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Ebola Virus


Presentation

  • The presentation of the glycoprotein was determined to be critical since virus-like particles, but not soluble glycoproteins, induced high levels of activation.[ncbi.nlm.nih.gov]
Death Anxiety
  • All three patients were mentally alert until shortly before death. Anxiety was very marked in Case 3. Laboratory findings.[enivd.de]
Weight Gain
  • Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.[ncbi.nlm.nih.gov]
Noncompliance
Aspiration
  • Few days after the admission the course of the illness was characterized by severe gastro-intestinal symptoms followed by respiratory failure, accompanied by pulmonary infiltration and high Ebola viral load in the bronchial aspirate and Plasmodium vivax[ncbi.nlm.nih.gov]
  • A 50-μl aliquot of denatured DNA from the infected cells was aspirated through the membrane, and then 50 μl of denaturation buffer and 50 μl of phosphate-buffered saline (PBS) were added.[oadoi.org]
Gallop Rhythm
  • On day 7, the pulse rate increased sharply; the patient complained of substernal pain and developed a gallop rhythm with a pulse rate of 136 beats/minute.[enivd.de]
Conjunctival Petechiae
  • Haemorrhage was manifested in Case 1 by oral and conjunctival petechiae on day 4 of illness, haematemesis and melaena from day 5, gingival bleeding on day 7, and bleeding injection sites on day 8. Case 2 had melaena from day 6.[enivd.de]
Retinal Scar
  • Ocular complications leading to vision loss include cataract, retinal scarring, optic neuropathy, hypotony and phthisis bulbi.[ncbi.nlm.nih.gov]
Cranial Neuropathy
  • The patient developed progressive meningoencephalitis with cranial neuropathies and radiculopathy. Clinical recovery was associated with addition of high-dose corticosteroids during GS-5734 treatment.[ncbi.nlm.nih.gov]
Radiculopathy
  • The patient developed progressive meningoencephalitis with cranial neuropathies and radiculopathy. Clinical recovery was associated with addition of high-dose corticosteroids during GS-5734 treatment.[ncbi.nlm.nih.gov]
Oligomenorrhea
  • Some 16 female survivors (10.8%) had miscarriages, whereas 9 (6.1%) had complaints of oligomenorrhea, 7 (4.7%) loss of sexual desire and 4 (2.7%) premature menopause.[ncbi.nlm.nih.gov]

Workup

Pulmonary Infiltrate
  • Few days after the admission the course of the illness was characterized by severe gastro-intestinal symptoms followed by respiratory failure, accompanied by pulmonary infiltration and high Ebola viral load in the bronchial aspirate and Plasmodium vivax[ncbi.nlm.nih.gov]
Human Herpesvirus 8
  • The human herpesvirus 6B (HHV-6B) [ 7 ] and the Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus 8 [HHV-8]) [ 8 ] are amongst typical blood-borne viral pathogens affecting humans.[oadoi.org]
Viral Inclusion Body
  • These aggregates were likely viral inclusion bodies. The aggregated inclusions became smaller at approximately 36 h.p.i. Approximately 100–200 aggregates with an average diameter of 10 nm were detected in the infected cells.[dx.doi.org]

Treatment

  • Treatment remains supportive although a variety of specific treatments are still in the early stages of investigation. This report reviews the clinical virology of Ebola virus, the reported proposed treatments, and the current outbreak.[ncbi.nlm.nih.gov]

Prognosis

  • ., Böhle, E. (1971) Clinical Course and Prognosis of Marburg Virus ('Green-Monkey') Disease, in Marburg Virus Disease, ed., Martini,G.A. and Siegert, R. New York, Springer, pp. 10-18. 5.[enivd.de]

Etiology

  • Explore the etiology of Ebola and other viral hematic fevers. Explain the epidemiology of the 2014 Ebola epidemic and why this outbreak is different than previous ones.[coursera.org]
  • The CDC confirmed EBO as the etiologic agent responsible for the disease in all 14 patients (the index patient and the medical personnel who subsequently contracted it nosocomially from him) ( 10 ).[web.stanford.edu]
  • “So you would have perhaps an infectious etiology that tips the balance of the immune system, causing a dysregulation that leads to overly active inflammatory processes.” 2 Take-Home Messages 1. Take precautions with post-Ebola patients.[aao.org]

Epidemiology

  • A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link.[ncbi.nlm.nih.gov]
  • Gire et al. describe Ebola epidemiology on the basis of 99 whole-genome sequences, including samples from 78 affected individuals.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Zaire ebolavirus is uniformly lethal in these macaques, and experts have assumed that its pathology and pathophysiology closely resemble those of ebolavirus infections in humans; immunosuppression, increased vascular permeability, and impaired coagulation[dx.doi.org]
  • Our understanding of the pathophysiological mechanisms of post-EVD sequelae is limited to uveitis and meningoencephalitis [ 19 ].[academic.oup.com]

Prevention

  • Ways to prevent ebola virus, Best way to prevent ebola virus, How to prevent ebola virus, Ways to prevent ebola virus disease, How to prevent ebola virus disease, Ways to prevent ebola virus spreading. 10 Ways To Prevent Ebola virus Infecting your Body[web.archive.org]
  • Author information 1 Social & Behavioral Research and Evaluation Branch, Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, & TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia[ncbi.nlm.nih.gov]
  • […] proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus. May directly bind to STAT1 to prevent its signaling.[viralzone.expasy.org]

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