Severe infection in neonates presenting as hepatic failure is rare. [journals.lww.com]

One patient presented with hepatitis without disseminated intravascular coagulopathy (3). [nature.com]

Generalized Disease of the Newborn Neonates often present with an illness resembling bacterial sepsis, with fever, irritability, and lethargy. [doctorslounge.com]

While these viruses are genetically similar, there is wide variation in clinical presentation, distribution, and prevalence. [culturecollections.org.uk]

Author information 1 Special Care Baby Unit, John Radcliffe Hospital, Oxford, UK. [email protected] Abstract We present a case of non-immune hydrops fetalis presenting acutely in the third trimester caused by echovirus infection. [ncbi.nlm.nih.gov]

• Fever

  dysphagia; vomiting, and fever. [lecturio.com]

  […] management — if you have a fever, your doctor may give you medicine to reduce it Organ transplant — if organs like your heart or liver are severely damaged and begin to fail, your doctor may recommend replacing them Outlook for Echovirus 11 Infection [webmd.com]

  Generalized Disease of the Newborn Neonates often present with an illness resembling bacterial sepsis, with fever, irritability, and lethargy. [doctorslounge.com]

  ECHO vi·rus an enterovirus from a large group of unrelated viruses belonging to the Picornaviridae, isolated from humans; although many inapparent infections occur, certain serotypes are associated with fever and aseptic meningitis, and some appear to [medical-dictionary.thefreedictionary.com]

  Common symptoms include shortness of breath, chest pain, fever, and weakness. [emedicine.medscape.com]

• Weakness

  Common symptoms include shortness of breath, chest pain, fever, and weakness. [emedicine.medscape.com]

  In this case, you might have severe neurological symptoms including palsy, muscle weakness, or paralysis. An echovirus 11 infection could severely damage your heart, liver, or kidneys. This may lead to permanent problems in these organs. [webmd.com]

  […] serotypes ( 1-9, 11-27, 29-30) SECTION II - HEALTH HAZARD PATHOGENICITY: Most infections are subclinical; clinical manifestations vary from mild to lethal and acute to chronic; associated with aseptic meningitis (mostly serotypes 2,5,6,7 and 9), muscle weakness [msdsonline.com]

  Enteroviruses can also produce the Guillian-Barr é syndrome, which involves weakness and paralysis of the extremities and even the muscles of respiration. [encyclopedia.com]

  One additional complication is the post-polio syndrome in which weakness suddenly worsens many years or even decades after the initial illness. This can be accompanied by pain and general fatigue. [infectiousdiseaseadvisor.com]

• Fatigue

  Encephalitis may present with mild symptoms such as headache, fever, fatigue, and muscle and joint pain or with severe symptoms such as seizures, altered consciousness, and paralysis. [lecturio.com]

  A 2007 study suggested that acute respiratory or gastrointestinal infections associated with enterovirus may be a factor in chronic fatigue syndrome. [getwellstaywellathome.com]

  This can be accompanied by pain and general fatigue. Management of post-polio syndrome is supportive, with pain control and a regular but non-strenuous exercise or physical therapy regimen. [infectiousdiseaseadvisor.com]

  Chronic fatigue. Liver inflammation (hepatitis). Inflammation of the pancreas (pancreatitis). Diabetes. Heart muscle disease (cardiomyopathy) . [patient.info]

• Movement Disorder

  Pharyngitis and other symptoms of upper respiratory tract infection are often present. [8] Complications such as febrile seizures, lethargy, coma, and movement disorders are reported in 5%-10% of cases and may overlap with an encephalitis-type illness [emedicine.medscape.com]

• Sore Throat

  Herpangina Herpangina is usually caused by coxsackievirus A and presents as acute-onset fever, sore throat, dysphagia, and grayish-white papulovesicular lesions on an erythematous base that ulcerate. [doctorslounge.com]

  Sore throat and dysphagia are the prominent symptoms and precede the appearance of the oral lesions. [emedicine.medscape.com]

  throat, bronchitis, bronchiolitis Echovirus respiratory tract infections will cause similar symptoms to those of rhinovirus, adenovirus and respiratory syncytial virus. [healthblurbs.com]

  Symptoms depend on the site of infection and may include: Croup (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis) Severe [medlineplus.gov]

  Symptoms include fever, muscle pain, sore throat, gastrointestinal distress, and headache. Abdominal discomfort may also be reported in some patients. Enteroviruses are by far the most common causes of aseptic meningitis in children. [getwellstaywellathome.com]

• Cough

  Symptoms depend on the site of infection and may include: Croup (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis) Severe [medlineplus.gov]

  […] cord Myocarditis — inflammation of your heart muscle Hepatitis — inflammation of your liver Encephalitis — swelling of your brain Symptoms of echovirus 11 infections in babies, as well as adults, can include: Fever Diarrhea Rash Jaundice Congested nose Cough [webmd.com]

  It is a good idea to cover the mouth and nose when coughing and sneezing and to avoid contact with other people who are coughing and sneezing. [humanillnesses.com]

  Symptoms Symptoms depend on the site of infection and may include: Croup (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis [account.allinahealth.org]

  Respiratory illness Echovirus, similar to many enteroviruses, may be associated with pyrexial illness (the so-called summer grippe), with sore throat, cough, or coryza. Echovirus 11 can be associated with croup. [emedicine.medscape.com]

• Common Cold

  They’re second only to rhinoviruses as the most common viruses that affect people. (Rhinoviruses are often responsible for causing the common cold.) [healthline.com]

  cold, sore throat, bronchitis, bronchiolitis Echovirus respiratory tract infections will cause similar symptoms to those of rhinovirus, adenovirus and respiratory syncytial virus. [healthblurbs.com]

  However, it is now known that echoviruses can cause a number of different diseases, including rashes, diarrhea, respiratory infections (such as the common cold, sore throat, bronchitis, and bronchiolitis), muscle inflammation, meningitis, encephalitis [medicinenet.com]

  An Enteric Cytopathic Human Orphan virus or ECHOvirus is a type of RNA-virus (a similar structure to the common cold ). The virus enters the body through the digestive tract, replicates in the intestines, and then spreads to the rest of the body. [house.wikia.com]

  Viruses cause familiar infectious diseases such as the common cold, flu and warts. They also cause severe illnesses such as HIV/AIDS, smallpox, and Ebola. Viruses are like hijackers. [icdlist.com]

• Pharyngitis

  Nuchal rigidity, conjunctival suffusion, oral ulcerations, and pharyngeal injection were present. Laboratory examination revealed a white blood cell count of 13,900 per mm3 (60% lymphocytes), AST 189 U/l, ALT 205 U/l, and γ-GT 100 U/l. [ejinme.com]

  Symptoms include elevated temperature, pharyngitis, and dysphagia. It is commonly observed in summer outbreaks involving younger children, often younger than 10 years, and less common in adolescents and young adults. [emedicine.medscape.com]

  Echovirus pathogens can cause a broad range of health conditions and symptoms, like: croup diarrhea myositis paralysis herpangina pneumonia pericarditis pleurodynia myocarditis encephalitis neonatal sepsis viral meningitis viral pharyngitis respiratory [healthblurbs.com]

  These patients were afflicted consecutively with febrile illnesses, and ECHO 9 virus was isolated from the pharyngeal secretions of both patients. [annals.org]

• Dyspnea

  Symptoms consist of fever with dyspnea (shortness of breath) and chest pain. Arrhythmias, heart failure, and myocardial infarction have also been reported. Acute hemorrhagic conjunctivitis (eye) can be caused by enteroviruses. [getwellstaywellathome.com]

  Pericarditis and/or myocarditis are typically caused by enteroviruses; symptoms consist of fever with dyspnea and chest pain. Arrhythmias, heart failure, and myocardial infarction have also been reported. [en.wikipedia.org]

• Vomiting

  Echovirus 30 was isolated from the case who vomited into the pool and from six other cases. [ncbi.nlm.nih.gov]

  Three days after admission, the patient was afebrile but she experienced acute mid-epigastric pain and multiple episodes of vomiting. [ejinme.com]

  (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis) Severe headache, mental status changes, fever and chills, nausea and vomiting [medlineplus.gov]

  Nausea and vomiting are also common. Pleurodynia (Bornholm Disease) Patients with pleurodynia present with an acute onset of fever and spasms of pleuritic chest or upper abdominal pain. [doctorslounge.com]

• Nausea

  […] include: Croup (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis) Severe headache, mental status changes, fever and chills, nausea [medlineplus.gov]

  Nausea and vomiting are also common. Pleurodynia (Bornholm Disease) Patients with pleurodynia present with an acute onset of fever and spasms of pleuritic chest or upper abdominal pain. [doctorslounge.com]

  The most frequent symptoms were headache (100%), photophobia (87.5%), nausea (67.5%), vomiting (65%), fever (65%), and neck stiffness (62.5%). [ncbi.nlm.nih.gov]

  […] it travels to regional lymph nodes and central nervous system Prognosis most infections with echovirus are asymptomatic neonates with aseptic meningitis are at highest risk of death with mortality up to 10% Presentation Symptoms prodrome with fever, nausea [medbullets.com]

• Abdominal Pain

  Pleurodynia (Bornholm Disease) Patients with pleurodynia present with an acute onset of fever and spasms of pleuritic chest or upper abdominal pain. Chest pain is more frequent in adults, and abdominal pain is more common in children. [doctorslounge.com]

  Coxsackie viruses cause sore throat or fever with chest or abdominal pains. [britannica.com]

  Pleurodynia: Pleurodynia is typified by the abrupt onset of chest and abdominal pain and spasms. Commonly caused by coxsackie A and echoviruses, this is more common in teens and adults. Most people have symptoms for 4-6 days. [pedclerk.bsd.uchicago.edu]

  Although some children with enteroviral infections may have no signs and symptoms, other youngsters can develop a high fever as well as a wide range of other symptoms, including a sore throat, vomiting, diarrhea, abdominal pain, skin eruptions, eye inflammation [healthychildren.org]

  Most people have a high temperature (fever), and you might also have headache, generally aching muscles, cough, sore throat, abdominal pain or diarrhoea. [patient.info]

• Dysphagia

  Sore throat and dysphagia are the prominent symptoms and precede the appearance of the oral lesions. [emedicine.medscape.com]

  Herpangina Herpangina is usually caused by coxsackievirus A and presents as acute-onset fever, sore throat, dysphagia, and grayish-white papulovesicular lesions on an erythematous base that ulcerate. [doctorslounge.com]

  Coxiella/Q Fever Clinical URTI Herpangina Herpangina Acute types of coxsackievirus infections or echovirus infections that usually affect children during the summer and are characterized by vesiculoulcerative lesions on the mucous membranes of the throat; dysphagia [lecturio.com]

  Herpangina is caused by Coxsackie A virus and results in a vesicular rash in the oral cavity and on the pharynx, along with high fever, sore throat, malaise, and often dysphagia (difficulty swallowing), loss of appetite, back pain, and headache. [getwellstaywellathome.com]

  Herpangina is caused by Coxsackie A virus, and causes a vesicular rash in the oral cavity and on the pharynx, along with high fever, sore throat, malaise, and often dysphagia, loss of appetite, back pain, and headache. [en.wikipedia.org]

• Decreased Bowel Sounds

  Although gastrointestinal bleeding could be a DIC manifestation, abdominal distention with decreased bowel sounds along with bilious gastric tube suggested the presence of acute gastrointestinal injury. [ncbi.nlm.nih.gov]

• Chest Pain

  Common symptoms include shortness of breath, chest pain, fever, and weakness. [emedicine.medscape.com]

  Symptoms depend on the site of infection and may include: Croup (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis) Severe [medlineplus.gov]

  Pleurodynia (Bornholm Disease) Patients with pleurodynia present with an acute onset of fever and spasms of pleuritic chest or upper abdominal pain. Chest pain is more frequent in adults, and abdominal pain is more common in children. [doctorslounge.com]

  When to Call Your Pediatrician Call your pediatrician if your child complains of neck pain, chest pain, difficulty breathing, listlessness, or lethargy. [healthychildren.org]

  Symptoms Symptoms depend on the site of infection and may include: Croup (breathing difficulty and harsh cough) Mouth sores Skin rashes Sore throat Chest pain if the infection affects the heart muscle or sac-like covering around the heart (pericarditis [account.allinahealth.org]

• Myalgia

  A 40-year-old Caucasian woman was admitted to our hospital with high fever, intense frontal headache, multiple episodes of vomiting, rash, and myalgias that had started 2 days prior to her admission. [ejinme.com]

  Fever and myalgias with clinical defervescence followed by reappearance of fever and headache herald the onset of meningitis, similar to what is observed in poliomyelitis. Meningismus, when present, varies from mild to severe. [emedicine.medscape.com]

  Myalgia was specifically inquired about, and reported in 7 of 40 (17.5%). Twenty three of 40 (58%) had fever on admission, 30 of 38 (79%) had clinical photophobia, and 27 (68%) had meningism on examination. [ncbi.nlm.nih.gov]

  Other names for Bornholm disease are epidemic pleurodynia or epidemic myalgia. Bornholm disease symptoms The main symptom is pain in the lower part of the chest (pleurodynia) or the upper part of the tummy (abdomen). [patient.info]

  Rawlings, 2004 10 Neurotropic Viral Infections Echovirus infections may also result in paralysis, encephalitis, neonatal sepsis, exanthema, respiratory disease, myalgia, and myocarditis. [educalingo.com]

• Eruptions

  Rubelliform eruption ( rash looks like rubella ): E2 Morbilliform eruption ( rash looks like measles ): E6, E11, E25 Petechiae (tiny purple spots or purpura ): E11, E19 Punctate macular eruption : E19 A vesicular eruption (blisters): E11 Eczema coxsackium [dermnetnz.org]

  Meningitis Asymmetric flaccid paralysis Bulbar involvement URTI Exanthem Exanthem Diseases in which skin eruptions or rashes are a prominent manifestation. [lecturio.com]

  Zoster-like eruption due to echovirus 6. Am J Dis Child 1979; 133: 283–4. PubMed Google Scholar Foreman RE, Guiterrez A. Aseptic meningitis associated with echovirus type 6 and 9 infections in Carlsbad, New Mexico. [nature.com]

  Although some children with enteroviral infections may have no signs and symptoms, other youngsters can develop a high fever as well as a wide range of other symptoms, including a sore throat, vomiting, diarrhea, abdominal pain, skin eruptions, eye inflammation [healthychildren.org]

• Epistaxis

  DIC was evident from bleeding manifestation, including epistaxis, hematemesis, and hematochezia along with thrombocytopenia, increased PTT and aPTT. [ncbi.nlm.nih.gov]

• Meningism

  […] for pathogens implicated in viral meningitis. [ncbi.nlm.nih.gov]

  Varicella-Zoster Virus/Chickenpox Aseptic meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. [lecturio.com]

  Epidemics of viral meningitis caused by echovirus 6 and 30 in Korea in 2008. Virol J. 2012 Feb 15. 9:38. [QxMD MEDLINE Link]. Guan H, Wang J, Wang C, Yang M, Liu L, Yang G, et al. [emedicine.medscape.com]

  Postmortem findings in two neonates showed massive hepatic necrosis, aseptic meningitis, and varying amounts of adrenal and renal hemorrhage with necrosis. [jamanetwork.com]

  Polymorphonuclear pleocystosis of the cerebrospinal fluid (CSF) sometimes suggested bacterial meningitis, so that antibiotics were given in 38% of cases. [adc.bmj.com]

• Headache

  Abstract Forty-six people became ill with vomiting, diarrhoea and headache within days of an outdoor swimming pool opening for the summer season in a small seaside village. During the weekend of the outbreak, 185 tickets to the pool had been sold. [ncbi.nlm.nih.gov]

  A 40-year-old Caucasian woman was admitted to our hospital with high fever, intense frontal headache, multiple episodes of vomiting, rash, and myalgias that had started 2 days prior to her admission. [ejinme.com]

  Fever and myalgias with clinical defervescence followed by reappearance of fever and headache herald the onset of meningitis, similar to what is observed in poliomyelitis. Meningismus, when present, varies from mild to severe. [emedicine.medscape.com]

  Symptoms include fever, muscle pain, sore throat, gastrointestinal distress, and headache. Abdominal discomfort may also be reported in some patients. Enteroviruses are by far the most common causes of aseptic meningitis in children. [getwellstaywellathome.com]

  […] cause for the headache was evident. [health.gov.au]

• Seizure

  […] between seizure episodes. [ncbi.nlm.nih.gov]

  Symptoms include lethargy, drowsiness, personality changes, seizures, paresis, and coma. [emedicine.medscape.com]

  Encephalitis may present with mild symptoms such as headache, fever, fatigue, and muscle and joint pain or with severe symptoms such as seizures, altered consciousness, and paralysis. [lecturio.com]

  […] meningitis distinguishing factor CSF with decreased glucose and increased protein Treatment Management approach mainstay of treatment is supportive care Conservative supportive care indication all patients modalities hemodynamic support Complications Seizures [medbullets.com]

  More frequent observable symptoms of aseptic meningitis in these patients included fever (78%), seizures (44%), vomiting (44%), and other symptoms that are shown in Table 1. [jjmicrobiol.com]

• Guillain-Barré Syndrome

  However, this view changed when echoviruses were later frequently isolated from patients suffering from a range of serious human diseases including aseptic meningitis, encephalitis and Guillain–Barré syndrome. [culturecollections.org.uk]

  Guillain-Barré syndrome has been reported rarely in patients infected with echovirus serotypes 6, 7, [20] and 22. Transverse myelitis has been reported with echovirus 2, 5, 18, [21] 19, 25, and 30 [22]. [emedicine.medscape.com]

• Lethargy

  Symptoms include lethargy, drowsiness, personality changes, seizures, paresis, and coma. [emedicine.medscape.com]

  Generalized Disease of the Newborn Neonates often present with an illness resembling bacterial sepsis, with fever, irritability, and lethargy. [doctorslounge.com]

  When to Call Your Pediatrician Call your pediatrician if your child complains of neck pain, chest pain, difficulty breathing, listlessness, or lethargy. [healthychildren.org]

There aren’t currently any antiviral treatments available for echovirus infection, but research is being conducted on possible treatments. Usually, there are no long-term complications. [healthline.com]

Your specific treatment will depend on your symptoms, but may include: Breathing support — using treatments like supplemental oxygen and mechanical ventilation, your doctor can make sure your body is getting enough oxygen Medication to reduce inflammation [webmd.com]

Treatment No specific treatment for echovirus infection is currently available. Care is directed at relief of symptoms. [bionity.com]

Immune system treatment called IVIG may help people with severe ECHO virus infections who have a weakened immune system. Antibiotics are not effective against this virus, or any other virus. [medlineplus.gov]

Form a definitive diagnosis and create the best treatment plans possible using evidence-based recommendations and expert guidance from world authorities. [books.google.de]

Prognosis for neonates with enterovirus hepatitis and coagulopathy. Pediatr Infec Dis J. 2001;20:758–763. Cited Here 2. Chen CA, Tsao PN, Chou HC, Hsieh WS, Huang LM. Severe echovirus 30 infection in twin neonates. [journals.lww.com]

Your doctor will make specific decisions on your treatment and individual prognosis, depending on your other conditions and the symptoms you experience. [webmd.com]

Older children and adults have a better prognosis. Myocarditis is the most frequent complication in adults. Echovirus infections can occur in people of all age groups. [bionity.com]

ECHO virus can be identified from: Rectal culture Spinal fluid culture Stool culture Throat culture Outlook (Prognosis) People who have the less severe types of illness should recover completely without treatment. [account.allinahealth.org]

Enterovirus infections in acute pancreatitis—a possible etiological connection.Scand. J. Gastroenterol. 1976; 11: 645-649 Monif G.R. Lee C.W. Hsiung G.D. Isolated myocarditis with recovery of ECHO type 9 virus from the myocardium.New Engl. J. [ejinme.com]

Laboratory results obtained showed a white blood cell count of 18.500/μL (31% segmented neutrophils, 20% band forms, 12% metamyelocytes), C-reactive protein (CPR) Potential indicators of an enteroviral etiology 1 include presentation during summer and [journals.lww.com]

Aseptic Meningitis and Encephalitis Enteroviruses are the cause of up to 90% of cases of aseptic meningitis in children and young adults in which an etiologic agent can be identified. [doctorslounge.com]

Seventy-five cases of IUFD of unknown etiology during a five-year period were retrospectively tested for enterovirus in the amniotic fluid samples. [virologyj.biomedcentral.com]

Etiology of Multiple Non-EV71 and Non-CVA16 Enteroviruses Associated with Hand, Foot and Mouth Disease in Jinan, China, 2009-June 2013. PLoS One. 2015. 10 (11):e0142733. [QxMD MEDLINE Link]. [emedicine.medscape.com]

The epidemiologic features of type 22 echovirus infections with regard to age and seasonal distribution, contagiousness and a relative lack of protection by neutralizing antibodies differed from most enterovirus infections. [pubmed.ncbi.nlm.nih.gov]

The results of the epidemiological investigation are given in Table 2. [health.gov.au]

Epidemiology Frequency United States Echoviruses are common and are associated with both epidemic and endemic patterns of infection in individuals of all ages. [emedicine.medscape.com]

Ehrnst, A. and Erikson, M. (1993): Epidemiological features of type 22 echovirus infection. Scand. J. Infect. Dis., 25, 275-281. Joki-Korpela, P. and Hyypia, T. (1998): Diagnosis and epidemiology of echovirus 22 infections. Clin. Infect. [www0.nih.go.jp]

Urea Cycle Disorders: Diagnosis, Pathophysiology, and Therapy. Adv Pediatr. 1996;43:127-70. Mazzella M, Cerone R, Bonacci W, Caruso U, Munnich A, Rustin P, et al. [ama.ba]

Pathophysiology Human echoviral infection occurs via fecal-oral transmission. Host susceptibility depends on the presence of specific cellular membrane receptor proteins that bind different enteroviral types along taxonomic lines. [emedicine.medscape.com]

You can help prevent the spread of the virus simply by keeping your hands and your environment clean. [healthline.com]

[…] and Treatment There are no vaccines or known ways to completely prevent the spread of echoviruses like echovirus 11. [webmd.com]

Prevention The predominantly mild symptoms and the ubiquitous nature of these infections, means that preventative measures are not usually necessary or recommended. Back to Top [hps.scot.nhs.uk]

Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization [books.google.com]

Healthcare workers should monitor health conditions of neonates and enhance infection control measures in baby rooms to prevent from spreading of infections. [cdc.gov.tw]