The present review summarizes the current knowledge on clinical presentation, diagnosis and prognosis. Tumors secreting GHRH are neuroendocrine tumors, usually well differentiated and mainly from pancreatic or bronchial origin. [semanticscholar.org]

Ectopic pituitary adenoma presenting as midline nasopharyngeal mass. Ir J Med Sci 2010;179:593-5 - Warczy,ska A, Zieli,ski G, Koziarski A, Podgórski JK. Ectopic pituitary adenoma. Case report and review of literature. [cuerpomedico.hdosdemayo.gob.pe]

(See Presentation .) Growth hormone and insulinlike growth factor GH is necessary for normal linear growth. [emedicine.medscape.com]

Raynaud's disease is present in one-third of cases. [ncbi.nlm.nih.gov]

• Hodgkin Lymphoma

  Acromegaly caused by secretion of growth hormone by a non-Hodgkin's lymphoma. N Engl J Med. 2000; 342 :1871–6. doi: 10.1056/NEJM200006223422504. [ PubMed ] [ CrossRef ] [ Google Scholar ] Seth J, Ellis A, Al-Sadie R. [ncbi.nlm.nih.gov]

• Osteophyte

  Vertebral enlargement, widened intervertebral spaces and osteophyte formation also being observed. [ncbi.nlm.nih.gov]

(See Presentation and Workup .) Robert Wadlow, 19 years of age, with his father (postcard photo prior to 1937). Courtesy of Wikimedia Commons (https://commons.wikimedia.org/wiki/File:Robert_Wadlow_postcard.jpg). [emedicine.medscape.com]

• Polyps

  Most studies suggest that as many as 30% of patients may have a premalignant colon polyp at diagnosis and that as many as 5% may have a colonic malignancy. [21] In studies, polyps were generally multiple and proximal to the splenic flexure, making them [emedicine.medscape.com]

  As colon cancer may be the consequence of colon polyps degeneration, many studies have been done to assess the prevalence of colon polyps in patients with acromegaly. [ncbi.nlm.nih.gov]

Effect of different dopaminergic agents in the treatment of acromegaly. J Clin Endocrinol Metab 1997;82:518-23. Abs R, Verhelst J, Maiter D, et al. Cabergoline in the treatment of acromegaly: a study in 64 patients. [medigraphic.com]

Currently, if surgical treatment fails to cure acromegaly, medical treatment with somatostatin analogs is recommended rather than radiotherapy. [ncbi.nlm.nih.gov]

(See Prognosis, Treatment, and Medication .) [emedicine.medscape.com]

It contains information on symptoms, proper testing, how to get a diagnosis, and the treatment options that are available. It also includes Pituitary Network Association's patient resource listings for expert medical care. [pituitary.org]

American Association of clinical Endocrinologists Medical Guidelines for clinical Practice for the Diagnosis and Treatment of Acromegaly Endocrine Practice Vol 10 N° 3 May /june 2004 (214-225). - Etxabe J, Gaztambide S. La Torre P et al. [cuerpomedico.hdosdemayo.gob.pe]

The present review summarizes the current knowledge on clinical presentation, diagnosis and prognosis. Tumors secreting GHRH are neuroendocrine tumors, usually well differentiated and mainly from pancreatic or bronchial origin. [semanticscholar.org]

(See Prognosis, Treatment, and Medication .) [emedicine.medscape.com]

High GH/IGF-I concentrations, arterial hypertension, and cardiomyopathy are factors in a poor prognosis, while the duration of symptoms and other factors (diabetes, lipid disorders and cancer) are less important [ 30 ]. [ncbi.nlm.nih.gov]

(See Pathophysiology and Etiology .) GH acts indirectly, by stimulating the formation of IGF hormones (also called somatomedins). [emedicine.medscape.com]

Etiology [ 34, 35 ] Acromegaly of pituitary origin More than 95% of patients with acromegaly have a benign monoclonal pituitary adenoma which develops from the somatotrope cells that normally produce GH in the pituitary. [ncbi.nlm.nih.gov]

Acromegaly: an epidemiological study. J. Endocrinol Invest 1993. 16: 181 – 189. - Guerra García R. Vásquez C (1979) Mayor prevalencia de acromegalia en los sisbib.unmsm.edu.pe/Bv Revista/Acta Andina/V09. - Krepostman Unger, Abraham. [cuerpomedico.hdosdemayo.gob.pe]

Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry. European Journal of Endocrinology 2004;151:439-46. Philippe C and Sylvie S. Acromegaly Orphanet. [medigraphic.com]

Systemic complications of acromegaly: epidemiology, pathogenesis, and management. [ncbi.nlm.nih.gov]

Epidemiology Gigantism is extremely rare, with approximately 100 reported cases to date. [emedicine.medscape.com]

(See Pathophysiology and Etiology .) GH acts indirectly, by stimulating the formation of IGF hormones (also called somatomedins). [emedicine.medscape.com]

Author Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public [emedicine.medscape.com]

Treatment is aimed at correcting (or preventing) tumor compression by excising the disease-causing lesion, and at reducing GH and IGF-I levels to normal values. Transsphenoidal surgery is often the first-line treatment. [ncbi.nlm.nih.gov]