In the present study, nucleotide, amino acid, and phylogenetic analyses for all genomic regions were conducted. For the detection of recombination events, Simplot and bootscan analyses were carried out. [ncbi.nlm.nih.gov]

Generalized Disease of the Newborn Neonates often present with an illness resembling bacterial sepsis, with fever, irritability, and lethargy. [doctorslounge.com]

• Unconsciousness

  He had convulsions, right hemiplegia, cortical motor aphasia, left abducens nerve paralysis, left hypoglossal nerve paralysis, and later became unconscious. [ncbi.nlm.nih.gov]

• Hyperthermia

  The pattern of illness in the neonatal period was diphasic, marked by hyperthermia and the occurrence of seizures. Echovirus was recovered from the cerebrospinal fluid. [ncbi.nlm.nih.gov]

• Poor Feeding

  At 5 days of age, both twins experienced poor feeding, lethargy and hypothermia, and evidence of coagulopathy and hepatitis. [ncbi.nlm.nih.gov]

• Hypothermia

  At 5 days of age, both twins experienced poor feeding, lethargy and hypothermia, and evidence of coagulopathy and hepatitis. [ncbi.nlm.nih.gov]

• Diarrhea

  Clinical manifestations of neonatal echovirus type 18 infections include a nonspecific febrile illness, diarrhea, and meningitis with or without exanthem. [ncbi.nlm.nih.gov]

  At the time of the isolation of the viruses the diseases they caused were not known, hence the term “orphan,” but it is now known that they cause many different types of human disease, especially viral meningitis, diarrhea, and various respiratory diseases [medical-dictionary.thefreedictionary.com]

• Left Ventricular Dysfunction

  Echovirus 7 infection associated with encephalomyelitis could be fatal due to indirect involvement of the heart resulting in severe left ventricular dysfunction. [ncbi.nlm.nih.gov]

• Heart Disease

  Coxsakievirus B3 (CVB3) is a member of enterovirus B (EVB) group, which can cause serious heart diseases such as viral myocarditis. [ncbi.nlm.nih.gov]

• Altered Mental Status

  Some patients also showed cold symptoms, sore throat, altered mental status, and seizures. We did not observe a higher fatality rate in children with E6 or E30 infection. Most of the patients recovered uneventfully. [ncbi.nlm.nih.gov]

• Tremor

  In the course of a prolonged upper respiratory-tract infection, the patient developed muscular hypotonia, resting tremor, ataxia, sleepiness, hyperaesthesia, and indistinct speech. [ncbi.nlm.nih.gov]

• Aphasia

  He had convulsions, right hemiplegia, cortical motor aphasia, left abducens nerve paralysis, left hypoglossal nerve paralysis, and later became unconscious. [ncbi.nlm.nih.gov]

• Resting Tremor

  In the course of a prolonged upper respiratory-tract infection, the patient developed muscular hypotonia, resting tremor, ataxia, sleepiness, hyperaesthesia, and indistinct speech. [ncbi.nlm.nih.gov]

• Focal Seizure

  A fatal case of echovirus type 9 infection is reported in a 9 month old boy who presented with a fever and a macular rash followed by two focal seizures. Echovirus type 9 was isolated from lung tissue after seven days. [ncbi.nlm.nih.gov]

• Cholesterol Increased

  Loading of lipid starved cells with cholesterol increased infection to some extent but could not completely restore EV1 infection to control levels. [ncbi.nlm.nih.gov]

• White Matter Lesions

  A case of fatal encephalitis with white matter lesions caused by echovirus 18 is described, and it highlights the role of EV CNS infection as a potential cause of leukoencephalitis in infants. [ncbi.nlm.nih.gov]

Based on IVIg treatment failure, we predict that one of these factors could be immune related. [ncbi.nlm.nih.gov]

Older children and adults have a better prognosis. Myocarditis is the most frequent complication in adults. Echovirus, like the other Enteroviruses Coxsackievirus A and B, typically causes a mild, nonspecific illness with a low fever. [en.wikipedia.org]

[…] immunosuppressed status exposure to others with echovirus public swimming pool Pathogenesis echovirus binds to decay-accelerating factor, a receptor the virus then replicates in Peyer’s patches it travels to regional lymph nodes and central nervous system Prognosis [step1.medbullets.com]

Prognosis Neonates with disseminated encephalitis have a poor prognosis and many die. Children and older patients have a better prognosis, but the disease is occasionally fatal. [emedicine.medscape.com]

Thirty-four samples which were positive for enterovirus were subject to group-specific PCR, sequencing, and phylogenetic analysis to identify the etiological agent of the outbreak. [ncbi.nlm.nih.gov]

KEYWORDS: Enterovirus; Germany; Lineages; Meningitis; Molecular epidemiology; RNA-sequencing; Recogroups; Recombination MeSH terms, Substance MeSH terms Cerebrospinal Fluid/virology Child Child, Preschool Disease Outbreaks* Echovirus Infections/epidemiology [ncbi.nlm.nih.gov]

Pathophysiology Human echoviral infection occurs via fecal-oral transmission. Host susceptibility depends on the presence of specific cellular membrane receptor proteins that bind different enteroviral types along taxonomic lines. [emedicine.medscape.com]

The measures taken to prevent further spread of infection with special reference to the use of human normal immunoglobulin are described. [ncbi.nlm.nih.gov]

Prevention The predominantly mild symptoms and the ubiquitous nature of these infections, means that preventative measures are not usually necessary or recommended. Back to Top [hps.scot.nhs.uk]