Herein we report a patient who presented with the symptoms of early onset sarcoidosis and also had partial interferon-γ receptor 1 deficiency that presented with BCG-osis. [ncbi.nlm.nih.gov]

Childhood sarcoidosis in Denmark 1979-1994: Incidence, clinical features and laboratory results at presentation in 48 children. Acta Paediatr 2004;93:30-6. 2. Schaller JG. Juvenile rheumatoid arthritis. [ijdvl.com]

Workup for recurrent disease revealed thrombocytopenia, hepatosplenomegaly, and a left pleural effusion. Cultures obtained from pleural fluid were positive for Mycobacterium tuberculosis. The infection was treated and the patient recovered. [omicsonline.org]

"Sarcoidosis Workup". Medscape Reference. WebMD. Archived from the original on 1 March 2014. Retrieved 19 February 2014. Allmendinger A, Perone R (2009). "Case of the Month". Diagnostic Imaging. 31 (9): 10. Joanne Mambretti (2004). [en.wikipedia.org]

Involvement of the orbit and posterior segment of the eye in early-onset sarcoidosis may necessitate prompt and aggressive immunosuppressive treatment to prevent a poor visual outcome. [ncbi.nlm.nih.gov]

Master the latest advances in ophthalmology: radical changes in the management of macular disease, including the widespread introduction of VEGF inhibitor therapy; recent developments in the investigation and treatment of retinal vascular disease; new [books.google.com]

The clinical characteristics, diagnosis, treatment, and outcome for neurosarcoidosis in China are poorly understood. [readbyqxmd.com]

Early and correct diagnosis is important in light of the severe disease prognosis, and the possible therapeutic options. [ncbi.nlm.nih.gov]

Secondary glaucoma, together with sarcoid uveitis, may be severe and portends a poor prognosis with associated severe visual loss. Posterior segment lesions occur in up to 20% of patients with ocular sarcoidosis. [aao.org]

Early sarcoid arthritis is often self-limited, lasting for days to months, and the prognosis is excellent. [rheumaknowledgy.com]

Genetic factors may also be important in defining the pattern of disease presentation, its severity, and the prognosis. [emedicine.medscape.com]

However, the activity of the disease may fluctuate over time. 2.10 What is the long-term prognosis (predicted outcome and course) of the disease? The available data concerning the prognosis in the long-term is limited. [printo.it]

The aim of this study was to assess the efficacy of thalidomide in patients with severe EOS, based on etiology supporting an initial role of NF-kappaB in activation of this disease. [ncbi.nlm.nih.gov]

These findings indicate that the majority of EOS cases reported in Japan shows the genetic etiology of NOD2 mutations that cause constitutive NF-kappaB activation. [jstage.jst.go.jp]

DISEASE: Sarcoidosis, early-onset Entry H01309 Disease Name Sarcoidosis, early-onset Description Early-onset sarcoidosis (EOS) is a special subtype of sarcoidosis, a systematic inflammatory disease with unknown etiology. [genome.jp]

Sarcoidosis and juvenile idiopathic arthritis are both multisystem disorders with poorly understood etiologies. The diagnosis of juvenile idiopathic arthritis depends on the history, clinical features and radiological findings. [ijdvl.com]

References: [1] [2] Epidemiological data refers to the US, unless otherwise specified. Etiology The cause of sarcoidosis is still unknown ;. [amboss.com]

There are very few epidemiological data on children. [elsevier.es]

The purpose of the prospective study was to review epidemiologic data on incidence, prevalence, and clinical characteristics of sarcoidosis. Data was obtained through surveys obtained twice a year. [omicsonline.org]

"The epidemiology of sarcoidosis in Rochester, Minnesota: a population-based study of incidence and survival" (PDF). American Journal of Epidemiology. 123 (5): 840–5. doi : 10.1093/oxfordjournals.aje.a114313. PMID 3962966. [en.wikipedia.org]

Epidemiology Sarcoidosis occurs worldwide, with a prevalence of about 4.7-64 in 100,000, and an incidence of 1.0-35.5 in 100,000 per year [ 1 ]. The highest rates are reported in northern European/Scandinavian and African-American individuals. [patient.info]

Signaling protein and cytokine expression were examined, and the results of these experiments challenge current theories of constitutive NOD2 activation in the pathophysiology of Blau syndrome... [readbyqxmd.com]

Current hypotheses suggest that the etiology is multifactorial : References: [3] Pathophysiology Sarcoidosis is a systemic disorder characterized by both T-cell dysfunction and increased B-cell activity with subsequent local immune hyperactivity and inflammation [amboss.com]

The exact mechanism of this relation is not known, but some evidence supports the hypothesis that this is a consequence of Th1 lymphokine prevalence. [55] [82] Tests of delayed cutaneous hypersensitivity have been used to measure progression. [83] Pathophysiology [en.wikipedia.org]

Involvement of the orbit and posterior segment of the eye in early-onset sarcoidosis may necessitate prompt and aggressive immunosuppressive treatment to prevent a poor visual outcome. [ncbi.nlm.nih.gov]

Conclusion: TNF inhibitors appear to be more effective than IL-6 inhibitor in the treatment of EOS, and may have a potential to prevent the onset of uveitis. Disclosure: T. Nagakura, None; T. Yamatou, None; T. Kubota, None; H. Wakiguchi, None; Y. [acrabstracts.org]

A 1, 5 Calcitonin (Miacalcin) and bisphosphonates may be useful in preventing osteoporosis in patients with sarcoidosis taking long-term steroid therapy. [aafp.org]