In the present study, nucleotide, amino acid, and phylogenetic analyses for all genomic regions were conducted. For the detection of recombination events, Simplot and bootscan analyses were carried out. [ncbi.nlm.nih.gov]

Generalized Disease of the Newborn Neonates often present with an illness resembling bacterial sepsis, with fever, irritability, and lethargy. [doctorslounge.com]

• Pain

  Pleurodynia (Bornholm Disease) Patients with pleurodynia present with an acute onset of fever and spasms of pleuritic chest or upper abdominal pain. Chest pain is more frequent in adults, and abdominal pain is more common in children. [doctorslounge.com]

  Symptoms consist of fever with dyspnea (shortness of breath) and chest pain. Arrhythmias, heart failure, and myocardial infarction have also been reported. Acute hemorrhagic conjunctivitis (eye) can be caused by enteroviruses. [getwellstaywellathome.com]

  The illness is characterized by an abrupt onset of fever and sharp spasms of pain involving the intercostal muscles. Pain may also involve abdominal muscles and mimic acute abdomen. [emedicine.medscape.com]

• Sepsis

  Neonates infected with nonpolio enteroviruses are at high risk for developing significant illness, including sepsis-like illness, meningoencephalitis, myocarditis and/or hepatitis. [ncbi.nlm.nih.gov]

• Vomiting

  Table 1 E30 isolate used for phylogenetic analysis 2012EM1C1 20-May-2012 CSF 8 Headache, Fever, Vomiting 2012EM3C1 20-May-2012 CSF 7 Headache, Fever, Vomiting 2012EM4C1 20-May-2012 CSF 8 Headache, Fever, Vomiting 2012EM11C1 21-May-2012 CSF 7 Headache, [virologyj.com]

  Meanwhile, vomiting occurred in majority of the patients and diarrhea in parts of them. White blood cells in cerebrospinal fluid (CSF) exceeded normal range in all patients. Protein levels in CSF were above normal range in half of the patients. [ncbi.nlm.nih.gov]

  […] travels to regional lymph nodes and central nervous system Prognosis most infections with echovirus are asymptomatic neonates with aseptic meningitis are at highest risk of death with mortality up to 10% Presentation Symptoms prodrome with fever, nausea, vomiting [step1.medbullets.com]

  The headache became more severe the following day, and he vomited three times. He was admitted to Children's Hospital, Buffalo, on the sixth day of illness. Five family associates of the patient were well. [jamanetwork.com]

• Diarrhea

  Clinical manifestations of neonatal echovirus type 18 infections include a nonspecific febrile illness, diarrhea, and meningitis with or without exanthem. [ncbi.nlm.nih.gov]

  At the time of the isolation of the viruses the diseases they caused were not known, hence the term “orphan,” but it is now known that they cause many different types of human disease, especially viral meningitis, diarrhea, and various respiratory diseases [medical-dictionary.thefreedictionary.com]

• Myalgia

  Fever and myalgias with clinical defervescence followed by reappearance of fever and headache herald the onset of meningitis, similar to what is observed in poliomyelitis. Meningismus, when present, varies from mild to severe. [emedicine.medscape.com]

  Myalgia was specifically inquired about, and reported in 7 of 40 (17.5%). Twenty three of 40 (58%) had fever on admission, 30 of 38 (79%) had clinical photophobia, and 27 (68%) had meningism on examination. [ncbi.nlm.nih.gov]

  Echovirus 30 detection in an outbreak of acute myalgia and rhabdomyolysis, Brazil 2016-2017. Clin. Microbiol. Infect. 25:e255. Google Scholar Tao, Z., Song, Y., Li, Y., Liu, Y., Jiang, P., Lin, X., et al. (2012). [frontiersin.org]

  Other systemic features of myalgia and arthralgia were also typical. 1 The laboratory findings were also consistent with viral meningitis. [health.gov.au]

  The patient experienced intense myalgia in her legs and lower back, for which she required a patient-controlled analgesic pump for pain control. [academic.oup.com]

• Kernig's Sign

  cardiovascular or respiratory symptoms), signs (temperature, photophobia, neck stiffness, Kernig's sign, focal neurological signs) and laboratory data (full blood count, differential white cell count, biochemistry including liver function tests). [health.gov.au]

  Kernig's sign was positive in 3 of 22 (14%), and fundoscopy was abnormal in 2 of 30 (7%). Nine of 40 patients had a CT scan of the head performed, all of which were normal. [ncbi.nlm.nih.gov]

• Testicular Pain

  CASE A previously healthy man in his 20s developed unilateral testicular pain and swelling. Four days later, he developed headache and fever. [academic.oup.com]

• Toxoplasma Gondii

  gondii [24] Aspergillus species Cryptococcus species Schistosoma species a Epididymitis and orchitis typically present. [academic.oup.com]

Based on IVIg treatment failure, we predict that one of these factors could be immune related. [ncbi.nlm.nih.gov]

Rare symptoms include viral meningitis, which affects the brain and spinal cord.[5] Treatment[edit] Echovirus infection mostly clears up on its own. [en.wikipedia.org]

There aren’t currently any antiviral treatments available for echovirus infection, but research is being conducted on possible treatments. Usually, there are no long-term complications. [healthline.com]

[…] species, but treatment with lecithinase D had little or no effect. [jimmunol.org]

Prognosis Neonates with disseminated encephalitis have a poor prognosis and many die. Children and older patients have a better prognosis, but the disease is occasionally fatal. [emedicine.medscape.com]

[…] immunosuppressed status exposure to others with echovirus public swimming pool Pathogenesis echovirus binds to decay-accelerating factor, a receptor the virus then replicates in Peyer’s patches it travels to regional lymph nodes and central nervous system Prognosis [step1.medbullets.com]

Outlook (Prognosis) People who have the less severe types of illness should recover completely without treatment. Infections of organs such as the heart may cause severe disease and can be deadly. [nicklauschildrens.org]

Thirty-four samples which were positive for enterovirus were subject to group-specific PCR, sequencing, and phylogenetic analysis to identify the etiological agent of the outbreak. [ncbi.nlm.nih.gov]

ABSTRACT Background and objective: Aseptic meningitis can be caused by several agents, and in many cases the etiology remains unknown. [pesquisa.bvsalud.org]

KEYWORDS: Enterovirus; Germany; Lineages; Meningitis; Molecular epidemiology; RNA-sequencing; Recogroups; Recombination MeSH terms, Substance MeSH terms Cerebrospinal Fluid/virology Child Child, Preschool Disease Outbreaks* Echovirus Infections/epidemiology [ncbi.nlm.nih.gov]

Chinese Journal of Epidemiology. 2006, 27: 793-797. [virologyj.com]

Pathophysiology Human echoviral infection occurs via fecal-oral transmission. Host susceptibility depends on the presence of specific cellular membrane receptor proteins that bind different enteroviral types along taxonomic lines. [emedicine.medscape.com]

Abstract Replacement therapy using intravenous immunoglobulin (IVIG) preparations in people with antibody deficiencies is effective in preventing the majority of common bacterial and viral infections, yet echovirus break-through infections have occurred [ncbi.nlm.nih.gov]

Prevention The predominantly mild symptoms and the ubiquitous nature of these infections, means that preventative measures are not usually necessary or recommended. Back to Top [hps.scot.nhs.uk]

Infection with an Echovirus cannot be directly prevented, and there’s no vaccine available. It can be challenging to control the spread of the virus. [healthline.com]