[…] and pedunculated fibromas (ie, skin tags) Hypertrichosis Oily skin (acne is not common) Hyperpigmentation (40% of patients) Acanthosis nigricans (a small percentage of patients) Excessive eccrine and apocrine sweating Breast tissue becoming atrophic; galactorrhea [emedicine.medscape.com]

widely spaced teeth, bone proliferation in extremities, soft tissue thickening, hyperhidrosis, macroglossia, headache, amenorrhoea, impotence, somnolence, moodiness, glucose intolerance, cardiomegaly with heart failure (acromegalic heart disease), hypertension [medical-dictionary.thefreedictionary.com]

Insulin resistance and diabetes may also play a role in the onset of hypertension [ 20, 21 ]. Sleep apnea syndrome is likely to contribute also to the pathogenesis of hypertension. [ncbi.nlm.nih.gov]

Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance. [medigraphic.com]

[…] necessarily correct the disorder Cardiovascular complications A study by Berg et al found an increased prevalence of cardiovascular risk factors in patients with acromegaly compared with controls. [1] Cardiovascular complications include the following: Hypertension [emedicine.medscape.com]

Enlargement of the lower lip and nose (the nose takes on a triangular configuration) Wide spacing of the teeth and prognathism Cutis verticis gyrata (ie, furrows resembling gyri of the scalp) [6] Small sessile and pedunculated fibromas (ie, skin tags) Hypertrichosis [emedicine.medscape.com]

Skin thickening is due to glycosaminoglycan deposition and to increased collagen production by connective tissue. Skin tags are frequent and may be a marker of colonic polyps. Raynaud's disease is present in one-third of cases. [ncbi.nlm.nih.gov]

The arthralgia is mainly mechanical, degenerative, non-inflammatory in origin but features of osteoarthritis may develop in some patients. Joint mobility (especially of the shoulders) can be limited in the later stages of the disease. [ncbi.nlm.nih.gov]

A gonadotrope deficiency will cause sexual dysfunction and decreased plasma testosterone levels in men, and menstrual disorders in women (amenorrhea in some cases) together with a decline in estradiol levels (without rise in gonadotrophin levels). [ncbi.nlm.nih.gov]