disease that is diagnosed if characteristic symptoms such as excess skin pigmentation, nail dystrophy and leukoplakia are detected. Indeed, bone marrow failure is of utmost clinical importance but less obvious than the aforementioned symptoms and is therefore not part of the original definition of DC. And although this generic term comprises several genetic disorders, DC is a rare disease and incidence rates have been estimated to be less than 1 per 1,000,000 individuals [5].

Because the majority of mutations that account for DC is X-linked, males are affected more frequently than females [6]. Symptoms often manifest during childhood, but due to the above mentioned heterogeneity, age at symptom onset, symptoms themselves and severity may vary widely.

Pathophysiology

Chromosomes consist of DNA strands whose ends are formed by non-coding sequence repeats called telomeres. In humans, they may measure several thousand base pairs. However, during DNA replication after successful mitosis, telomeres are shortened. At one point, telomeres are too short for further cell division, chromosomal stability can no longer be guaranteed and cells either remain in a senescent state of indivisibility or undergo apoptosis to avoid malignant degeneration. Indeed, telomere shortening seems to be the molecular basis of aging.

Telomerase is an enzyme capable of adding telomeric sequence repeats to shortened telomeres. It thus prolongs the life cycle of cells, particularly of stem cells and germ cells, and contributes to cellular cancer prevention. Telomerase dysfunctions will mainly affect tissues with fast rates of cell division, e.g., skin, skin appendages, mucosa and bone marrow - those tissues showing symptoms of DC. So far, all gene mutations that have been identified as possible triggers of DC could be linked to telomerase function, telomere protection and replication [7] [8]. DKC1, TERC and TERT gene products are part of the telomerase complex, while other affected proteins fulfill additional functions, e.g., telomere protection. Consequently, dysfunction of proteins defective in DC patients leads to reduced telomerase activity, premature telomere shortening and cellular senescence [9]. In fact, telomeric DNA in DC patients is significantly shorter than in healthy controls of the same age.

In detail, DKC1 encodes for dyskerin, a protein involved in ribosomal RNA metabolism that forms part of the telomerase complex. More than 50 DKC1 mutations have been described so far. Mutations in TERC affect the telomerase RNA component and this molecule serves as the template for telomere replication. TERT, telomerase reverse transcriptase, forms the catalytic subunit of the telomerase complex.

Prevention

No preventive measures can be recommended.

Families with known problems of DC may benefit from genetic counseling.

Summary

Dyskeratosis congenita (DC) is a general term utilized for a variety of genetic disorders whose most characteristic symptoms are excess skin pigmentation, nail dystrophy and mucosal leukoplakia. Disease progress often consists in malignant degeneration of precancerous mucosal lesions, development of squamous cell carcinoma, pulmonary fibrosis or lung cancer [1]. Also, the majority of DC patients eventually suffers from bone marrow failure and possibly subsequent hematologic malignancies. 

Because DC may be triggered by different gene mutations, it may be inherited with an X-linked or autosomal trait, in form of a dominant or recessive allele. To date, ten mutations affecting function and activity of telomerase or associated proteins have been described as potential causes of DC. Presumably, additional mutations may also account for DC since there is a considerable share of DC patients who does not display any of the known gene defects. These mutations lead to premature telomere shortening, tissue and stem cell senescence and predisposition for cancer [2].

The main cause of death in DC patients is bone marrow failure. Only a hematopoietic stem cell transplantation may be effective in avoiding it and in improving the patient's prognosis [3]. Otherwise, there is no causative treatment for DC and only palliative therapy can be provided.

Patient Information

Dyskeratosis congenita (DC) is a general term for genetic disorders associated with premature aging of cells.

Causes

Distinct gene mutations may trigger DC. All these mutations interfere with telomere protection and replication, whereby telomeres are non-coding DNA sequences that confer stability to chromosomes. Each time a cell divides, these telomeres are shortened a little bit. After a determined number of divisions, a cell cannot divide any longer without an increased risk for malignant degeneration and cancer development. Thus, the cell initiates what is called a programmed cell death. However, there are certain cell types that need to maintain their ability to divide, particularly stem cells located in the bone marrow. These cells dispose of an enzyme called telomerase whose function is to re-extend shortened telomeres. Telomerase activity is reduced in DC patients, telomeres are shortened prematurely and cells tend to age much faster than in healthy individuals.

Symptoms

The above explained mechanisms of reduced telomerase activity and accelerated telomere shortening mainly affect tissues characterized by a rapid turn over, e.g. skin, skin appendages, mucosa and bone marrow. Therefore, DC may manifest in form of excess skin pigmentation, nail dystrophy and mucosal leukoplakia, i.e., white patches that become visible on the oral mucosa, as well as bone marrow failure. The latter, in turn, leads to anemia, thrombocytopenia and leukopenia which manifest in fatigue, breathing difficulties, bluish discoloration of the skin, a tendency to bleed, bleeding gums and nosebleed and recurrent infections with any type of pathogen. DC patients also have a high risk of developing cancer.

Diagnosis

A tentative diagnosis may be based on the presence of several of the above mentioned symptoms. Laboratory analyses of blood and bone marrow samples confirm low cell counts of virtually all cell types. If the patient presents alterations that cannot be clearly identified, tissue biopsies may be taken and histopathologically examined. Diagnostic imaging may be applied to evaluate the condition of the patient's lungs and to detect possible tumors. A new diagnostic technique allows for measuring the length of telomeres. Abnormally short telomeres support the diagnosis of DC.

Positive testing for gene mutations known to trigger DC may confirm the diagnosis. However, about one in three DC patients suffers from other, as of yet unknown mutations that cannot be easily detected with genetic analysis.

Treatment

There is no cure for DC. Therapy with androgens or growth hormones may stimulate production of red and white blood cells in the bone marrow. The tendency to bleed may be somewhat counteracted with corticosteroids. However, these drugs only mediate short- to mid-term effects. Patients who suffer mainly from bone marrow failure may benefit from bone marrow or stem cell transplantation. Otherwise, only supportive therapy can be provided.

DC patients should avoid consumption of tobacco and alcohol. Skin care and good oral hygiene are also important and may delay the onset of certain symptoms.

References

  1. Alder JK, Parry EM, Yegnasubramanian S, et al. Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene. Hum Mutat. 2013; 34(11):1481-1485.
  2. Nishio N, Kojima S. Recent progress in dyskeratosis congenita. Int J Hematol. 2010; 92(3):419-424.
  3. Nelson ND, Bertuch AA. Dyskeratosis congenita as a disorder of telomere maintenance. Mutat Res. 2012; 730(1-2):43-51.
  4. Allenspach EJ, Bellodi C, Jeong D, et al. Common variable immunodeficiency as the initial presentation of dyskeratosis congenita. J Allergy Clin Immunol. 2013; 132(1):223-226.
  5. Dokal I. Dyskeratosis congenita. Hematology Am Soc Hematol Educ Program. 2011:480-486.
  6. Karunakaran A, Ravindran R, Arshad M, Ram MK, Laxmi MK. Dyskeratosis congenita: a report of two cases. Case Rep Dent. 2013:845125.
  7. Islam A, Rafiq S, Kirwan M, et al. Haematological recovery in dyskeratosis congenita patients treated with danazol. Br J Haematol. 2013; 162(6):854-856.
  8. Ballew BJ, Joseph V, De S, et al. A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet. 2013; 9(8):e1003695.
  9. Touzot F, Le Guen T, de Villartay JP, Revy P. [Dyskeratosis congenita: short telomeres are not the rule]. Med Sci (Paris). 2012; 28(6-7):618-624.
  10. Scoggins RB, Prescott KJ, Asher GH, et al. Dyskeratosis congenita with Fanconi-type anemia: investigations of immunologic and other defects. Clin Res. 1971; 19:409.
  11. Dokal I, Vulliamy T. Dyskeratosis congenita: its link to telomerase and aplastic anaemia. Blood Rev. 2003; 17(4):217-225.
  12. Rackley S, Pao M, Seratti GF, et al. Neuropsychiatric conditions among patients with dyskeratosis congenita: a link with telomere biology? Psychosomatics. 2012; 53(3):230-235.
  13. Bessler M, Wilson DB, Mason PJ. Dyskeratosis congenita. FEBS Lett. 2010; 584(17):3831-3838.
  14. Alter BP, Baerlocher GM, Savage SA, et al. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood. 2007; 110(5):1439-1447.
  15. Giri N, Pitel PA, Green D, Alter BP. Splenic peliosis and rupture in patients with dyskeratosis congenita on androgens and granulocyte colony-stimulating factor. Br J Haematol. 2007; 138(6):815-817.
  16. Sinha S, Trivedi V, Krishna A, Rao N. Dyskeratosis congenita- management and review of complications: a case report. Oman Med J. 2013; 28(4):281-284.
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