Presentation
One patient had a brain hydatid cyst which presented as a space-occupying lesion. The second patient presented with symptoms and signs of cardiac tamponade due to pericardial hydatidosis. [ncbi.nlm.nih.gov]
Entire Body System
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Inflammation
This infection is characterized by the growth in internal organ parenchymae of fluid-filled structures (hydatids) that elicit surprisingly little inflammation in spite of their massive size and persistence. [ncbi.nlm.nih.gov]
Salim, Natalia Macchiaroli, Marcela Cucher, Federico Camicia, Adolfo Fox, Mara Rosenzvit, Guilherme Oliveira & Laura Kamenetzky BMC Genomics (2017) Echinococcus granulosus Antigen B binds to monocytes and macrophages modulating cell response to inflammation [dx.doi.org]
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Wheelchair Bound
At the time of referral, the patient was wheelchair bound and unable to walk by herself (Frankel Grade C). Standard antiinfectious therapy of Echinococcus granulosus requires a minimum treatment period of 3 months. [ncbi.nlm.nih.gov]
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Soft Tissue Mass
Hydatid disease, albeit rare, should be considered in the differential diagnosis of a soft tissue mass. [ncbi.nlm.nih.gov]
Gastrointestinal
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Abdominal Pain
A 32-year-old woman was admitted to hospital complaining of right upper quadrant and epigastrium abdominal pain, and nausea. On routine physical examination an abdominal mass was discovered on the right upper quadrant. Liver tests were normal. [ncbi.nlm.nih.gov]
Initial symptoms include abdominal pain, jaundice, hepatomegaly, sometimes fever and anaemia, weight loss, and pleural pain ( 3, 48, 178 ). The advanced stage is characterized by severe hepatic dysfunction, often associated with portal hypertension. [doi.org]
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Abdominal Mass
On routine physical examination an abdominal mass was discovered on the right upper quadrant. Liver tests were normal. Magnetic resonance imaging of the abdomen revealed a low-density cystic mass. A cystectomy was performed. [ncbi.nlm.nih.gov]
The main clinical manifestations include abdominal pain, palpable abdominal masses, loss of weight, jaundice, hepatomegaly, anaemia, fever, hemoptysis (in cases of lung involvement), and, in about 25% of patients, signs of portal hypertension and biliary [doi.org]
Neurologic
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Rabies
Nancy Laboratory for Rabies and Wildlife, Wildlife Surveillance and Eco-epidemiology Unit, Technopôle Agricole et Vétérinaire, B.P. 40009, 54220, Malzéville, France, [email protected] [ncbi.nlm.nih.gov]
Evidence is accumulating that in parts of Europe the fox population densities have increased in recent years ( 23 ), possibly due to reduced fox mortality after the introduction of anti-rabies vaccination. [doi.org]
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Unable to Walk
At the time of referral, the patient was wheelchair bound and unable to walk by herself (Frankel Grade C). Standard antiinfectious therapy of Echinococcus granulosus requires a minimum treatment period of 3 months. [ncbi.nlm.nih.gov]
Workup
Microbiology
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Penicillium
Therefore, the objective of this study was to evaluate the scolicidal efficacies of synthesized silver nanoparticles (AgNPs) derived from the aqueous aerial extract of Penicillium aculeatum against protoscolices of CHD in-vitro. [ncbi.nlm.nih.gov]
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Fusarium
An average anticestodal activity was observed with different endophytic fungal strains, that is, Nigrospora (479 2.9), Colletotrichum (469 25.8), Fusarium (355 14.5), and Chaetomium (332 28.3) showing 64 to 70% protoscolicidal activity, except Pestalotiopsis [ncbi.nlm.nih.gov]
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Malassezia Furfur
The protein, named EA21, has close homology with Malassezia furfur cyclophilin allergen (Mal f 6) and with human cyclophilin. [ncbi.nlm.nih.gov]
Biopsy
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Liver Biopsy
Liver biopsy samples from patients with steatohepatitis (SH, n 11) and chronic hepatitis (CH, n 11) were used as non-inflammatory and chronic inflammatory controls, respectively. [ncbi.nlm.nih.gov]
Treatment
No apparently successful cases of drug treatment of E. granulosus infection have been verified by animal inoculation of cyst material; therefore, surgery must still be considered the treatment of choice. [ncbi.nlm.nih.gov]
If a human becomes infected there are a variety of methods for treatment. The most common treatment in the past years has been surgical removal of the hydatid cysts. [en.wikipedia.org]
Prognosis
[…] hydatid serology Reliable antibody detection tests exist for E. multilocularis and E. granulosus Radiology images Images hosted on other servers: Large primary hydatid cyst Prognostic factors Unilocular cysts appropriately treated have an excellent prognosis [pathologyoutlines.com]
Chemotherapy of human cystic hydatid disease: indications, effectiveness, prognosis. Mediterran. J. Infect. Parasit. Dis. 13 : 89 -94. Torgerson, P. 2002. Transmission dynamics of taeniid parasites in animal hosts, p. 221 -235. In P. Craig and Z. [doi.org]
Etiology
The etiological agent, Echinococcus granulosus sensu lato, implies dogs and other canids as definitive hosts and different herbivore species as intermediate hosts. [ncbi.nlm.nih.gov]
Lightowlers Echinococcus granulosus sensu lato (s. l.) is the etiological agent causing cystic echinococcosis (CE) in animals and humans. [journals.elsevier.com]
[…] multilocularis (alveolar hydatid disease) or E. vogeli (polycystic hydatid disease) Humans become infected by eating food contaminated with tapeworm eggs, becoming intermediate hosts ( Wikipedia: Echinococcus [Accessed 5 January 2018] ) Pathophysiology / etiology [pathologyoutlines.com]
Epidemiology
The present study describes a fast and simple method for the differentiation of CE causing Echinococcus species which can facilitate epidemiological studies in endemic countries. Copyright 2013 Elsevier B.V. All rights reserved. [ncbi.nlm.nih.gov]
Pathophysiology
[…] commonly E. multilocularis (alveolar hydatid disease) or E. vogeli (polycystic hydatid disease) Humans become infected by eating food contaminated with tapeworm eggs, becoming intermediate hosts ( Wikipedia: Echinococcus [Accessed 5 January 2018] ) Pathophysiology [pathologyoutlines.com]
Prevention
This study increases the basic molecular data needed for the molecular diagnosis, epidemiology, prevention, and control of Echinococcus diseases. [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]
In order to prevent transmission to dogs from intermediate hosts, dogs can be given anthelminthic vaccinations. [en.wikipedia.org]